CN211222080U

CN211222080U - Equipment suitable for preparing nerve conduit

Info

Publication number: CN211222080U
Application number: CN201922047608.0U
Authority: CN
Inventors: 尹志华; 胡斌; 戴红莲; 高建桂
Original assignee: Hubei Joye 3d High-Tech Co ltd
Current assignee: Hubei Joye 3d High-Tech Co ltd
Priority date: 2019-11-25
Filing date: 2019-11-25
Publication date: 2020-08-11
Anticipated expiration: 2029-11-25

Abstract

The embodiment of the utility model discloses equipment suitable for preparing nerve conduit, including frame and stand, the upper surface of frame transversely installs drive belt, coarse adjusting hand wheel, fixing base connecting plate and tailstock slide, installs apical axis tailstock and fine adjusting hand wheel on the tailstock slide, and the fixed mounting is installed to the fixing base connecting plate, installs the chucking dish on the fixed mounting, the chucking is gone up the card and is equipped with the shaping axle on the chucking dish; the screw extruder is characterized in that an extrusion hole of an extrusion head of the screw extruder is vertically and correspondingly arranged with a forming shaft, the screw extruder is arranged on an extruder Y-axis module through an extruder Y-axis sliding seat, the extruder Y-axis module is connected with an extruder X-axis sliding seat, the extruder X-axis sliding seat is arranged on an extruder X-axis sliding table, and the extruder X-axis sliding table is fixed at the top of the upright column. The equipment suitable for preparing the nerve conduit overcomes the problems of support, non-smoothness and difficult forming when the traditional additive manufacturing process is used for manufacturing the thin-wall long-tube nerve conduit, and the printed conduit has high strength and can be repeatedly customized.

Description

Equipment suitable for preparing nerve conduit

Technical Field

The utility model relates to an additive manufacturing field especially relates to an equipment suitable for preparation nerve pipe.

Background

The existing safe and effective method for treating the severe defects of the two severed ends of the peripheral nerve is autologous nerve transplantation and allogeneic nerve transplantation, but the problems are large, the autologous nerve transplantation faces the problems of difficult matching of transplanted nerves, loss of sensory functions of supply areas and the like, the allogeneic nerve transplantation is mainly used for repairing long-segment nerve defects, but an immunosuppressant is needed after operation, and the chance of infection and inflammation of a patient is increased. In view of the limitation of nerve transplantation, the manufacture of nerve conduits to repair peripheral nerve defects has become a hot research topic.

Currently, nerve conduits are mostly manufactured based on an electrospinning process. The electrostatic spinning process needs several kilovolts due to high voltage, so the equipment cost and the use cost are expensive and are not suitable for industrial production; in addition, the electrostatic spinning process is influenced by a plurality of factors such as polymer parameters, solvent parameters, solution parameters, process control parameters, environmental parameters and the like, the manufacturing process is not easy to control, and the repeatability is low, so that the effect of manufacturing the nerve conduit is influenced.

The nerve conduit is the thin wall long tube, when adopting traditional vibration material disk manufacturing process to print the nerve conduit, if the level is placed and is printed, need print the inside and outside support of nerve conduit, follow-up demolish the smooth nature that the support reduces the inside and outside wall of nerve conduit easily to because the nerve conduit is thin wall structure, demolish and support and destroy its integrality easily. If the vertical printing is carried out, because the traditional material increase manufacturing process is contact type layer-by-layer printing, an upper layer needs to be in contact with a lower layer during printing, the nerve conduit is a thin-walled long tube, the upper layer is easy to scrape the lower layer during printing, printing drift is caused, the printing quality is influenced, the nerve conduit is stressed axially during use, and because a layer-by-layer printing mode is adopted, the strength between layers of the printed nerve conduit is not enough, and the nerve conduit is easy to break, so the traditional material increase manufacturing process is limited.

SUMMERY OF THE UTILITY MODEL

The embodiment of the utility model provides a technical problem that will solve lies in, to adopting electrostatic spinning technology to make the nerve pipe, the expense is expensive, can not industrial production, and the manufacturing process is wayward, and repeatability is low, and adopts traditional vibration material disk (vibration) manufacturing process to print the nerve pipe, destroys its integrality easily, and the easy cracked problem is not enough in intensity, has provided an equipment suitable for preparing the nerve pipe.

In order to solve the technical problem, an embodiment of the present invention provides an apparatus suitable for preparing a nerve conduit, including a frame and a screw extruder; the machine frame comprises a machine base and a stand column vertically connected to the machine base, a transmission belt is transversely installed on the upper surface of the machine base and is connected with a rough adjusting hand wheel, two rough adjusting hand wheels are respectively installed at two ends of the machine base, a fixed seat connecting plate and a tailstock sliding seat are both arranged on the transmission belt and are in sliding connection with the transmission belt, a tailstock fixing rod is arranged on the tailstock sliding seat and controls the tailstock sliding seat to loosen and fix on the transmission belt, a top shaft tailstock and a fine adjusting hand wheel are installed on the tailstock sliding seat, the fine adjusting hand wheel is connected with the end part of the top shaft tailstock, a fixed seat fixing rod is arranged on the fixed seat connecting plate and controls the fixed seat connecting plate to loosen and fix on the transmission belt, a fixed seat is fixedly installed on the fixed seat connecting plate, a clamping disc is installed at one end of the fixed seat facing the top shaft tailstock, a forming shaft is clamped on the, the clamping disc rotating motor is fixed on the fixed seat, and a motor shaft of the clamping disc rotating motor penetrates through the fixed seat to be connected with the clamping disc to drive the clamping disc and the forming shaft to rotate; the top and the bottom of screw extruder are connected respectively and are provided with extruder motor and extrude the head, the extrusion hole of extruding the head corresponds the setting from top to bottom with the shaping axle, screw extruder passes through extruder Y axle slide and installs on extruder Y axle module, extruder Y axle module is connected with extruder X axle slide, extruder X axle slide is installed on extruder X axle slip table, extruder X axle slip table is fixed in the top of stand, the one end connection of extruder X axle slip table has extruder X axle motor, the motor shaft and the extruder X axle slide of extruder X axle motor are connected.

The fine adjustment hand wheel is connected with one end, far away from the forming shaft, of the tail seat of the top shaft.

Wherein, be provided with the bayonet socket on the apical axis tailstock, the tip of shaping axle inserts in the bayonet socket and pushes up with the apical axis tailstock tightly.

The two upright columns are arranged on the base at intervals and are arranged on the base in parallel, and the tops of the two upright columns are fixedly connected with the two ends of the X-axis sliding table of the extruder respectively.

The forming shaft is sleeved with the sleeve, the sleeve is axially provided with a plurality of small gaps, when the forming shaft is installed, the gaps on the sleeve are expanded and enlarged without influencing material forming, the sleeve is taken down from the forming shaft after printing is finished, the gaps on the sleeve are contracted and reduced, and the printed nerve conduit is conveniently taken down.

Implement the embodiment of the utility model provides a, following beneficial effect has: the device is suitable for preparing the nerve conduit, overcomes the problem of higher voltage required by the manufacturing of the electrostatic spinning process, has low equipment cost and use cost, and is suitable for industrial production; the electrostatic spinning process is influenced by multiple factors such as polymer parameters, solvent parameters, solution parameters, process control parameters, environmental parameters and the like, and the manufacturing process of the process method is easy to control; the problem that the thin-wall long-tube nerve conduit is supported, unsmooth and not easy to form when manufactured by a traditional additive manufacturing process is solved, the forming shaft and the sleeve provide a supporting function, printing support is not needed, the forming shaft and the sleeve rotate, and forming is easier in the printing process. The problems that the strength between nerve conduit layers is not enough and the nerve conduit layers are easy to break caused by printing of the traditional additive manufacturing process are solved, and the nerve conduit with high axial strength is printed through a new process; due to the stability of the mechanical structure of the equipment and the high precision of the control system, the equipment has high repeatability and can realize personalized customization; because the code editability of the control system in the device is high, the setting can be easily changed, the multi-specification multi-material forming is realized, and the defects of high speciality and low controllability of the electrostatic spinning device are overcome.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic front view of an apparatus for preparing a nerve conduit according to the present invention;

fig. 2 is a schematic side view of an apparatus for preparing a nerve conduit according to the present invention;

fig. 3 is a schematic top view of an apparatus for preparing a nerve conduit according to the present invention;

FIG. 4 is a print trajectory with the forming shaft rotating clockwise and the extrusion head moving to the right;

FIG. 5 is a print trace of the movement of the extrusion head to the left with the forming shaft rotating counterclockwise after the movement of FIG. 4;

FIG. 6 is a trace of a first layer of material printed on the surface of a forming shaft;

fig. 7 shows a printing completion track of the second layer material on the surface of the forming shaft.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-3, fig. 1 is a schematic front view of an apparatus for preparing a nerve conduit according to the present invention; fig. 2 is a schematic side view of an apparatus for preparing a nerve conduit according to the present invention; fig. 3 is a schematic top view of an apparatus for preparing a nerve conduit according to the present invention. The equipment and the manufacturing process suitable for preparing the nerve conduit comprise the following steps: the device comprises an extruder X-axis motor 1, an extruder X-axis sliding table 2, an extruder motor 3, a screw extruder 4, an extrusion head 5, a stand column 6, an extruder X-axis sliding seat 7, an extruder Y-axis module 8, an extruder Y-axis sliding seat 9, a machine base 10, a transmission belt 11, a fine adjustment hand wheel 12, a top shaft tailstock 13, a tailstock fixing rod 14, a tailstock sliding seat 15, a forming shaft 16, a clamping disc 17, a fixing seat 18, a coarse adjustment hand wheel 19, a fixing seat fixing rod 20, a fixing seat connecting plate 21 and a clamping disc rotating motor 22.

The equipment suitable for preparing the nerve conduit comprises a frame and a screw extruder 4.

The frame includes frame 10 and vertical column 6 of connecting on frame 10, and the upper surface of frame 10 transversely installs drive belt 11, and drive belt 11 is connected with coarse adjusting hand wheel 19, and coarse adjusting hand wheel 19 is provided with two, installs respectively in the both ends of frame 10. In this embodiment, the connection between the rough adjustment hand wheel and the conveyor belt is made by the prior art, one end of the rough adjustment hand wheel is a hand wheel, the other end of the rough adjustment hand wheel is provided with a section of toothed shaft, the toothed shaft is inserted into the toothed hole of the belt wheel, the rough adjustment hand wheel is rotated to enable the rough adjustment hand wheel to drive the belt wheel to rotate, and the belt wheel is connected with the conveyor belt to drive the conveyor belt to.

The fixing seat connecting plate 21 and the tailstock slide seat 15 are both arranged on the transmission belt 11 and are in sliding connection with the transmission belt 11. A tailstock fixing rod 14 is arranged on the tailstock slide seat 15, the tailstock fixing rod 14 controls the tailstock slide seat 15 to loosen and fix on the transmission belt 11, a top shaft tailstock 13 and a fine adjustment hand wheel 12 are arranged on the tailstock slide seat 15, the fine adjustment hand wheel 12 is connected with one end, far away from a forming shaft 16, of the top shaft tailstock 13, and a bayonet 131 is arranged on the top shaft tailstock 13. In this embodiment, the fine setting hand wheel adopts prior art with being connected of apical axis tailstock, has one section external screw thread axle on the fine setting hand wheel, installs in the internal thread hole of apical axis tailstock, and rotatory fine setting hand wheel can let the external screw thread axle of fine setting hand wheel stretch out from the bayonet socket of the other end of apical axis tailstock, and the tight shaping axle in top as required.

Be provided with fixing base dead lever 20 on the fixing base connecting plate 21, the fixing base dead lever 20 control fixing base connecting plate 21 is loosened on drive belt 11 and is fixed, fixed mounting has fixing base 18 on the fixing base connecting plate 21, fixing base 18 is installed chucking dish 17 towards one of jackshaft tailstock 13 and is served, the card is equipped with shaping axle 16 on the chucking dish 17, the one end tip of keeping away from chucking dish 17 of shaping axle 16 inserts in bayonet 131 with jackshaft tailstock 13 top tightly. The chuck disk rotating motor 22 is fixed on the fixed seat 18, and a motor shaft thereof penetrates through the fixed seat 18 to be connected with the chuck disk 17, so as to drive the chuck disk 17 and the forming shaft 16 to rotate. The forming shaft 16 is sleeved with a sleeve 161 which is made of polytetrafluoroethylene material and has self-lubricating property inside, a plurality of tiny slits are axially arranged on the sleeve 161, when the forming shaft 16 is installed, the slits on the sleeve 161 are expanded and enlarged without influencing the forming of the material, after printing is finished, the sleeve 161 is taken down from the forming shaft 16, the slits on the sleeve 161 are contracted and reduced, and the printed nerve conduit is convenient to take down.

The top and the bottom of the screw extruder 4 are respectively connected with an extruder motor 3 and an extrusion head 5, and the extrusion holes of the extrusion head 5 and the forming shaft 16 are correspondingly arranged up and down in the extrusion holes 5 and are internally provided with a heating rod and a temperature sensor for temperature control and feedback. Screw extruder 4 is installed on extruder Y axle module 8 through extruder Y axle slide 9, extruder Y axle module 8 is connected with extruder X axle slide 7, extruder X axle slide 7 is installed on extruder X axle slip table 2, extruder X axle slip table 2 is fixed in the top of stand 6, the one end connection of extruder X axle slip table 2 has extruder X axle motor 1, extruder X axle motor 1's motor shaft is connected with extruder X axle slide 7. In other embodiments, the screw extruder 4 may be any extrusion device.

In this embodiment, there are two vertical columns 6, which are installed on the base 10 at intervals and in parallel, and the tops of the two vertical columns 6 are respectively and fixedly connected with two ends of the X-axis sliding table 2 of the extruder.

The utility model also provides a manufacturing process suitable for preparation nerve pipe, including following step:

the method comprises the following steps: the control system sends control information to drive an extruder X-axis motor, an extruder Y-axis module and a clamping disc rotating motor to start; the above motors include, but are not limited to, servo motors.

Step two: the control system moves the extrusion head to a proper position to prepare for printing according to the wall thickness requirement of the designed nerve conduit and drives the extrusion head to extrude the nerve conduit forming material;

step three: the printing position of the forming shaft is accurately positioned by manually adjusting a tailstock fixing rod, a fixing seat fixing rod, a rough adjusting hand wheel and a fine adjusting hand wheel;

step four: after the extrusion head extrudes the nerve conduit forming material, the material is coated on the sleeve of the forming shaft, and the material extruded by the extrusion head makes axial spiral motion in the axial direction of the forming shaft along with the low-speed rotation of the forming shaft and the high-speed reciprocating motion of the extrusion head in the X-axis direction;

step five: and after printing, taking down the whole sleeve from the forming shaft, and then taking down the printed nerve conduit.

Referring to fig. 4-7 (the dotted lines in the figures are the center lines of the rotating shafts), fig. 4 shows the printing trace of the forming shaft rotating clockwise and the extrusion head moving rightward; FIG. 5 is a print trace of the movement of the extrusion head to the left with the forming shaft rotating counterclockwise after the movement of FIG. 4; FIG. 6 is a trace of a first layer of material printed on the surface of the forming shaft after a plurality of cycles of the actions of FIGS. 4 and 5; FIG. 7 shows the second layer of material printed on the surface of the forming shaft after the operations of FIG. 6 are repeated for a plurality of times, wherein the forming shaft rotates counterclockwise, the extrusion head moves to the right, then the forming shaft rotates clockwise, and the extrusion head moves to the left.

In the production process, the nerve conduit with the reticular structure can be printed out after a plurality of cycles by adjusting the rotation direction of the forming shaft and the moving direction of the extrusion head according to the actual condition of a patient; the nerve conduits with different axial inclination angles can be printed by adjusting the rotating speed of the forming shaft and the moving speed of the extrusion head; controlling the thickness of the printed wall of the nerve conduit by controlling the distance between an extrusion hole on the extrusion head and the forming shaft; by selecting a proper forming shaft and the shaft diameter of the sleeve thereof, nerve conduits with different specifications and inner diameters can be printed; the control system controls the extrusion head to perform reciprocating coating back and forth to manufacture the multilayer multi-material nerve conduit; the formation of the air-break grids can be realized by controlling the extrusion amount of the extruder, and the neural growth is facilitated.

Implement the embodiment of the utility model provides a, following beneficial effect has: the device and the manufacturing process are suitable for preparing the nerve conduit, and the problem of higher voltage required by the manufacturing of the electrostatic spinning process is solved, so that the device cost and the use cost are low, and the device and the manufacturing process are suitable for industrial production; the electrostatic spinning process is influenced by multiple factors such as polymer parameters, solvent parameters, solution parameters, process control parameters, environmental parameters and the like, and the manufacturing process of the process method is easy to control; the problem that the thin-wall long-tube nerve conduit is supported, unsmooth and not easy to form when manufactured by a traditional additive manufacturing process is solved, the forming shaft and the sleeve provide a supporting function, printing support is not needed, the forming shaft and the sleeve rotate, and forming is easier in the printing process. The problems that the strength between nerve conduit layers is not enough and the nerve conduit layers are easy to break caused by printing of the traditional additive manufacturing process are solved, and the nerve conduit with high axial strength is printed through a new process; due to the stability of the mechanical structure of the equipment and the high precision of the control system, the equipment has high repeatability and can realize personalized customization; because the code editability of the control system in the device is high, the setting can be easily changed, the multi-specification multi-material forming is realized, and the defects of high speciality and low controllability of the electrostatic spinning device are overcome.

The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. An apparatus suitable for preparing a nerve conduit, comprising a frame and a screw extruder;

the machine frame comprises a machine base and a stand column vertically connected to the machine base, a transmission belt is transversely installed on the upper surface of the machine base and is connected with a rough adjusting hand wheel, two rough adjusting hand wheels are respectively installed at two ends of the machine base, a fixed seat connecting plate and a tailstock sliding seat are both arranged on the transmission belt and are in sliding connection with the transmission belt, a tailstock fixing rod is arranged on the tailstock sliding seat and controls the tailstock sliding seat to loosen and fix on the transmission belt, a top shaft tailstock and a fine adjusting hand wheel are installed on the tailstock sliding seat, the fine adjusting hand wheel is connected with the end part of the top shaft, a fixed seat fixing rod is arranged on the fixed seat connecting plate and controls the fixed seat connecting plate to loosen and fix on the transmission belt, and a fixed seat is fixedly installed on the fixed seat connecting plate, a clamping disc is mounted at one end, facing the top shaft tailstock, of the fixed seat, a forming shaft is clamped on the clamping disc, one end, far away from the clamping disc, of the forming shaft is tightly abutted against the top shaft tailstock, a clamping disc rotating motor is fixed on the fixed seat, and a motor shaft of the clamping disc rotating motor penetrates through the fixed seat to be connected with the clamping disc to drive the clamping disc and the forming shaft to rotate;

the utility model discloses a screw extruder, including screw extruder, shaping axle, screw extruder's top and bottom are connected respectively and are provided with the extruder motor and extrude the head, extrude the extrusion hole of head with the shaping axle corresponds the setting from top to bottom, screw extruder installs on extruder Y axle module through extruder Y axle slide, extruder Y axle module is connected with extruder X axle slide, extruder X axle slide is installed on extruder X axle slide, extruder X axle slide is fixed in the top of stand, the one end connection of extruder X axle slide has extruder X axle motor, the motor shaft of extruder X axle motor with extruder X axle slide is connected.

2. The apparatus of claim 1, wherein the fine adjustment hand wheel is connected to an end of the tailstock of the shaft distal from the shaping shaft.

3. The apparatus according to claim 1, wherein the tailstock of the shaft is provided with a bayonet, and the end of the shaping shaft is inserted into the bayonet to be tightly pressed against the tailstock of the shaft.

4. The apparatus according to claim 1, wherein two of the pillars are arranged on the base, spaced and parallel to each other, and the tops of the two pillars are fixedly connected to two ends of the X-axis sliding table of the extruder respectively.

5. The apparatus according to claim 1, wherein a sleeve is sleeved on the shaping shaft, a plurality of tiny slits are axially formed in the sleeve, the slits in the sleeve are expanded and enlarged when the apparatus is mounted on the shaping shaft, but the material shaping is not affected, and after the apparatus is printed, the sleeve is removed from the shaping shaft, and the slits in the sleeve are reduced, so that the printed nerve conduit can be conveniently removed.