CN211190196U - Reaction equipment for continuously producing amikacin - Google Patents
Reaction equipment for continuously producing amikacin Download PDFInfo
- Publication number
- CN211190196U CN211190196U CN201922090913.8U CN201922090913U CN211190196U CN 211190196 U CN211190196 U CN 211190196U CN 201922090913 U CN201922090913 U CN 201922090913U CN 211190196 U CN211190196 U CN 211190196U
- Authority
- CN
- China
- Prior art keywords
- intermediate layer
- reation kettle
- layer reation
- solvent
- kettle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 49
- 229960004821 amikacin Drugs 0.000 title claims abstract description 12
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 20
- 238000010924 continuous production Methods 0.000 claims abstract description 6
- 239000010410 layer Substances 0.000 claims description 27
- 239000011229 interlayer Substances 0.000 claims description 24
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- 150000002148 esters Chemical class 0.000 description 8
- 238000002444 silanisation Methods 0.000 description 5
- 239000012267 brine Substances 0.000 description 4
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
- 230000010933 acylation Effects 0.000 description 3
- 238000005917 acylation reaction Methods 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- YWMSSKBMOFPBDM-UHFFFAOYSA-N 4-carbamoylbenzenesulfonyl chloride Chemical compound NC(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 YWMSSKBMOFPBDM-UHFFFAOYSA-N 0.000 description 2
- 229960001656 amikacin sulfate Drugs 0.000 description 2
- 150000002337 glycosamines Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 238000013517 stratification Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000006884 silylation reaction Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Saccharide Compounds (AREA)
Abstract
The utility model discloses a reaction unit of continuous production amikacin, including first intermediate layer reation kettle, second intermediate layer reation kettle, third intermediate layer reation kettle, the jar is received to the solvent, the viscometer, condenser and flowmeter, first intermediate layer reation kettle goes up the bottom and is equipped with the viscometer and it passes through pipe connection third intermediate layer reation kettle, third intermediate layer reation kettle has second intermediate layer reation kettle through the pipe connection, second vacuum pump is equipped with at second intermediate layer reation kettle top, second intermediate layer reation kettle has the solvent through two pipe connections to receive the jar, be equipped with first valve on the pipeline, be equipped with second valve and condenser on another pipeline, the solvent is received the jar and is connected with first vacuum pump, the utility model discloses reaction unit is simple, can continuous production, retrieves the solvent fast, and production efficiency is high and practice thrift the cost.
Description
The technical field is as follows:
the utility model relates to a biological medicine technical field especially relates to a reaction equipment of continuous production amikacin.
Background art:
amikacin, disclosed in 1972 by Yagisawa in the journal of Antibiotics, is an aminosugar antibiotic with aminosugar and aminocyclitol structures and is used to treat a variety of bacterial infections. Since the appearance of amikacin sulfate on the market, amikacin sulfate is widely cited due to its definite therapeutic effect, and is mainly used for treating serious multidrug-resistant gram-negative bacteria such as pseudomonas aeruginosa, enterobacter and the like.
In the amikacin synthesis process, the silanization reaction involves high-temperature reaction and low-temperature layering; the preparation of active ester involves low temperature reaction and high temperature solvent recovery; the steps of low-temperature acylation condensation, acidification hydrolysis and the like involve a plurality of reaction steps, and meanwhile, a plurality of reaction equipment is needed.
The utility model has the following contents:
to the above problem, the to-be-solved technical problem of the utility model is to provide a reaction equipment of continuous production amikacin, receive jar, viscosimeter, condenser and flowmeter including first intermediate layer reation kettle, second intermediate layer reation kettle, third intermediate layer reation kettle, solvent, first intermediate layer reation kettle goes up the bottom and is equipped with viscosimeter and it passes through pipe connection third intermediate layer reation kettle, third intermediate layer reation kettle has second intermediate layer reation kettle through the pipe connection, the second vacuum pump is equipped with at second intermediate layer reation kettle top, second intermediate layer reation kettle has the solvent through two pipe connections to receive the jar, is equipped with first valve on the pipeline, is equipped with second valve and condenser on another pipeline, the solvent is received the jar and is connected with first vacuum pump.
Preferably, a flowmeter is arranged on a pipeline connecting the first interlayer reaction kettle and the third interlayer reaction kettle.
Preferably, a flowmeter is arranged on a pipeline connecting the third interlayer reaction kettle and the second interlayer reaction kettle.
The utility model discloses beneficial effect: the utility model discloses need not to change over to other equipment after the silanization liquid layering, directly heat up and carry out next batch silanization reaction. After the preparation of the active ester is finished, the temperature is raised to recover the acetone solvent, after the lower part of the active ester transfer is reacted, the acetone is directly recovered from the receiving tank to carry out the next batch of preparation of the active ester, and meanwhile, the acylation condensation and other reactions are carried out. The whole equipment is operated continuously, the production efficiency is improved, and the cost is saved by recovering the solvent.
Description of the drawings:
for ease of illustration, the invention is described in detail by the following detailed description and accompanying drawings.
Fig. 1 is a schematic view of the overall structure of the present invention.
In the figure: 1-a first interlayer reaction kettle; 2-a second interlayer reaction kettle; 3-a third interlayer reaction kettle; 4-a solvent receiving tank; 5-a first vacuum pump; 6-a condenser; 7-viscometer; 8-a flow meter; 9-a first valve; 10-a second valve; 11-second vacuum pump.
The specific implementation mode is as follows:
in order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described below with reference to specific embodiments shown in the accompanying drawings. It should be understood that the description is intended to be illustrative only and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
As shown in fig. 1, the utility model discloses a reaction unit of continuous production amikacin, receive jar 4, viscosimeter 7, condenser 6 and flowmeter 8 including first intermediate layer reation kettle 1, second intermediate layer reation kettle 2, third intermediate layer reation kettle 3, solvent, viscosimeter 7 is equipped with viscosimeter 7 and its third intermediate layer reation kettle 3 through the pipe connection in first intermediate layer reation kettle 1 upper bottom, third intermediate layer reation kettle 3 has second intermediate layer reation kettle 2 through the pipe connection, second vacuum pump 11 is equipped with at 2 tops of second intermediate layer reation kettle, second intermediate layer reation kettle 2 has solvent to receive jar 4 through two pipe connections, is equipped with first valve 9 on one pipeline, is equipped with second valve 10 and condenser 6 on another pipeline, solvent is received jar 4 and is connected with first vacuum pump 5.
Specifically, a flow meter 8 is arranged on a pipeline connecting the first interlayer reaction kettle 1 and the third interlayer reaction kettle 3, and a flow meter 8 is arranged on a pipeline connecting the third interlayer reaction kettle 3 and the second interlayer reaction kettle 2.
The working principle is as follows: and (3) opening a steam valve of the first interlayer reaction kettle 1 to perform silanization reaction, closing the steam valve after the reaction is finished, opening a cold brine valve to perform cooling stratification, and recording the reaction process and the viscosity after the cooling stratification by using a viscometer 7.
And (3) opening a cold brine valve of the second interlayer reaction kettle 2 to prepare active ester, closing the cold brine valve after the reaction is finished, opening a steam valve, opening a condenser 6 condensing system, opening a first vacuum pump 5, closing a bottom valve of the solvent receiving tank 4, and opening a second valve 10 to recover the solvent.
The flow rate was controlled by a flow meter 8, and the change in the value of the viscometer 7 was observed to introduce the silylation liquid into the third jacketed reaction vessel 3. After the introduction is finished, the bottom valve of the first interlayer reaction kettle 1 is closed, the temperature is raised, and the next batch of silanization reaction is continued.
After the acetone in the second interlayer reaction kettle 2 is recovered, starting cold brine for cooling, adding a solvent to dissolve active ester, controlling the flow rate through a flowmeter 8, allowing the active ester to flow into a third interlayer reaction kettle 3, closing a bottom valve of the second interlayer reaction kettle 2 after the acetone in the second interlayer reaction kettle 2 flows in, opening a second vacuum pump 11, and pumping the acetone to prepare the active ester in the next batch; the third interlayer reaction kettle 3 carries out reactions such as low-temperature acylation condensation, acidification and the like. And 3, discharging the feed liquid from a bottom valve after the crude amikacin is produced in the third interlayer reaction kettle 3, and preparing for the next batch of reaction.
The basic principles and the main features of the invention and the advantages of the invention have been shown and described above. It will be understood by those skilled in the art that the present invention is not limited to the above embodiments, and that the foregoing embodiments and descriptions are provided only to illustrate the principles of the present invention without departing from the spirit and scope of the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. The utility model provides a reaction unit of continuous production amikacin, a serial communication port, receive jar, viscosimeter, condenser and flowmeter including first intermediate layer reation kettle, second intermediate layer reation kettle, third intermediate layer reation kettle, solvent, first intermediate layer reation kettle goes up the bottom and is equipped with viscosimeter and its third intermediate layer reation kettle of through the pipe connection, third intermediate layer reation kettle has second intermediate layer reation kettle through pipe connection, second vacuum pump is equipped with at second intermediate layer reation kettle top, second intermediate layer reation kettle has the solvent to receive the jar through two pipe connections, is equipped with first valve on the pipeline, is equipped with second valve and condenser on another pipeline, the solvent is received the jar and is connected with first vacuum pump.
2. The reaction apparatus for continuously producing amikacin according to claim 1, wherein: and a flowmeter is arranged on a pipeline connected with the first interlayer reaction kettle and the third interlayer reaction kettle.
3. The reaction apparatus for continuously producing amikacin according to claim 1, wherein: and a flowmeter is arranged on a pipeline connected with the third interlayer reaction kettle and the second interlayer reaction kettle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922090913.8U CN211190196U (en) | 2019-11-28 | 2019-11-28 | Reaction equipment for continuously producing amikacin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922090913.8U CN211190196U (en) | 2019-11-28 | 2019-11-28 | Reaction equipment for continuously producing amikacin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211190196U true CN211190196U (en) | 2020-08-07 |
Family
ID=71883895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922090913.8U Active CN211190196U (en) | 2019-11-28 | 2019-11-28 | Reaction equipment for continuously producing amikacin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211190196U (en) |
-
2019
- 2019-11-28 CN CN201922090913.8U patent/CN211190196U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A reaction equipment for continuous production of amikacin Effective date of registration: 20220420 Granted publication date: 20200807 Pledgee: Fujian Straits bank Limited by Share Ltd. Fuqing branch Pledgor: FUJIAN KANGHONG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2022350000042 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230413 Granted publication date: 20200807 Pledgee: Fujian Straits bank Limited by Share Ltd. Fuqing branch Pledgor: FUJIAN KANGHONG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2022350000042 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A reaction equipment for continuous production of amikacin Effective date of registration: 20230418 Granted publication date: 20200807 Pledgee: Fujian Straits bank Limited by Share Ltd. Fuqing branch Pledgor: FUJIAN KANGHONG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2023350000121 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20200807 Pledgee: Fujian Straits bank Limited by Share Ltd. Fuqing branch Pledgor: FUJIAN KANGHONG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2023350000121 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A reaction equipment for continuous production of amikacin Granted publication date: 20200807 Pledgee: Fujian Straits bank Limited by Share Ltd. Fuqing branch Pledgor: FUJIAN KANGHONG BIOTECHNOLOGY Co.,Ltd. Registration number: Y2024350000040 |