CN211160249U

CN211160249U - Separation and purification device for drug synthesis

Info

Publication number: CN211160249U
Application number: CN201921609587.0U
Authority: CN
Inventors: 夏万东
Original assignee: Chengde Petroleum College
Current assignee: Chengde Petroleum College
Priority date: 2019-09-26
Filing date: 2019-09-26
Publication date: 2020-08-04
Anticipated expiration: 2029-09-26

Abstract

The utility model relates to a synthetic technical field of medicine, and a synthetic separation and purification device of using of medicine is disclosed, the power distribution box comprises a box body, the last inside wall fixedly connected with cylinder of box, a plurality of evenly distributed's separation hole is seted up to the lateral wall of cylinder, the first motor of last outside wall fixedly connected with of box, the output of first motor is rotated through first shaft coupling and is connected with first pivot, the lower extreme of first pivot runs through the last lateral wall of box and extends to inside the cylinder, and the axle wall of first pivot passes through antifriction bearing and rotates with the last lateral wall of box to be connected, the fixed cover of the axle wall of first pivot in the inside one end of cylinder has connect the spiral leaf, the last outside wall fixedly connected with of box and cylinder position corresponding feed liquor pipe. The utility model discloses can separate purification synthetic medicine fast effectively, improve the efficiency of separation and purification, save a large amount of time, convenient to use does benefit to people and uses.

Description

Separation and purification device for drug synthesis

Technical Field

The utility model relates to a pharmaceutical synthesis technical field especially relates to a separation and purification device is used in pharmaceutical synthesis.

Background

The synthetic drugs are drugs prepared by chemical synthesis or biosynthesis and the like, the chemical synthesis comprises organic synthesis and inorganic synthesis, the biosynthesis comprises total biosynthesis and partial chemical synthesis, the drug synthesis occupies an important position in the pharmaceutical industry, the synthetic drugs are widely applied in medical practice, and some synthetic drugs have similar but not identical structures with natural drugs.

At present, in the process of drug synthesis, required components in drugs need to be separated and purified, and the existing purification device is slow in separation and purification speed, needs a large amount of time, is poor in purification effect, and is not beneficial to people to use, so that the separation and purification device for drug synthesis is provided.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the existing purification device in the prior art, the speed of separation and purification is slower, needs a large amount of time, and the purification effect is relatively poor, is unfavorable for the problem that people used, and the synthetic separation and purification device that uses of a medicine that provides.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a separation and purification device for drug synthesis comprises a box body, wherein a separation barrel is fixedly connected to the upper inner side wall of the box body, a plurality of uniformly distributed separation holes are formed in the side wall of the separation barrel, a first motor is fixedly connected to the upper outer side wall of the box body, the output end of the first motor is rotatably connected with a first rotating shaft through a first coupler, the lower end of the first rotating shaft penetrates through the upper side wall of the box body and extends into the separation barrel, the shaft wall of the first rotating shaft is rotatably connected with the upper side wall of the box body through a rolling bearing, a spiral blade is fixedly sleeved at one end, located inside the separation barrel, of the shaft wall of the first rotating shaft, a liquid inlet pipe corresponding to the position of the separation barrel is fixedly connected to the upper outer side wall of the box body, a liquid storage barrel is arranged above the box body, a liquid inlet hopper is fixedly connected to the upper end of the, the utility model discloses a liquid storage tank, including liquid storage tank, connecting rod, liquid transfer barrel, piston, lower extreme fixedly connected with device box, the lower extreme of liquid transfer barrel, the lower extreme of piston, the upper end fixedly connected with device box of the left lateral wall upper end of box, the lower extreme of liquid transfer barrel and the upper end fixed connection of device box, the lower extreme of connecting rod once runs through the lower extreme of liquid transfer barrel and the upper end of device box and extends to inside, and the pole wall of connecting rod respectively with the lower extreme of liquid transfer barrel and the upper end sliding connection of device box, the internal connection of device box has reciprocating motion mechanism and is connected with the lower extreme of connecting rod through reciprocating motion mechanism, the lower extreme fixedly connected with drain pipe of box, the equal fixedly connected with supporting leg of lateral wall lower extreme about the box.

Preferably, the reciprocating mechanism comprises a second motor, a deflection plate, a connecting plate and a slide bar, the rear end of the second motor is fixedly connected with the rear inner side wall of the device box, the output end of the second motor is rotatably connected with a second rotating shaft through a second coupler, the front end of the second rotating shaft is fixedly connected with the side wall of the deflection plate, one end of the side wall of the deflection plate, far away from the second rotating shaft, is fixedly connected with the deflection rod, the lower end of the rod wall of the connecting rod is fixedly connected with the rear end of the slide bar, first strip-shaped through holes matched with the slide bar and the deflection rod are respectively formed in the side wall of the connecting plate, a second strip-shaped through hole matched with the connecting plate is formed in the right side wall of the device box, and the right end of the side wall of the connecting plate is rotatably connected.

Preferably, the inside below of box is equipped with the packing layer, the inside wall all is connected with latch mechanism and is connected with both ends about the packing layer respectively through two latch mechanism about the box, the opening corresponding with the packing layer position has been seted up to the preceding lateral wall of box, and open-ended one side border is connected with the chamber door through the hinge rotation.

Preferably, two the latch mechanism includes two fixture blocks and two bolts, two fixture block both ends in opposite directions respectively with the packing layer about both ends fixed connection, the box about the inside wall all seted up with fixture block assorted draw-in groove, the lateral wall all through first screw hole respectively with the pole wall threaded connection of two bolts about the box, and two bolt opposite directions both ends extend to the inside of two draw-in grooves respectively, two the lateral wall of fixture block all seted up with bolt assorted second screw hole.

Preferably, the packing layer is sequentially divided into an ion exchange resin layer, an aluminum oxide layer and a reversed phase C-layer from top to bottom.

Preferably, the left outer side wall of the box body is fixedly connected with a V-shaped supporting plate, and the upper end of the V-shaped supporting plate is fixedly connected with the lower outer side wall of the device box.

Compared with the prior art, the utility model provides a separation and purification device for drug synthesis possesses following beneficial effect:

1. this separation and purification device is used in medicine synthesis, through the stock solution bucket that is equipped with, the connecting pipe, change the liquid bucket, a piston, the connecting rod, the device box, mutually supporting of reciprocating motion mechanism and feed liquor pipe, can intermittent type put in synthetic medicine to the cylinder inside, through the first motor that is equipped with, first pivot, mutually supporting of spiral leaf and cylinder, can make the synthetic medicine of putting in high-speed rotatory, thereby can separate purification synthetic medicine fast effectively, improve the efficiency of separation purification, a large amount of time has been saved, it uses to be convenient for people.

2. This separation and purification device for drug synthesis through the packing layer that is equipped with, can adsorb the layering to the liquid medicine after the separation purification, improves the separation purity of medicine, improves two latch mechanism that are equipped with, people's quick replacement packing layer of can being convenient for to guarantee to the effective adsorption layering of medicine after the separation purification, and dismantle the convenience, do benefit to people and use.

The part that does not relate to in the device all is the same with prior art or can adopt prior art to realize, the utility model discloses can separate purification synthetic medicine fast effectively, improve the efficiency of separation and purification, saved a large amount of time, convenient to use does benefit to people and uses.

Drawings

FIG. 1 is a schematic structural view of a separation and purification device for drug synthesis according to the present invention;

FIG. 2 is an enlarged view of the portion A in FIG. 1;

FIG. 3 is an enlarged view of the portion B of FIG. 1;

fig. 4 is a schematic view of the position of the door of fig. 1.

In the figure: the device comprises a box body 1, a separating cylinder 2, a first motor 3, a first rotating shaft 4, a spiral blade 5, a liquid inlet pipe 6, a liquid storage barrel 7, a liquid inlet hopper 8, a connecting pipe 9, a liquid transfer barrel 10, a piston 11, a connecting rod 12, a device box 13, a liquid outlet pipe 14, supporting legs 15, a second motor 16, a deflection plate 17, a connecting plate 18, a sliding rod 19, a deflection rod 20, a packing layer 21, a box door 22, a clamping block 23, a bolt 24 and a V-shaped supporting plate 25.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

Referring to fig. 1-4, a separation and purification device for drug synthesis comprises a box body 1, a separation cylinder 2 is fixedly connected to the upper inner side wall of the box body 1, a plurality of separation holes are uniformly distributed on the side wall of the separation cylinder 2, a first motor 3 is fixedly connected to the upper outer side wall of the box body 1, the output end of the first motor 3 is rotatably connected with a first rotating shaft 4 through a first coupler, the lower end of the first rotating shaft 4 penetrates through the upper side wall of the box body 1 and extends into the separation cylinder 2, the shaft wall of the first rotating shaft 4 is rotatably connected with the upper side wall of the box body 1 through a rolling bearing, a spiral blade 5 is fixedly sleeved at one end of the shaft wall of the first rotating shaft 4, a liquid inlet pipe 6 corresponding to the position of the separation cylinder 2 is fixedly connected to the upper outer side wall of the box body 1, a liquid storage barrel 7 is arranged above the box body 1, a liquid inlet, the lower end of the liquid storage barrel 7 is fixedly connected with a connecting pipe 9, a liquid transferring barrel 10 is arranged below the liquid storage barrel 7, the upper end of the liquid transferring barrel 10 is fixedly connected with the lower end of the connecting pipe 9, the right side wall of the liquid transferring barrel 10 is fixedly connected with the left end of the liquid inlet pipe 6, a piston 11 is arranged inside the liquid transferring barrel 10, the lower end of the piston 11 is fixedly connected with a connecting rod 12, the upper end of the left outer side wall of the box body 1 is fixedly connected with a device box 13, the lower end of the liquid transferring barrel 10 is fixedly connected with the upper end of the device box 13, the lower end of the connecting rod 12 once penetrates through the lower end of the liquid transferring barrel 10 and the upper end of the device box 13 and extends to the inside, the rod wall of the connecting rod 12 is respectively connected with the lower end of the liquid transferring barrel 10 and the upper end of the device box 13 in a sliding manner, the inside of the device box, the equal fixedly connected with supporting leg 15 of lateral wall lower extreme about box 1.

The reciprocating mechanism comprises a second motor 16, a deflection plate 17, a connecting plate 18 and a slide rod 19, the rear end of the second motor 16 is fixedly connected with the rear inner side wall of the device box 13, the output end of the second motor 16 is rotatably connected with a second rotating shaft through a second coupler, the front end of the second rotating shaft is fixedly connected with the side wall of the deflection plate 17, one end of the side wall of the deflection plate 17, which is far away from the second rotating shaft, is fixedly connected with a deflection rod 20, the lower end of the rod wall of the connecting rod 12 is fixedly connected with the rear end of the slide rod 19, the side wall of the connecting plate 18 is respectively provided with a first strip-shaped through hole matched with the slide rod 19 and the deflection rod 20, the right side wall of the device box 13 is provided with a second strip-shaped through hole matched with the connecting plate 18, the right end of the side wall of the connecting plate 18 is rotatably connected with the side wall of the second strip-, and then can make deflection pole 20 deflect, deflection pole 20 deflect and can make connecting plate 18 rotate to can make slide bar 19 slide, and then can make connecting rod 12 remove downwards, connecting rod 12 removes downwards, can make piston 11 remove downwards, thereby can improve separation purity to feed liquor pipe 6 intermittent type, do benefit to people and use.

The inside below of box 1 is equipped with packing layer 21, the inside wall all is connected with latch mechanism and is connected with both ends about packing layer 21 respectively through two latch mechanism about box 1, box 1's preceding lateral wall seted up with the corresponding opening in packing layer 21 position, and open-ended one side border is connected with chamber door 22 through the hinge rotation, can adsorb the layering to the liquid medicine after the separation purification, improve the separation purity of liquid medicine, chamber door 22's lateral wall fixedly connected with sealing strip guarantees box 1's leakproofness, this is prior art.

Two latch mechanisms include two fixture blocks 23 and two bolts 24, two fixture blocks 23 opposite ends respectively with packing layer 21 about both ends fixed connection, box 1 about the inside wall all seted up with fixture block 23 assorted draw-in groove, box 1 about the lateral wall all through first screw hole respectively with two bolt 24's pole wall threaded connection, and two bolt 24 opposite ends extend to the inside of two draw-in grooves respectively, two fixture block 23's lateral wall all seted up with bolt 24 assorted second screw hole, twist and move two bolts 24, can make packing layer 21 and box 1's lateral wall separation, thereby be convenient for people dismantle the change to packing layer 21, and it is convenient to dismantle, convenient for people use.

The packing layer 21 is sequentially divided into an ion exchange resin layer, an aluminum oxide layer and a reversed phase C-18 layer from top to bottom, can effectively adsorb and stratify liquid medicines with different concentrations, improves the separation purity of the liquid medicines, and is beneficial to people.

The left outer side wall of the box body 1 is fixedly connected with a V-shaped supporting plate 25, the upper end of the V-shaped supporting plate 25 is fixedly connected with the lower outer side wall of the device box 13, supporting force of the box body 1 to the device box 13 is enhanced, and supporting is stable.

The utility model discloses in, during the use, through stock solution bucket 7 that is equipped with, connecting pipe 9, change liquid bucket 10, piston 11, connecting rod 12 and device box 13, reciprocating motion about piston 11, can make the liquid medicine of stock solution bucket 7 inner zone separation purification carry out the intermittent type feeding, it is too big to prevent to put in the liquid medicine volume, influence the separation purity of liquid medicine, through the first motor 3 that is equipped with, first pivot 4, spiral leaf 5 and cylinder 2, first motor 3 work, can make first pivot 4 rotate, thereby can make spiral leaf 5 high-speed rotation, and then can make to put in the high-speed rotation of liquid medicine, under the effect of centrifugal force, the liquid medicine of different components and concentration can be separated in proper order away, the separation rate is fast, and the separation purity is high, do benefit to people's use, through drain pipe 14 that is equipped with, can collect the liquid medicine after the separation purification.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims

1. The separation and purification device for drug synthesis comprises a box body (1) and is characterized in that a separation cylinder (2) is fixedly connected to the upper inner side wall of the box body (1), a plurality of uniformly distributed separation holes are formed in the side wall of the separation cylinder (2), a first motor (3) is fixedly connected to the upper outer side wall of the box body (1), the output end of the first motor (3) is rotatably connected with a first rotating shaft (4) through a first coupler, the lower end of the first rotating shaft (4) penetrates through the upper side wall of the box body (1) and extends into the separation cylinder (2), the shaft wall of the first rotating shaft (4) is rotatably connected with the upper side wall of the box body (1) through a rolling bearing, a spiral blade (5) is fixedly connected to one end, located inside the separation cylinder (2), of the shaft wall of the first rotating shaft (4), a liquid inlet pipe (6) corresponding to the position of the separation cylinder (2) is fixedly connected to the upper outer side wall of the box body, a liquid storage barrel (7) is arranged above the box body (1), the upper end of the liquid storage barrel (7) is fixedly connected with a liquid inlet hopper (8), the lower end of the liquid storage barrel (7) is fixedly connected with a connecting pipe (9), a liquid transferring barrel (10) is arranged below the liquid storage barrel (7), the upper end of the liquid transferring barrel (10) is fixedly connected with the lower end of the connecting pipe (9), the right side wall of the liquid transferring barrel (10) is fixedly connected with the left end of the liquid inlet pipe (6), a piston (11) is arranged inside the liquid transferring barrel (10), the lower end of the piston (11) is fixedly connected with a connecting rod (12), the upper end of the left outer side wall of the box body (1) is fixedly connected with a device box (13), the lower end of the liquid transferring barrel (10) is fixedly connected with the upper end of the device box (13), and the lower end of the connecting rod (12) once penetrates through the lower end of the liquid transferring barrel (10) and the upper, and the pole wall of connecting rod (12) respectively with the lower extreme of commentaries on classics liquid bucket (10) and the upper end sliding connection of device box (13), the internal connection of device box (13) has reciprocating motion mechanism and is connected with the lower extreme of connecting rod (12) through reciprocating motion mechanism, the lower extreme fixedly connected with drain pipe (14) of box (1), the equal fixedly connected with supporting leg (15) of lateral wall lower extreme about box (1).

2. The separation and purification device for drug synthesis according to claim 1, wherein the reciprocating mechanism comprises a second motor (16), a deflection plate (17), a connecting plate (18) and a sliding rod (19), the rear end of the second motor (16) is fixedly connected with the rear inner side wall of the device box (13), the output end of the second motor (16) is rotatably connected with a second rotating shaft through a second coupling, the front end of the second rotating shaft is fixedly connected with the side wall of the deflection plate (17), one end of the side wall of the deflection plate (17), which is far away from the second rotating shaft, is fixedly connected with a deflection rod (20), the lower end of the rod wall of the connecting rod (12) is fixedly connected with the rear end of the sliding rod (19), the side wall of the connecting plate (18) is respectively provided with a first strip-shaped through hole matched with the sliding rod (19) and the deflection rod (20), the right side wall of the device box (13) is provided with a second strip-shaped through hole matched with the connecting plate (18), and the right end of the side wall of the connecting plate (18) is rotatably connected with the side wall of the second strip-shaped through hole through a pin rod.

3. The separation and purification device for drug synthesis according to claim 1, wherein a packing layer (21) is arranged below the inside of the box body (1), the left and right inner side walls of the box body (1) are connected with clamping mechanisms and are respectively connected with the left and right ends of the packing layer (21) through the two clamping mechanisms, an opening corresponding to the packing layer (21) is formed in the front side wall of the box body (1), and a box door (22) is rotatably connected with one side edge of the opening through a hinge.

4. The separation and purification device for drug synthesis according to claim 3, wherein the two clamping mechanisms comprise two clamping blocks (23) and two bolts (24), opposite ends of the two clamping blocks (23) are fixedly connected with the left end and the right end of the packing layer (21), clamping grooves matched with the clamping blocks (23) are formed in the left inner side wall and the right inner side wall of the box body (1), the left side wall and the right side wall of the box body (1) are respectively in threaded connection with rod walls of the two bolts (24) through first threaded holes, opposite ends of the two bolts (24) extend into the two clamping grooves respectively, and second threaded holes matched with the bolts (24) are formed in the side walls of the two clamping blocks (23).

5. The separation and purification device for drug synthesis as claimed in claim 3, wherein the packing layer (21) is divided into an ion exchange resin layer, an aluminum oxide layer and a reversed phase C-18 layer from top to bottom.

6. The separation and purification device for drug synthesis according to claim 1, wherein a V-shaped support plate (25) is fixedly connected to the left outer side wall of the box body (1), and the upper end of the V-shaped support plate (25) is fixedly connected to the lower outer side wall of the device box (13).