CN211131519U - A kind of atomization inhalation drug delivery device for mice - Google Patents

Abstract

The utility model discloses an aerosol inhalation drug delivery device for mice, which comprises a cylinder body and an upper cover, wherein a containing cavity is arranged in the cylinder body, a drug inlet hole is arranged on the outer wall of the cylinder body, a first support, a second support, an annular isolation plate and a rotary motor are also arranged, the first support and the second support are arranged on the inner wall of the cylinder body, one end of the first support is provided with a mounting seat, a through hole is arranged on the mounting seat, the annular isolation plate comprises a hinged ball, an annular isolation net and a swing rod, the annular isolation net is fixedly sleeved on the hinged ball, one end of the swing rod is connected on the hinged ball, the other end of the swing rod passes through the through hole, the rotary motor is connected on one end of the second support, a sleeve is arranged on the side wall of an output shaft of the rotary motor, one end of the swing rod, which is far away from the hinged ball, is fixedly connected with the sleeve, the utility model discloses a swinging of the annular isolation plate, the difference of the drug inhalation dosage between individual mice is small, and finally, the measured biological experiment data is reliable.

Description

A kind of atomization inhalation drug delivery device for mice

technical field

The utility model relates to the field of biomedical experimental instruments, in particular to an atomization inhalation drug delivery device for mice.

Background technique

Atomization inhalation administration refers to a kind of administration method in which one or more medicaments, through a special drug delivery device, enter the lungs to exert local or systemic effects, so as to achieve the purpose of prevention, treatment or diagnosis. The medicine does not pass through the enterohepatic circulation, thus avoiding the first-pass effect of the oral medicine, avoiding the destruction of the medicine, and helping to improve the bioavailability of the medicine.

In biological and medical experiments, for mice, aerosol inhalation is the most uniform way of pulmonary drug delivery, but there are also drawbacks, such as mice easily huddled together, or some mice are in a sleep state while others are in a state of sleep. Being in a awake state makes the inhaled doses of the mice vary greatly, resulting in large errors in the biological experimental data measured between subsequent individuals, and it is impossible to carry out experimental analysis on the biological experimental data.

Utility model content

In view of the deficiencies in the prior art, the purpose of this utility model is to provide an atomized inhalation drug delivery device for mice, which enables all experimental mice to inhale drugs in a awake state through the swinging of the annular isolation plate, The difference in the dose of inhaled drug between individual mice is small, and the measured biological experimental data is reliable, so that more scientific conclusions can be made in the subsequent experimental analysis.

In order to achieve the above purpose, the present utility model provides the following technical solutions: an atomized inhalation drug delivery device for mice, comprising a cylinder body and an upper cover, the cylinder body is provided with a accommodating cavity, and the upper cover is used for sealing The accommodating cavity is detachably arranged on the cylinder body, and the outer wall of the cylinder body is provided with a medicine feeding hole that communicates with the accommodating cavity. A first bracket, a second bracket, an annular isolation plate and a rotating motor are arranged inside, the first bracket and the second bracket are sequentially arranged on the inner wall of the cylinder in the direction facing away from the upper cover, and the first bracket is far away from the inner wall of the cylinder One end is provided with a mounting seat, the mounting seat is provided with a through hole, the through hole and the cylinder are coaxially arranged, the annular isolation plate includes a hinge ball, an annular isolation net and a swing rod, the hinge ball is located in The through hole is close to the side of the upper cover, the annular isolation net is fixedly sleeved on the hinge ball, the swing rod is perpendicular to the annular isolation net, one end of the swing rod is connected to the hinge ball, and the other end passes through the pipe perforation. The motor is connected to one end of the second bracket away from the inner wall of the cylinder, the rotating motor includes an output shaft arranged coaxially with the cylinder, a sleeve is provided on the side wall of the output shaft, and the axis of the sleeve is The axis of the cylinder body is inclined and the end of the swing rod away from the hinged ball is fixedly connected to the inner wall of the sleeve. When the oscillating rod is moved, the end of the swinging rod away from the hinged ball makes a circular motion, which drives the annular isolation net to swing in an annular shape.

As a further improvement of the present invention, a spherical groove is provided on the side of the mounting seat close to the upper cover, and the hinge ball rotates along the inner wall of the spherical groove. Balls.

As a further improvement of the present utility model, a palace-style mesh plate is also provided installed on the annular isolation plate, the annular isolation mesh is provided with insertion rods, and the side of the palace-style mesh plate that is attached to the annular isolation plate is provided with There are slots for plunger insertion and recesses for accommodating hinged balls, and the side of the grid facing away from the slots is used to place mice.

As a further improvement of the present invention, a baffle plate is also provided, the baffle plate is arranged in a ring shape along the periphery of the palace mesh plate, and the baffle plate and the palace mesh plate form an accommodation groove for accommodating mice.

As a further improvement of the present invention, the cylinder body is composed of an annular cylinder wall and a bottom cover, the medicine feeding hole is arranged on the annular cylinder wall, and the outer side wall of the end of the annular cylinder wall away from the upper cover is provided with an external thread The inner surface of the bottom cover is provided with an internal thread, the cylinder wall and the bottom cover are connected by threads, and a feces collection box is placed on the side of the bottom cover facing the annular isolation plate.

Beneficial effects of the utility model: The utility model uses the swing of the ring-shaped isolation plate to make it difficult for all the mice to push together on the ring-shaped isolation net, the mice are evenly distributed on the annular isolation net, and the gas contact area with the aerosolized agent is approximately The same; secondly, the mice move from time to time, so that the mice are always kept in a awake state, avoiding the prior art that some mice are in a sleeping state while another is in a awake state, which is caused by different breathing rates. The inhaled amount of the drug changes, which eventually leads to errors in the measured biological experimental data, which is difficult to use for subsequent experimental analysis.

Description of drawings

FIG. 1 is a longitudinal cross-sectional view of a cylindrical body.

Reference numerals: 1. Cylinder body; 10. Receiving cavity; 11. Upper cover; 12. Ring-shaped cylinder wall; 120. Medicine inlet; 13. Bottom cover; 2. First bracket; Hole; 211, spherical groove; 3, second bracket; 4, annular isolation plate; 41, hinged ball; 42, annular isolation net; 421, insertion rod; 43, swing rod; 5, rotary motor; 51, output shaft; 52, casing; 6, palace grid; 60, accommodating slot; 61, slot; 62, baffle; 63, groove; 7, feces collection box.

Detailed ways

The present utility model will be described in further detail below in conjunction with the accompanying drawings and embodiments. Wherein the same parts are denoted by the same reference numerals.

Referring to FIG. 1 , an atomized inhalation drug delivery device for mice according to the present embodiment includes a cylinder body 1 and an upper cover 11 . The container is sealed in the accommodating cavity 10 and is detachably arranged on the cylinder body 1. The outer wall of the cylinder body 1 is provided with a medicine feeding hole 120 which communicates with the accommodating cavity 10. Enter the accommodating cavity 10 , the accommodating cavity 10 is provided with a first bracket 2 , a second bracket 3 , an annular isolation plate 4 and a rotating motor 5 , the first bracket 2 and the second bracket 3 are in turn facing away from the upper cover 11 . It is arranged on the inner wall of the cylinder body 1, and the end of the first bracket 2 away from the inner wall of the cylinder body 1 is provided with a mounting seat 21, the mounting seat 21 is provided with a through hole 210, Coaxially arranged, the annular isolation plate 4 includes a hinged ball 41, an annular isolation net 42 and a swing rod 43, the hinged ball 41 is located on the side of the through hole 210 close to the upper cover 11, and the annular isolation net 42 is fixedly sleeved On the hinged ball 41 , the swing rod 43 is perpendicular to the annular isolation net 42 , one end of which is connected to the hinged ball 41 , and the other end is perforated through the pipe. On one end of the inner wall, the rotating electrical machine 5 includes an output shaft 51 coaxially arranged with the cylinder body 1 , and a sleeve 52 is provided on the side wall of the output shaft 51 , and the axis of the sleeve 52 is connected to the cylinder body 1 . The axis of the swing rod 43 is set at an inclination, the end of the swing rod 43 away from the hinged ball 41 is fixedly connected with the inner wall of the sleeve 52, and the side of the annular isolation plate 4 close to the upper cover 11 is used for placing mice. When the output shaft 51 rotates, the end of the swing rod 43 away from the hinged ball 41 makes a circular motion, which drives the annular isolation net 42 to swing in an annular shape.

In the initial state of this embodiment, the upper cover 11 is sleeved on the cylinder body 1, the accommodating cavity 10 is in a sealed state, and the drug inlet pipe is connected with a drug atomizer. For the medicament atomizer with medicine function, the inner wall of the upper cover 11 is provided with a sealing rubber ring, which is sleeved on the outer wall of the cylinder body 1 through the upper cover 11, or the upper cover 11 and the cylinder body 1 are detachably connected by threads. The use process of the example is as follows: first open the upper cover 11, one end of the swing rod 43 connected to the hinge ball 41 is located in the through hole 210, and one end of the swing rod 43 away from the hinge ball 41 is fixedly connected to the inner wall of the sleeve 52, so that the swing rod 43 The shaft center of the cylinder body 1 is inclined and arranged, and the swing rod 43 is perpendicular to the annular isolation net 42, so the annular isolation plate 4 is in an inclined state with the horizontal plane, and the mice are placed one by one on the annular isolation plate 4 away from the rotating motor 5. , a number of mice are evenly distributed on the inclined annular isolation plate 4, and are mainly distributed on the annular isolation net 42, and then close the upper cover 11, the rotary motor 5 in this embodiment can be controlled by a remote control, and the rotary motor is turned on. The switch of 5 turns on the medicament atomizer at the same time, the medicament atomizer sends the medicament gas into the accommodating cavity 10 through the medicine hole, the output shaft 51 of the rotary motor 5 rotates, and the swing rod 43 is connected to the sleeve 52 on the side wall of the output shaft 51. One end makes a circular motion to drive the ring-shaped isolation net 42 to swing in a circular shape, making it difficult for all the mice to hug and push on the ring-shaped isolation net 42, and the mice move from time to time, so that the mice are always kept awake, avoiding existing In the technology, some mice are in a sleeping state, while the other is in a awake state. Due to the different breathing frequency, the inhaled amount of the drug changes, which eventually leads to errors in the measured biological experimental data, which is difficult to use in subsequent experiments. Analysis, the upper cover 11 is provided with a medicament recovery pump, and the medicament recovery pump communicates with the accommodating cavity 10 through the trachea equipped with filter cotton and wire mesh, so that the part of the aerosolized medicament that is not absorbed by the mouse can be recovered. Recycle.

As an improved specific embodiment, a spherical groove 211 is provided on the side of the mounting seat 21 close to the upper cover 11 , and the hinge ball 41 rotates along the inner wall of the spherical groove 211 . Several balls that assist the hinge ball 41 to rotate.

In this embodiment, the hinge ball 41 rotates in the spherical groove 211, and the mounting seat 21 provides a support force to the annular spacer plate 4, so that the swing of the annular spacer plate 4 is more stable; The friction between them is reduced, and the rotation of the transfer ball is more flexible.

As an improved specific embodiment, there is also provided a palace grid plate 6 installed on the annular isolation plate 4, and the annular isolation net 42 is provided with insertion rods 421, and the palace grid plate 6 is isolated from the ring. A slot 61 for inserting the rod 421 and a groove 63 for accommodating the hinged ball 41 are provided on the side where the board 4 is attached, and the side of the grid plate 6 facing away from the slot 61 is used for placing mice.

In this embodiment, by setting the palace-style screen plate 6, the mice can be placed on the palace-style screen plate 6 at one time, and then the palace-style screen plate 6 is installed on the annular isolation plate 4 by inserting the rod 421 into the slot 61. On the other hand, by setting the grooves 63, the collision between the hinged ball 41 and the grid 6 is avoided, the process of releasing the mice one by one is avoided, and the process is simplified.

As an improved specific embodiment, a baffle 62 is also provided, and the baffle 62 is arranged in a ring shape along the periphery of the palace mesh plate 6, and the baffle 62 and the palace mesh plate 6 are formed for accommodating mice accommodating slot 60.

Through the above technical solution, during the swinging process of the annular isolation plate 4 for the mouse located in the accommodating groove 60, the mouse will collide with the inner wall of the baffle plate 62, and will not be clamped between the annular isolation plate 4 and the inner wall of the cylinder 1. The safety of the mice is ensured in the gap between them.

As an improved specific embodiment, the cylinder body 1 is composed of an annular cylinder wall 12 and a bottom cover 13 , the medicine feeding hole 120 is provided on the annular cylinder wall 12 , and the annular cylinder wall 12 is at one end away from the upper cover 11 . An external thread is provided on the outer side wall of the bottom cover 13, an internal thread is provided on the inner side of the bottom cover 13, the cylinder wall and the bottom cover 13 are connected by threads, and a side of the bottom cover 13 facing the annular isolation plate 4 is placed with Feces collection box 7.

In this embodiment, the excrement of mice can be dropped to the bottom of the cover through the grid plate 6 and the annular isolation net 42. Since the bottom of the cover is detachably connected with the annular cylinder wall 12 through threads, the bottom of the cover can be removed by removing the bottom of the cover. For cleaning, for convenient cleaning, a feces collection box 7 can be placed on the bottom of the cover, and the feces collection box 7 can be removed separately for cleaning, and the bottom of the cover can be re-screwed. The feces collection box 7 can also be made of disposable materials.

The above are only the preferred embodiments of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions that belong to the idea of the present invention belong to the protection scope of the present invention. It should be pointed out that for those skilled in the art, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims (5)

1. An atomization inhalation drug delivery device for mice, characterized in that: it comprises a cylinder (1) and an upper cover (11), and an accommodation chamber (10) is provided in the cylinder (1), and the The upper cover (11) is used to seal the accommodating cavity (10) and is detachably arranged on the cylinder body (1), and the outer wall of the cylinder body (1) is provided with a medicine feeding hole (120) that communicates with the accommodating cavity (10). ), the medicine feeding hole (120) is used for the air flow of the medicine after atomization to enter the accommodating cavity (10), and the accommodating cavity (10) is provided with a first support (2), a second support (3), a ring-shaped The isolation plate (4) and the rotating motor (5), the first bracket (2) and the second bracket (3) are sequentially arranged on the inner wall of the cylinder (1) in the direction facing away from the upper cover (11). A mounting seat (21) is provided at one end of the bracket (2) away from the inner wall of the cylindrical body (1), the mounting seat (21) is provided with a through hole (210), and the through hole (210) is connected to the cylindrical body (1). ), the annular isolation plate (4) includes a hinged ball (41), an annular isolation net (42) and a swing rod (43), the hinged ball (41) is located in the through hole (210) close to the upper cover On one side of (11), the annular isolation net (42) is fixedly sleeved on the hinge ball (41), the swing rod (43) is perpendicular to the annular isolation net (42), and one end thereof is connected to the hinge ball (41). ), the other end passes through the through hole (210), the rotating motor (5) is connected to the end of the second bracket (3) away from the inner wall of the cylinder (1), and the rotating motor (5) includes a connection with the cylinder (1). The output shaft (51) is coaxially arranged in the body (1), the side wall of the output shaft (51) is provided with a sleeve (52), and the axis of the sleeve (52) is the same as the axis of the cylinder (1). The axis is inclined and arranged, the end of the swing rod (43) away from the hinge ball (41) is fixedly connected with the inner wall of the sleeve (52), and the side of the annular spacer plate (4) close to the upper cover (11) is used for When the mouse is placed, when the output shaft (51) of the rotary motor (5) rotates, the end of the swing rod (43) away from the hinged ball (41) makes a circular motion, driving the ring-shaped isolation net (42) to swing in a ring shape. 2. A kind of atomization inhalation drug delivery device for mice according to claim 1, characterized in that: a spherical groove (211) is provided on the side of the mounting seat (21) close to the upper cover (11), so that the The hinge ball (41) rotates along the inner wall of the spherical groove (211), and several balls for assisting the rotation of the hinge ball (41) are provided on the inner wall of the spherical groove (211). 3. a kind of atomization inhalation drug delivery device for mice according to claim 1, is characterized in that: also be provided with the palace grid plate (6) that is installed on the annular isolation plate (4), described annular The isolation net (42) is provided with an insertion rod (421), and a slot (61) for the insertion rod (421) to be embedded is provided on the side of the palace grid plate (6) that is fitted with the annular isolation plate (4). ) and a groove (63) for accommodating the hinged ball (41), the side of the grid plate (6) facing away from the slot (61) is used for placing mice. 4. a kind of atomization inhalation drug delivery device for mice according to claim 3, is characterized in that: also be provided with baffle plate (62), described baffle plate (62) along the palace grid plate (6) The outer periphery of the mouse is annularly arranged, and the baffle plate (62) and the grid plate (6) form an accommodation groove (60) for accommodating mice. 5. A kind of atomization inhalation drug delivery device for mice according to claim 1, is characterized in that: described cylinder (1) is made up of annular cylinder wall (12) and bottom cover (13), described The medicine feeding hole (120) is arranged on the annular cylinder wall (12), the outer side wall of one end of the annular cylinder wall (12) away from the upper cover (11) is provided with an external thread, and the inner side of the bottom cover (13) An internal thread is provided on the cylinder wall and the bottom cover (13) is threadedly connected, and a feces collection box (7) is placed on the side of the bottom cover (13) facing the annular isolation plate (4).

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