Artificial lung branch connecting structure with foolproof effect
Technical Field
The utility model relates to the technical field of medical equipment, it is comparatively concrete, involve an artifical lung branch connection structure with prevent slow-witted effect.
Background
The inhalation preparation has wide application prospect as a drug delivery mode which can target the lung and can deliver drug systemically. At present, relevant inhalation therapeutic drugs are used for treating diseases such as asthma, COPD (chronic obstructive pulmonary disease) and diabetes at home and abroad, but the inhalation therapeutic drugs are still in the imitation stage at home. The evaluation of the inhalation preparation is needed in the imitation of the inhalation preparation and the development of new drugs, and the currently in vitro evaluation and test device guided by the U.S. FDA and Chinese pharmacopoeia is the NGI (cascade impactor). The structure for in vitro evaluation test by adopting the cascade impactor comprises: the air flow outlet is connected with a vacuum pump. The agent enters the inlet through the dispersion device and is deposited at various locations of the device, and the aerodynamic diameter distribution of the agent is calculated by testing the amount of deposition at each location. The L-shaped connecting pipe is the American FDA right-angle larynx, the oral cavity and the throat of a human body are idealized into two round pipes which are connected in a right-angle mode, the structural difference between the L-shaped connecting pipe and the real human body is large, so some ideal oral cavity and throat models are developed at present, even the ideal oral cavity and throat models only comprise the oral cavity and throat structures of a respiratory system, the difference between the other respiratory structures such as a main trachea, a bronchus and the like and the real human body throat structure is not considered, and the ideal oral cavity and throat models cannot represent different groups due to the fact that the respiratory structures of different ages, sexes, race, disease history and the like are large in difference; in addition, the same person in different respiratory states has different oral cavity volumes, tongue positions, glottis sizes and the like, so that the ideal oral-laryngeal model cannot cover respiratory tracts in all different respiratory states. Moreover, the test result of the structure which adopts the traditional in-vitro evaluation test by adopting the cascade impactor is only the aerodynamic characteristics of the fine particles, and then the lung entering amount of the preparation is calculated according to the generally accepted lung entering diameter of the aerodynamic diameter less than 5 μm in the industry. However, in the real drug particle deposition, particles smaller than 5 μm are also likely to be deposited at the croup position without entering the deep lung, and the structure adopting the cascade impactor for in vitro evaluation test cannot test the deposition amount of the particles at a specific position of the respiratory tract, and has no guiding significance for the evaluation of inhalation preparations requiring the definite drug preparation deposition position.
In view of the above, in order to solve the above problems, it is urgently needed to develop a model capable of simulating the real human respiratory tract structure and improving the in vitro and in vivo correlation, so as to improve the correlation of the in vitro test result and reduce the development cost of the inhalation preparation imitation drug and the new drug. Technicians in this company intend to develop an artificial lung model based on the actual human respiratory tract structure, the artificial lung model includes all features of the human respiratory tract structure, including: the structure of the oral cavity, oropharynx, epiglottis, larynx, main bronchus and bronchus, etc. can be used as an inhalation preparation evaluation device to replace the ideal oropharynx; the artificial lung model is reconstructed based on human respiratory tract CT data, so that the respiratory tracts of different people such as age, sex, race, medical history and the like can be tested; meanwhile, the parameters of the artificial lung model can be adjusted according to different crowds and different respiratory states, so that the evaluation of inhalation preparations on different respiratory structures can be realized; the last point is that technicians of the company design the artificial lung model into a detachable and quick-connectable form, so that the accurate measurement of the deposition amount of the preparation at different fine parts of the respiratory tract can be realized, and certainly, if only one part of the artificial lung is assembled, the rapid measurement of a part of the whole assembled parts can be realized, so that different test requirements can be met; because the artificial lung provided by technicians of the company can truly and directly reflect the deposition amount of the inhaled preparation at each position of the respiratory tract, the relevance of in-vitro and in-vivo tests is improved. The artificial lung model developed by technicians of the company is adopted to carry out drug imitation evaluation before clinical test and in the development stage, so that the development time and cost can be greatly saved, the passing rate of clinical experiments is improved, and great convenience is provided for enterprises or scientific research.
Specifically, the artificial lung model developed by technicians of this company includes the following characteristic structures: oral cavity, oropharynx, epiglottis, larynx, trachea, cricoid cartilage, left main bronchus, retroapical bronchus, anterior bronchus, left superior lobar bronchus, inferior lobar bronchus, left inferior lobar bronchus, anterior basal bronchus, lateral segmental bronchus, posterior basal bronchial bronchus, right main bronchus, right superior lobar bronchus, apical bronchial bronchus, posterior segmental bronchus, right medial lobar bronchus, right inferior lobar bronchus, lateral segmental bronchus, medial segmental bronchus, lateral basal bronchial bronchus, and medial (cardiac) basal bronchial bronchus. Sometimes, for different testing requirements, the artificial lung model may also only include some of the features, such as only: oral, oropharyngeal, epiglottis and laryngeal models. In the artificial lung model, segmentation is needed from the oropharynx to the bronchus at the rear end, the segmentation principle is that at least one time of branching is needed as long as one stage of bronchus is generated, and in the artificial lung model, 20 bronchus are provided in total, so the number of the segmentation is at least 20, and the number of the segmentation can exceed 20, so that the more deposition positions can be quantitatively measured, and the more accurate the test result can be; and the adoption of the method of the segmented model can test the deposition amount of each segment independently and can also carry out combined test on the quick-connection segments.
However, due to the fact that the number of the segmented structures is large, the problems that assembly is prone to error and troublesome, and airtightness of the whole artificial lung is poor exist, so that testing efficiency is reduced, more importantly, the testing result is inaccurate directly, and the artificial lung model is deviated from the original purpose of designing the artificial lung model.
SUMMERY OF THE UTILITY MODEL
In view of the above, the above artificial lung is easy to make mistakes and is relatively troublesome to assemble. And the poor problem of gas tightness, the utility model provides an artificial lung branch structure with prevent slow-witted effect, it is including connecing public head and the female head of connecing soon, set up first spacing guide way and second locking guide way on the public head of connecing soon, set up first spacing boss and the spacing boss of second on the female head of connecing soon, first spacing boss and first spacing guide way can match, the spacing boss of second and second locking guide way can match, and the opening radian of first spacing guide way and second locking guide way is different, just so can prevent that first spacing boss and the spacing boss of second from being adorned the mistake, and all have the subassembly code on the public head of connecing soon of every artificial lung branch structure and the female head of connecing soon, can prevent to assemble the public head of connecing soon and the female head of connecing of the branch structure of difference. In addition, the quick-connection male connector is also provided with a locking guide groove, the locking guide groove has a certain inclination angle, sealing rings are arranged below a first limiting boss and a second limiting boss of the quick-connection female connector, and the sealing rings are compressed by rotating the first limiting boss and the second limiting boss in the assembling process of the quick-connection male connector and the quick-connection female connector, so that a good sealing effect is achieved.
An artificial pulmonary branch junction structure with foolproof effect, comprising: connect public head 1, the female head 2 of fast connecing, sealing washer or seal ring 3, wherein connect the end of one of them section in the segmentation of artificial lung soon 1's one end, the end of another section in the segmentation of artificial lung is connected to the one end of the female head 2 of fast connecing, and can match each other between the public head 1 of fast connecing and the female head 2 of fast connecing for the end of one of them section in the segmentation of artificial lung can with the end-to-end connection of another section in the segmentation of artificial lung, its characterized in that: the quick-connection male head main body 15 of the quick-connection male head 1 is cylindrical, a gas channel 4 penetrates through the quick-connection male head main body 15, a first limiting guide groove 11, a first locking guide groove 12, a second limiting guide groove 13 and a second locking guide groove 14 are arranged on the quick-connection male head main body 15, the first limiting guide groove 11 and the second limiting guide groove 13 are located on the outer side of the quick-connection male head main body 15 and close to the free end face 16, the first limiting guide groove 11 is connected with the first locking guide groove 12 at a position far away from the free end face 16, the second limiting guide groove 13 is connected with the second locking guide groove 14 at a position far away from the free end face 16, and the included angle between the first locking guide groove 12 and the free end face 16 is theta1The angle between the second locking guide groove 14 and the free end surface 16 is theta2(ii) a The female head main part 23 of the quick-connection female head 2 is a cylinder with an upper part hollowed, the female head main part 23 comprises a side wall 232 and a bottom plate, a gas channel 4 is arranged at the center of the bottom plate, a first limit boss 21 and a second limit boss 22 are arranged inside the side wall 232 of the female head main part 23, the width of the first limit boss 21 is equal to that of the first limit guide groove 11, and the second limit boss is arrangedThe width of the table 22 is equal to the width of the second limit guide groove 13, the first limit projection 21 can be inserted into the first limit guide groove 11 and rotate along the first locking guide groove 12, and the second limit projection 22 can be inserted into the second limit guide groove 13 and rotate along the second locking guide groove 14; the sealing ring or sealing washer 3 is located below the free end face 16 of the assembled quick connect male 1 on the upper surface 231 of the base plate of the quick connect female 2, the first limit projection 21 rotates in the first lock guide groove 12, and the second limit projection 22 compresses the sealing ring or sealing washer 3 when rotating in the second lock guide groove 14.
Further, the sealing ring or gasket 3 may be fixed to the bottom plate upper surface 231 of the quick connector female 2, or may be fixed to the free end surface 16 of the quick connector male 1.
Further, the sealing ring or gasket 3 may be fixed on the upper surface 231 of the base plate of the female quick connector 2 or the free end surface 16 of the male quick connector 1 by gluing.
Further, the free end surface of the male quick connector body 15 is a plane, and the sealing ring or the sealing gasket 3 is placed on the upper surface 231 of the bottom plate of the female quick connector 2.
Further, the upper surface 231 of the base plate of the quick coupling female head 2 is a plane or a concave surface, and when the upper surface 231 of the base plate of the quick coupling female head 2 is a plane, the sealing ring or the sealing washer 3 is directly placed on the plane of the upper surface 231 of the base plate; when the upper surface 231 of the bottom plate of the quick-coupling female head 2 is a concave surface, the concave area forms a sealing ring limiting groove 32, and the sealing ring or the sealing washer 3 is placed in the sealing ring limiting groove 32.
Further, a sealing ring limiting groove 32 is formed in the free end face of the quick-connection male head main body 15, and a sealing ring or a sealing washer 3 is placed in the sealing ring limiting groove 32 of the quick-connection male head main body 15.
Further, the sealing ring or the sealing washer 3 can use a standard circular or square sealing ring or a standard sealing washer, or can be a customized sealing ring or a customized sealing washer with an internal special-shaped opening, the shape of the special-shaped opening is consistent with the shape of the internal gas channel 4 of the quick-connection male head main body 15 and the shape of the internal gas channel 4 contacted with the upper surface 231 of the bottom plate of the quick-connection female head 2, and a better sealing effect can be realized by using the customized sealing ring or the customized sealing washer with the internal special-shaped opening.
Further, the angle θ between the first locking guide groove 12 and the free end surface 161The angle θ between the second locking guide groove 14 and the free end face 162And theta1And theta2And the angle is acute, so that better sealing effect can be realized.
Further, one or more sealing ring fixing slots 2321 are formed in the side wall 232 of the quick coupling female body 23 near the upper surface 231 of the bottom plate. When the sealing washer 3 is used, one or more sealing washer limiting bosses 31 are arranged on the outer side of the sealing washer 3, and the sealing washer limiting bosses 31 can be just matched with the sealing washer fixing clamping grooves 2321, so that the sealing washer 3 can be better fixed on the upper surface 231 of the base plate of the quick-connection female head 2.
Furthermore, each segment of the artificial lung is marked with a code, so that assembly errors of the artificial lung can be prevented, and the assembly efficiency is improved.
Therefore, adopt the utility model discloses an artifical lung branch connection structure with prevent slow-witted effect can prevent segmentation subassembly direction of connection mistake to can eliminate the influence of joint gap between the segmentation subassembly to the test result.
Drawings
FIG. 1 is a schematic diagram of the connection structure of the artificial pulmonary branch with foolproof effect in embodiment 1.
Fig. 2 is a schematic diagram of the artificial pulmonary branch junction structure with foolproof effect in embodiment 2.
FIG. 3 is a schematic diagram of the connection structure of the artificial pulmonary branch with foolproof effect in embodiment 3.
FIG. 4 is a schematic diagram of the connection structure of the artificial pulmonary branch with foolproof effect in embodiment 3.
FIG. 5 is a schematic diagram of the connection structure of the artificial pulmonary branch with foolproof effect in embodiment 3.
Fig. 6 is a schematic structural view of the quick-connect male.
The drawings are described in detail below with reference to specific embodiments.
Detailed Description
Specific embodiment example 1:
as shown in fig. 1, a schematic diagram of the artificial pulmonary branch junction structure with foolproof effect in embodiment 1 is shown, which includes: the quick-connection male head comprises a quick-connection male head 1, a quick-connection female head 2 and a sealing washer 3, wherein one end of the quick-connection male head 1 is connected with the tail end of one section of the artificial lung, one end of the quick-connection female head 2 is connected with the tail end of the other section of the artificial lung, a quick-connection male head main body 15 of the quick-connection male head 1 is cylindrical, a gas channel 4 penetrates through the quick-connection male head main body 15, a first limiting guide groove 11, a first locking guide groove 12, a second limiting guide groove 13 and a second locking guide groove 14 are arranged on the quick-connection male head main body 15, the first limiting guide groove 11 and the second limiting guide groove 13 are located on the outer side of the quick-connection male head main body 15 and close to a free end face 16, the position of the first limiting guide groove 11 far away from the free end face 16 is connected with the first locking guide groove 12, the position of the second limiting guide groove 13 far away from the free end face 16 is connected with the second locking, and the included angle between the first locking guide groove 12 and the free end surface 16 is theta1The angle between the second locking guide groove 14 and the free end surface 16 is theta2The angle theta between the first locking guide groove 12 and the free end face 161The angle θ between the second locking guide groove 14 and the free end face 162And theta1And theta2Is acute angle; the quick-connection female head main body 23 of the quick-connection female head 2 is a cylinder with a hollow upper part, the quick-connection female head main body 23 comprises a side wall 232 and a bottom plate, a gas channel 4 is arranged in the center of the bottom plate, the upper surface 231 of the bottom plate of the quick-connection female head 2 is a plane, and four sealing ring fixing clamping grooves 2321 are arranged at the position, close to the upper surface 231 of the bottom plate, of the side wall 232 of the quick-connection female head main body 23; seal for a motor vehicleThe outer side of the gasket 3 is provided with four sealing ring limiting bosses 31, the sealing gasket 3 is directly placed on the plane of the upper surface 231 of the base plate, and the sealing ring limiting bosses 31 can be just matched with the sealing ring fixing clamping grooves 2321; a first limiting boss 21 and a second limiting boss 22 are arranged inside the side wall 232 of the quick-connection female head main body 23, the width of the first limiting boss 21 is equal to that of the first limiting guide groove 11, the width of the second limiting boss 22 is equal to that of the second limiting guide groove 13, the first limiting boss 21 can be inserted into the first limiting guide groove 11 and rotate along the first locking guide groove 12, and the second limiting boss 22 can be inserted into the second limiting guide groove 13 and rotate along the second locking guide groove 14; the sealing gasket 3 is located below the free end face 16 of the assembled male quick connector 1 on the upper surface 231 of the base plate of the female quick connector 2, the first limiting projection 21 rotates in the first locking guide groove 12, and the second limiting projection 22 compresses the sealing gasket 3 when rotating in the second locking guide groove 14.
The sealing washer 3 is a customized sealing washer or sealing washer with an internal special-shaped opening, the shape of the special-shaped opening is consistent with the shape of the internal gas channel 4 of the quick-connection male head main body 15 and the shape of the internal gas channel 4 contacted with the upper surface 231 of the bottom plate of the quick-connection female head 2, and a better sealing effect can be realized by the customized sealing washer or sealing washer with the internal special-shaped opening. And each segment of the artificial lung is marked with a code, so that assembly errors of the artificial lung can be prevented, and the assembly efficiency is improved.
Specific embodiment example 2:
FIG. 2 is a schematic view of the connection structure of the artificial pulmonary branch with foolproof effect in embodiment 2; it includes: connect public head 1, the female head 2 of connecing soon, sealing washer 3, wherein connect the end of one of them section in the segmentation of artificial lung, connect the end of another section in the segmentation of artificial lung, its characterized in that in the one end of the female head 2 of connecing soon: the quick-connection male head main body 15 of the quick-connection male head 1 is cylindrical, a gas channel 4 penetrates through the quick-connection male head main body 15, and a first limiting guide groove 11, a first locking guide groove 12 and a second limiting guide groove are arranged on the quick-connection male head main body 15Spacing guide way 13, second locking guide way 14, first spacing guide way 11 and second spacing guide way 13 are located the outside of the male first main part 15 of connecing soon and are close to the position of free end face 16, first locking guide way 12 is connected to the position that first spacing guide way 11 keeps away from free end face 16, second locking guide way 14 is connected to the position that second spacing guide way 13 keeps away from free end face 16, and the contained angle of first locking guide way 12 and free end face 16 is theta1The angle between the second locking guide groove 14 and the free end surface 16 is theta2(ii) a The included angle theta between the first locking guide groove 12 and the free end surface 161The angle θ between the second locking guide groove 14 and the free end face 162And theta1And theta2Is acute angle; the quick-connection female head main body 23 of the quick-connection female head 2 is a cylinder with a hollowed upper part, the quick-connection female head main body 23 comprises a side wall 232 and a bottom plate, a gas channel 4 is arranged in the center of the bottom plate, the free end face of the quick-connection male head main body 15 is a plane, when the upper surface 231 of the bottom plate of the quick-connection female head 2 is a concave surface, a sealing ring limiting groove 32 is formed in the concave area, a sealing ring 3 is placed in the sealing ring limiting groove 32, and the sealing ring 3 is a standard circular sealing ring; a first limiting boss 21 and a second limiting boss 22 are arranged inside the side wall 232 of the quick-connection female head main body 23, the width of the first limiting boss 21 is equal to that of the first limiting guide groove 11, the width of the second limiting boss 22 is equal to that of the second limiting guide groove 13, the first limiting boss 21 can be inserted into the first limiting guide groove 11 and rotate along the first locking guide groove 12, and the second limiting boss 22 can be inserted into the second limiting guide groove 13 and rotate along the second locking guide groove 14; the sealing ring 3 is located below the free end surface 16 of the assembled quick-coupling male joint 1 and on the upper surface 231 of the bottom plate of the quick-coupling female joint 2, the first limiting boss 21 rotates in the first locking guide groove 12, and the second limiting boss 22 compresses the sealing ring 3 when rotating in the second locking guide groove 14.
Wherein, all mark the code on each segmentation of artifical lung, can prevent the subassembly equipment mistake of artifical lung, promote the packaging efficiency.
Specific embodiment example 3:
fig. 3 is a schematic diagram of the artificial pulmonary branch junction structure with foolproof effect in embodiment 3. The only difference between the artificial lung branch connection structure with foolproof effect in this technical solution and the specific embodiment 2 is that the sealing ring limiting groove 32 is disposed on the free end surface of the quick-coupling male connector main body 15, and the upper surface 231 of the bottom plate of the quick-coupling female connector 2 is a plane, so this solution is not described again.
Specific embodiment example 4:
fig. 4 is a schematic diagram of the artificial pulmonary branch junction structure with foolproof effect in embodiment 4. The only difference between the foolproof artificial lung branch connecting structure in this technical solution and the specific embodiment 2 is that the sealing ring 3 is a customized sealing ring with an inner specially-shaped opening, and the shape of the specially-shaped opening is consistent with the shape of the inner gas channel 4 of the male quick connector main body 15 and the shape of the inner gas channel 4 contacted with the upper surface 231 of the bottom plate of the female quick connector 2. Therefore, the scheme is not described in detail.
Specific embodiment example 5:
fig. 5 is a schematic diagram of the artificial pulmonary branch junction structure with foolproof effect in embodiment 5. The only difference between the foolproof artificial lung branch connecting structure in this technical solution and the specific embodiment 3 is that the sealing ring 3 is a customized sealing ring with an inner specially-shaped opening, and the shape of the specially-shaped opening is consistent with the shape of the inner gas channel 4 of the male quick connector main body 15 and the shape of the inner gas channel 4 contacted with the upper surface 231 of the bottom plate of the female quick connector 2. Therefore, the scheme is not described in detail.
The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.