CN210863698U - Differential dissolving device for simulating internal dissolving and absorption of oral medicinal preparation - Google Patents
Differential dissolving device for simulating internal dissolving and absorption of oral medicinal preparation Download PDFInfo
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Abstract
The utility model discloses a differential dissolving device for simulating the dissolution and absorption in the body of an oral medicinal preparation, which comprises a dissolving container, an infusion device and a sampling device, wherein the infusion device comprises a medium storage, a liquid inlet pump and a liquid inlet pipeline; two ends of the liquid inlet pipeline are respectively communicated with the medium reservoir and a liquid inlet of the dissolution container so as to pump the solvent medium in the medium reservoir into the dissolution container; the sampling device is used for collecting a dissolved sample; at least two layers of filter sheets are arranged between the medicine and the liquid outlet in the dissolving-out container along the flowing direction of the solvent medium, and the aperture of each layer of filter sheet is gradually reduced along the flowing direction of the solvent medium. The utility model discloses because of the filtration pore of each layer filter disc reduces along menstruum flow direction gradually, plays filterable effect step by step to the menstruum that has dissolved the medicine, not only can solve the easy problem of blockking up of sampling pipeline, but also the sample of collecting can on-line measuring, need not to do other filtration again.
Description
Technical Field
The utility model belongs to the technical field of medicine degree of dissolving out is experimental, especially, relate to a differential dissolving out device that internal dissolving out of simulation oral drug preparation is dissolved out and is absorbed.
Background
In vitro dissolution studies of oral solid formulations not only play an irreplaceable role in their development and quality control of the final product, but are also the basis for establishing In Vivo and In Vitro Correlation (IVIVC). In conjunction with the biopharmaceutical classification system of drugs, for solid oral formulations, the main limiting factors affecting their absorption into the blood are the in vivo release of the solid formulation, the solubility of the drug, and the rate of absorption across the membrane in the gastrointestinal tract. Wherein, the in vivo dissolution rate of the BCS II medicament is slower than the transmembrane absorption rate, so that the in vivo absorption is limited by the in vivo dissolution process of the medicament, and the in vitro dissolution rate of the medicinal preparation is adjusted to be consistent with the in vivo dissolution rate, so that IVIVC can be established. However, the dissolution rate of BCS III drugs is faster than the transmembrane absorption rate, and belongs to the transmembrane absorption rate-limiting drugs, and under the condition that the difficulty of in vitro transmembrane simulation is high, the establishment of a proper IVIVC in vitro dissolution method is generally difficult.
Patent 201721212406.1 discloses a differential dissolution apparatus for simulating the dissolution and absorption of an oral pharmaceutical preparation in vivo, wherein the volume of a drug dissolution tank is about 10mL, and for poorly soluble drugs, the drug is easily accumulated at the bottom and adheres to the side wall of a flow cell, and the accumulated drug cannot be dispersed by the action of media flushing of a fluid line alone, thus limiting the application of the apparatus to the dissolution of BCS class ii drugs in vitro. On the other hand, the dissolution tank can not retain insoluble micro particles of some preparations, and the dissolution sample is not filtered thoroughly. In vitro permeability studies for BCS class iii drugs have primarily utilized cell membranes and other biological membrane systems, such as Caco-2 cells, but none of these permeability studies have provided a complex kinetic relationship between drug release and passage through an absorbent membrane. Permeability studies also have some disadvantages, such as long time consumption, animal model-based studies, mainly applicable to mechanistic studies, and inability to accurately predict drug absorption in vivo.
Based on the above situation, there is an urgent need to develop a new dissolution apparatus to dynamically simulate dissolution conditions such as digestive juice volume and hydrodynamic characteristics of different digestive tract segments in a living body, and establish in vivo and in vitro correlation of dissolution/absorption of BCS class ii and class iii drugs.
SUMMERY OF THE UTILITY MODEL
The present application is directed to solving at least one of the problems in the prior art. Accordingly, an object of the present invention is to provide a differential dissolution apparatus for simulating dissolution and absorption of an oral pharmaceutical preparation in vivo, which can prevent clogging of a pipeline.
In order to solve the technical problem, the following technical scheme is adopted in the application:
a differential dissolution apparatus for simulating in vivo dissolution and absorption of an oral pharmaceutical formulation comprising:
a dissolution vessel for dissolution of the drug;
the transfusion device comprises a medium storage, a liquid inlet pump and a liquid inlet pipeline;
the two ends of the liquid inlet pipeline are respectively communicated with the liquid inlets of the medium reservoir and the dissolution container, and the liquid inlet pump is arranged on the liquid inlet pipeline so as to pump the solvent medium in the medium reservoir into the dissolution container;
the sampling device is communicated with a liquid outlet of the dissolution container through a liquid outlet pipeline and is used for collecting a dissolution sample;
at least two layers of filter sheets are arranged between the medicine and the liquid outlet in the dissolution container along the flow direction of the solvent medium, and the aperture of each layer of filter sheet is gradually reduced along the flow direction of the solvent medium.
Furthermore, the solvent containers are multiple, the liquid inlet pipeline is divided into multiple liquid inlet branch circuits which are respectively and correspondingly communicated with the medium reservoirs through the medium selector, and liquid inlet control valves are arranged on the liquid inlet branch circuits.
Further, sampling device is including collection appearance three-way valve, collection appearance ware and waste liquid receiving flask, the one end of collection appearance three-way valve with drain pipe intercommunication, in addition both ends respectively with collection appearance ware and waste liquid receiving flask intercommunication.
Furthermore, a sample collection control valve is arranged on a pipeline between the sample collector and the sample collection three-way valve.
Further, the device also comprises a water bath, and the medium storage is placed in the water bath. Further, the liquid outlet is arranged at the top of the dissolution container, and the liquid inlet is arranged at the bottom of the dissolution container.
The device further comprises a circulating pump, wherein the inlet end of the circulating pump is communicated with a circulating loop liquid outlet on the side part of the top end of the dissolution container, and the outlet end of the circulating pump is communicated with a circulating loop liquid inlet on the side part of the bottom end of the dissolution container so as to circularly stir a solvent medium in the dissolution container.
A liquid outlet at the side part of the top end of the dissolving-out cup and a liquid inlet at the side part of the bottom end of the dissolving-out cup are provided with a circulating loop, the circulating loop is provided with a circulating pump, a liquid outlet at the side part of the top end is connected with a liquid inlet pipeline of the circulating pump, and a liquid inlet at the side part of the bottom end is connected with a liquid outlet pipeline. The liquid inlet and outlet of the circulating pipeline satisfies the principle of downward inlet and upward outlet, and can play a role in uniformly mixing the medium in the dissolution cup to the greatest extent. The circulating injection port and the medium input pipeline injection port are both arranged at the bottom of the dissolution cup, so that the requirement that the accumulated insoluble medicines can be circularly washed can be met to the maximum extent. The circulation device enables the dissolution medium with a specific volume (equivalent to the volume of the dissolution cup) to generate longitudinal circulation flow inside the dissolution tank, enhances the liquid flow scouring effect on the medicine, and simulates the fluid dynamics characteristics of digestive juice in a living body. Compared with the mechanical stirring action of the traditional differential dissolution device, the circulating action of the circulating device is weaker and is close to the real physiological condition. And the circulation loop is provided with a heat insulation sleeve for insulating the medium of the loop.
Further, dissolve out the container and include the awl end, middle barrel and the conical roof that from the bottom up connected in order, be equipped with the inert microballon in the conical roof, and its and middle barrel junction be equipped with the cassette, be equipped with the inert microballon in the awl end, and its and middle barrel junction be equipped with the cassette that prevents the medicine backward flow.
Furthermore, one end of the middle cylinder body is provided with a first bell mouth with internal threads, the conical bottom is screwed with the first bell mouth, and the filter sheet is pressed between the conical bottom and the first bell mouth;
the filter disc comprises a middle cylinder body, a second bellmouth and filter discs, wherein a connecting cylinder body is connected into the second bellmouth at the other end of the middle cylinder body through an internal thread, a third bellmouth with an internal thread is arranged at the other end of the connecting cylinder body, the conical top is connected with the third bellmouth in a screwing mode, the number of the filter discs is two, and the two layers of the filter discs are respectively pressed between the connecting cylinder body and the second bellmouth and between the conical top and the third bellmouth.
Compared with the prior art, the beneficial effects of the utility model reside in that:
1. the whole differential dissolution device is in an open working mode, the disintegration and dissolution of the drug preparation in the dissolution container are continuously carried out of the dissolution system in a differential mode by a liquid outlet pipeline after being filtered in multiple stages by multiple layers of filter sheets in the dissolution container, and the in-vivo transmembrane absorption process of the drug is simulated. Because the filtration pore of each layer of filter disc reduces along the menstruum flow direction gradually, play filterable effect step by step to the menstruum that has dissolved the medicine, not only can solve the easy problem of blockking up of sampling pipeline, but also the sample of collection can on-line measuring, need not to do other filtration processing again.
2. The dissolution container is provided with a circulating system, so that the insoluble drug stacked at the bottom of the dissolution container can achieve the effect of dispersing and uniformly mixing, and the uniform mixing of a newly-fed solvent medium and a solvent medium dissolved with the drug in the dissolution container is accelerated. Wherein, the liquid inlet is arranged at the bottom of the dissolution container, and the new solvent medium longitudinally flows from bottom to top, thus playing a role of longitudinally scouring the medicine at the bottom of the container; the one-way valve is arranged on the liquid inlet pipeline, so that the backflow of a solvent medium at the bottom of the dissolution container is effectively prevented.
3. The medium selector selects different bionic solvent media (different pH values, different surfactant concentrations and the like) at different time periods and sets the speed of the circulating pump to exert different stirring effects on the solvent media, gastrointestinal fluid, gastrointestinal peristalsis, gastrointestinal fluid hydrodynamic characteristics and the like of different digestive tract parts in a living body are simulated respectively, the dissolution behavior of the medicine is comprehensively regulated and controlled, the in-vitro dissolution process (first-order and zero-order kinetic processes and the like) and the in-vivo dissolution rate of the medicine are consistent, and the in-vivo and in-vitro correlation of the medicine dissolution is realized.
Drawings
FIG. 1 is a schematic structural diagram of the present application;
wherein: 1-a dissolution vessel; 101-cone bottom; 102-an intermediate cylinder; 103-connecting cylinder; 104-cone apex; 2-medium storage and 3-liquid inlet pump; 4-a liquid inlet pipeline; 5-a liquid outlet pipeline; 6-a filter disc; 7-a drug; 8-inert microspheres; 9-a flow-stopping filter sheet; 10-a media selector; 11-a liquid inlet branch; 12-a liquid inlet control valve; 13-sample collection three-way valve; 14-a sample collector; 15-waste liquid collecting bottle; 16-a sample collection control valve; 17-a circulation pump; 18-circulation loop liquid outlet; 19-a liquid inlet of the circulation loop; 20-a one-way valve; 21-a pipeline; 22-insulating sleeve.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
Example 1
Referring to fig. 1, a differential dissolution device for simulating in vivo dissolution and absorption of an oral drug preparation comprises a dissolution container 1, an infusion device and a sampling device, wherein the dissolution container 1 is used for dissolution of the drug, and the drug is placed in the dissolution container 1 when the drug needs to be dissolved. The transfusion device comprises a medium reservoir 2, a liquid inlet pump 3 and a liquid inlet pipeline 4; the two ends of the liquid inlet pipeline 4 are respectively communicated with the medium reservoir 2 and the liquid inlet of the dissolution container 1, the liquid inlet pump 3 is arranged on the liquid inlet pipeline 4, and the solvent medium in the medium reservoir 2 enters the dissolution container 1 from the liquid inlet of the dissolution container 1 through the liquid inlet pipeline 4 under the pumping action of the liquid inlet pump 3.
The sampling device is communicated with a liquid outlet of the dissolution container 1 through a liquid outlet pipeline 5 and is used for collecting a dissolution sample flowing out of the liquid outlet, wherein the dissolution sample is a solvent medium dissolved with a medicine.
Referring to fig. 1, at least two layers of filter sheets 6 are disposed between the drug and the liquid outlet along the flow direction of the solvent medium in the dissolution container 1 of this embodiment, and the aperture of each layer of filter sheet 6 gradually decreases along the flow direction of the solvent medium.
The whole differential dissolution device of the embodiment is in an open working mode, the disintegration and dissolution of the drug 7 in the dissolution container 1 are subjected to multi-stage filtration by the multi-layer filter sheets 6 in the dissolution container 1, and then are continuously brought out of a dissolution system in a differential form by the liquid outlet pipe 5, so that the in-vivo transmembrane absorption process of the drug is simulated. Because the filtration pore of each layer of filter 6 reduces along the menstruum flow direction gradually, play filterable effect step by step to the menstruum that has dissolved the medicine, not only can solve the easy problem of blockking up of sampling pipeline, but also the sample of collection can on-line measuring, need not to do other filtration processing again.
This example presents a specific structure of a dissolution vessel:
the dissolution container 1 comprises a conical bottom 101, a middle cylinder 102, a connecting cylinder 103 and a conical top 104 which are sequentially connected from bottom to top, wherein inert microspheres 8 are arranged in the conical top 104, a filter sheet 6 is arranged at the joint of the inert microspheres and the connecting cylinder 103, the inert microspheres 8 are also arranged in the conical bottom 101, a flow stopping filter sheet 9 for preventing medicine backflow is arranged at the joint of the inert microspheres and the middle cylinder 102, a liquid inlet is arranged on the conical bottom 101, and a liquid outlet is arranged on the conical top 104. By arranging the inert microspheres 8, the friction effect of food can be simulated, and the physiological structure condition can be more truly approached.
When the medicine is dissolved out, if the density of the medicine 7 is greater than that of the solvent medium, the medicine 7 can be directly placed on the filter sheet 9, and if the density of the medicine is less than that of the solvent medium, the medicine needs to be fixed on the flow stopping filter sheet 9 through an auxiliary clamp; because the filter disc 9 is embedded in the bottom cavity of the dissolution container 1, the medicine and the auxiliary materials in the dissolution container are filtered to prevent the medicine and the auxiliary materials from flowing back to the liquid inlet pipeline 4. In addition, the liquid inlet is arranged at the bottom of the dissolution container 1, and the new solvent medium longitudinally flows from bottom to top, so that the medicine at the bottom of the container can be longitudinally flushed, and after the medicine is dissolved, the medicine is taken away after being filtered by the filter 6 in the dissolution container 1.
It should be explained that, in practical application, one end of the middle cylinder 102 is provided with a first socket with internal threads, the conical bottom 101 is screwed with the first socket, and the flow stopping filter 9 is pressed between the conical bottom and the first socket; the connecting cylinder body 103 is connected in the second bellmouth at the other end of the middle cylinder body through an internal thread, a third bellmouth with an internal thread is arranged at the other end of the connecting cylinder body 103, the conical top 104 is screwed with the third bellmouth, the number of the filter sheets 6 is two, and the two layers of the filter sheets 6 are respectively pressed between the connecting cylinder body 103 and the second bellmouth and between the conical top 104 and the third bellmouth.
In this embodiment, the cone bottom 101, the middle cylinder 102, the connecting cylinder 103 and the cone top 104 are connected by a thread structure, so that the filter sheet 6 and the flow-stopping filter sheet 9 can be conveniently replaced by being conveniently disassembled and assembled.
Example 2
Referring to fig. 1, in this embodiment, there are a plurality of solvent containers 2, the liquid inlet pipeline 4 is divided into a plurality of liquid inlet branches 11 respectively corresponding to the medium reservoirs 2 by the medium selector 10, and each liquid inlet branch 11 is provided with a liquid inlet control valve 12. Sampling device includes collection appearance three-way valve 13, collection appearance ware 14 and waste liquid receiving flask 15, and collection appearance three-way valve 13's one end and drain pipe 5 intercommunication, both ends communicate with collection appearance ware 14 and waste liquid receiving flask 15 respectively in addition. A sample collection control valve 16 is arranged on a pipeline between the sample collector 14 and the sample collection three-way valve 13. The rest of the structure in this embodiment is the same as that in embodiment 1, and is not described herein again.
In this embodiment, a solvent medium enters the dissolution container 1 from a liquid inlet and then flows through the inert microspheres 8 to stabilize the flow, and then dissolves out the drug, and the structures such as the liquid outlet pipeline 5 and the sample collection three-way valve 13 output the dissolution sample with the dissolved drug to the sample collection device 14, and according to the difference of the specific drugs, the medium selector 10 can select different solvent media to enter the dissolution container 1 at different time periods to dissolve out the drug.
Example 3
Different from the embodiment 2, the differential dissolution apparatus of this embodiment further includes a circulation pump 17, an inlet end of the circulation pump 17 is communicated with a circulation loop liquid outlet 18 at a top end side portion of the middle cylinder, and an outlet end is communicated with a circulation loop liquid inlet 19 at a bottom end side portion of the middle cylinder 102, so as to circularly stir the solvent medium in the dissolution vessel 1.
The dissolution container of the embodiment is provided with a circulating system, so that the insoluble drug stacked at the bottom of the dissolution container 1 can achieve the effect of dispersing and uniformly mixing, and the uniformly mixing of the newly-entered solvent medium and the solvent medium dissolved with the drug in the dissolution container is accelerated. In addition, the one-way valve 20 is arranged on the liquid inlet pipeline 4, so that the backflow of the solvent medium can be effectively prevented. In order to keep the temperature of the solvent medium in the circulation loop, a heat-insulating sleeve 22 is arranged on the circulation pump 17 and the pipeline 21 of the dissolution container 1.
In this embodiment, the medium selector 10 selects different bionic solvent media (different pH, different surfactant concentrations, etc.) at different time periods and sets the speed of the circulation pump 17 to apply different stirring effects to the solvent media, so as to respectively simulate gastrointestinal fluid, gastrointestinal motility, gastrointestinal fluid hydrodynamic characteristics, etc. of different gastrointestinal tract parts in a living body, thereby comprehensively regulating and controlling the dissolution behavior of the drug, so that the in vitro dissolution process (first order, zero order kinetic process, etc.) and the in vivo dissolution rate of the drug are consistent, and the in vivo and in vitro correlation of the drug dissolution is realized.
In this embodiment, the flow rate of the circulation pump 17 is adjusted, so that the solvent medium in the middle cylinder 102 has a stirring effect, and the influence of physiological peristalsis of the gastrointestinal tract in vivo on drug dissolution can be simulated, and the longitudinal flushing effect of the liquid inlet pipeline 4 on the drug 7 makes the device more suitable for solving the problem of accumulation of large-dose insoluble drugs. If the drug 7 is more difficult to dissolve/release, it is necessary to enhance the longitudinal flow of the dissolution vessel media by adjusting the flow rate of the sample and the flow rate of the infusion.
Example 4
Unlike embodiment 3, the differential dissolution apparatus of this embodiment further includes a water bath 23, and the medium reservoir 2 is placed in the water bath 23. Different liquid inlet hoses extend into each medium storage 2 respectively to absorb the solvent medium, are connected to a liquid inlet pipeline 4 controlled by a one-way valve 20 through a medium selector 2 and are conveyed into the dissolution container 1 through a liquid inlet. The dissolution system is placed in a constant temperature water bath 23, and the solvent medium inside the dissolution system is heated and insulated.
In addition, a constant temperature insulation structure (not shown in the figure) can be arranged outside the dissolution container 1 to ensure that the solvent medium in the dissolution container 1 maintains constant temperature, so that the release medium is close to the physiological temperature of the gastrointestinal tract in vivo.
It should be noted that, for those skilled in the art, the volume of the solvent medium that can be accommodated in the dissolution vessel 1 is 50-250 mL, which is close to the actual liquid volume in the gastrointestinal tract of the living body, and provides a leak tank condition that is closer to the actual situation of the living body for dissolution of BCS class ii and class iii drugs.
Application example
The differential dissolution device can be applied to the establishment of in vivo and in vitro correlation of BCS III medicines. BCS III drugs have the characteristics of high solubility, low permeability and the like, and the permeation is the rate-limiting step of absorption. However, the permeation rate of the drug is a fixed value, and when the permeation rate is calculated, the transmembrane permeation process can be simulated by setting the in vitro output flow rate consistent with the permeation rate. The specific operation is as follows:
and (3) carrying out atrioventricular model fitting on the in-vivo data of the oral administration of the preparation, and analyzing an in-vivo absorption curve by adopting a corresponding method (Wagner-Nelson method or Loo-Riegelman method) according to different atrioventricular models. And (5) carrying out dynamic process fitting on the absorption curve to obtain a rate constant K. The required transmembrane flow rate was calculated according to the formula Cl-KV. Wherein Cl is the clearance rate, i.e. the transmembrane flow rate of the medium to be carried away in the dissolution vessel, unit: mL/min; v is the volume of the solvent medium, unit: mL; k is the removal rate, i.e. the absorption rate of the dissolved out vessel by the entrained medium, in units: min-1. For example, an absorption rate of 0.02min-1The volume of the solvent medium is 100mL, the Cl is calculated to be 2mL/min, namely the flow rate of the output medium is set to be 2mL/min, so that the in-vivo permeation rate of the in-vitro permeation rate can be reached. Because BCS III drugs have high solubility but low permeability, a differential release curve can easily reach a permeability rate limiting platform, and whether BE in a simulated preparation and a reference preparation is equivalent or not is predicted by calculating the similarity degree of the dissolution rates before the platform.
The above examples are merely illustrative of the present invention clearly and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Nor is it intended to be exhaustive of all embodiments. And obvious changes and modifications may be made without departing from the scope of the present invention.
Claims (10)
1. A differential dissolution apparatus for simulating in vivo dissolution and absorption of an oral pharmaceutical formulation comprising:
a dissolution vessel for dissolution of the drug;
the transfusion device comprises a medium storage, a liquid inlet pump and a liquid inlet pipeline;
the two ends of the liquid inlet pipeline are respectively communicated with the liquid inlets of the medium reservoir and the dissolution container, and the liquid inlet pump is arranged on the liquid inlet pipeline so as to pump the solvent medium in the medium reservoir into the dissolution container;
the sampling device is communicated with a liquid outlet of the dissolution container through a liquid outlet pipeline and is used for collecting a dissolution sample;
at least two layers of filter sheets are arranged between the medicine and the liquid outlet in the dissolution container along the flow direction of the solvent medium, and the aperture of each layer of filter sheet is gradually reduced along the flow direction of the solvent medium.
2. The differential dissolution apparatus of claim 1, wherein: the medium storage device is provided with a plurality of medium storage devices, the liquid inlet pipeline is divided into a plurality of liquid inlet branch circuits which are respectively and correspondingly communicated with the medium storage devices through the medium selector, and liquid inlet control valves are arranged on the liquid inlet branch circuits.
3. The differential dissolution apparatus of claim 1, wherein: sampling device is including collection appearance three-way valve, collection appearance ware and waste liquid receiving flask, the one end of collection appearance three-way valve with drain pipe intercommunication, in addition both ends respectively with collection appearance ware and waste liquid receiving flask intercommunication.
4. The differential dissolution apparatus of claim 3, wherein: and a sample collection control valve is arranged on a pipeline between the sample collector and the sample collection three-way valve.
5. The differential dissolution apparatus of claim 1, wherein: also included is a water bath in which the media reservoir is disposed.
6. The differential dissolution apparatus according to any one of claims 1 to 5, characterized in that: the liquid outlet is arranged at the top of the dissolving-out container, and the liquid inlet is arranged at the bottom of the dissolving-out container.
7. The differential dissolution apparatus of claim 6, wherein: the device also comprises a circulating pump, wherein the inlet end of the circulating pump is communicated with a circulating loop liquid outlet on the side part of the top end of the dissolution container, and the outlet end of the circulating pump is communicated with a circulating loop liquid inlet on the side part of the bottom end of the dissolution container so as to circularly stir a solvent medium in the dissolution container.
8. The differential dissolution apparatus of claim 7, wherein: and a heat insulation sleeve is arranged on a pipeline connecting the circulating pump and the digestion vessel.
9. The differential dissolution apparatus of claim 6, wherein: the dissolving-out container comprises a conical bottom, an intermediate cylinder and a conical top which are sequentially connected from bottom to top, wherein an inert microsphere is arranged in the conical top, the junction of the inert microsphere and the intermediate cylinder is provided with the filter sheet, the inert microsphere is arranged in the conical bottom, and the junction of the inert microsphere and the intermediate cylinder is provided with the filter sheet for preventing medicine from flowing back.
10. The differential dissolution apparatus of claim 9, wherein: one end of the middle cylinder is provided with a first bell mouth with internal threads, the conical bottom is screwed with the first bell mouth, and the filter disc is pressed between the conical bottom and the first bell mouth;
the filter disc comprises a middle cylinder body, a second bellmouth and filter discs, wherein a connecting cylinder body is connected into the second bellmouth at the other end of the middle cylinder body through an internal thread, a third bellmouth with an internal thread is arranged at the other end of the connecting cylinder body, the conical top is connected with the third bellmouth in a screwing mode, the number of the filter discs is two, and the two layers of the filter discs are respectively pressed between the connecting cylinder body and the second bellmouth and between the conical top and the third bellmouth.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112285304A (en) * | 2020-09-30 | 2021-01-29 | 深圳市锐拓仪器设备有限公司 | Flow cell device of dissolution instrument by flow cell method |
| CN113311126A (en) * | 2021-07-30 | 2021-08-27 | 湖南慧泽生物医药科技有限公司 | Dissolution instrument system for simulating in-vivo dissolution of medicine and method for detecting dissolution of medicine |
| CN113433277A (en) * | 2021-08-08 | 2021-09-24 | 湖南慧泽生物医药科技有限公司 | Circulating dissolution instrument system for in-vitro dissolution of medicine and method for detecting dissolution of medicine |
| CN113514370A (en) * | 2021-04-14 | 2021-10-19 | 广州健康元呼吸药物工程技术有限公司 | Device and method for determining one-way permeability of drug-loaded non-vascular stent drug |
| CN113777207A (en) * | 2021-09-09 | 2021-12-10 | 安徽省食品药品检验研究院(安徽国家农副加工食品质量监督检验中心) | Determination method of gliclazide sustained release tablet dissolution curve, similarity evaluation method and application thereof |
| CN114858986A (en) * | 2022-07-11 | 2022-08-05 | 湖南慧泽生物医药科技有限公司 | In-vitro dissolution method of mirabegron sustained release tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112285304A (en) * | 2020-09-30 | 2021-01-29 | 深圳市锐拓仪器设备有限公司 | Flow cell device of dissolution instrument by flow cell method |
| CN113514370A (en) * | 2021-04-14 | 2021-10-19 | 广州健康元呼吸药物工程技术有限公司 | Device and method for determining one-way permeability of drug-loaded non-vascular stent drug |
| CN113514370B (en) * | 2021-04-14 | 2024-09-27 | 广州呼吸药物工程技术有限公司 | Unidirectional permeability device and method for measuring drug-carrying non-vascular stent drug |
| CN113311126A (en) * | 2021-07-30 | 2021-08-27 | 湖南慧泽生物医药科技有限公司 | Dissolution instrument system for simulating in-vivo dissolution of medicine and method for detecting dissolution of medicine |
| CN113311126B (en) * | 2021-07-30 | 2021-11-02 | 湖南慧泽生物医药科技有限公司 | Dissolution instrument system for simulating in-vivo dissolution of medicine and method for detecting dissolution of medicine |
| CN113433277A (en) * | 2021-08-08 | 2021-09-24 | 湖南慧泽生物医药科技有限公司 | Circulating dissolution instrument system for in-vitro dissolution of medicine and method for detecting dissolution of medicine |
| CN113433277B (en) * | 2021-08-08 | 2022-04-01 | 湖南慧泽生物医药科技有限公司 | Circulating dissolution instrument system for in-vitro dissolution of medicine and method for detecting dissolution of medicine |
| CN113777207A (en) * | 2021-09-09 | 2021-12-10 | 安徽省食品药品检验研究院(安徽国家农副加工食品质量监督检验中心) | Determination method of gliclazide sustained release tablet dissolution curve, similarity evaluation method and application thereof |
| CN114858986A (en) * | 2022-07-11 | 2022-08-05 | 湖南慧泽生物医药科技有限公司 | In-vitro dissolution method of mirabegron sustained release tablet |
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