CN210855927U - Sodium hyaluronate gel extraction tool - Google Patents
Sodium hyaluronate gel extraction tool Download PDFInfo
- Publication number
- CN210855927U CN210855927U CN201921932659.5U CN201921932659U CN210855927U CN 210855927 U CN210855927 U CN 210855927U CN 201921932659 U CN201921932659 U CN 201921932659U CN 210855927 U CN210855927 U CN 210855927U
- Authority
- CN
- China
- Prior art keywords
- stirring tank
- heat
- sodium hyaluronate
- gel extraction
- preservation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 18
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 18
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 18
- 238000000605 extraction Methods 0.000 title claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 61
- 238000004321 preservation Methods 0.000 claims abstract description 42
- 239000000872 buffer Substances 0.000 claims abstract description 26
- 239000000654 additive Substances 0.000 claims abstract description 16
- 230000000996 additive effect Effects 0.000 claims abstract description 16
- 230000005540 biological transmission Effects 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims 1
- 230000008859 change Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 238000005119 centrifugation Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000007853 buffer solution Substances 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000561734 Celosia cristata Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Images
Landscapes
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model discloses a sodium hyaluronate gel extraction tool, including the heat preservation agitator tank, the upper surface of heat preservation agitator tank installs three additive inlets, the inside wall symmetry of heat preservation agitator tank is fixed with the mount pad, arbitrary the upper surface of mount pad all installs servo motor, servo motor's side all is connected with the driving chain, the other end of driving chain is connected with the epitrochoid, and the tip of epitrochoid clamps at the inside wall of heat preservation agitator tank, and two the inboard of epitrochoid is installed down the flitch, the upper end of heat preservation agitator tank is installed the buffer seat, the upper surface of buffer seat is installed agitator motor; through the flitch down of the uniform velocity luffing motion that sets up, can provide the cushioning effect to the additive, and can change along with the position that flitch bottom corresponds down when the additive whereabouts for the additive can evenly unrestrained in the heat preservation agitator tank, improves stirring efficiency.
Description
Technical Field
The utility model relates to a technical field is drawed to the gel, specifically is a sodium hyaluronate gel draws instrument.
Background
Sodium hyaluronate (sodium hyaluronate) is a high molecular polysaccharide existing in cockscomb and animal connective tissue, is obtained by extracting and refining animal connective tissue, and has good water retention property and lubricity. The sodium alginate gel is widely used as a main raw material of cosmetics, a viscoelastic agent for ophthalmic surgery, a lubricant for bone joint cavities and an anti-adhesion agent in gynecology and surgical operations, and the sodium alginate gel can be extracted for use;
patent application No.: CN201720034607.0, a crosslinked sodium hyaluronate gel's extraction element, characterized by: connect gradually including heat preservation agitator tank, filter centrifuge, second agitator tank, chromatography post, secondary centrifugation subassembly and holding vessel, the entry end of heat preservation agitator tank is equipped with zymotic fluid entry and water inlet, and the top is equipped with the pipeline and is connected with filter centrifuge's top layer including three additive entry, bottom one side, filter centrifuge includes filter layer, centrifugation layer and washing layer from top to bottom in proper order, washing layer both sides are equipped with a water pipeling that advances respectively, and the bottom is equipped with the pipeline and is connected with the second agitator tank, second agitator tank bottom one side is equipped with the pipeline and is connected with chromatography capital portion, chromatography capital portion is equipped with the pipeline and is connected with secondary centrifugation subassembly. The utility model is designed aiming at the extraction process of the cross-linked sodium hyaluronate gel, has novel structure, modularizes the process flow and improves the operability of continuous production;
when the additive is added into the heat-preservation stirring tank, the additive vertically falls into the bottom of the heat-preservation stirring tank, so that the additive is accumulated, the stirring difficulty is increased, and the stirring efficiency is reduced; meanwhile, when the stirring motor operates, the stirring motor can cause vibration of the heat-preservation stirring tank, potential safety hazards exist, and therefore the sodium hyaluronate gel extraction tool is provided for people.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a sodium hyaluronate gel extraction tool to solve the problem that proposes among the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme: a sodium hyaluronate gel extraction tool comprises a heat-preservation stirring tank, wherein the upper surface of the heat-preservation stirring tank is provided with three additive inlets, the inner side wall of the heat-preservation stirring tank is symmetrically fixed with mounting seats, the upper surface of any mounting seat is provided with a servo motor, the side surfaces of the servo motors are connected with transmission chains, the other ends of the transmission chains are connected with outward rotating shafts, the end parts of the external rotating shafts are clamped on the inner side wall of the heat-preservation stirring tank, the inner sides of the two external rotating shafts are provided with blanking plates, the upper end of the heat-preservation stirring tank is provided with a buffer seat, the upper surface of the buffer seat is provided with a stirring motor, the surfaces of two sides of the buffer seat are provided with limit blocks, the inner side of the heat-preservation stirring tank is provided with a limit groove, the outer end of the limiting block is located inside the limiting groove, and a buffer spring is installed between the buffer seat and the heat-preservation stirring tank.
Preferably, the bottom end of the stirring motor is connected with an output shaft, and the bottom end of the output shaft is connected with a stirring blade.
Preferably, one side of the heat-preservation stirring tank is connected with a filtering centrifuge through a pipeline, and one side of the filtering centrifuge is connected with a stirring tank II through a pipeline.
Preferably, one side of the second stirring tank is connected with a chromatographic column through a pipeline, and one side of the chromatographic column is connected with a second centrifugal component through a pipeline.
Preferably, one side of the centrifugal assembly II is connected with a centrifugal assembly I through a pipeline, and the bottom ends of the centrifugal assembly I and the centrifugal assembly II are both connected with a collecting tank through pipelines.
Preferably, the top end of the buffer spring is connected with the bottom of the buffer seat, and the other end of the buffer spring is connected with the inner side wall of the heat-preservation stirring tank.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the utility model discloses in, through the lower flitch of the at the uniform velocity luffing motion that sets up, can provide the cushioning effect to the additive, and can change along with the position that the flitch bottom corresponds down when the additive whereabouts for the additive can evenly spill in the heat preservation agitator tank, improves stirring efficiency.
2. The utility model discloses in, through the buffer that sets up, can be so that the vibrations furthest that agitator motor produced weakens to provide a stable stirring environment, improve the security of work, reduce equipment failure rate.
3. The utility model discloses in, drive by servo motor through setting up down the flitch, the amplitude of fluctuation can be adjusted to adapt to different unloading volume, and whole device structure is fairly simple, assembles easily, and the cost is lower.
Drawings
FIG. 1 is a schematic front view of the present invention;
FIG. 2 is a schematic view of the installation plane structure of the blanking plate of the present invention;
fig. 3 is the schematic sectional structural view of the buffering mechanism of the present invention.
In the figure: the device comprises an additive inlet 1, a servo motor 2, a heat-preservation stirring tank 3, an output shaft 4, a stirring blade 5, a first centrifugal assembly 6, a collection tank 7, a second centrifugal assembly 8, a chromatographic column 9, a second stirring tank 10, a filtering centrifuge 11, a mounting seat 12, a blanking plate 13, a stirring motor 14, an external rotating shaft 15, a transmission chain 16, a buffer seat 17, a limiting block 18, a limiting groove 19 and a buffer spring 20.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the technical scheme in the utility model, all other embodiments that ordinary skilled person in the art obtained under the prerequisite of not making the creative work all belong to the scope of the utility model protection.
Referring to fig. 1 to 3, the present invention provides a technical solution: a sodium hyaluronate gel extraction tool comprises a heat preservation stirring tank 3, three additive inlets 1 are arranged on the upper surface of the heat preservation stirring tank 3, mounting bases 12 are symmetrically fixed on the inner side wall of the heat preservation stirring tank 3, a servo motor 2 is arranged on the upper surface of any mounting base 12, a transmission chain 16 is connected on the side surface of the servo motor 2, an external rotating shaft 15 is connected with the other end of the transmission chain 16, the end part of the external rotating shaft 15 is clamped on the inner side wall of the heat preservation stirring tank 3, blanking plates 13 are arranged on the inner sides of the two external rotating shafts 15, a buffer base 17 is arranged at the upper end of the heat preservation stirring tank 3, a stirring motor 14 is arranged on the upper surface of the buffer base 17, limiting blocks 18 are arranged on the surfaces of the two sides of the buffer base 17, a limiting groove 19 is arranged on the inner side of the heat preservation stirring tank 3, the outer ends of the limiting blocks 18 are positioned, diatomaceous earth and active carbon can fall down the upper surface of flitch 13 at first, and flitch 13 regular luffing motion is down driven through driving chain 16 to this moment servo motor 2, but the bottom of flitch 13 can not reach horizontal position down, and diatomaceous earth and active carbon can be along flitch 13 bottom of down falling down the continuous whereabouts of continuing, and spill in the different positions in heat preservation agitator tank 3 bottom, can not cause and pile up.
Further, the bottom end of the stirring motor 14 is connected with an output shaft 4, and the bottom end of the output shaft 4 is connected with a stirring blade 5.
Further, one side of the heat preservation stirring tank 3 is connected with a filtering centrifuge 11 through a pipeline, and one side of the filtering centrifuge 11 is connected with a stirring tank II 10 through a pipeline.
Furthermore, one side of the second stirring tank 10 is connected with a chromatographic column 9 through a pipeline, and one side of the chromatographic column 9 is connected with a second centrifugal component 8 through a pipeline.
Further, one side of the second centrifugal assembly 8 is connected with a first centrifugal assembly 6 through a pipeline, and the bottom ends of the first centrifugal assembly 6 and the second centrifugal assembly 8 are both connected with a collecting tank 7 through a pipeline.
Further, the top end of the buffer spring 20 is connected with the bottom of the buffer seat 17, and the other end is connected with the inner side wall of the heat-preservation stirring tank 3.
The working principle is as follows: the fermentation liquor and water are injected into a heat preservation stirring tank 3 for dilution, diatomite and active carbon are added into the diluted fermentation liquor through an additive inlet 1, the diatomite and the active carbon firstly fall on the upper surface of a blanking plate 13, at the moment, a servo motor 2 drives the blanking plate 13 to regularly swing up and down through a transmission chain 16, but the bottom end of the blanking plate 13 cannot reach a horizontal position, the diatomite and the active carbon continuously fall along the bottom end of the blanking plate 13 and are scattered at different positions at the bottom of the heat preservation stirring tank 3 without accumulation, a stirring motor 14 drives a stirring blade 5 to rotate through an output shaft 4 for stirring, when the stirring motor 14 rotates, a buffer spring 20 supports a buffer seat 17 to buffer vibration force, then the vibration force flows to a filtering centrifuge 11 through a pipeline and then flows into a stirring tank II 10, and the solution obtained after dissolution flows through a chromatographic column 9 at a certain speed, the solution passing through the chromatographic column 9 enters a second centrifugal component 8 and a first centrifugal component 6 for centrifugation, and is finally collected by a collection tank 7.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a sodium hyaluronate gel extraction instrument, includes heat preservation agitator tank (3), its characterized in that: the upper surface of the heat-preservation stirring tank (3) is provided with three additive inlets (1), the inner side wall of the heat-preservation stirring tank (3) is symmetrically fixed with a mounting seat (12), a servo motor (2) is installed on the upper surface of the mounting seat (12) randomly, the side surface of the servo motor (2) is connected with a transmission chain (16), the other end of the transmission chain (16) is connected with an outer rotating shaft (15), the end part of the outer rotating shaft (15) is clamped on the inner side wall of the heat-preservation stirring tank (3), a lower material plate (13) is installed on the inner side of the outer rotating shaft (15), a buffer seat (17) is installed at the upper end of the heat-preservation stirring tank (3), the upper surface of the buffer seat (17) is provided with a stirring motor (14), the surfaces of the two sides of the buffer seat (17) are provided with limiting blocks (18), and the inner side of the heat-preservation stirring tank, the outer end of the limiting block (18) is arranged in the limiting groove (19), and a buffer spring (20) is arranged between the buffer seat (17) and the heat-preservation stirring tank (3).
2. The sodium hyaluronate gel extraction tool of claim 1, wherein: the bottom end of the stirring motor (14) is connected with an output shaft (4), and the bottom end of the output shaft (4) is connected with a stirring blade (5).
3. The sodium hyaluronate gel extraction tool of claim 1, wherein: one side of the heat-preservation stirring tank (3) is connected with a filtering centrifuge (11) through a pipeline, and one side of the filtering centrifuge (11) is connected with a stirring tank II (10) through a pipeline.
4. The sodium hyaluronate gel extraction tool of claim 3, wherein: one side of the second stirring tank (10) is connected with a chromatographic column (9) through a pipeline, and one side of the chromatographic column (9) is connected with a second centrifugal component (8) through a pipeline.
5. The sodium hyaluronate gel extraction tool of claim 4, wherein: one side of the second centrifugal assembly (8) is connected with a first centrifugal assembly (6) through a pipeline, and the bottom ends of the first centrifugal assembly (6) and the second centrifugal assembly (8) are connected with a collecting tank (7) through pipelines.
6. The sodium hyaluronate gel extraction tool of claim 1, wherein: the top end of the buffer spring (20) is connected with the bottom of the buffer seat (17), and the other end of the buffer spring is connected with the inner side wall of the heat-preservation stirring tank (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921932659.5U CN210855927U (en) | 2019-11-11 | 2019-11-11 | Sodium hyaluronate gel extraction tool |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921932659.5U CN210855927U (en) | 2019-11-11 | 2019-11-11 | Sodium hyaluronate gel extraction tool |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210855927U true CN210855927U (en) | 2020-06-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921932659.5U Expired - Fee Related CN210855927U (en) | 2019-11-11 | 2019-11-11 | Sodium hyaluronate gel extraction tool |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210855927U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113336871A (en) * | 2021-06-28 | 2021-09-03 | 浙江美华鼎昌医药科技有限公司 | In-vitro dissolution method of cross-linked sodium hyaluronate gel |
| CN114012090A (en) * | 2021-11-11 | 2022-02-08 | 江苏立一新材料科技有限公司 | A multilayer combined material copper powder laying device for self-lubricating bearing preparation |
-
2019
- 2019-11-11 CN CN201921932659.5U patent/CN210855927U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113336871A (en) * | 2021-06-28 | 2021-09-03 | 浙江美华鼎昌医药科技有限公司 | In-vitro dissolution method of cross-linked sodium hyaluronate gel |
| CN113336871B (en) * | 2021-06-28 | 2022-05-06 | 浙江美华鼎昌医药科技有限公司 | In-vitro dissolution method of cross-linked sodium hyaluronate gel |
| CN114012090A (en) * | 2021-11-11 | 2022-02-08 | 江苏立一新材料科技有限公司 | A multilayer combined material copper powder laying device for self-lubricating bearing preparation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200626 |