CN210752630U - Preparation device of tedizolid key intermediate - Google Patents

Abstract

The utility model discloses a preparation facilities of tedizolid key midbody, first motor is arranged in the top of lid, the output of first motor with the one end fixed connection of first (mixing) shaft, the other end of first (mixing) shaft runs through the lid, first puddler the second puddler with the third puddler all with first (mixing) shaft fixed connection, just first puddler the second puddler with the third puddler is followed the axial line of first (mixing) shaft is arranged in proper order, first puddler the second puddler with the length of third puddler increases in proper order, heating element passes through the conveyer pipe with reaction vessel intercommunication. The preparation speed and the reaction yield of the tedizolid phosphate key intermediate are improved, and the purpose of industrial production is achieved.

Description

Preparation device of tedizolid key intermediate

Technical Field

The utility model relates to a bulk drug preparation technical field especially relates to a preparation facilities of tedizolid key midbody.

Background

Tedizolid phosphate (Tedizolid phosphate) is a novel oxazolidinone antibiotic, and shows higher activity against Staphylococcus aureus, methicillin-resistant bacteria, methicillin-sensitive bacteria and streptococcus in clinical trials, 2-4 times that of linezolid, and has other advantages over linezolid: in clinical trials, fewer gastrointestinal side effects of tedizolid phosphate are found; no drug interaction phenomena similar to linezolid occurred.

However, the existing Tedizolid phosphate ester key intermediate has slow preparation rate and low reaction yield in the preparation process, and is not easy to realize industrial production.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a preparation facilities of tedizolid key intermediate, aim at solving the tedizolid phosphate ester key intermediate among the prior art in the preparation process, preparation speed is slow, reaction yield is low, is difficult for realizing the production technical problem of industrialization.

In order to achieve the above object, the utility model discloses a preparation facilities of key midbody of tedizolid, including reaction vessel, lid, first pipe, second pipe, stirring subassembly, conveyer pipe and heating element, the lid with reaction vessel can dismantle the connection, first pipe with the second pipe all with lid fixed connection, and run through the lid, the stirring subassembly includes first motor, first (mixing) shaft, first puddler, second puddler, third puddler and stirring piece, first motor is arranged in the top of lid, the output of first motor with the one end fixed connection of first (mixing) shaft, the other end of first (mixing) shaft runs through the lid, first puddler, the second puddler with the third puddler all with first (mixing) shaft fixed connection, just first puddler, second puddler, The second stirring rod and the third stirring rod are sequentially arranged along the axial line of the first stirring shaft, the lengths of the first stirring rod, the second stirring rod and the third stirring rod are sequentially increased, one end of the first stirring shaft, which is far away from the second stirring rod, is fixedly connected with the stirring block, and the heating component is communicated with the reaction container through the conveying pipe.

The cross sections of the first stirring rod, the second stirring rod and the third stirring rod are all isosceles trapezoids.

The first stirring rod, the second stirring rod and the third stirring rod are provided with through holes, the number of the through holes is multiple, and the through holes are uniformly distributed on the first stirring rod, the second stirring rod and the third stirring rod.

The stirring assembly further comprises a first connecting rod, one end of the first connecting rod is fixedly connected with the first stirring rod, the other end of the first connecting rod is fixedly connected with the second stirring rod, and the first connecting rod is arranged between the first stirring rod and the second stirring rod in an inclined angle mode.

Wherein, the stirring subassembly still includes the second connecting rod, the one end of second connecting rod with second puddler fixed connection, the other end of second connecting rod with third puddler fixed connection, just the second connecting rod is in the second puddler with be inclination setting between the third puddler.

The stirring assembly further comprises a supporting rod, and the supporting rod is fixedly connected with each stirring block and is positioned between every two adjacent stirring blocks.

The stirring assembly further comprises a second motor, a second stirring shaft and a stirring blade, the second motor is arranged on the side wall of the reaction container, the output end of the second motor is fixedly connected with one end of the second stirring shaft, the other end of the second stirring shaft penetrates through the side wall of the reaction container and is arranged in the reaction container, and the stirring blade is fixedly connected with the second stirring shaft and is positioned on the outer surface wall of the stirring shaft.

Wherein, heating element includes heating container, end cover, heating member, third pipe and fourth pipe, the heating container passes through the conveyer pipe with reaction vessel intercommunication, the end cover with the connection can be dismantled to the heating container, and be located the top of heating container, the heating member with heating container fixed connection, and be located the inside of heating container, the third pipe with the fourth pipe all with end cover fixed connection, and run through the end cover.

The heating container comprises a first container barrel and a second container barrel, the first container barrel is sleeved outside the second container barrel, and a cavity for placing the heating element is formed between the first container barrel and the second container barrel.

The utility model discloses a preparation facilities of Tedizolid key midbody, through the lid with reaction vessel can dismantle the connection, first pipe with the second pipe all with lid fixed connection, and run through the lid, first motor is arranged in the top of lid, the output of first motor with the one end fixed connection of first (mixing) shaft, the other end of first (mixing) shaft runs through the lid, first puddler the second puddler with the third puddler all with first (mixing) shaft fixed connection, just first puddler the second puddler with the third puddler is followed the axial line of first (mixing) shaft is arranged in proper order, first puddler the second puddler with the length of third puddler increases in proper order, first puddler the second puddler with the third puddler is kept away from the one end of first (mixing) shaft all with puddler fixed connection And the heating assembly is communicated with the reaction vessel through the conveying pipe. The length of the first stirring rod, the length of the second stirring rod and the length of the third stirring rod are sequentially distributed on the stirring shaft from large to small, so that the stirring component can more fully stir the reaction mixture in the reaction container, the reaction of the reaction mixture is accelerated, the preparation speed and the reaction yield of the Tedizolid phosphate key intermediate are further improved, and industrial production is realized.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a preparation device of a tedizolid key intermediate of the present invention.

100-Tedizolid key intermediate preparation device, 10-reaction vessel, 11-cover body, 12-first conduit, 13-second conduit, 14-conveying pipe, 20-stirring component, 21-first motor, 22-first stirring shaft, 23-first stirring rod, 24-second stirring rod, 25-third stirring rod, 251-through hole and 26-stirring block, 27-a first connecting rod, 28-a second connecting rod, 281-a supporting rod, 29-a second motor, 291-a second stirring shaft, 292-a stirring blade, 30-a heating component, 31-a heating container, 311-a first container barrel, 312-a second container barrel, 32-an end cover, 33-a heating element, 34-a third conduit and 35-a fourth conduit.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present invention, and should not be construed as limiting the present invention.

In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. In addition, in the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.

Referring to fig. 1, the present invention provides a device 100 for preparing a tedizolid key intermediate, including a reaction vessel 10, a cover 11, a first conduit 12, a second conduit 13, a stirring assembly 20, a conveying pipe 14 and a heating assembly 30, where the cover 11 is detachably connected to the reaction vessel 10, the first conduit 12 and the second conduit 13 are both fixedly connected to the cover 11 and penetrate through the cover 11, the stirring assembly 20 includes a first motor 21, a first stirring shaft 22, a first stirring rod 23, a second stirring rod 24, a third stirring rod 25 and a stirring block 26, the first motor 21 is disposed above the cover 11, an output end of the first motor 21 is fixedly connected to one end of the first stirring shaft 22, the other end of the first stirring shaft 22 penetrates through the cover 11, the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are all fixedly connected to the first stirring shaft 22, and the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are arranged along the axial line of the first stirring shaft 22 in sequence, the lengths of the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are increased in sequence, the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are far away from one end of the first stirring shaft 22 and the stirring block 26 are fixedly connected, and the heating component 30 is communicated with the reaction container 10 through the conveying pipe 14.

In this embodiment, a control panel with a built-in microprocessor is disposed on an outer side wall of the reaction vessel 10, the first motor 21 and the heating assembly 30 are electrically connected to the control panel, when tedizolid phosphate, which is a key intermediate of tedizolid, is prepared, toluene is added into the reaction vessel 10, then the cover body 11 is opened to dissolve an initial raw material SM in the toluene, the cover body 11 is closed to react to obtain an SM-format reagent, then n-butyl lithium is added into the reaction vessel 10 by using the first conduit 12, the temperature in the reaction vessel 10 is controlled at-15 to 0 ℃, then the control panel is manually started, and then the microprocessor in the control panel controls the first motor 21 to operate, the first motor 21 drives the stirring shaft to rotate, and the first stirring shaft 23 and the first stirring shaft are sequentially disposed thereon, The second stirring rod 24 and the third stirring rod 25 can further make the mixture mixed more uniformly, and at the same time, the time and the speed for uniformly mixing the mixture in the reaction vessel 10 can be accelerated, and the reaction of the mixture can be accelerated, so that the preparation speed and the reaction yield of the tedizolid key intermediate can be improved, the industrial production can be realized, meanwhile, the lengths of the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are sequentially increased, the turbulent action on the mixture in the reaction vessel 10 can be enhanced, the mixture mixing is more uniform, the time and the speed for uniformly mixing are greatly improved, and simultaneously, the stirring blocks 26 matched on the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 can further improve the turbulent action on the mixture in the reaction vessel 10, the mixture is mixed more uniformly, the time and the speed for mixing uniformly are also greatly improved, the preparation speed and the reaction yield of the tedizolid key intermediate are further improved, then trimethyl borate is added through the second conduit 13, the stirring component 20 is used for stirring again to obtain a tedizolid key intermediate solution, then the electronic valve on the conveying pipe 14 is opened through the manual control microprocessor, so that the tedizolid key intermediate solution in the reaction container 10 flows into the heating component 30 for heating and drying, the tedizolid key intermediate is prepared, the preparation speed and the reaction yield of the tedizolid key intermediate are improved, and the industrial production is easy to realize.

Further, the cross sections of the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are all isosceles trapezoids.

In this embodiment, the cross sections of the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are all arranged in an isosceles trapezoid structure, so that the turbulence effect on the mixture in the reaction vessel 10 can be effectively enhanced, the mixture is mixed more uniformly, the time and the speed of uniform mixing are greatly improved, and the preparation rate and the reaction yield of the tedizolid key intermediate are improved.

Further, the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25 are all provided with a plurality of through holes 251, and the through holes 251 are uniformly distributed on the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25.

In this embodiment, the uniform distribution of the plurality of through holes 251 can further improve the turbulence effect on the mixture in the reaction vessel 10, so that the mixture is more uniformly mixed, the time and the speed for uniform mixing are greatly improved, and the preparation speed and the reaction yield of the tedizolid key intermediate are improved.

Further, the stirring assembly 20 further includes a first connecting rod 27, one end of the first connecting rod 27 is fixedly connected to the first stirring rod 23, the other end of the first connecting rod 27 is fixedly connected to the second stirring rod 24, and the first connecting rod 27 is disposed between the first stirring rod 23 and the second stirring rod 24 at an inclined angle. Stirring subassembly 20 still includes second connecting rod 28, the one end of second connecting rod 28 with second puddler 24 fixed connection, the other end of second connecting rod 28 with third puddler 25 fixed connection, just second connecting rod 28 is in second puddler 24 with be inclination setting between the third puddler 25.

In this embodiment, the first connecting rod 27 is obliquely arranged between the first stirring rod 23 and the second stirring rod 24, the second connecting rod 28 is obliquely arranged between the second stirring rod 24 and the third stirring rod 25, and the arrangement of the first connecting rod 27 and the second connecting rod 28 can not only improve the structural strength of the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25, but also improve the turbulent flow effect on the mixture in the reaction vessel 10, so that the mixture is more uniformly mixed, the time and the speed for uniformly mixing are greatly improved, and the preparation speed and the reaction yield of the Tedizolid key intermediate are improved.

Further, the stirring assembly 20 further includes a supporting rod 281, and the supporting rod 281 is fixedly connected to each of the stirring blocks 26 and is located between two adjacent stirring blocks 26.

In this embodiment, the supporting rod 281 is disposed between two adjacent stirring blocks 26, and the supporting rod 281 can improve the structural strength of the apparatus 100 for preparing the tedizolid key intermediate, and can also improve the turbulent action on the mixture in the reaction container 10, so that the mixture is more uniformly mixed, the time and speed for uniformly mixing are greatly improved, and the preparation speed and reaction yield of the tedizolid key intermediate are improved.

Further, the stirring assembly 20 further includes a second motor 29, a second stirring shaft 291 and a stirring blade 292, the second motor 29 is disposed on the sidewall of the reaction vessel 10, an output end of the second motor 29 is fixedly connected to one end of the second stirring shaft 291, the other end of the second stirring shaft 291 penetrates through the sidewall of the reaction vessel 10 and is disposed inside the reaction vessel 10, and the stirring blade 292 is fixedly connected to the second stirring shaft 291 and is located on an outer wall of the stirring shaft.

In this embodiment, the second motor 29 is electrically connected to a microprocessor in the control panel, when the first motor 21 is started, the second motor 29 drives the second stirring shaft 291 to rotate, so as to drive the stirring blade 292 on the second stirring shaft 291 to rotate, and the turbulence effect on the mixture in the reaction container 10 can be further improved by the difference between the rotation direction of the stirring blade 292 and the stirring directions of the first stirring rod 23, the second stirring rod 24 and the third stirring rod 25, so that the mixture is mixed more uniformly, the time and the speed for mixing uniformly are also greatly improved, the preparation speed and the reaction yield of the tedizolid key intermediate are improved, and the industrial production is facilitated.

Further, the heating assembly 30 includes a heating container 31, an end cap 32, a heating element 33, a third conduit 34 and a fourth conduit 35, the heating container 31 is communicated with the reaction container 10 through the delivery pipe 14, the end cap 32 is detachably connected with the heating container 31 and is located at the top of the heating container 31, the heating element 33 is fixedly connected with the heating container 31 and is located inside the heating container 31, and both the third conduit 34 and the fourth conduit 35 are fixedly connected with the end cap 32 and penetrate through the end cap 32.

In this embodiment, the heating element 33 is an infrared heater, the heating element 33 is electrically connected to a microprocessor in the control panel, when the tedizolid key intermediate solution in the reaction vessel 10 flows into the heating vessel 31 through the delivery pipe 14, then, water is dripped into the heating container 31 through the third conduit 34, then ethyl acetate is added into the heating container 31 through the fourth conduit 35 for extraction, then a control panel is operated manually, a microprocessor in the control panel controls the heating element 33 to heat and dry a mixture reactant in the heating container 31, the mixture reactant is concentrated to dryness to obtain a tedizolid key intermediate 2-fluoro-4- (benzyloxycarbonyl) aminophenylboronic acid, and then the end cap 32 is opened to take out the tedizolid phosphate key intermediate.

Further, the heating container 31 includes a first container barrel 311 and a second container barrel 312, the first container barrel 311 is sleeved outside the second container barrel 312, and a cavity for placing the heating element 33 is formed between the first container barrel 311 and the second container barrel 312.

In this embodiment, the first container barrel 311 has a heat preservation and insulation function, the second container barrel 312 has a good heat conduction performance, the heating element 33 is disposed in a cavity formed between the first container barrel 311 and the second container barrel 312, on one hand, scalding caused by mistakenly touching the first container barrel 311 when the heating element 33 works can be avoided for an operator, on the other hand, due to the good heat conduction performance of the second container barrel 312, the mixture in the second container barrel 312 can be heated more uniformly, drying of the mixture is accelerated, and further, the preparation speed of the tedizolid phosphate key intermediate is increased.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention.

Claims (9)

1. A preparation device of a tedizolid key intermediate, which is characterized in that,

the stirring device comprises a reaction vessel, a cover body, a first conduit, a second conduit, a stirring assembly, a conveying pipe and a heating assembly, wherein the cover body is detachably connected with the reaction vessel, the first conduit and the second conduit are fixedly connected with the cover body and penetrate through the cover body, the stirring assembly comprises a first motor, a first stirring shaft, a first stirring rod, a second stirring rod, a third stirring rod and a stirring block, the first motor is arranged above the cover body, the output end of the first motor is fixedly connected with one end of the first stirring shaft, the other end of the first stirring shaft penetrates through the cover body, the first stirring rod, the second stirring rod and the third stirring rod are fixedly connected with the first stirring shaft, and the first stirring rod, the second stirring rod and the third stirring rod are sequentially arranged along the axial line of the first stirring shaft, the length of the first stirring rod, the length of the second stirring rod and the length of the third stirring rod are sequentially increased, the first stirring rod, the second stirring rod and the third stirring rod are far away from one end of the first stirring shaft and are fixedly connected with the stirring block, and the heating assembly is communicated with the reaction container through the conveying pipe.

2. The apparatus for preparing tedizolid key intermediate according to claim 1,

the cross sections of the first stirring rod, the second stirring rod and the third stirring rod are isosceles trapezoids.

3. The apparatus for preparing tedizolid key intermediate according to claim 2,

the first stirring rod, the second stirring rod and all have the through-hole on the third stirring rod, just the quantity of through-hole is a plurality of, and is a plurality of through-hole evenly distributed is in first stirring rod the second stirring rod with on the third stirring rod.

4. The apparatus for preparing tedizolid key intermediate according to claim 3,

the stirring assembly further comprises a first connecting rod, one end of the first connecting rod is fixedly connected with the first stirring rod, the other end of the first connecting rod is fixedly connected with the second stirring rod, and the first connecting rod is arranged between the first stirring rod and the second stirring rod in an inclined angle mode.

5. The apparatus for preparing tedizolid key intermediate according to claim 4,

the stirring assembly further comprises a second connecting rod, one end of the second connecting rod is fixedly connected with the second stirring rod, the other end of the second connecting rod is fixedly connected with the third stirring rod, and the second connecting rod is arranged between the second stirring rod and the third stirring rod in an inclined angle mode.

6. The apparatus for preparing tedizolid key intermediate according to claim 5,

the stirring assembly further comprises a supporting rod, and the supporting rod is fixedly connected with each stirring block and is positioned between every two adjacent stirring blocks.

7. The apparatus for preparing tedizolid key intermediate according to any one of claims 1 to 6,

the stirring assembly further comprises a second motor, a second stirring shaft and a stirring blade, the second motor is arranged on the side wall of the reaction container, the output end of the second motor is fixedly connected with one end of the second stirring shaft, the other end of the second stirring shaft penetrates through the side wall of the reaction container and is arranged in the reaction container, and the stirring blade is fixedly connected with the second stirring shaft and is positioned on the outer surface wall of the stirring shaft.

8. The apparatus for preparing tedizolid key intermediate according to claim 1,

heating element includes heating vessel, end cover, heating member, third pipe and fourth pipe, the heating vessel passes through the conveyer pipe with reaction vessel intercommunication, the end cover with the connection can be dismantled to the heating vessel, and is located the top of heating vessel, the heating member with heating vessel fixed connection, and be located the inside of heating vessel, the third pipe with the fourth pipe all with end cover fixed connection, and run through the end cover.

9. The apparatus for preparing tedizolid key intermediate according to claim 8,

the heating container comprises a first container barrel and a second container barrel, the first container barrel is sleeved outside the second container barrel, and a cavity for placing the heating element is formed between the first container barrel and the second container barrel.

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