CN210674410U - Automatic high-pressure online filtering device for separation equipment - Google Patents
Automatic high-pressure online filtering device for separation equipment Download PDFInfo
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- CN210674410U CN210674410U CN201921286736.4U CN201921286736U CN210674410U CN 210674410 U CN210674410 U CN 210674410U CN 201921286736 U CN201921286736 U CN 201921286736U CN 210674410 U CN210674410 U CN 210674410U
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Abstract
The utility model discloses an automatic high-pressure online filtering device for separation equipment, which comprises a power module, a pre-tightening module, a filtering column core and a filtering shell; the filter column core is a sample storage container to be filtered, and a filter plate is arranged at the bottom of the filter column core; the filter shell is arranged at the bottom of the filter column core and used for fixing the filter column core, and a liquid outlet is formed in the bottom of the filter shell; the pre-tightening module is arranged below the filter shell, and after the filter column core is placed in the filter shell, the pre-tightening module fixes the filter column core and keeps the tight connection of the filter column core and the filter shell; the power module is arranged above the filtering column core, and the power module is pressed into the filtering column core to compact the sample. The device can automatically compress a sample and is integrated into the whole liquid path system, the device can bear the high pressure of the whole system, and liquid leakage and splashing can not occur when the liquid flows through the device. Before the sample enters the chromatographic column, the sample is firstly filtered on line in real time, so that the chromatographic column is protected from being polluted.
Description
Technical Field
The utility model relates to a filter equipment especially relates to an automatic high pressure online filter equipment for splitter, and the device is applied to supplementary high pressure splitter and accomplishes the sample pretreatment.
Background
The high pressure preparative HPLC (high performance liquid chromatography) is used for separating products, a solid sample needs to be flushed into a chromatographic column by using a high pressure mixed flow term (petroleum ether and ethanol), but the solid sample has impurities, so that the sample directly enters the chromatographic column, the chromatographic column is polluted, the service life of the chromatographic column is seriously shortened, the price of the chromatographic column is high, and the sample needs to be filtered before entering the chromatographic column.
The technical means is as follows: the existing mode of filtering the separated sample is manual offline filtering, the sample is pretreated in advance by using an injector and a filter head, and the sample is manually filtered and then put into the separation equipment again. The existing filtering devices on the market can not bear the high pressure of 10-15mpa, are sealed by fixed parts and do not meet the automatic use requirement.
The prior art has the following defects:
1. manual operation wastes manpower and time.
2. The existing mode can not realize online real-time filtering.
3. The injector and the filter head are disposable articles, which can not be used repeatedly and wastes the cost.
4. Cannot withstand high pressures of 10-15 mpa.
5. Not conforming to the automatic use scene.
Chinese utility model patent CN201420865403.8 discloses a from clear formula filter, the device mainly used clear away the remaining filter residue at the lateral wall after filtering, make things convenient for next time to use. The device is not corrosion-resistant can not be applied to chemical reagent's filtration, can not tolerate high pressure, and filterable cylinder body can't be changed simultaneously, has restricted the variety of filtering the sample, can't solve the cross contamination problem of filtering different samples.
Therefore, there is a need to develop another automatic high pressure in-line filtering apparatus for a separation plant to overcome the above-mentioned drawbacks.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide an automatic high pressure online filter equipment for splitter, the device can compress tightly the sample automatically, and integrated to whole liquid way system, the device can bear entire system's high pressure (15 mpa), can not take place weeping and splash phenomenon when guaranteeing that liquid flows through the device. Before the sample enters the chromatographic column, the sample is firstly filtered on line in real time, so that the chromatographic column is protected from being polluted. After each filtration, the filter pressing hammer for pressing the sample is automatically lifted, the used filter core is automatically taken out, and a new filter core is replaced to wait for the next use.
In order to solve the technical problem, the utility model adopts the following technical scheme:
an automatic high-pressure online filtering device for separation equipment comprises a power module, a pre-tightening module, a filtering column core and a filtering shell; the filter column core is a sample storage container to be filtered, and a filter plate is arranged at the bottom of the filter column core; the filter shell is arranged at the bottom of the filter column core and used for fixing the filter column core, and a liquid outlet is formed in the bottom of the filter shell; the pre-tightening module is arranged below the filter shell, and after the filter column core is placed in the filter shell, the pre-tightening module fixes the filter column core and keeps the tight connection between the filter column core and the filter shell; the power module is arranged above the filtering column core, and the power module is pressed into the filtering column core to compact the sample.
As the preferable technical proposal of the utility model, the power module comprises a cylinder, a universal connector and a pressing hammer; the pressing hammer comprises a pipe penetrating sleeve, a column head and a universal plug seal; the cylinder provides downward pressing power for the pressing hammer; the universal connector is connected with the air cylinder and the pressing hammer; the pipe penetrating sleeve is used for guiding a liquid inlet path and protecting the safety of the liquid path, is positioned below the universal connector and is of a hollow structure; the column head is positioned at the bottom of the pressing hammer and is in direct contact with a sample to be filtered; the universal plug seal is positioned above the column head and between the pipe-penetrating sleeve and the column head, and is used for ensuring the seal between the pressing hammer and the filter column core; the pressing hammer is concentric with the filter column core.
As the preferable technical proposal of the utility model, the pre-tightening module comprises a gland, a pull rod, a pressure plate and a cylinder; the gland compresses the filter column core; the pull rod is connected with the pressure plate and the gland; the pressure plate is connected with a cylinder for providing power.
As the preferable technical proposal of the utility model, the filter column core comprises a shell and a filter plate; the shell is used for storing a sample to be filtered; the filter plate is a metal filter membrane, the aperture of the metal filter membrane is 2nm, and the filter plate is arranged at the bottom of the filter column core; the filter column core is replaceable.
As the preferable technical proposal of the utility model, the filtering shell comprises a shell for fixing the filtering column core and a liquid guide groove for collecting the filtering liquid; the diameter of the filtering shell is larger than that of the filtering column core, the circle center of the bottom of the filtering shell is a liquid outlet of a filtered sample, and the liquid outlet is connected with the separation equipment; and a plurality of liquid guide grooves are formed in the circle center of the bottom of the filtering shell in a diffused mode.
As the utility model discloses preferred technical scheme, the place of filtering shell bottom and the contact of filtering the post core is equipped with the fluororubber rubber circle, keeps filtering post core and filtering shell's sealed.
As the utility model discloses preferred technical scheme, filter the shell with the material of filtering the post core is 316L stainless steel.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the labor cost can be saved.
2. Can save the syringes and inner cores used by manual filtration and reduce the cost.
3. Can be matched with an automatic use scene.
4. Can be operated without being watched by people continuously for 24 hours.
5. The condition that manual operation fails to cause separation can be avoided.
6. The sample to be separated can be stored to the maximum extent, and the loss of the sample in the process is reduced.
7. Can resist the high pressure of 15mpa of the whole system, and ensures that liquid does not leak and splash when flowing through the device.
8. Before the sample enters the chromatographic column, the online real-time filtration of the sample can be realized, and the chromatographic column is protected from being polluted.
Drawings
The present invention will be further explained with reference to the drawings and examples.
Fig. 1 is a structural diagram of an automatic high-pressure on-line filtering device for a separation apparatus according to the present invention.
Fig. 2 is an enlarged schematic structural diagram of the power module of the present invention.
Fig. 3 is an enlarged schematic structural diagram of the pre-tightening module of the present invention.
Fig. 4 is an enlarged schematic structural view of the filter cartridge of the present invention.
Fig. 5 is an enlarged schematic structural view of the filter housing of the present invention.
The reference numerals in the figures are illustrated as follows:
a is a power module, B is a pre-tightening module, C is a filtering column core, D is a filtering shell, 1 is an air cylinder, 2 is a universal connector, 3 is a pipe-penetrating sleeve, 4 is a universal plug seal, 5 is a column cap, 6 is a gland, 7 is a pull rod, 8 is a pressure plate, 9 is an air cylinder, 10 is a shell, 11 is a filter plate, 12 is a shell, 13 is a liquid guide groove, and 14 is a fluororubber rubber ring.
Detailed Description
The invention will now be described in further detail with reference to the accompanying drawings and examples.
As shown in figure 1, the utility model discloses an automatic high pressure online filter equipment for splitter mainly contains power module A, pretension module B, filters post core C, filter shell D. Besides, the structure comprises a bracket, a table top and other structural components. The whole device structure thought comes from the injector.
And (3) filtering a column core D: the sample to be filtered is stored in a container, and the bottom of the container is provided with a metal filtering membrane, and the aperture of the filtering membrane is 0.25 micron.
And (3) filtering the shell C: filter shell C locates and filters post core D bottom for fixed filtration post core D, filter shell C bottom simultaneously is equipped with the liquid outlet of the sample that has filtered from filtering post core D bottom, and this liquid outlet is connected with splitter.
And (3) pre-tightening the module B: the pre-tightening module B is arranged below the filter shell C, after the filter column core D is placed on the filter shell C, the pre-tightening module B fixes the filter column core D, meanwhile, the tight connection between the filter column core D and the filter shell C is kept, and liquid leakage between the filter column core D and the filter shell C is avoided.
A power module A: the power module A is arranged above the filtering column core D, and after the filtering column core D is fixed, the power module A (pressing hammer) is pressed into the filtering column core D, so that the sample is compacted, and meanwhile, the compacted sample is used as a liquid inlet of the whole automatic high-pressure online filtering device.
As shown in fig. 2, the power module a mainly comprises four parts, namely a cylinder 1, a universal connector 2, a pipe-through sleeve 3 and a column head 5.
A cylinder 1: the key accessory is to provide the power for pressing the hammer.
Universal connector 2: used for connecting the cylinder 1 and the press hammer; the pressing hammer comprises a pipe-penetrating sleeve 3, a flooding plug seal 4 and a column head 5.
The pipe penetrating sleeve 3: the pipe-through sleeve 3 is positioned below the universal connector 2, the pipe-through sleeve 3 is of a hollow structure, and the pipe-through sleeve 3 is sleeved and connected with a liquid inlet pipeline of the separation equipment. The pipe-through sleeve 3 guides the liquid inlet pipeline to protect the safety of the pipeline. The liquid inlet pipeline is a matched product of the separation equipment. The liquid of splitter flows in through the feed liquor pipeline the utility model discloses automatic high pressure on-line filter equipment, power module A regard as whole automatic high pressure on-line filter equipment's inlet.
Column cap 5: the bottom of the pressing hammer is provided with a column head 5, and the column head 5 is in direct contact with a sample to be filtered, so that the pressing hammer is corrosion-resistant and prevents a liquid inlet pipeline from being blocked.
And (4) flooding plugging and sealing: the flooding plug seal 4 is positioned close to the upper part of the column head 5, namely between the pipe-penetrating sleeve 3 and the column head 5, and the flooding plug seal 4 ensures the sealing between the pressing hammer and the filtering column core D.
The power module A provides power for pressing the filler. In the experimental process, the column bed can be collapsed along with the scouring of liquid, the column bed which is not subjected to prepressing can be continuously collapsed along with the use, and the dynamic axial pressurization technology can be continuously compacted along with the collapse of the column bed. Therefore, the air pressure should be kept stable at any time during the experiment.
After the equipment is used for the first time or maintained, the power module A needs to be subjected to aligning treatment, and the concentricity of the pressing hammer and the filtering column core D is ensured.
As shown in fig. 3, the pre-tightening module B includes a gland 6, a pull rod 7, a pressure plate 8, and a cylinder 9. The pre-tightening module B is used for pressing the filter column core D to ensure concentricity at the beginning of an experiment and separating the filter column core D from a column head at the end of the experiment.
And (4) pressing cover 6: and the filter column core D is compressed, so that the filter shell C and the filter column core D are ensured to be in close contact without moving and liquid leakage.
The pull rod 7: connecting the pressure plate 8 with the gland 6.
And (4) pressing plate 8: the cylinder 9 is connected to transmit power.
The cylinder 9: and providing power.
As shown in fig. 4, the filter cartridge D includes a housing 10 and a filter plate 11.
A housing 10: the sample to be filtered is stored.
The filter plate 11: is a metal filtering membrane, the aperture of the metal filtering membrane is 2nm, and the filtering plate 11 is arranged at the bottom of the filtering column core D.
The filter column core that can change for the robot unattended operation can realize, changes convenient repeatedly usable.
As shown in FIG. 5, the filter housing C comprises a housing 12, a liquid guide groove 13, and a fluororubber rubber ring 14.
The housing 12: and fixing the filter column core D.
Liquid guide groove 13: the filtered liquid was collected.
Fluororubber gasket 14: maintaining the seal of the filter cartridge D to the housing 12.
The diameter of filter shell C is slightly greater than and filters post core D, and the place of filter shell C bottom and the contact of filtering post core D is fluororubber rubber ring 14, and filter shell C bottom centre of a circle department is solvent outlet (the liquid outlet of the sample that filters promptly), and this liquid outlet is connected with splitter. A plurality of liquid guide grooves 13 are arranged at the circle center of the bottom of the filtering shell C in a diffused mode and used for collecting filtered liquid and concentrating the filtered liquid to a solvent outlet at the circle center.
The material of the filter shell C and the filter column core D is 316L stainless steel, and the filter shell C comprises a sealing ring, namely a fluororubber rubber ring 14, which is made of perfluoroether.
The utility model discloses an application method for splitter's automatic high pressure online filter equipment, including following operating sequence:
the on-line filtration refers to real-time access to the whole filtration system, direct separation is completed without interruption, the filtration part does not need to be stripped like the original operation steps, and the separation is started after the filtration of the sample is completed.
1. The gas circuit condition is checked before use to ensure that each gas pressure meter reaches the specified pressure, the pressure of the power module A is not higher than 0.5MPa, and the pressure of the pre-tightening module B is 0.6-0.7 MPa.
2. Firstly, the cylinder 1 of the power module A and the cylinder 9 of the pre-tightening module B are both lifted to place the filter column core D. Putting the sample into a replaceable filter column core D, and putting the filter column core D with the sample on a filter shell C by a manipulator;
3. after the filter column core D is placed, the cylinder 9 of the pre-tightening module B is pressed tightly. After the pre-tightening module B is compacted, the filter column core D and the filter shell C are tightly sealed due to the fluororubber rubber ring, and liquid can completely flow away from the outlet of the filter shell C after flowing through the sieve plate of the filter column core D, so that liquid leakage at the joint of the filter column core D and the filter shell C can be avoided.
4. And then the cylinder 1 of the power module A is compressed. The power module A pushes down, and the hammer side has three sealing rubber ring (fill up promptly and seal 4), guarantees to push down the back and presses the hammer and filter the post core D sealed, and power module A bottom is entire system's inlet, and the system is whole compresses tightly the back, and liquid gets into from pressing the hammer bottom, and the sample that flows through and filters post core D bottom filter and from filter housing C bottom outflow.
5. After the filtration is finished, the cylinder 1 of the power module A is lifted, the cylinder 9 of the pre-tightening module B is lifted, the filter column core D used at this time is taken out and recycled by the manipulator, a new filter column core D is replaced again, and the next separation is started.
The above is only a specific application example of the present invention, and the protection scope of the present invention is not limited at all; other variations and modifications will be apparent to persons skilled in the art in light of the above description. All embodiments need not be described or illustrated herein. All technical solutions similar to the above embodiments formed by equivalent transformation or equivalent replacement fall within the protection scope of the present invention.
Claims (7)
1. An automatic high-pressure online filtering device for separation equipment is characterized by comprising a power module, a pre-tightening module, a filtering column core and a filtering shell; the filter column core is a sample storage container to be filtered, and a filter plate is arranged at the bottom of the filter column core; the filter shell is arranged at the bottom of the filter column core and used for fixing the filter column core, and a liquid outlet is formed in the bottom of the filter shell; the pre-tightening module is arranged below the filter shell, and after the filter column core is placed in the filter shell, the pre-tightening module fixes the filter column core and keeps the tight connection between the filter column core and the filter shell; the power module is arranged above the filtering column core, and the power module is pressed into the filtering column core to compact the sample.
2. The apparatus of claim 1, wherein the power module comprises a cylinder, a universal connector, and a ram; the pressing hammer comprises a pipe penetrating sleeve, a column head and a universal plug seal; the cylinder provides downward pressing power for the pressing hammer; the universal connector is connected with the air cylinder and the pressing hammer; the pipe penetrating sleeve is positioned below the universal connector, is of a hollow structure, is sleeved on and connected with a liquid inlet pipeline of the separation equipment, guides a liquid inlet pipeline and protects the safety of the liquid pipeline; the column head is positioned at the bottom of the pressing hammer and is in direct contact with a sample to be filtered; the universal plug seal is positioned above the column head and between the pipe-penetrating sleeve and the column head, and is used for ensuring the seal between the pressing hammer and the filter column core; the pressing hammer is concentric with the filter column core.
3. The apparatus of claim 1, wherein the pretensioning module comprises a gland, a tie rod, a pressure plate, and a cylinder; the gland compresses the filter column core; the pull rod is connected with the pressure plate and the gland; the pressure plate is connected with a cylinder for providing power.
4. The device of claim 1, wherein the filter cartridge comprises a housing, a filter plate; the shell is used for storing a sample to be filtered; the filter plate is a metal filter membrane, the aperture of the metal filter membrane is 2nm, and the filter plate is arranged at the bottom of the filter column core; the filter column core is replaceable.
5. The apparatus of claim 1, wherein the filter housing comprises a housing for holding a filter cartridge, a gutter for collecting filtered liquid; the diameter of the filtering shell is larger than that of the filtering column core, the circle center of the bottom of the filtering shell is a liquid outlet of a filtered sample, and the liquid outlet is connected with the separation equipment; and a plurality of liquid guide grooves are formed in the circle center of the bottom of the filtering shell in a diffused mode.
6. The device as claimed in claim 5, wherein the bottom of the filter housing is provided with a fluororubber rubber ring at the position contacting with the filter column core to keep the filter column core sealed with the filter housing.
7. The device of claim 1, wherein the filter housing and the filter cartridge are both made of 316L stainless steel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921286736.4U CN210674410U (en) | 2019-08-09 | 2019-08-09 | Automatic high-pressure online filtering device for separation equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921286736.4U CN210674410U (en) | 2019-08-09 | 2019-08-09 | Automatic high-pressure online filtering device for separation equipment |
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| CN210674410U true CN210674410U (en) | 2020-06-05 |
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| CN201921286736.4U Active CN210674410U (en) | 2019-08-09 | 2019-08-09 | Automatic high-pressure online filtering device for separation equipment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110433552A (en) * | 2019-08-09 | 2019-11-12 | 天津药明康德新药开发有限公司 | Automatic high pressure on-line filtration device and its application method for separation equipment |
| CN110433552B (en) * | 2019-08-09 | 2024-10-22 | 天津药明康德新药开发有限公司 | Automatic high-pressure online filtering device for separation equipment and application method thereof |
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2019
- 2019-08-09 CN CN201921286736.4U patent/CN210674410U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110433552A (en) * | 2019-08-09 | 2019-11-12 | 天津药明康德新药开发有限公司 | Automatic high pressure on-line filtration device and its application method for separation equipment |
| CN110433552B (en) * | 2019-08-09 | 2024-10-22 | 天津药明康德新药开发有限公司 | Automatic high-pressure online filtering device for separation equipment and application method thereof |
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Effective date of registration: 20211223 Address after: 300450 No. 168, Nanhai Road, economic and Technological Development Zone, Binhai New Area, Tianjin Patentee after: WUXI APPTEC (TIANJIN) CO.,LTD. Patentee after: Shanghai Hequan Pharmaceutical Co., Ltd Address before: 300457 No. 168, Nanhai Road, Tianjin Economic and Technological Development Zone, Binhai New Area, Tianjin Patentee before: WUXI APPTEC (TIANJIN) CO.,LTD. |