CN210673488U - Thin endometrium model building device for rat - Google Patents
Thin endometrium model building device for rat Download PDFInfo
- Publication number
- CN210673488U CN210673488U CN201920996142.6U CN201920996142U CN210673488U CN 210673488 U CN210673488 U CN 210673488U CN 201920996142 U CN201920996142 U CN 201920996142U CN 210673488 U CN210673488 U CN 210673488U
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- Prior art keywords
- scraping rod
- rat
- uterus
- scraping
- rod
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- 210000004696 endometrium Anatomy 0.000 title claims abstract description 30
- 238000007790 scraping Methods 0.000 claims abstract description 73
- 210000004291 uterus Anatomy 0.000 claims abstract description 35
- 239000002775 capsule Substances 0.000 claims description 4
- 238000000465 moulding Methods 0.000 abstract description 7
- 238000002474 experimental method Methods 0.000 abstract description 4
- 241000700159 Rattus Species 0.000 description 19
- 230000006378 damage Effects 0.000 description 10
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 230000000149 penetrating effect Effects 0.000 description 4
- 239000004576 sand Substances 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 208000018380 Chemical injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 206010046810 Uterine perforation Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002357 endometrial effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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Abstract
The utility model relates to a medical science experiment field, concretely relates to slim endometrium molding device of rat, include: the scraping rod is placed in a rat uterus, and the outer surface of the scraping rod consists of a rough surface and a smooth surface which are arranged along the length direction of the scraping rod; the rough surface is uniformly and densely distributed with sawtooth grains, and the central angle of the cross section of the rough surface is 90-110 degrees; the scraping rod is also provided with a plurality of warning rings; the handle is used for fixing the scraping rod and comprises a first body and a second body, and the first body is rotationally connected with the second body; the first body is provided with a pointer, and the periphery of the second body is provided with angle scale marks; the scraping rod is in threaded connection with the handle. The utility model discloses the device scrape the pole shape size and accord with the uterus's of rat "Y" type structural feature, simple structure science, convenient operation can effectively avoid causing the perforation to the uterus, alleviates operator's psychological burden, can improve the degree of accuracy of experimental result simultaneously.
Description
Technical Field
The utility model relates to a medical science experiment field, concretely relates to slim endometrium molding device of rat.
Background
Thin endometrium means the thickness of endometrium is lower than the threshold thickness capable of obtaining pregnancy, and the pregnancy can not be maintained, which is one of the difficulties in the reproductive medicine field, and for further research, an animal model for establishing the thin endometrium is generally adopted. At present, rats, mice, New Zealand rabbits and the like are generally selected as the endometrial models at home and abroad, and the modeling methods include mechanical injury, infection injury, thermal injury, chemical injury, optical injury and the like, wherein the rats are most widely used and the modeling methods are relatively more. Mechanical injury is most similar to the condition of clinical patients in a plurality of molding methods, and particularly, a stainless steel needle or a syringe needle with a rough surface is used for penetrating into a uterine cavity to scratch an endometrium. However, the stainless steel needle and the syringe are easy to pierce the uterus of the rat, and the accuracy of the experiment is affected.
In addition, although a number of devices for scraping the endometrium of a human are disclosed in the patent, the uterus of a rat is in a Y-shaped double-horn uterus, and is slender and straight. The device is greatly different from the human uterus, and a device for scraping the human uterus cannot be used for molding the rat uterus. Application No.: 200820123202.5, patent name: an endometrium scraper is suitable for Y-shaped double-horn uterus, can be used for scraping the endometrium of common test animals, can also be suitable for molding the thin endometrium of a rat according to the description of the specification, and can finish scraping by sending a cone into a uterine cavity along the direction of the uterus and repeatedly entering and exiting. However, according to the actual situation, the uterus of the rat is very small, and the force direction can only be slightly emphasized during the operation, generally in the directions of 3 points, 6 points, 9 points and 12 points, and the force direction is changed when the rough feeling of sand grains is sensed. Because the appliance of scraping the tooth is covered with, the endometrium of 4 points and 5 points can be scraped when the dynamics direction is heavily weighted 3 points and 6 points, will appear scraping 4 points and 5 points excessively like this, cause the damage, injure the uterus basal lamina, foretell phenomenon can all appear when the dynamics direction is heavily weighted 6 points and 9 points, 9 points and 12 points, 12 points and 3 points to influence the accuracy of experiment. In order to reduce the condition that above-mentioned phenomenon appears, can reduce the setting of sawtooth line, strike off not equidirectional scraping rod through rotatory setting sawtooth line, but a problem can appear like this: the position of the sawtooth pattern after rotation can not be seen by human eyes.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information constitutes prior art already known to a person skilled in the art.
SUMMERY OF THE UTILITY MODEL
To the above-mentioned current problem, an object of the utility model is to provide a slim endometrium molding device of rat, its reduction strikes off the zigzag lines of endometrium to be convenient for the operator through setting up angle scale and pointer and judge the position of rotatory back zigzag lines, with the work of making the mould is accomplished to the convenient operator, improve the degree of accuracy of experimental result.
In order to achieve the above purpose, the utility model provides a following technical scheme:
a thin rat endometrium former, comprising:
the scraping rod is placed in the uterus of the rat, one end of the scraping rod extending into the uterus is the front end, and the other end of the scraping rod not extending into the uterus is the tail end; the outer surface of the scraping rod consists of a rough surface and a smooth surface, and the rough surface and the smooth surface are arranged along the length direction of the scraping rod; the rough surface is uniformly and densely distributed with sawtooth grains, and the central angle of the cross section of the rough surface is 90-110 degrees; the scraping rod is further provided with an external thread and a plurality of warning rings, the external thread is arranged at the tail end of the scraping rod, and the warning rings are close to the external thread;
the handle is used for fixing the scraping rod and comprises a first body and a second body, and the first body is rotationally connected with the second body; the first body is provided with a pointer, and the pointer is parallel to the central line of the first body; angle scale marks are arranged on the periphery of the second body and are positioned at the connecting end of the second body and the first body; the middle part of the second body is provided with a thread groove for fixing the scraping rod, and the thread of the thread groove is matched with the external thread.
The utility model provides a first body and second body rotatable coupling's concrete setting: a hollow connecting rod is arranged right above the thread groove and is integrally formed with the second body; the periphery of the hollow connecting rod is provided with an annular chute; a connecting hole is formed in the middle of the first body, and an annular convex strip matched with the sliding groove is arranged in the connecting hole.
Preferably, the front end of the scraping rod is in a bullet shape, and the rest part of the scraping rod is in a cylindrical shape; the handle is in a capsule shape, and the first body is in a semicircular shape. The head end of the scraping rod is in a bullet shape, so that the scraping rod can conveniently enter the uterine cavity; the handle is the design of capsule form, can conveniently realize the rotatable coupling of first body and second body, does not influence operator's use simultaneously.
Preferably, the central angle is 100 degrees, the number of the warning rings is 3, the width of the warning rings is 2-5mm, and the interval between every two adjacent warning rings is 2-3 mm. The central angle is 100 degrees, so that the contact area between the sawtooth lines and the endometrium is increased when the force direction is different, and the scraping efficiency is improved; meanwhile, the problem that the accuracy of an experimental result is influenced by excessive damage to a uterine basal layer due to overlarge contact area between the sawtooth lines and endometrium is avoided.
Preferably, the diameter of the scraping rod is 1.2-1.4mm, and the length of the scraping rod is 35-40 mm; the handle has a diameter of 10-12mm and a length of 20-25 mm. The diameter and the length of the scraping rod are more fit with the actual condition of the uterus of a rat, and the diameter and the length of the handle facilitate the operation during molding.
Compared with the prior art, the utility model discloses following beneficial effect has:
(1) the arrangement of the sawtooth veins is reduced, so that damage to an intima-basement layer caused by excessive scraping of the endometrium is avoided, the thin-type endometrium model of the rat is closer to the condition of a clinical patient, and the accuracy of an experimental result is improved; the pointer and the angle scale lines are arranged on the handle, so that an operator can conveniently distinguish the position of the rotated sawtooth pattern, and the working efficiency is improved; the warning ring has a warning function, an operator can be reminded of the depth of the scraping rod extending into the uterus, and the damage to the uterus caused by the excessively long extending depth is avoided. In addition, the threaded connection of the scraping rod and the handle is used for facilitating the replacement of the worn scraping rod or the worn handle.
(2) The utility model discloses the device scrape the pole shape size and accord with the uterus's of rat "Y" type structural feature, simple structure science, convenient operation can effectively avoid causing the perforation to the uterus, alleviates operator's psychological burden, can improve the degree of accuracy of experimental result simultaneously.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the whole structure of the scraping rod of the present invention;
fig. 3 is a schematic longitudinal sectional view of a first body of the present invention;
fig. 4 is a schematic view of the overall structure of the second body of the present invention;
figure 5 is a schematic longitudinal section of a second body of the invention;
description of the main reference numerals:
1-scraping rod, 2-sawtooth line, 3-external thread, 4-warning ring, 5-handle, 6-first body, 61-pointer, 7-second body, 71-angle scale mark, 8-thread groove, 9-hollow connecting rod, 10-annular sliding groove, 11-connecting hole and 12-annular convex strip.
Detailed Description
The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited by the following detailed description.
Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.
As shown in fig. 1-5, a thin endometrium model generator for rats comprises:
the scraping rod 1 is placed in the uterus of a rat, one end of the scraping rod extending into the uterus is a front end, and the other end of the scraping rod not extending into the uterus is a tail end; the diameter of the scraping rod 1 is 1.2-1.4mm, and the length is 35-40 mm; in order to facilitate the scraping rod 1 to enter the uterus, the front end of the scraping rod 1 is in a bullet shape, and the rest part is in a cylindrical shape;
the outer surface of the scraping rod 1 consists of a rough surface and a smooth surface, and the rough surface and the smooth surface are arranged along the length direction of the scraping rod 1; the rough surface is uniformly and densely distributed with the sawtooth grains 2, the central angle of the cross section of the rough surface is 90-110 degrees, the optimal central angle is 100 degrees, the contact area of the sawtooth grains 2 and endometrium is increased when the force directions are different, and the scraping efficiency is improved; meanwhile, the problem that the accuracy of an experimental result is influenced by excessive damage to a uterine basal layer due to overlarge contact area of the sawtooth lines 2 and endometrium is avoided; the scraping rod 1 is also provided with an external thread 3 and a plurality of warning rings 4, the external thread 3 is arranged at the tail end of the scraping rod 1, and the warning rings 4 are close to the external thread 3; in the embodiment, the number of the warning rings is 3, the width is 2-5mm, and the interval between the adjacent warning rings is 2-3 mm; meanwhile, the traffic light can be set by referring to the external thread 3 as a reference point, and the external thread 3 is far away from the external thread 3 to be close to the external thread 3 and is green, yellow and red in sequence, so that an operator can clearly know the depth of the scraping rod 1 penetrating into the uterine cavity, the depth of the scraping rod 1 penetrating into the uterine cavity is consistent, and meanwhile, the phenomenon that the depth of the scraping rod penetrating into the uterine cavity is too long to cause perforation of the uterus can be prevented;
the handle 5 for fixing the scraping rod is in a capsule shape, the diameter is 10-12mm, the length is 20-25mm, the handle comprises a first body 6 and a second body 7, and the first body 6 is rotatably connected with the second body 7; the first body 6 is semicircular, and a pointer 61 is arranged on the first body 6, and the pointer 61 is parallel to the central line of the first body 6; the pointer 61 can be a double-head pointer which respectively points to the scraping rod 1 and the second body 7, so that the initial position of the arc sawtooth pattern 2 can be conveniently adjusted; the periphery of the second body 7 is provided with angle scale lines 71, and the angle scale lines 71 are positioned at the connecting end of the second body 7 and the first body 6; the middle part of the second body 7 is provided with a thread groove 8 for fixing the scraping rod 1, and the thread of the thread groove 8 is matched with the external thread 3;
the first body 6 and the second body 7 are rotatably connected in this embodiment specifically configured as follows: a hollow connecting rod 9 is arranged right above the thread groove 8, and the hollow connecting rod 9 and the second body 7 are integrally formed; the periphery of the hollow connecting rod 9 is provided with an annular chute 10; a connecting hole 11 is formed in the middle of the first body 6, and an annular convex strip 12 matched with the sliding groove 10 is arranged in the connecting hole 11; wherein the diameter of the hollow connecting rod 9 corresponds to the diameter of the threaded groove 8 and the scraper bar 1.
When in use, the experimental rat is anesthetized and disinfected under the aseptic condition, then the abdomen is opened, the near vaginal end and the ovarian end of the uterus on one side are exposed, and the longitudinal incision is made in the middle of the uterus; adjusting the position of the pointer 61 to enable the pointer 61 to be located in the 12 o' clock direction, and then adjusting the relative positions of the arc-shaped sawtooth lines 2 and the pointer 61 to enable the pointer 61 to point in the middle of the arc-shaped sawtooth lines; then fixing the uterus section to be scraped with the left hand, holding the handle 5 with the right hand, inserting the head end of the scraping rod 1 into the upper section of the uterine cavity from the longitudinal incision, wherein the scraping force emphasizes 12 o 'clock direction, repeatedly passing in and out for scraping, when coarse sand feeling is sensed, rotating the handle 2 clockwise with the rotation radian of 90 degrees, keeping the position of the pointer 61 unchanged, continuously scraping, wherein the scraping force emphasizes 3 o' clock direction, and when coarse sand feeling is sensed, scraping in 6 o 'clock and 9 o' clock directions by repeating the above actions; scraping the upper end of the uterine cavity, continuously scraping the lower end of the uterine cavity, scraping the endometrium on the other side after the endometrium on the side is scraped, and finally suturing the abdomen of the rat. Can know the degree of depth deep into uterus with the help of warning ring 4 in this operation process, can also prevent deep into the uterus degree of depth overlength when guaranteeing to scrape that pole 1 deep into the uterus degree of depth is unanimous, causes the uterus perforation.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (5)
1. A thin endometrium model generator for rat is characterized in that it includes:
the scraping rod is placed in the uterus of the rat, one end of the scraping rod extending into the uterus is the front end, and the other end of the scraping rod not extending into the uterus is the tail end; the outer surface of the scraping rod consists of a rough surface and a smooth surface, and the rough surface and the smooth surface are arranged along the length direction of the scraping rod; the rough surface is uniformly and densely distributed with sawtooth grains, and the central angle of the cross section of the rough surface is 90-110 degrees; the scraping rod is further provided with an external thread and a plurality of warning rings, the external thread is arranged at the tail end of the scraping rod, and the warning rings are close to the external thread;
the handle is used for fixing the scraping rod and comprises a first body and a second body, and the first body is rotationally connected with the second body; the first body is provided with a pointer, and the pointer is parallel to the central line of the first body; angle scale marks are arranged on the periphery of the second body and are positioned at the connecting end of the second body and the first body; the middle part of the second body is provided with a thread groove for fixing the scraping rod, and the thread of the thread groove is matched with the external thread.
2. The thin endometrium forming device for the rat according to claim 1, wherein a hollow connecting rod is arranged right above the thread groove arranged in the middle of the second body, and the hollow connecting rod and the second body are integrally formed; the periphery of the hollow connecting rod is provided with an annular chute; a connecting hole is formed in the middle of the first body, and an annular convex strip matched with the sliding groove is arranged in the connecting hole.
3. The thin endometrium forming device for rat of claim 1, wherein the front end of the scraping rod is bullet-shaped, and the rest part is cylindrical; the handle is in a capsule shape, and the first body is in a semicircular shape.
4. The thin endometrium former of rat of claim 1, wherein the central angle is 100 °, the number of the warning rings is 3, the width is 2-5mm, and the adjacent warning rings are spaced 2-3 mm.
5. The thin endometrium forming device for rat according to claim 1, wherein the scraping rod has a diameter of 1.2-1.4mm and a length of 35-40 mm; the handle has a diameter of 10-12mm and a length of 20-25 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920996142.6U CN210673488U (en) | 2019-06-28 | 2019-06-28 | Thin endometrium model building device for rat |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920996142.6U CN210673488U (en) | 2019-06-28 | 2019-06-28 | Thin endometrium model building device for rat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210673488U true CN210673488U (en) | 2020-06-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920996142.6U Expired - Fee Related CN210673488U (en) | 2019-06-28 | 2019-06-28 | Thin endometrium model building device for rat |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210673488U (en) |
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2019
- 2019-06-28 CN CN201920996142.6U patent/CN210673488U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200605 |