CN210644863U - Device for treating different types of tumors or cells based on infrared photodynamic force - Google Patents
Device for treating different types of tumors or cells based on infrared photodynamic force Download PDFInfo
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- CN210644863U CN210644863U CN201921072253.4U CN201921072253U CN210644863U CN 210644863 U CN210644863 U CN 210644863U CN 201921072253 U CN201921072253 U CN 201921072253U CN 210644863 U CN210644863 U CN 210644863U
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Abstract
The utility model discloses a device based on infrared ray photodynamic treatment different grade type tumour or cell, include: the device comprises a device body, a control unit and a control unit, wherein one side of the device body facing an operator is configured to be a polycarbonate PC glass plate, and the other sides are configured to be black heat-preservation cotton foam plates; the infrared laser is arranged on the top of the device main body; the platform is matched with the light emitting position of the infrared laser; a three-dimensional moving assembly; one side of the device main body is provided with a first handle which can extend into the upper part of the platform in a penetrating way, and a power meter is arranged on the first handle. The utility model provides a device based on infrared ray photodynamic treatment different grade type tumour or cell, it has simple structure, convenient to use's characteristics, not only can accurately adjust the facula size in order to adapt to the regional size of focus, guarantees to shine the stability of longer time power, can also reduce the injury to experiment operator's eyes, helps the error that the loaded down with trivial details operation of the reduction of supplementary experimenter brought, obtains good experiment or treatment.
Description
Technical Field
The utility model relates to a device that uses under supplementary experimental condition. More specifically, the utility model relates to a device based on infrared ray photodynamic therapy different grade type tumour or cell under the condition of photodynamic therapy is carried out to tumour cell, animal model tumour position to being used in basic biology experiment.
Background
The incidence of tumors is increasing due to the poor lifestyle and unhealthy mood of the current generation. In the field of basic biomedical research, we generally study the mechanism of tumor development and therapeutic approaches through tumor cell experiments, subcutaneous tumors and in situ tumor models.
Photodynamic therapy (PDT) is a photosensitized chemical reaction with biological effects involving oxygen molecules. The process is that the laser irradiation with specific wavelength makes the photosensitizer in the tissue excited, and the excited photosensitizer transfers the energy to the surrounding oxygen to generate active oxygen, especially singlet oxygen with strong activity, and the singlet oxygen and the adjacent biological macromolecules undergo oxidation reaction to produce cytotoxicity effect, thereby causing cell damage and death. Realizes the physical therapy ablation of the tumor and has good inhibiting effect on the affected part of the tumor.
With the rapid development of nanotechnology, people are trying to combine the nano-drug with photodynamic therapy, i.e. a new method for treating tumor diseases by using photosensitive drugs and laser activation. PDT has the advantage over conventional tumor therapies of being able to perform an effective treatment with precision and minimal side effects, by irradiating the tumor site with specific wavelengths that activate photosensitizing drugs that selectively accumulate in the tumor tissue and initiate photochemical reactions that destroy the tumor.
However, in actual operation, the laser emitter takes a long time to irradiate, the irradiation power is unstable, the inconvenience is easily caused by errors caused by operators, and meanwhile, the infrared laser with higher power easily causes damage to the eyes and the like of the operators.
SUMMERY OF THE UTILITY MODEL
An object of the present invention is to solve at least the above problems and/or disadvantages and to provide at least the advantages which will be described later.
The utility model discloses it is also an object to provide a device based on infrared ray photodynamic treatment different grade type tumour or cell, it has simple structure, convenient to use's characteristics, not only can accurately adjust the facula size in order to adapt to the regional size of focus, guarantees to shine the stability of longer time power, can also reduce the injury to experiment operator's eyes, helps supplementary experimenter's the error that the loaded down with trivial details operation brought, obtains good experiment or treatment.
To achieve these objects and other advantages in accordance with the purpose of the invention, there is provided an apparatus for infrared photodynamic therapy of different types of tumors or cells, comprising:
the device comprises a device body, a control unit and a control unit, wherein one side of the device body facing an operator is configured to be a polycarbonate PC glass plate, and the other sides are configured to be black heat-preservation cotton foam plates;
an infrared laser arranged on the top of the device main body;
a platform matched with the light-emitting position of the infrared laser to place an object to be treated;
the platform is adjusted in the vertical, horizontal and front-back directions through the three-dimensional moving assembly matched with the platform;
one side of the device main body is provided with a first handle which can extend into the upper part of the platform in a penetrating way, and a power meter is arranged on the first handle.
Preferably, the three-dimensional moving assembly is configured to include:
the power output end of the first power mechanism is connected with the platform through a first telescopic mechanism;
the first mounting plate is arranged below the first power mechanism, the second mounting plate is parallel to the first mounting plate in space, a first sliding groove is formed in the second mounting plate, a first sliding block matched with the first sliding groove is arranged on the first mounting plate, a second power mechanism is arranged at one end of the first sliding groove, and the power output end of the second power mechanism is connected with the first mounting plate through a second telescopic mechanism;
the device comprises a device main body, a first mounting plate, a second mounting plate, at least one first sliding groove, at least one second sliding groove and a third power mechanism, wherein the first sliding groove is arranged at the bottom of the device main body and is mutually vertical to the second mounting plate in space, one end of the first sliding groove is provided with the third power mechanism, the power output end of the third power mechanism is connected with the second mounting plate through a second telescopic mechanism, and the second mounting plate is provided with a second sliding.
Preferably, the device body is provided with a timer and a thermometer, and the control switch of each power mechanism is disposed on a side wall of the device body.
Preferably, an oxygen content meter is arranged in the device main body, and a ventilation assembly is arranged at one corner of the top of the device main body;
wherein the air exchange assembly is configured to include:
an inflation tube extending into the device main body for introducing oxygen of sufficient volume;
and a gas exchange tube extending from the inside to the outside of the device body and provided with a pressure valve.
Preferably, one end of the first telescopic mechanism, which is matched with the platform, is configured as a T-shaped end;
the platform bottom is provided with the first heavy groove that can supply T shape end to stretch into, the tank bottom of first heavy groove is provided with the second heavy groove that can supply T shape end rotation to fix.
Preferably, the platform forms a double-layer structure by the bottom plate and the panel, and the bottom plate and the panel are connected in a clamping manner;
the bottom plate is provided with a third heavy groove for accommodating the heating mechanism, the bottom of the bottom plate is provided with a storage battery, and one side of the third heavy groove is communicated with the storage battery through a wire in the fourth heavy groove.
Preferably, the device further comprises an aeroanesthesia device which is connected with the platform through a matched air duct.
Preferably, wherein, the platform top is provided with the light-emitting plate of black material, and it is provided with the light trap on the light-emitting position with infrared laser matched with.
The infrared power emitted by the infrared laser is configured to be 10 mW-1W, the wavelength is configured to be 650nm, and the spot size is adjusted to be configured to be 3mm-1 cm.
The utility model discloses at least, include following beneficial effect: one of them, the utility model discloses an in basic biology experiment, to tumor cell, the photodynamic treatment is carried out at animal model tumour position to the device, has easy and simple to handle, labour saving and time saving, science effective.
Secondly, the utility model discloses a design to device major structure for the environment has the seal in the treatment device main part, prevents the injury of infrared ray to operator (eyes).
Thirdly, the utility model discloses a densitometer detects the optical density of light-emitting for it can accurately adjust the size of facula size in order to adapt to the regional size of focus as required, guarantees to shine the stability of longer time power.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Drawings
FIG. 1 is a perspective view of a structural connection of an apparatus for infrared photodynamic therapy of different types of tumors or cells in accordance with an embodiment of the present invention;
FIG. 2 illustrates a schematic view of the first handle in cooperation with an optical power meter;
fig. 3 is a schematic top view of a three-dimensional moving assembly according to another embodiment of the present invention;
fig. 4 is a schematic cross-sectional structure diagram of a three-dimensional moving assembly and a platform according to another embodiment of the present invention;
fig. 5 is a schematic cross-sectional structure view of the first telescoping mechanism and the platform in another embodiment of the present invention.
Detailed Description
The present invention is further described in detail below with reference to the drawings so that those skilled in the art can implement the invention with reference to the description.
It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.
Fig. 1 shows an implementation form of the device for treating different types of tumors or cells based on infrared photodynamic, which comprises:
the device main body 1, its one side facing the operator is configured as the polycarbonate PC glass board 2, the other sides are configured as the black heat preservation cotton foam board 3, the therapeutic device main body is configured as the cube, its five sides are the heat preservation cotton foam board of the black material, the side is the polycarbonate PC glass material, can guarantee the internal environment seal of therapeutic device main body, prevent the injury of infrared ray to the operator (eyes);
the infrared laser 4 is arranged at the top of the device body and used for generating laser for treatment, the infrared laser is sealed with the top of the treatment device body, the emitted infrared power is 10 mW-1W, the wavelength is 650nm, the size of a light spot is adjusted to be 3mm-1cm, and the power stability in the irradiation process is controllable through the arrangement of a fixed position;
a platform 5 which is matched with the light-emitting position of the infrared laser to place an object to be treated and is used for placing an animal or cell tissue to be treated;
the platform is adjusted in the vertical, left and right and front and back directions through the three-dimensional moving assembly 6 which is matched with the platform, the position of the platform in three dimensions can be adjusted through the three-dimensional moving assembly, the position to be irradiated is guaranteed to be corresponding to the laser emitting position all the time, the three-dimensional moving assembly can also position the platform through the supporting piece 8 which is matched with the platform, the position of the platform is adjusted through the action of the second handle 7, and a sliding groove which is matched with the supporting piece can be formed in the bottom of the platform, so that the moving stability of the platform is better;
one side of the device main part is provided with the first handle 9 that can stretch into to the platform top through running through, install the dynamometer 10 on it, it reaches the optical density who shines the position through the dynamometer measurement that sets up on the handle, and then guarantee it and shine treatment, simultaneously can be according to the optical density that detects to accurate regulation facula size in order to adapt to the regional size of focus, guarantee to shine the stability of longer time power, can also reduce the injury to experiment operator's eyes, help the error that alleviates loaded down with trivial details operation and bring of supplementary experimenter, obtain good experiment effect, the device main part is provided with rubber seal ring on the position with handle matched with simultaneously, the handle can be configured into multistage formula to connect through the mode of screw thread.
3-4, in another example, the three-dimensional movement assembly is configured to include:
the power output end of a first power mechanism 11 arranged at the bottom of the platform is further connected with the platform through a first telescopic mechanism 12, and the platform can be adjusted in the upper and lower spatial positions through the design of the first telescopic mechanism;
the platform comprises a first mounting plate 13 arranged below a first power mechanism, and a second mounting plate 14 parallel to the first mounting plate in space, wherein a first chute 15 is arranged on the second mounting plate, a first sliding block 16 matched with the first chute is arranged on the first mounting plate, a second power mechanism 17 is arranged at one end of the first chute, the power output end of the second power mechanism is connected with the first mounting plate through a second telescopic mechanism 18, the platform can be adjusted in the left-right or front-back space position in the device main body through the matching of the second power mechanism and the second telescopic mechanism, and the platform can be guided when the spatial position of the platform is adjusted through the matching of the first chute and the first sliding block;
the device comprises a device body, at least one second sliding groove 19 which is arranged at the bottom of the device body and is mutually vertical to a second mounting plate in space, a third power mechanism 22 is arranged at one end of the second sliding groove, the power output end of the third sliding groove is connected with the second mounting plate through a second telescopic mechanism 20, the platform can be adjusted in the left-right or front-back space position in the device body through the matching of the third power mechanism and the third telescopic mechanism, a second sliding block 21 matched with the second sliding groove is arranged on the second mounting plate, the platform can be guided when the space position is adjusted through the matching of the second sliding groove and the second sliding block, the telescopic mechanism can be configured into a screw rod and sleeve structure to realize the adjustment, and each power mechanism can be set into a motor to realize the simple structure and easy realization.
In another example, as shown in fig. 1, a timer 22 and a thermometer 23 are disposed on the device body, and are used for detecting the environmental conditions in the sealed space in the cartridge body, so as to facilitate monitoring the environment in the therapeutic device body and facilitate recording of the irradiation time, and a control switch (not shown) of each power mechanism is disposed on a side wall of the device body, and switches the working state of each power mechanism through the control switches disposed respectively, so that the platform can move to a designated position, thereby ensuring the irradiation effect.
In another example, as shown in fig. 1, an oxygen content measuring instrument (not shown) is disposed inside the device body, and is used for detecting the amount of ambient oxygen inside the device body so as to control the oxygen environment when irradiating the living body for treatment to ensure that the environment is suitable for living things, and a ventilation assembly is disposed at one corner of the top of the device body and is used for exhausting the internal foul air to ensure the oxygen content in the internal space;
wherein the air exchange assembly is configured to include:
an inflation tube 24 extending into the interior of the device body to introduce oxygen of a sufficient amount for introducing oxygen thereinto when the interior is deficient in oxygen;
and a ventilation pipe 25 extending from the inside to the outside of the device body, and provided with a pressure valve 26, such as a unit valve, for opening the ventilation pipe by pressure lift when the internal pressure is too high, so that the inside foul air can be gradually discharged.
In another example, as shown in fig. 5, the end of the first telescoping mechanism that is engaged with the platform is configured as a T-shaped end 27, which is used to engage with the platform, so that the connection relationship between the two is detachable, which facilitates the adaptive replacement of the platform as required;
the platform bottom is provided with the first heavy groove 28 that can supply the T shape end to stretch into, the tank bottom of first heavy groove is provided with the heavy groove 29 of second that can supply the T shape end rotation to fix, and it is through the setting of first heavy groove for the T shape end can cooperate with first heavy groove, realizes being connected, and the heavy groove of second can set up to cooperate mutually with the horizontal portion of T shape end, and it can set up to cooperate annular structure mutually with horizontal portion, also can set up to the semiannulus, and then prescribe a limit to the position of the two, in order to guarantee its combination effect.
In another example, as shown in fig. 4, the platform is a double-layer structure formed by a bottom plate 30 and a face plate 31, and the two are connected by clamping;
be provided with the third that holds heating structure 32 on the bottom plate and sink groove 33, the bottom plate bottom is provided with the battery, one side that the third sinks the groove through the wire in the fourth sinks the inslot and then with the battery intercommunication, its setting through heating mechanism for it can heat the live object according to ambient temperature's needs, in order to guarantee that it is in under comparatively excellent ambient temperature, and then guarantees treatment and therapentic personnel's treatment experience.
In another example, as shown in fig. 1, the device further comprises an aeroanesthesia device 34 connected with the platform through a matched air duct 35, which is used for aeroanesthesia treatment of living things on the platform, and the position of the aeroanesthesia device can correspond to the position of the nose of the living things;
as shown in fig. 4, in another example, a light-emitting plate 36 made of black material is disposed above the platform, and a light-transmitting hole is disposed at a light-emitting position matched with the infrared laser, and is used for shielding the living body except the tumor from other positions through the light-emitting plate made of black material, so as to prevent the living body from affecting other parts, and simultaneously, the light is guided to the tumor position through the light-transmitting hole, so that the treatment effect is better.
The above embodiments are merely illustrative of a preferred embodiment, but not limiting. When the utility model is implemented, the proper replacement and/or modification can be carried out according to the requirements of users.
Example 1: cell irradiation treatment
As shown in fig. 1, an irradiation apparatus based on an infrared ray treatment animal model includes: the device comprises an infrared laser, a power meter, a treatment device main body and a three-dimensional moving platform. Place this device in superclean bench, ultraviolet disinfection 30min, place the probe on the platform, the laser spot will be beaten in the middle of the probe, adjust the facula to suitable size, place the culture dish that has the cell in the three-dimensional moving platform in, move the handle, the cell culture dish that will shine removes to the laser spot, and the timing is shone, moves the platform after finishing shining, takes out the cell orifice plate, puts back the cell culture case with the orifice plate.
Example 2: subcutaneous tumor irradiation treatment
As shown in fig. 1, an irradiation apparatus based on an infrared ray treatment animal model includes: the device comprises an infrared laser, a power meter, a treatment device main body and a three-dimensional moving platform. The device is placed in a super-clean workbench, ultraviolet disinfection is carried out for 30min, a probe is placed on a platform, a laser spot is shot in the middle of the probe, the light spot is adjusted to be in a proper size, the nude mouse is rapidly inflated and wrapped by black edge-isolating cloth, the tumor position is exposed, the treated nude mouse is fixed on a three-dimensional moving platform, the mouth and the nose are connected with an inflation hose, a handle is moved, the tumor part needing irradiation is moved to the laser spot, timing irradiation is carried out, the platform is moved after the irradiation is finished, the nude mouse is taken out, the nude mouse is placed back to a constant-temperature incubator to be resuscitated, and the nude mouse is placed.
Example 3: in situ tumor (intracranial glioma) irradiation treatment
As shown in fig. 1, an irradiation apparatus based on an infrared ray treatment animal model includes: the device comprises an infrared laser, a power meter, a treatment device main body and a three-dimensional moving platform. The device is placed in a super-clean workbench, ultraviolet disinfection is carried out for 30min, a probe is placed on a platform, a laser spot is shot in the middle of the probe, the light spot is adjusted to be in a proper size, the nude mouse is anesthetized by aeroanesthesia, the head is exposed by wrapping with black cloth, the treated nude mouse is fixed on a three-dimensional moving platform, the aeroanesthesia device is connected, a handle is moved, the part needing irradiation is moved to the laser spot, timing irradiation is carried out, the platform is moved after the irradiation is finished, the nude mouse is taken out, the nude mouse is placed back to a constant temperature incubator to be resuscitated, and the nude mouse is placed back to a cage after the.
The number of apparatuses and the scale of the process described here are intended to simplify the description of the present invention. The application, modifications and variations of the device for infrared photodynamic based treatment of different types of tumors or cells of the present invention will be apparent to those skilled in the art.
While embodiments of the invention have been disclosed above, it is not intended to be limited to the applications listed in the specification and the examples. It can be applicable to various and be fit for the utility model discloses a field completely. Additional modifications will readily occur to those skilled in the art. The invention is therefore not to be limited to the specific details and illustrations shown and described herein, without departing from the general concept defined by the claims and their equivalents.
Claims (9)
1. An apparatus for infrared-based photodynamic therapy of different types of tumors or cells, comprising:
the device comprises a device body, a control unit and a control unit, wherein one side of the device body facing an operator is configured to be a polycarbonate PC glass plate, and the other sides are configured to be black insulating cotton foam plates;
an infrared laser arranged on the top of the device main body;
a platform matched with the light-emitting position of the infrared laser to place an object to be treated;
the platform is adjusted in the vertical, horizontal and front-back directions through the three-dimensional moving assembly matched with the platform;
one side of the device main body is provided with a first handle which can extend into the upper part of the platform in a penetrating way, and a power meter is arranged on the first handle.
2. The infrared-based photodynamic therapy device for different types of tumors or cells as claimed in claim 1, wherein the three-dimensional moving assembly is configured to include:
the power output end of the first power mechanism is connected with the platform through a first telescopic mechanism;
the first mounting plate is arranged below the first power mechanism, the second mounting plate is parallel to the first mounting plate in space, a first sliding groove is formed in the second mounting plate, a first sliding block matched with the first sliding groove is arranged on the first mounting plate, a second power mechanism is arranged at one end of the first sliding groove, and the power output end of the second power mechanism is connected with the first mounting plate through a second telescopic mechanism;
the device comprises a device main body, a first mounting plate, a second mounting plate, at least one first sliding groove, at least one second sliding groove and a third power mechanism, wherein the first sliding groove is arranged at the bottom of the device main body and is mutually vertical to the second mounting plate in space, one end of the first sliding groove is provided with the third power mechanism, the power output end of the third power mechanism is connected with the second mounting plate through a second telescopic mechanism, and the second mounting plate is provided with a second sliding.
3. The device for infrared photodynamic therapy of different types of tumors or cells as claimed in claim 2, wherein a timer and a thermometer are provided on the device body, and the control switch of each of the photodynamic means is provided on a side wall of the device body.
4. The infrared photodynamic therapy device as claimed in claim 1, wherein the oxygen content meter is arranged in the device body, and a ventilation component is arranged at one corner of the top of the device body;
wherein the air exchange assembly is configured to include:
an inflation tube extending into the device main body for introducing oxygen of sufficient volume;
and a gas exchange tube extending from the inside to the outside of the device body and provided with a pressure valve.
5. The infrared-based photodynamic therapy device for treating different types of tumors or cells as claimed in claim 2, wherein the end of the first telescopic mechanism which is engaged with the platform is configured as a T-shaped end;
the platform bottom is provided with the first heavy groove that can supply T shape end to stretch into, the tank bottom of first heavy groove is provided with the second heavy groove that can supply T shape end rotation to fix.
6. The device for the photodynamic therapy of different types of tumors or cells as claimed in claim 1, wherein the platform is a double-layer structure formed by the base plate and the face plate, and the base plate and the face plate are connected by means of clamping;
the bottom plate is provided with a third heavy groove for accommodating the heating mechanism, the bottom of the bottom plate is provided with a storage battery, and one side of the third heavy groove is communicated with the storage battery through a wire in the fourth heavy groove.
7. The infrared-based photodynamic therapy device as claimed in claim 1, further comprising a anesthesia device connected to the platform by a cooperating airway tube.
8. The infrared photodynamic therapy device as claimed in claim 1, wherein a light-emitting plate made of black material is disposed above the platform, and a light-transmitting hole is disposed at a position where the light-emitting plate is matched with the infrared laser.
9. The infrared-based photodynamic therapy device for different types of tumors or cells as claimed in claim 1, wherein the infrared power emitted by the infrared laser is configured to 10 mW-1W, the wavelength is configured to 650nm, and the spot size is adjusted to be configured to 3mm-1 cm.
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| CN201921072253.4U CN210644863U (en) | 2019-07-10 | 2019-07-10 | Device for treating different types of tumors or cells based on infrared photodynamic force |
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| CN201921072253.4U CN210644863U (en) | 2019-07-10 | 2019-07-10 | Device for treating different types of tumors or cells based on infrared photodynamic force |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201312A (en) * | 2019-07-10 | 2019-09-06 | 中国人民解放军陆军军医大学第一附属医院 | Device based on infrared ray dynamic therapy different type tumour or cell |
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2019
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110201312A (en) * | 2019-07-10 | 2019-09-06 | 中国人民解放军陆军军医大学第一附属医院 | Device based on infrared ray dynamic therapy different type tumour or cell |
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