CN210644737U - Ultrasonic medicine feeder with nerve navigation aid - Google Patents
Ultrasonic medicine feeder with nerve navigation aid Download PDFInfo
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- CN210644737U CN210644737U CN201920880072.8U CN201920880072U CN210644737U CN 210644737 U CN210644737 U CN 210644737U CN 201920880072 U CN201920880072 U CN 201920880072U CN 210644737 U CN210644737 U CN 210644737U
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Abstract
The utility model aims at providing a device is with low costs, and the supplementary supersound of nerve navigation that guide and monitoring time are short is dosed device. In order to achieve the above purpose, the utility model adopts the following technical scheme: the utility model provides a supplementary supersound of nerve navigation device of dosing, includes the open condition monitoring mechanism of focus ultrasonic focus positioning mechanism, ultrasonic energy emission mechanism, blood brain barrier and the mechanism of dosing, focus ultrasonic focus positioning mechanism is including the host computer of installing nerve navigation software, the host computer has the display screen and is used for data transmission's USB interface, the host computer is put together and is equipped with navigation probe, adapter, reference frame, infrared positioning appearance is connected with the host computer electricity, ultrasonic energy emission mechanism is at least including focus ultrasonic probe, the open condition monitoring mechanism of blood brain barrier includes B type ultrasonic probe at least, B type ultrasonic probe is connected with the host computer electricity.
Description
Technical Field
The utility model relates to a diagnosis and treatment technical field, concretely relates to supplementary supersound of nerve navigation device of dosing.
Background
At present, many drugs have significant effects on the treatment of central nervous system diseases, but the existence of the blood brain barrier limits the treatment effect of the drugs in clinical application. Therefore, opening the blood-brain barrier to allow the drug to smoothly enter the brain and accumulate a sufficient therapeutic amount at the target area is critical for the treatment of central nervous system diseases.
The current ultrasonic drug delivery device firstly opens the blood brain barrier through magnetic resonance guided focused ultrasound and then injects drugs into veins. The method comprises the steps of firstly positioning a target area and focusing an ultrasonic focus through scanning imaging in magnetic resonance, then transmitting ultrasonic energy to the target area by using a focusing ultrasonic device, then monitoring the opening condition of a blood brain barrier through scanning imaging in the magnetic resonance, and finally injecting a medicament into a human body. The opening of the blood brain barrier by utilizing focused ultrasound is different from thermal ablation, and the instant observation cannot be realized by magnetic resonance imaging; that is, the operator needs to inject the contrast medium again after the ultrasonic irradiation, and then perform the magnetic resonance scanning again to confirm whether the blood brain barrier is opened. The focusing ultrasonic device is a conventional device and comprises a function generator serving as a signal source, a power amplifier amplifying the signal source, an electric power measuring instrument capable of measuring the electric power, a power inductor matched with the electric power measuring instrument, a focusing ultrasonic probe converting an electric signal into an ultrasonic signal and an impedance matching box improving the efficiency of converting electric energy into sound energy.
The administration mode depends on expensive magnetic resonance imaging equipment, has high requirements on the environment condition of an operating room and magnetic compatible surgical instruments, and consumes quite long time and quite a lot of medical resources if magnetic resonance scanning is needed during each administration, thereby not only increasing the treatment time, but also increasing the treatment cost of patients. In summary, the magnetic resonance assisted ultrasound drug delivery device is increasingly unable to meet clinical needs due to its great problems in terms of application cost and convenience.
Disclosure of Invention
The utility model aims at providing a device is with low costs, and the supplementary supersound of nerve navigation that guide and monitoring time are short is dosed device.
In order to achieve the above purpose, the utility model adopts the following technical scheme: a nerve navigation auxiliary ultrasonic drug delivery device comprises a focusing ultrasonic focus positioning mechanism, an ultrasonic energy transmitting mechanism, a blood brain barrier open condition monitoring mechanism and a drug delivery mechanism, wherein the focusing ultrasonic focus positioning mechanism comprises a host provided with nerve navigation software, the host is provided with a display screen and a USB interface used for data transmission, the host is matched with a navigation probe, an adapter, a reference frame and an infrared locator, the infrared locator is electrically connected with the host, the adapter comprises a first fixed support and three reflective balls fixed on the first fixed support, the reference frame comprises a second fixed support and four reflective balls fixed on the second fixed support, the second fixed support is fixed on an operating table, the ultrasonic energy transmitting mechanism at least comprises a focusing ultrasonic probe, the first fixed support is fixed on the focusing ultrasonic probe, the blood brain barrier opening condition monitoring mechanism at least comprises a B-type ultrasonic probe, and the B-type ultrasonic probe is electrically connected with a host.
The utility model discloses the device replaces the magnetic resonance imaging equipment that the price is expensive through the host computer by installing the neural navigation software to make the disease need not use magnetic resonance imaging equipment to focus the guide of ultrasonic energy when dosing. The surgical instruments used in combination with the device of the user do not need magnetic compatibility, and the device is more convenient to use and lower in surgical cost.
When the device is used, the MRI image of the head of the patient scanned before the operation is led into the host through the USB interface, and the three-dimensional reconstruction is carried out on the image through the built-in nerve navigation system of the host; and selecting six to eight mark points on the head of the patient by using the navigation probe, and selecting corresponding six to eight mark points on the three-dimensional model by using a mouse matched with the host machine so as to enable the three-dimensional image on the host machine to coincide with the spatial coordinates of the head of the real patient, thereby realizing spatial registration. After the spatial registration is completed, the navigation system establishes a set of spatial position corresponding relationship between points on the tomographic image and the three-dimensional model image and corresponding points on the body of the patient. The infrared positioning instrument tracks the space positions of the navigation probe and the head of the patient in real time, and can display the image information and the adjacent structure content of the position of the probe on the display screen in different directions and angles, so that the position of a target point is accurately positioned; the focused ultrasonic probe is calibrated, and the calibrated focused ultrasonic probe is tracked through the infrared locator and the virtual focus is displayed on the preoperative image by utilizing the established spatial position corresponding relation, so that the position of the real focus on the target area can be determined according to the position of the virtual focus. Injecting micro bubbles into a patient, performing ultrasonic irradiation on a target area by using pulse type ultrasonic waves emitted by a focused ultrasonic probe, and monitoring the opening condition of a blood brain barrier by using a blood brain barrier opening condition monitoring mechanism. After the blood brain barrier is opened, the drug is administered by using a drug administration mechanism, and continuous drug infusion is carried out in the body of a patient in an intravenous mode.
The blood brain barrier opening condition monitoring mechanism is matched with the host and used for generating a two-dimensional ultrasonic image in a microbubble rupture process to monitor the opening condition of the blood brain barrier and obtain the position where the cavitation effect occurs, the B-type ultrasonic probe is used for receiving the sound wave intensity and the distribution condition when the cavitation effect occurs, the B-type ultrasonic probe can be matched with an analog-to-digital converter, and the digital converter is used for converting an analog signal into a digital signal. The intensity and frequency of the focused ultrasonic probe are different from those of the B ultrasonic probe, and after the focused ultrasonic probe is used, whether the blood brain barrier is opened or not is detected through the B ultrasonic probe. The reflective ball is used for providing spatial position information for the infrared positioning instrument.
The utility model discloses need not fix a position focus supersound focus through magnetic resonance imaging equipment, reduced equipment cost, the device is with low costs. The utility model discloses a human body that image and art before the nerve navigation utilized carries out the space registration, can confirm target area and focus after the space registration is accomplished, and guide and monitoring time are short, use more swiftly convenient.
Preferably, a water storage box is arranged on the lower side of the focusing ultrasonic probe, the focusing ultrasonic probe sends out ultrasonic waves downwards, the water storage box is made of transparent materials, and a water injection hole is formed in the upper end of the water storage box. The water is more convenient to be used as a medium for ultrasonic wave propagation, and the water can be injected into the water storage box to remove the water, so that the ultrasonic wave propagation is more convenient; wherein, can adopt various modes to realize the degasification of water. The water storage box is transparent, so that doctors can conveniently observe water in the water storage box.
Preferably, a fixing ring with an annular cross section is arranged on the lower side of the shell of the focused ultrasound probe, the fixing ring comprises an upper ring part and a lower ring part, an internal thread structure is formed on the circumferential inner wall of the upper ring part, at least one limiting block is arranged on the circumferential inner wall of the lower ring part, the water storage box comprises a water storage part for storing water and a fixing part for fixing with the shell of the focused ultrasound probe, the circumferential outer edge of the cross section of the fixing part is circular, the fixing part comprises a fixed upper part and a fixed lower part, the outer diameter of the fixed upper part is larger than the outer diameter of the fixed lower part, an external thread structure matched with the internal thread structure is formed on the circumferential outer wall of the fixed upper part, the circumferential outer edge of the fixed upper part is inwards concave to form a plurality of through grooves, the through grooves vertically penetrate through the fixed upper part, so that the stopper is located on the fixed lower portion circumferential side and below the fixed upper portion.
The above-mentioned setting is so that the utility model discloses water storage box is more convenient with focusing ultrasonic probe's fixed, and can avoid taking place because of the not hard up condition of the water storage box whereabouts that leads to of screw thread. When carrying out the fixed of water storage box and focus ultrasonic probe, make the water storage box be located under the solid fixed ring of focus ultrasonic probe casing, make every stopper all be located one and pass through directly over the groove, then lift up the water storage box so that the stopper passes through and pass through the groove and make the stopper be located under the fixed upper portion of water storage box, carry out the screw thread rotation of water storage box afterwards.
Preferably, the number of the limiting blocks is at least three, the limiting blocks are arranged on the circumferential inner wall of the fixing ring at annular intervals by taking the circle center of the fixing ring as the center, and the through grooves correspond to the limiting blocks one to one. The above arrangement makes the support of the water storage box by the limiting block more stable, and the subsequent water storage box is convenient to rotate and fix by the screw thread.
Preferably, the water injection hole is located the water storage portion, water injection hole department is connected with the water receiving pipe, the one end that the water storage box was kept away from to the water receiving pipe can be dismantled and be connected with the delivery hose, delivery hose collocation has the delivery pump, the one end that the water receiving pipe was connected with the delivery hose is located relatively the water storage box top, the one end that the water storage box was kept away from to the water receiving pipe is equipped with the stop valve, and when the water storage box was fixed with the focus ultrasonic probe, the water receiving pipe was located the below of focus ultrasonic probe rear side cantilever. The water storage box is convenient to inject water into the water storage box, and the water storage box does not need to be detached. When water is injected, the water supply hose is connected with the water receiving pipe, then the water supply pump is started to supply water, when water exists at the upper end of the water receiving pipe, the water storage box can be ensured to be filled with water, and then the stop valve is closed. The water supply hose can be detachably fixed with the water receiving pipe in a joint connection mode, and any one of the existing joints can be selected.
Preferably, the focused ultrasound probe is a 256-array element phased array ultrasound probe, the phased array probe has a diameter of 120mm, a curve radius of 100 mm, a focal ratio number of =0.83, a frequency of =500 kHz, and a size of each array element is 5.5 × 5.5mm2. The probe can adjust the depth and offset position of the focus by adjusting the phased array.
Preferably, the drug delivery mechanism comprises a constant-speed infusion set.
The utility model has the advantages of low device cost, reduced guide time and monitoring time, and reduced treatment cost.
Drawings
Fig. 1 is a schematic structural view of the present invention;
fig. 2 is a schematic structural diagram of the focusing ultrasonic probe and the water storage box of the present invention.
Detailed Description
The invention will be further described with reference to the drawings and the specific embodiments.
As shown in fig. 1 and fig. 2, a nerve navigation-assisted ultrasonic drug delivery device comprises a focused ultrasonic focus positioning mechanism, an ultrasonic energy emission mechanism, a blood brain barrier opening condition monitoring mechanism and a drug delivery mechanism, wherein the focused ultrasonic focus positioning mechanism comprises a host 1 provided with nerve navigation software, the host 1 is provided with a display screen 11 and a USB interface 12 for data transmission, the host 1 is matched with a navigation probe, an adapter 2, a reference frame 3 and an infrared locator 4, the infrared locator 4 is electrically connected with the host 1, the adapter 2 comprises a first fixing support 21 and three reflective balls 20 fixed on the first fixing support 21, the reference frame 3 comprises a second fixing support 31 and four reflective balls 20 fixed on the second fixing support 31, the second fixing support 31 is fixed on an operating table 5, the ultrasonic energy emission mechanism at least comprises a focused ultrasonic probe 6, the first fixing support 21 is fixed on the focused ultrasound probe 6, the blood brain barrier opening condition monitoring mechanism at least comprises a B-type ultrasound probe 7, and the B-type ultrasound probe 7 is electrically connected with the host 1. Wherein the administration mechanism comprises a constant-speed infusion set 15.
The lower side of the focusing ultrasonic probe 6 is provided with a water storage box 8, the focusing ultrasonic probe 6 downwards sends out ultrasonic waves, the water storage box 8 is made of transparent materials, and the upper end of the water storage box 8 is provided with a water injection hole.
A fixing ring 61 with a ring-shaped cross section is arranged on the lower side of the shell of the focusing ultrasonic probe 6, the fixing ring 61 comprises a ring upper part 611 and a ring lower part 612, an internal thread structure is formed on the circumferential inner wall of the ring upper part 611, at least one limiting block 62 is arranged on the circumferential inner wall of the ring lower part 612, the water storage box comprises a water storage part 81 for storing water and a fixing part 82 for fixing with the shell of the focusing ultrasonic probe 6, the circumferential cross section outer edge of the fixing part 82 is circular, the fixing part 82 comprises a fixing upper part 821 and a fixing lower part 822, the outer diameter of the fixing upper part 821 is larger than that of the fixing lower part 822, an external thread structure matched with the internal thread structure is formed on the circumferential outer wall of the fixing upper part 821, the circumferential outer edge of the fixing upper part 821 is concave inwards to form a plurality of through grooves 83, the fixing upper, so that the stopper 62 is located on the circumferential side of the fixed lower portion 822 and below the fixed upper portion 821. Wherein, the number of the limiting blocks 62 is at least three, and the plurality of limiting blocks 62 are arranged on the circumferential inner wall of the ring upper part 611 at annular intervals by taking the circle center of the fixing ring 61 as the center, and are in one-to-one correspondence with the limiting blocks 62 through the grooves 83.
The water injection hole is located water storage portion 81, water injection hole department is connected with water receiving pipe 84, the one end that water storage box 8 was kept away from to water receiving pipe 84 can be dismantled and be connected with the delivery hose, delivery hose collocation has the delivery pump, water receiving pipe 84 and the one end that the delivery hose is connected are located water storage box 8 top relatively, the one end that water storage box 8 was kept away from to water receiving pipe 84 is equipped with stop valve 85, when water storage box 8 was fixed with focus ultrasonic probe, water receiving pipe 84 was located the below of focus ultrasonic probe rear side cantilever 9.
The focused ultrasound probe 6 is a 256-array element phased array ultrasound probe, the diameter of the phased array probe is 120mm, the radius of a curve is 100 mm, the focal ratio is =0.83, the frequency =500 kHz, and the size of each array element is 5.5 × 5.5mm 2.
The utility model has the advantages of low device cost, reduced guide time and monitoring time, and reduced treatment cost.
Claims (7)
1. The utility model provides a supplementary supersound of nerve navigation device of dosing which characterized in that includes focus supersound focus positioning mechanism, ultrasonic energy emission mechanism, the open condition monitoring mechanism of blood brain barrier and the mechanism of dosing, focus supersound focus positioning mechanism is including the host computer of installing nerve navigation software, the host computer has the display screen and is used for data transmission's USB interface, the host computer is put up and is furnished with navigation probe, adapter, reference frame, infrared positioning appearance is connected with the host computer electricity, the adapter includes first fixed bolster and fixes three reflection of light ball on first fixed bolster, reference frame includes the second fixed bolster and fixes four reflection of light balls on the second fixed bolster, the second fixed bolster is fixed on the operating table, ultrasonic energy emission mechanism is at least including focus ultrasonic probe, first fixed bolster is fixed on focus ultrasonic probe, the blood brain barrier opening condition monitoring mechanism at least comprises a B-type ultrasonic probe, and the B-type ultrasonic probe is electrically connected with a host.
2. The ultrasonic drug delivery device with nerve navigation assistance of claim 1, wherein a water storage box is arranged at the lower side of the focused ultrasonic probe, the focused ultrasonic probe emits ultrasonic waves downwards, the water storage box is made of transparent materials, and a water injection hole is formed at the upper end of the water storage box.
3. The ultrasound drug delivery device with the assistance of nerve navigation according to claim 2, wherein the lower side of the housing of the focused ultrasound probe is provided with a fixing ring having an annular cross section, the fixing ring comprises an upper ring portion and a lower ring portion, the circumferential inner wall of the upper ring portion is formed with an internal thread structure, the circumferential inner wall of the lower ring portion is provided with at least one limiting block, the water storage box comprises a water storage portion for storing water and a fixing portion for fixing with the housing of the focused ultrasound probe, the circumferential outer edge of the cross section of the fixing portion is circular, the fixing portion comprises a fixing upper portion and a fixing lower portion, the outer diameter of the fixing upper portion is larger than that of the fixing lower portion, the circumferential outer wall of the fixing upper portion is formed with an external thread structure matched with the internal thread structure, the circumferential outer edge of the fixing upper portion is recessed to form a, when the water storage box is fixed with the focused ultrasound probe, the fixing part is fixed with the fixing ring through threads, so that the limiting block is located on the circumferential side of the fixed lower part and below the fixed upper part.
4. The ultrasound drug delivery device with the assistance of nerve navigation of claim 3, wherein the number of the limiting blocks is at least three, the limiting blocks are arranged on the circumferential inner wall of the fixing ring at annular intervals by taking the circle center of the fixing ring as the center, and the through grooves are in one-to-one correspondence with the limiting blocks.
5. The ultrasonic drug delivery device with the nerve navigation assistance function as claimed in claim 3, wherein the water injection hole is located in the water storage portion, a water receiving pipe is connected to the water injection hole, a water delivery hose is detachably connected to one end, away from the water storage box, of the water receiving pipe, a water delivery pump is matched with the water delivery hose, one end, connected with the water delivery hose, of the water receiving pipe is located above the water storage box, a stop valve is arranged at one end, away from the water storage box, of the water receiving pipe, and when the water storage box and the focused ultrasonic probe are fixed, the water receiving pipe is located below a cantilever behind the focused ultrasonic probe.
6. The ultrasound-assisted neuronavigation device of claim 1The ultrasonic focusing probe is a 256-array element phased array ultrasonic probe, the diameter of the phased array probe is 120mm, the curve radius is 100 mm, the focal length ratio is =0.83, the frequency is =500 kHz, and the size of each array element is 5.5 multiplied by 5.5mm2。
7. The neuronavigation-assisted ultrasound drug delivery device of claim 1, wherein the drug delivery mechanism comprises a constant-speed infusion set.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920880072.8U CN210644737U (en) | 2019-06-12 | 2019-06-12 | Ultrasonic medicine feeder with nerve navigation aid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920880072.8U CN210644737U (en) | 2019-06-12 | 2019-06-12 | Ultrasonic medicine feeder with nerve navigation aid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210644737U true CN210644737U (en) | 2020-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920880072.8U Expired - Fee Related CN210644737U (en) | 2019-06-12 | 2019-06-12 | Ultrasonic medicine feeder with nerve navigation aid |
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| Country | Link |
|---|---|
| CN (1) | CN210644737U (en) |
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2019
- 2019-06-12 CN CN201920880072.8U patent/CN210644737U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200602 Termination date: 20210612 |