CN210620663U

CN210620663U - Ibuprofen sodium salt refining plant

Info

Publication number: CN210620663U
Application number: CN201921642551.2U
Authority: CN
Inventors: 王亮; 苏莉; 康朴华; 秦塞男
Original assignee: Henan Normal University
Current assignee: Henan Normal University
Priority date: 2019-09-29
Filing date: 2019-09-29
Publication date: 2020-05-26
Anticipated expiration: 2029-09-29

Abstract

The utility model discloses an ibuprofen sodium salt refining plant, include and loop through the sedimentation tank that the pipeline links to each other along liquid flow direction, the filter, buffer tank and electrodialyzer, wherein electrodialyzer comprises cation exchange membrane, anion exchange membrane, cation exchange membrane, anion exchange membrane alternate arrangement and constitutes utmost point liquid A cavity, utmost point liquid B cavity and utmost point liquid A cavity alternate arrangement's electrodialysis device, and utmost point liquid A cavity passes through the pipeline and is connected with the waste liquid jar, and utmost point liquid B cavity passes through the pipeline and is connected with pure ibuprofen sodium storage jar. The utility model discloses need not pass through the rectification process, reduced the running cost in the production process, do not have simultaneously through high temperature and can not produce dark accessory substance, need not to use activated carbon to decolor in the follow-up treatment process, further the cost is reduced.

Description

Ibuprofen sodium salt refining plant

Technical Field

The utility model belongs to the technical field of the refining of ibuprofen sodium salt, concretely relates to ibuprofen sodium salt refining plant.

Background

The chemical name of ibuprofen is isobutylphenylpropionic acid, and ibuprofen is a non-steroidal anti-inflammatory analgesic, and has 16-32 times greater anti-inflammatory, analgesic and antipyretic effects than aspirin. Compared with common antiphlogistic and analgesic drugs, the product has strong action and small side effect, has no obvious side effect on liver, kidney and hematopoietic system, and especially has small side effect on gastrointestinal tract.

In the ibuprofen production process, a refining process of ibuprofen sodium salt exists, and organic impurities such as petroleum ether, chlorohydrin and the like in the ibuprofen sodium salt are removed. The method is generally used at home and abroad to remove organic matters in the ibuprofen sodium salt by a steam distillation method, and then the colored impurities are removed by using active carbon. Steam distillation causes steam consumption and large power consumption, meanwhile, dark byproducts generated in the high-temperature process affect the quality of products, colored impurities need to be removed by using activated carbon, and the market competitiveness of the products is reduced due to the increase of the cost. An economic and feasible process route is developed, the energy consumption and the consumption of the active carbon are reduced, and the method has important environmental benefit and economic value.

Disclosure of Invention

The utility model provides a technical problem provide a simple and low cost's ibuprofen sodium salt refining plant of process, effectively solved the organic matter among the current ibuprofen sodium salt refining process and remained the higher problem of manufacturing cost.

The utility model adopts the following technical scheme for solving the technical problem, an ibuprofen sodium salt refining device, a serial communication port includes and loops through the sedimentation tank that the pipeline links to each other along liquid flow direction, a filter, buffer tank and electrodialyzer, wherein electrodialyzer is by cation exchange membrane, anion exchange membrane, cation exchange membrane, anion exchange membrane alternate arrangement constitutes utmost point liquid A cavity, utmost point liquid B cavity and the electrodialysis device of utmost point liquid A cavity alternate arrangement, cation exchange membrane side adds the negative pole in this electrodialysis device, anion exchange membrane side adds the positive pole, cation exchange membrane is for having the ion exchange membrane of selective permeability to the sodion, anion exchange membrane is for having the ion exchange membrane of selective permeability to the ibuprofen, utmost point liquid A is the crude solution of ibuprofen sodium salt, utmost point liquid B is sodium chloride solution or sodium hydroxide solution, utmost point liquid A cavity passes through the pipeline and is connected with waste liquid tank, the polar liquid B chamber is connected with a pure ibuprofen sodium storage tank through a pipeline.

Preferably, the concentration of the polar liquid A is 5-10%, the concentration of the polar liquid B is 0.1-0.5%, the purity of the refined crude ibuprofen sodium salt is more than 99.3%, and the removal rate of petroleum ether and chlorohydrin is more than 99.9%.

The utility model discloses a when ibuprofen sodium salt refining plant used, deposit ibuprofen sodium salt aqueous solution through the sedimentation tank, the filter becomes for the clarified solution after filtering, the clarified solution is through the electrodialyzer who is equipped with anion exchange membrane and cation exchange membrane, make ibuprofen and sodium ion see through ion exchange membrane and dissolve and form pure ibuprofen sodium salt solution to aquatic, get into pure ibuprofen sodium storage jar, and organic matter chlorohydrin and petroleum ether can not pass through ion exchange membrane, the waste liquid of desorption ibuprofen sodium salt gets into the waste liquid jar. The refining device does not need a rectification process, so that the running cost in the production process is reduced, dark byproducts can not be generated due to high temperature, activated carbon is not needed for decoloring in the subsequent treatment process, and the cost is further reduced.

Drawings

FIG. 1 is a diagram of the apparatus of the present invention;

FIG. 2 is a schematic view of the construction of an electrodialyzer in accordance with the present invention.

In the figure: 1-a sedimentation tank, 2-a filter, 3-a buffer tank, 4-an electrodialyzer, 5-a pure ibuprofen sodium storage tank, and 6-a waste liquid tank.

Detailed Description

Combine the technical scheme of the utility model of the attached drawing detailed description, an ibuprofen sodium salt refining plant, include along liquid flow direction loop through the sedimentation tank 1 that the pipeline links to each other, filter 2, buffer tank 3 and electrodialyzer 4, wherein electrodialyzer 4 is by cation exchange membrane, anion exchange membrane, cation exchange membrane, anion exchange membrane alternate arrangement constitutes polar liquid A cavity, the electrodialysis device of polar liquid B cavity and polar liquid A cavity alternate arrangement, cation exchange membrane side adds the negative pole in this electrodialysis device, anion exchange membrane side adds the positive pole, cation exchange membrane is for having the ion exchange membrane of selective permeability to the sodion, anion exchange membrane is for having the ion exchange membrane of selective permeability to the ibuprofen, polar liquid A is the crude solution of ibuprofen sodium salt, polar liquid B is sodium chloride solution or sodium hydroxide solution, polar liquid A cavity passes through the pipeline and is connected with waste liquid jar 6, the polar liquid B chamber is connected with a pure ibuprofen sodium storage tank 5 through a pipeline; the concentration of the polar liquid A is 5-10%, the concentration of the polar liquid B is 0.1-0.5%, the purity of the refined crude ibuprofen sodium salt is more than 99.3%, and the removal rate of petroleum ether and chlorohydrin is more than 99.9%.

Referring to fig. 1, the ibuprofen sodium salt crude solution sequentially passes through a sedimentation tank 1 and a filter 2 to become a clear solution, the clear solution enters a buffer tank 3, the clear solution is introduced into an electrodialyzer 4 from the buffer tank 3, sodium ions in the ibuprofen sodium salt solution enter a polar liquid B chamber through a cation exchange membrane, meanwhile, ibuprofen enters the polar liquid B chamber through an anion exchange membrane, ibuprofen and the sodium ions are reformed into ibuprofen sodium salt in the polar liquid B chamber, organic matter petroleum ether and chlorohydrin cannot pass through the ion exchange membrane, and finally, the separation of the ibuprofen sodium salt and organic impurities is realized, and the principle is shown in fig. 2. The device adopts lower energy consumption to realize the refinement of ibuprofen sodium salt, has saved the cost.

Example 1

40g of crude ibuprofen sodium salt are dissolved in 500mL of deionized water, and the pH value is 8.5.

The implementation steps are as follows: filtering the crude ibuprofen sodium salt solution sequentially through a plate frame filter and a precise filter at normal temperature, injecting the precipitated and filtered 480mL solution into a buffer tank and introducing the solution into an electrodialyzer, wherein the current density in the electrolysis process is 200A/m²The flow rate of the feed liquid chamber is 0.2L/h, and electricity is suppliedDialyzing for 1.5h, slowly dripping hydrochloric acid at room temperature, adjusting pH to 2-3, separating out ibuprofen as white powder, and obtaining purity of ibuprofen sodium salt of 99.3%, wherein the removal rate of petroleum ether and chlorohydrin is 99.95%.

Example 2

30g of crude ibuprofen sodium salt is dissolved in 320mL of deionized water, and the pH value is 9.2.

The implementation steps are as follows: filtering the crude ibuprofen sodium salt solution sequentially through a plate frame filter and a precise filter at normal temperature, injecting the precipitated and filtered 300mL solution into a buffer tank and introducing into an electrodialyzer, wherein the current density in the electrolysis process is 200A/m²The flow rate of a feed liquid chamber is 0.2L/h, electrodialysis is carried out for 1h, hydrochloric acid is slowly dropped at room temperature, the pH value is adjusted to 2-3, the color of the separated ibuprofen is white powder, the purity of ibuprofen sodium salt reaches 99.5%, and the removal rate of petroleum ether and chlorohydrin is 99.96%.

Example 3

60g of crude ibuprofen sodium salt is dissolved in 700mL of deionized water, and the pH value is 8.1.

The implementation steps are as follows: filtering the crude ibuprofen sodium salt solution sequentially through a plate frame filter and a precise filter at normal temperature, injecting the precipitated and filtered 680mL solution into a buffer tank and introducing the solution into an electrodialyzer, wherein the current density in the electrolysis process is 200A/m²The flow rate of a feed liquid chamber is 0.2L/h, electrodialysis is carried out for 5h, hydrochloric acid is slowly dropped at room temperature, the pH value is adjusted to 2-3, the color of the separated ibuprofen is white powder, the purity of ibuprofen sodium salt reaches 99.7%, and the removal rate of petroleum ether and chlorohydrin is 99.92%.

The foregoing shows and describes the general principles of the present invention, with its principal features and advantages, and further, various changes and modifications can be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims

1. A refining device of ibuprofen sodium salt, which is characterized by comprising a sedimentation tank, a filter, a buffer tank and an electrodialyzer which are connected in turn by pipelines along the flowing direction of liquid, wherein the electrodialyzer is an electrodialysis device which is formed by alternately arranging cation exchange membranes, anion exchange membranes, cation exchange membranes and anion exchange membranes into an electrode solution A chamber, an electrode solution B chamber and an electrode solution A chamber, the negative pole is added to the cation exchange membrane side in this electrodialysis device, and the positive pole is added to the anion exchange membrane side, and cation exchange membrane is the ion exchange membrane that has the permselectivity to sodium ion, and anion exchange membrane is the ion exchange membrane that has the permselectivity to ibuprofen, and utmost point liquid A is the crude solution of ibuprofen sodium salt, and utmost point liquid B is sodium chloride solution or sodium hydroxide solution, and utmost point liquid A cavity passes through the pipeline and is connected with the waste liquid jar, and utmost point liquid B cavity passes through the pipeline and is connected with pure ibuprofen sodium storage jar.