CN210520954U - Pressure pain measuring instrument for mouse tail - Google Patents
Pressure pain measuring instrument for mouse tail Download PDFInfo
- Publication number
- CN210520954U CN210520954U CN201920960177.4U CN201920960177U CN210520954U CN 210520954 U CN210520954 U CN 210520954U CN 201920960177 U CN201920960177 U CN 201920960177U CN 210520954 U CN210520954 U CN 210520954U
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- China
- Prior art keywords
- body fixing
- mouse body
- fixing cylinder
- base plate
- mouse
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- 208000002193 Pain Diseases 0.000 title claims abstract description 14
- 230000036407 pain Effects 0.000 title claims abstract description 14
- 241000581650 Ivesia Species 0.000 title claims description 7
- 238000009434 installation Methods 0.000 claims abstract description 24
- 239000004744 fabric Substances 0.000 claims description 6
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 230000006978 adaptation Effects 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 238000013461 design Methods 0.000 abstract description 4
- 238000011160 research Methods 0.000 abstract description 4
- 230000000638 stimulation Effects 0.000 abstract description 4
- 230000006378 damage Effects 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000036592 analgesia Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000003014 reinforcing effect Effects 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 40
- 239000000758 substrate Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 210000004907 gland Anatomy 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 2
- 235000017491 Bambusa tulda Nutrition 0.000 description 2
- 241001330002 Bambuseae Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- 238000001467 acupuncture Methods 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 208000000114 Pain Threshold Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000036267 drug metabolism Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 230000037040 pain threshold Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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Abstract
The rat tail pressurizing pain measuring instrument comprises a base plate, wherein supporting columns are fixed at four corners of the bottom of the base plate, a rat body fixing cylinder and two installation strip plates are arranged on the upper surface of the base plate, the section of the rat body fixing cylinder is arched, the front end surface of the rat body fixing cylinder is blocked, the rear end surface of the rat body fixing cylinder is open, the left side edge of the rat body fixing cylinder is hinged to the base plate through a pin shaft, and the right side edge of the rat body fixing cylinder is connected to the base plate through a buckle; to sum up, the utility model discloses an experimental apparatus of research analgesia medicine in the pharmacology research, this instrument is classic analgesia medicine experimental method-based on the pressure reinforcing of mechanics principle designs the used typical equipment of stimulation method, overall structure reasonable in design, convenient operation, and the practicality is strong, avoids causing the harm to the mouse.
Description
Technical Field
The utility model belongs to the technical field of the medical treatment, concretely relates to rat tail pressurization pain measuring instrument.
Background
A pain measuring instrument is usually needed in measuring physiological nerve conduction, nerve reflection, pharmacological drug effect and drug metabolism related data in physiological and pharmacological biological function experiments, the existing pain measuring instruments are various, and common photo-thermal pain measuring instruments, acupuncture pain measuring instruments and the like are adopted. The existing pain measuring instrument often has the following defects that the stimulation intensity above a pain threshold value is too large, so that animals are damaged, such as acupuncture or photothermal and the like, and in addition, stimulation cannot be quantitatively measured, so that the research is inconvenient.
SUMMERY OF THE UTILITY MODEL
The utility model discloses a solve the weak point among the prior art, provide a painful threshold value controllable, avoid causing the mouse tail pressurization pain measuring apparatus of damage to the animal.
In order to solve the technical problem, the utility model adopts the following technical scheme: the rat tail pressurizing pain measuring instrument comprises a base plate, pillars are fixed at four corners of the bottom of the base plate, a rat body fixing cylinder and two installation strip plates are arranged on the upper surface of the base plate, the section of the rat body fixing cylinder is arched, the front end face of the rat body fixing cylinder is blocked, the rear end face of the rat body fixing cylinder is open, the left side edge of the rat body fixing cylinder is hinged to the base plate through a pin shaft, the right side edge of the rat body fixing cylinder is connected to the base plate through a buckle, the rear end face of the rat body fixing cylinder is connected with lining blocking cloth matched with the rat body fixing cylinder, and a notch is formed in the middle position of the lower portion;
the two installation long strip plates are positioned at the rear side of the mouse body fixing cylinder and are fixed on the base plate in parallel left and right, the two installation long strip plates are bilaterally symmetrical about the gap, a mouse tail placing groove is formed between the two installation long strip plates, sliding grooves are formed in opposite side surfaces of the two installation long strip plates, a limiting strip plate is arranged between the two installation long strip plates and is connected to the two sliding grooves in a sliding manner, a pressurizing insertion hole is formed in the limiting strip plate, and the pressurizing insertion hole is correspondingly positioned at the rear side of the gap; the top of two installation rectangular boards all is fixed with branch, is fixed with the thread bush between two branches, and the central line of thread bush sets up and passes the pressurization jack along vertical direction, and thread bush internal thread is connected with interior hexagonal screw, and the thread bush is upwards worn out to the upper end of interior hexagonal screw, and the upper end of interior hexagonal screw is equipped with the pressure lid, and the bottom center department of pressure lid is fixed with hexagonal prism, hexagonal prism and interior hexagonal screw's hexagonal groove looks adaptation.
The mouse body fixing barrel is provided with a mouse body vertical limiting assembly and a mouse body lateral limiting assembly, the mouse body vertical limiting part comprises an inserting rod and two arched clamping plates, two slots are formed in the front portion and the rear portion of the mouse body fixing barrel, the two arched clamping plates are inserted into the two slots respectively, a handle is arranged at the upper end of each arched clamping plate, an arched limiting opening is formed in each arched clamping plate, a through hole is formed in the upper end portion of each arched clamping plate, a through hole is formed in the top barrel wall of the mouse body fixing barrel along the front-back horizontal direction, and the inserting rod is inserted into the through hole and penetrates through the through holes of the two;
the mouse body lateral limiting assembly comprises a fixing block and a bolt, the fixing block is fixed on the outer wall of the lateral portion of the mouse body fixing barrel, a threaded hole is formed in the fixing block, the bolt is connected in the threaded hole in a threaded mode, the inner end of the bolt extends into the mouse body fixing barrel, a limiting jacking plate is arranged at the inner end of the bolt, two nuts are connected with the inner end of the bolt in a threaded mode, a round hole is formed in the lower portion of the limiting jacking plate, the inner end of the bolt penetrates through the round hole, the two nuts are located on the two sides of the round hole, and the.
Adopt above-mentioned technical scheme, the utility model discloses following beneficial effect has: the utility model relates to an experimental instrument for researching analgesic in pharmacological research, which is a typical device used in a classical analgesic experimental method-a pressure enhancement design stimulation method based on the mechanics principle; the instrument is suitable for 15-30 g mice, the size of the instrument can be adjusted, during experiments, the mice are fixed in a mouse body fixing cylinder, the tail part of the mouse body fixing cylinder is fixed in a measuring area, an operator rotates a pressurizing cover, and the pressurizing cover can push the tail part of the mouse to apply force; when the mouse that is tested begins to struggle the point and calls, the operator loosens the hexagon socket head cap screw, and the number of revolutions is taken notes, and its painful value that represents the animal that is tested, overall structure reasonable in design, convenient operation, the practicality is strong, avoids causing the harm to the mouse.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
FIG. 2 is a schematic structural view of a lining cloth;
FIG. 3 is a schematic structural view of the arched pallet;
fig. 4 is an installation schematic diagram of the limiting jacking plate.
Detailed Description
As shown in fig. 1-4, the pressure pain measuring instrument for rat tail of the utility model comprises a substrate 1, pillars 2 are fixed at four corners of the bottom of the substrate 1, a rat body fixing cylinder 3 and two installation strip plates 4 are arranged on the upper surface of the substrate 1, the cross section of the rat body fixing cylinder 3 is arched, the front end surface of the rat body fixing cylinder 3 is blocked and the rear end surface is open, the left side edge of the rat body fixing cylinder 3 is hinged on the substrate 1 through a pin shaft, the right side edge of the rat body fixing cylinder 3 is connected on the substrate 1 through a buckle, the rear end surface of the rat body fixing cylinder 3 is connected with a lining cloth 5 matched with the rat body fixing cylinder, and a gap 6 is arranged at the middle position of the lower part of the lining cloth 5;
the two installation strip plates 4 are positioned at the rear side of the mouse body fixing barrel 3, the two installation strip plates 4 are fixed on the base plate 1 side by side from left to right, the two installation strip plates 4 are bilaterally symmetrical about the gap 6, a mouse tail placing groove is formed between the two installation strip plates 4, sliding grooves 7 are formed in opposite side surfaces of the two installation strip plates 4, a limiting strip plate 8 is arranged between the two installation strip plates 4, the limiting strip plate 8 is connected to the two sliding grooves 7 in a sliding mode, a pressurizing jack is formed in the limiting strip plate 8, and the pressurizing jack is correspondingly positioned behind the gap 6; the top of two installation rectangular boards 4 all is fixed with branch 9, is fixed with thread bush 10 between two branch 9, and the central line of thread bush 10 sets up and passes the pressurization jack along vertical direction, and thread bush 10 female connection has interior hexagonal screw 11, and thread bush 10 is upwards worn out to the upper end of interior hexagonal screw 11, and the upper end of interior hexagonal screw 11 is equipped with pressure lid 12, and the bottom center department of pressure lid 12 is fixed with hexagonal prism, hexagonal prism and interior hexagonal screw 11's hexagonal recess looks adaptation.
A mouse body vertical limiting component and a mouse body lateral limiting component are arranged on the mouse body fixing barrel 3, the mouse body vertical limiting component comprises an inserting rod 13 and two arched clamping plates 14, two slots are formed in the front portion and the rear portion of the mouse body fixing barrel 3 respectively, the two arched clamping plates 14 are inserted into the two slots respectively, a handle 15 is arranged at the upper end of each arched clamping plate 14, an arched limiting opening 16 is formed in each arched clamping plate 14, a through hole 17 is formed in the upper end portion of each arched clamping plate 14, a through hole is formed in the top barrel wall of the mouse body fixing barrel 3 in the front-back horizontal direction, and the inserting rod 13 is inserted into the through holes and penetrates through the through holes 17 of the two;
mouse body lateral spacing subassembly includes fixed block 18 and bolt 19, fixed block 18 is fixed at the lateral part outer wall of the fixed section of thick bamboo 3 of mouse body, be equipped with the screw hole on the fixed block 18, bolt 19 threaded connection is in the screw hole and the inner of bolt 19 stretches into in the fixed section of thick bamboo 3 of mouse body, the inner of bolt 19 is equipped with spacing roof pressure board 20, the interior end threaded connection of bolt 19 has two nuts 21, the round hole has been seted up to the lower part of spacing roof pressure board 20, the interior end of bolt 19 is worn to establish in the round hole, two nuts 21 are located the both sides of round hole, the lower border and the laminating of base plate 1 upper surface.
The use process comprises the following steps: the utility model is placed on a stable workbench, the environment is clean and tidy, the temperature is moderate, and the ventilation is good; before use, checking whether all parts of the device are complete; opening the mouse body fixing barrel 3, then flatly placing a mouse in the mouse body fixing barrel 3, closing the mouse body fixing barrel 3, penetrating the tail of the mouse out of the gap 6 of the lining cloth 5 and placing the tail of the mouse in the mouse placing groove, and then inserting the limiting strip plates 8 into the two sliding grooves 7, wherein the height of the limiting strip plates 8 from the base plate 1 is larger than the thickness of the tail of the mouse, so that the pressure of the limiting strip plates 8 on the tail of the mouse is avoided; then, the two arched clamping plates 14 are inserted into the two slots, the two arched clamping plates are inserted into the through holes through the inserting rods 13 for fixing, then the bolts 19 are screwed, the bolts 19 rotate to push the limiting jacking plates 20, the limiting jacking plates 20 jack the mouse body, the two arched clamping plates 14 can limit the mouse body to move upwards, and the limiting jacking plates 20 can limit the mouse body to swing left and right; then cover the upper end of hexagonal socket head cap screw 11 with gland 12, rotatory gland 12, hexagonal socket head cap screw 11 downstream to pass and exert pressure to the mouse afterbody behind the pressurization jack, when the mouse begins to struggle the point and call, record gland 12 and rotate the number of turns, show the painful threshold value of mouse under test, loosen hexagonal socket head cap screw 11.
The present embodiment is not intended to limit the shape, material, structure, etc. of the present invention in any form, and all of the technical matters of the present invention belong to the protection scope of the present invention to any simple modification, equivalent change and modification made by the above embodiments.
Claims (2)
1. The mouse tail pressurizing pain measuring instrument is characterized in that: the mouse body fixing device comprises a base plate, pillars are fixed at four corners of the bottom of the base plate, a mouse body fixing cylinder and two installation strip plates are arranged on the upper surface of the base plate, the cross section of the mouse body fixing cylinder is arched, the front end face of the mouse body fixing cylinder is blocked, the rear end face of the mouse body fixing cylinder is open, the left side edge of the mouse body fixing cylinder is hinged to the base plate through a pin shaft, the right side edge of the mouse body fixing cylinder is connected to the base plate through a buckle, the rear end face of the mouse body fixing cylinder is connected with lining blocking cloth matched with the mouse body fixing cylinder, and a notch is formed in the middle;
the two installation long strip plates are positioned at the rear side of the mouse body fixing cylinder and are fixed on the base plate in parallel left and right, the two installation long strip plates are bilaterally symmetrical about the gap, a mouse tail placing groove is formed between the two installation long strip plates, sliding grooves are formed in opposite side surfaces of the two installation long strip plates, a limiting strip plate is arranged between the two installation long strip plates and is connected to the two sliding grooves in a sliding manner, a pressurizing insertion hole is formed in the limiting strip plate, and the pressurizing insertion hole is correspondingly positioned at the rear side of the gap; the top of two installation rectangular boards all is fixed with branch, is fixed with the thread bush between two branches, and the central line of thread bush sets up and passes the pressurization jack along vertical direction, and thread bush internal thread is connected with interior hexagonal screw, and the thread bush is upwards worn out to the upper end of interior hexagonal screw, and the upper end of interior hexagonal screw is equipped with the pressure lid, and the bottom center department of pressure lid is fixed with hexagonal prism, hexagonal prism and interior hexagonal screw's hexagonal groove looks adaptation.
2. The rat tail compression pain tester of claim 1, wherein: the mouse body fixing barrel is provided with a mouse body vertical limiting assembly and a mouse body lateral limiting assembly, the mouse body vertical limiting part comprises an inserting rod and two arched clamping plates, two slots are formed in the front portion and the rear portion of the mouse body fixing barrel, the two arched clamping plates are inserted into the two slots respectively, a handle is arranged at the upper end of each arched clamping plate, an arched limiting opening is formed in each arched clamping plate, a through hole is formed in the upper end portion of each arched clamping plate, a through hole is formed in the top barrel wall of the mouse body fixing barrel along the front-back horizontal direction, and the inserting rod is inserted into the through hole and penetrates through the through holes of the two;
the mouse body lateral limiting assembly comprises a fixing block and a bolt, the fixing block is fixed on the outer wall of the lateral portion of the mouse body fixing barrel, a threaded hole is formed in the fixing block, the bolt is connected in the threaded hole in a threaded mode, the inner end of the bolt extends into the mouse body fixing barrel, a limiting jacking plate is arranged at the inner end of the bolt, two nuts are connected with the inner end of the bolt in a threaded mode, a round hole is formed in the lower portion of the limiting jacking plate, the inner end of the bolt penetrates through the round hole, the two nuts are located on the two sides of the round hole, and the.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920960177.4U CN210520954U (en) | 2019-06-25 | 2019-06-25 | Pressure pain measuring instrument for mouse tail |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920960177.4U CN210520954U (en) | 2019-06-25 | 2019-06-25 | Pressure pain measuring instrument for mouse tail |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210520954U true CN210520954U (en) | 2020-05-15 |
Family
ID=70595748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920960177.4U Active CN210520954U (en) | 2019-06-25 | 2019-06-25 | Pressure pain measuring instrument for mouse tail |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210520954U (en) |
-
2019
- 2019-06-25 CN CN201920960177.4U patent/CN210520954U/en active Active
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240105 Address after: 450000 Building 2, phase I, ZTE energy conservation and environmental protection industrial park, No. 1776, hanghai East Road, economic and Technological Development Zone, Zhengzhou City, Henan Province Patentee after: Zhengzhou Weisa Biotechnology Co.,Ltd. Address before: 450000 Jinshui East Road, Zheng Dong New District, Zhengzhou, Henan, 156 Patentee before: HENAN University OF CHINESE MEDICINE |