CN210442378U

CN210442378U - Be used for limulus reagent method endotoxin detection device

Info

Publication number: CN210442378U
Application number: CN201921138189.5U
Authority: CN
Inventors: 唐忆琳; 陈巧林
Original assignee: Zhongke Cell Technology Guangzhou Co Ltd
Current assignee: Zhongke Cell Technology Guangzhou Co Ltd
Priority date: 2019-07-18
Filing date: 2019-07-18
Publication date: 2020-05-01
Anticipated expiration: 2029-07-18

Abstract

The utility model relates to the field of experimental apparatus, in particular to a device for detecting endotoxin by a limulus reagent method, which comprises a bottle arranging frame, a constant temperature water bath device, a camera device and a display device electrically connected with the camera device; the ampoule rack comprises a rotating rod for placing ampoules, a clamping mechanism for clamping ampoules is arranged on the rotating rod, and the rotating rod is connected with a driving device for driving the rotating rod to rotate. After the ampoule is bathed for 1 hour, the ampoule is inverted through the detection device, images are photographed before and after inversion, detection and data recording of all ampoules are completed within 2 minutes, and data cannot be recorded due to time-out.

Description

Be used for limulus reagent method endotoxin detection device

Technical Field

The utility model relates to an experimental apparatus field, more specifically relates to a be used for limulus reagent method endotoxin detection device.

Background

The limulus reagent method for detecting endotoxin requires that the ampoule is incubated in a 37 + -1 deg.C constant temperature water bath for 1 hour, and the result is observed within a short time of about 2 minutes, and the ampoule is inverted 180 deg.C when the result is observed. Because the test-tube rack on the market at present does not have the function of fixing the ampoule, if a large amount of ampoules are operated at one time, one ampoule is inverted, and the time is very easy to exceed, so that the data cannot be read in time, the endotoxin detection result fails or is inaccurate, and meanwhile, the experimental result cannot be traced because the result maintenance time is short, no image data exists and the experimental result cannot be traced.

SUMMERY OF THE UTILITY MODEL

The utility model discloses an overcome among the above-mentioned prior art can not in the short time all ampoules of reversing lead to the problem that can not in time read data, provide one kind and be used for limulus reagent method endotoxin detection device, once reverse all ampoules to note testing result in real time.

In order to solve the technical problem, the utility model discloses a technical scheme is: a device for detecting endotoxin by a limulus reagent method comprises a bottle mounting frame, a constant temperature water bath device for detecting the reaction of a sample and a reagent, a camera device and a display device electrically connected with the camera device; the ampoule rack comprises a rotating rod for placing ampoules, a clamping mechanism for clamping ampoules is arranged on the rotating rod, and the rotating rod is connected with a driving device for driving the rotating rod to rotate.

On the ampoule that will be used for the detection was put into the hole of placing of dwang, the water bath device was arranged in to lower part, and the upper portion is fixed through clamping mechanism. And starting the water bath device, heating in a water bath for 1 hour, starting the camera device, and shooting the ampoule. And starting the driving device again to drive the rotating rod to rotate by 180 degrees, and then using the camera device to shoot again. The image pickup device transmits the pictures shot twice to the display device and displays the pictures on the display device.

Preferably, the ampoule rack comprises supporting rods which are respectively rotatably connected with two ends of the rotating rod, a mounting plate is arranged on the supporting rods, and the driving device is arranged on the mounting plate. The support rod provides the effect of support for dwang and drive arrangement.

Preferably, the clamping mechanism comprises a first clamping plate fixed on the rotating rod and a second clamping plate connected with the first clamping plate and moving towards or away from the first clamping plate. The first clamping plate is abutted against one side of the ampoule, and the second clamping plate moves towards the first clamping plate and is abutted against the other side of the ampoule, so that the ampoule is clamped. When the ampoule needs to be loosened, the second clamping plate is moved in the direction away from the first clamping plate.

Preferably, a first arc-shaped plate is arranged on the first clamping plate and corresponds to the position, on the rotating rod, of the ampoule; the second clamping plate is provided with a second arc-shaped plate corresponding to the first arc-shaped plate, and the arc center positions of the first arc-shaped plate and the second arc-shaped plate are close to the rotating rod. The ampoule is cylindrical, and the arc can laminate more with the surface of ampoule, and it is better to press from both sides tight effect.

Preferably, the support rod comprises a fixed rod and a movable rod connected with a rotating rod, the fixed rod is provided with a lifting cylinder, and the movable rod is provided with a lifting plate connected with a cylinder rod of the lifting cylinder. Through promoting the cylinder, promote the height of movable rod for the ann bottle can break away from the scope of water bath device, touches the water bath device when avoiding the ann bottle rotatory.

Preferably, the fixed rod is provided with a guide post, the movable rod is provided with a guide hole, and the movable rod is sleeved on the guide post through the guide hole. The cooperation of guide post and guiding hole can let the up-and-down motion of movable rod more steady.

Preferably, the side of dwang is provided with the numbering frame. The serial number that corresponds with the ann's bottle can all be pasted on the two sides about the serial number frame, when first and shoot for the second time, can find the ann's bottle that corresponds in the image that obtains, can not lead to the confusion.

Preferably, the device further comprises a timer, the timer is electrically connected with the driving device and the image pickup device respectively, and the driving device is electrically connected with the image pickup device. After the timer counts 1 hour, the timer sends a starting signal to the image pickup device, the image pickup device performs picture shooting, then the driving device rotates 180 degrees, after the driving device rotates 180 degrees, the starting signal is sent to the image pickup device, and the image pickup device performs picture shooting again. The detection can be changed into automation, the working procedures of personnel operation are reduced, and the detection efficiency is improved.

Compared with the prior art, the beneficial effects are: after the ampoule is bathed for 1 hour, the ampoule is inverted by the detection device, images are taken before and after inversion, and a worker can obtain a detection result through the images. The detection and data recording of all ampoules are completed within 2 minutes, the data cannot be recorded due to overtime, and the traceability of the detection result is ensured.

Drawings

FIG. 1 is a schematic structural view of example 1 of the endotoxin detection device for limulus reagent of the present invention;

fig. 2 is a perspective view of a bottle mounting rack according to embodiment 1 of the present invention;

FIG. 3 is a schematic block diagram of the endotoxin detection device of example 2 of the present invention.

Wherein: 1. an ampoule rack; 2. a water bath device; 3. a camera device; 4. a display device; 5. rotating the rod; 6. A drive device; 7. a support bar; 701. fixing the rod; 702. a movable rod; 703. a guide post; 8. mounting a plate; 9. a lift cylinder; 10. a lifting plate; 11. a first clamping plate; 1101. a first arc-shaped plate; 12. a second clamping plate; 1201. a second arc-shaped plate; 13. a numbering frame; 14. a timer.

Detailed Description

The drawings are for illustrative purposes only and are not to be construed as limiting the patent; for the purpose of better illustrating the embodiments, certain features of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted. The positional relationships depicted in the drawings are for illustrative purposes only and are not to be construed as limiting the present patent.

The same or similar reference numerals in the drawings of the embodiments of the present invention correspond to the same or similar parts; in the description of the present invention, it should be understood that if there are the terms "upper", "lower", "left", "right", "long", "short", etc. indicating the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, it is only for convenience of description and simplification of description, but it is not intended to indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and therefore the terms describing the positional relationship in the drawings are only for illustrative purposes and are not to be construed as limiting the present patent, and those skilled in the art will understand the specific meaning of the terms according to their specific circumstances.

The technical solution of the present invention is further described in detail by the following specific embodiments in combination with the accompanying drawings:

example 1

As shown in fig. 1-2, a device for detecting endotoxin by limulus reagent method comprises a bottle rack 1, a thermostatic water bath device 2, a camera device 3 and a display device 4 (which can be a computer or a mobile terminal) electrically connected with the camera device 3 (which can be a high-speed scanner); the ampoule rack 1 comprises a rotating rod 5 for placing ampoules, a clamping mechanism 501 for clamping ampoules is arranged on the rotating rod 5, and the rotating rod 5 is connected with a driving device 6 (which can be a steering engine) for driving the rotating rod 5 to rotate.

Specifically, ann's bottle frame 1 includes and rotates the bracing piece 7 of being connected respectively with dwang 5 both ends, is provided with mounting panel 8 on the bracing piece 7, and drive arrangement 6 sets up on mounting panel 8. The support bar 7 provides a supporting function for the turning bar 5 and the driving device 6.

Wherein, the support rod 7 comprises a fixed rod 701 and a movable rod 702 connected with the rotating rod 5, a lifting cylinder 9 is arranged on the fixed rod 701, and a lifting plate 10 connected with a cylinder rod of the lifting cylinder 9 is arranged on the movable rod 702. Through promoting cylinder 9, promote the height of movable rod 702 for the ann bottle can break away from water bath device 2's scope, touches water bath device 2 when avoiding the ann bottle rotatory.

In order to make the up-and-down movement of the movable rod more stable, the fixed rod 701 is provided with a guide post 703, the movable rod 702 is provided with a guide hole, and the movable rod 702 is sleeved on the guide post 703 through the guide hole.

Further, the clamping mechanism includes a first clamping plate 11 fixed to the rotating lever 5 and a second clamping plate 12 connected to the first clamping plate 11 and moving in a direction to approach or separate from the first clamping plate 11. The first clamping plate 11 and the second clamping plate 12 are connected through fasteners at two ends, the fasteners are tightened, so that the second clamping plate 12 approaches to the first clamping plate 11, the fasteners are loosened, and the second clamping plate 12 approaches to the first clamping plate 11. Because the ampoule is cylindrical, in order to be more attached to the outer surface of the ampoule and achieve better clamping effect, the first clamping plate 11 is provided with a first arc-shaped plate 1101, and the first arc-shaped plate 1101 corresponds to the position of the rotating rod 5 where the ampoule is placed; the second clamping plate 12 is provided with a second arc plate 1201 corresponding to the first arc plate 1101, and the arc centers of the first arc plate 1101 and the second arc plate 1201 are close to the rotating rod 5.

The first clamping plate 11 is abutted against one side of the ampoule, the fastener is screwed, and the second clamping plate 12 moves towards the first clamping plate 11 and is abutted against the other side of the ampoule, so that the ampoule is clamped. When the ampoule needs to be loosened, the second clamping plate 12 is moved in the direction away from the first clamping plate 11.

In addition, a numbering frame 13 is arranged on the side surface of the rotating rod 5. The serial number that corresponds with the ann's bottle can all be pasted to two sides about serial number frame 13, when first and shoot for the second time, can find the ann's bottle that corresponds in the image that obtains, can not lead to the confusion.

The utility model discloses a theory of operation or work flow: the ampoule is placed on a rotating rod 5, part of the ampoule body is immersed in a water bath device 2, and the ampoule is clamped by a clamping mechanism. After the water bath is carried out for one hour, the lifting cylinder is started, and the movable rod 12 moves upwards, so that the ampoule is separated from the water bath device 2. And starting the camera device 3 to shoot the ampoule. The driving device 6 is started again to drive the rotating rod 5 to rotate 180 degrees, and then the camera device 3 is used to shoot again. The image pickup device 3 transmits the pictures shot twice to the display device 4 and displays the pictures on the display device, so that the staff can obtain the detection result from the images, and the traceability of the detection result is ensured.

The utility model has the advantages that: after the ampoule is bathed for 1 hour, the ampoule is inverted through the detection device, images are photographed before and after inversion, and workers can know the detection result through the images. The detection and data recording of all ampoules are completed within 2 minutes, and the data cannot be recorded due to time-out.

Example 2

The present embodiment is based on embodiment 1, and is different from embodiment 1 in that, as shown in fig. 3, the present embodiment further includes a timer 14, the timer 14 is electrically connected to the driving device 6 and the imaging device 3, respectively, and the driving device 6 is electrically connected to the imaging device 3. The timer 14 performs transmission between signals by a control unit (not shown in the figure).

After the timer 14 counts 1 hour, the timer 14 sends a start signal to the image pickup device 3, the image pickup device 3 performs image pickup, then the driving device 6 rotates 180 degrees, after the driving device 6 rotates 180 degrees, the start signal is sent to the image pickup device 3, and the image pickup device 3 performs image pickup again. The detection can be changed into automation, the working procedures of personnel operation are reduced, and the detection efficiency is improved.

The rest of the technical features of the present embodiment are the same as those of embodiment 1, and the working principle and the beneficial effects thereof are the same as those of embodiment 1.

It is obvious that the above embodiments of the present invention are only examples for clearly illustrating the present invention, and are not limitations to the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. The device for detecting endotoxin by a limulus reagent method is characterized by comprising a bottle mounting frame (1), a constant-temperature water bath device (2), a camera device (3) and a display device (4) electrically connected with the camera device (3); ampoule rack (1) is including dwang (5) that are used for placing the ampoule, be provided with clamping mechanism (501) that are used for pressing from both sides tight ampoule on dwang (5), dwang (5) are connected with the drive dwang (5) pivoted drive arrangement (6).

2. The device for detecting endotoxin from the limulus reagent method according to claim 1, wherein the rack (1) comprises support rods (7) rotatably connected to both ends of the rotating rod (5), respectively, wherein a mounting plate (8) is provided on the support rods (7), and the driving device (6) is provided on the mounting plate (8).

3. The device for detecting endotoxin from the limulus reagent method according to claim 2, wherein the support rod (7) comprises a fixed rod (701) and a movable rod (702) connected to the rotating rod (5), the fixed rod (701) is provided with a lifting cylinder (9), and the movable rod (702) is provided with a lifting plate (10) connected to a cylinder rod of the lifting cylinder (9).

4. The device for detecting endotoxin from the limulus reagent method according to claim 3, wherein the fixed rod (701) is provided with a guide column (703), the movable rod (702) is provided with a guide hole, and the movable rod (702) is fitted over the guide column (703) through the guide hole.

5. The device for detecting endotoxin from the limulus reagent method according to claim 1, wherein the clamping mechanism (501) comprises a first clamping plate (11) fixed to the rotating lever (5) and a second clamping plate (12) connected to the first clamping plate (11) and moving in a direction approaching or separating from the first clamping plate (11).

6. The device for detecting endotoxin from the limulus reagent method according to claim 5, wherein a first arc plate (1101) is provided on the first clamping plate (11), and the first arc plate (1101) corresponds to a position on the rotating lever (5) where a vial is placed; a second arc-shaped plate (1201) corresponding to the first arc-shaped plate (1101) is arranged on the second clamping plate (12), and the arc centers of the first arc-shaped plate (1101) and the second arc-shaped plate (1201) are close to the rotating rod (5).

7. The device for detecting endotoxin from the limulus reagent method according to claim 1, wherein the rotating lever (5) is provided at a side thereof with a numbering shelf (13).

8. The device for detecting endotoxin from a limulus reagent according to any one of claims 1 to 7, further comprising a timer (14), wherein the timer (14) is electrically connected to the driving means (6) and the imaging means (3), respectively, and the driving means (6) is electrically connected to the imaging means (3).