CN210409034U - Concentrated purification device of high-efficient bacterin - Google Patents
Concentrated purification device of high-efficient bacterin Download PDFInfo
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- CN210409034U CN210409034U CN201920678647.8U CN201920678647U CN210409034U CN 210409034 U CN210409034 U CN 210409034U CN 201920678647 U CN201920678647 U CN 201920678647U CN 210409034 U CN210409034 U CN 210409034U
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Abstract
The utility model provides a high-efficiency vaccine concentration and purification device, which comprises a crawling ladder, a feeding port, a liquid storage barrel, a stirring device, a filtering mechanism, a pressure gauge, a controller, a pneumatic control cabinet, an installation stand, an embedded plate and a cylinder, wherein the magnetic stirring rod of the utility model integrates crushing and stirring, effectively improves the crushing effect of cells, and can more mix cell sap and venom; the arrangement of the pneumatic control cabinet and the filtering mechanism can separate the cell sap from the cell debris by using the air pressure, thereby effectively increasing the filtering effect of the cell sap; the cylinder, the setting of embedded plate and filtering mechanism, the convenience is to the clearance of cell debris on the filter membrane or to the change of filter membrane, and effectual realization equipment integration sets up, has reduced manufacturing cost.
Description
Technical Field
The utility model belongs to the technical field of the concentrated purification of bacterin, especially, relate to a concentrated purification device of high-efficient bacterin.
Background
In the field of animal biomedicine, virus inactivated vaccines are generally propagated and cell-inoculated by adopting an old rotary bottle technology, and are inactivated after naturally releasing viruses after virus inoculation, so that the vaccine has poor quality uniformity, large pollution risk, low toxicity price, incapability of removing foreign proteins and cell fragments and strong side reaction due to an old production process.
The invention discloses a vaccine concentration and purification device with Chinese patent publication No. CN 205198511U, and the name created by the invention is vaccine concentration and purification device, which is characterized by comprising a bioreactor, a cell crusher, a hollow fiber column and an inactivation tank, wherein the bottom of the bioreactor is connected with one end of the cell crusher through an output pipeline, the other end of the cell crusher is connected with a stock solution input end of the hollow fiber column through a high-pressure pump, and a filtrate output end of the hollow fiber column is connected with the inactivation tank through a conveying pipeline. However, the existing vaccine concentration and purification device also has the problems that a plurality of devices are needed to be used jointly, the production cost and expenditure are increased, the cell disruption effect is poor, the concentration effect is poor, and the filter pressing of viruses is incomplete.
Therefore, it is necessary to invent a high-efficiency vaccine concentration and purification device.
SUMMERY OF THE UTILITY MODEL
In order to solve the technical problem, the utility model provides a high-efficient concentrated purification device of bacterin to solving current concentrated purification device of bacterin and still having needs multiple equipment to carry out the combined use, increased manufacturing cost and spending, the cell disruption effect is poor, and concentrated effect is poor, the incomplete problem of virus filter-pressing also. A high-efficiency vaccine concentration and purification device comprises a crawling ladder, a feeding port, a liquid storage barrel, a stirring device, a filtering mechanism, a pressure gauge, a controller, a pneumatic control cabinet, an installation stand, an embedded plate and an air cylinder, wherein the crawling ladder is installed on one side of the installation stand through bolts; the feeding port is arranged on one side of the liquid storage barrel; the stirring device is connected with the liquid storage barrel through a flange and is connected with the controller through a lead; the filtering mechanism is arranged at the bottom of the liquid storage barrel through a flange; the pressure gauge is arranged on one side of the liquid storage barrel; the controller is arranged outside the liquid storage barrel through a bolt; the pneumatic control cabinet is arranged on one side of the liquid storage barrel through a bolt and is respectively connected with the compressed air source and the liquid storage barrel through an air pipe; the mounting rack is clamped outside the liquid storage barrel; the embedded plate is embedded outside the filtering mechanism; the cylinder adopts 4, sets up respectively in the four corners department of embedding the board, is connected with the installation pallet through the bolt to pass through the trachea with gas accuse cabinet and be connected.
The stirring device comprises a top cover, a sealing ring and a magnetic stirring rod, wherein the top cover is buckled at the top of the liquid storage barrel and is fixedly reinforced with the liquid storage barrel through a flange welded at the bottom of the top cover; the sealing ring is arranged between the top cover and the liquid storage barrel; the magnetic stirring rod is of a FLUKO type, is arranged at the upper end of the top cover, penetrates into the liquid storage barrel and is connected with the top cover in a sealing mode through a sealing ring.
The filtering mechanism comprises a bottom tank, a liquid outlet, an embedded block, a membrane placing disc, a filtering membrane and an O-shaped ring, and the bottom tank is arranged at the bottom of the liquid storage barrel through a flange; the liquid outlet is arranged at the bottom of the bottom tank; 2-4 embedded blocks are arranged at the upper end of the inner part of the bottom tank through bolts; the film placing disc is embedded on the embedding block; the filter membrane is attached to the membrane placing disc; the O-shaped ring is arranged at the joint of the bottom tank and the liquid storage barrel.
It sets up to discoid to put the membrane dish, and the strip that inside was made by a plurality of horizontal and a plurality of fore-and-aft ya keli materials is crisscross to be supported.
The pressure gauge is Y-100 type; the controller is particularly an IVC1-1410 type PLC controller; the cylinder is particularly of an SC100X25 type.
Compared with the prior art, the utility model discloses following beneficial effect has:
1. the utility model discloses the setting of magnetic stirring rod, the crushing effect that collects broken and the integrative effectual cell that has improved of stirring more enables the mixture of cell sap and venom.
2. The utility model discloses gas accuse cabinet and filtering mechanism's setting, after cell breakage and inactivation, gas accuse cabinet passes through the trachea and discharges compressed air to the stock solution bucket in, and the cell liquid after the breakage begins to be extrudeed under the pressure of atmospheric pressure, and the cell liquid filters through the filter membrane, then flows to the bottom tank in, utilizes atmospheric pressure to carry out the separation of cell liquid and cell piece, the filter effect of effectual increase cell liquid.
3. The utility model discloses the cylinder, the setting of embedded plate and filtering mechanism, the cell liquid after having filtered passes through the leakage fluid dram discharge, loosens the bolt between filtering mechanism and the stock solution bucket, and the cylinder moves the downstream of filtering mechanism through inlaying the panel, and the convenience is to the clearance of cell piece on the filter membrane or to the change of filter membrane, and effectual realization equipment integration sets up, has reduced manufacturing cost.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic structural view of the stirring device of the present invention.
Fig. 3 is a schematic structural diagram of the filtering mechanism of the present invention.
Fig. 4 is a top view of the membrane placing tray of the present invention.
In the figure:
1-ladder stand, 2-pan feeding mouth, 3-stock solution bucket, 4-agitating unit, 41-top cap, 42-sealing washer, 43-magnetic stirring rod, 5-filter mechanism, 51-end jar, 52-leakage fluid dram, 53-inlay the dress piece, 54-put membranous disc, 55-filter membrane, 56-O type circle, 6-manometer, 7-controller, 8-pneumatic control cabinet, 9-installation stand, 10-inlay the dress board, 11-cylinder.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
example (b):
as shown in figures 1 to 4
The utility model provides a high-efficiency vaccine concentration and purification device, which comprises a ladder stand 1, a feeding port 2, a liquid storage barrel 3, a stirring device 4, a filtering mechanism 5, a pressure gauge 6, a controller 7, a pneumatic control cabinet 8, an installation stand 9, an embedded plate 10 and a cylinder 11, wherein the ladder stand 1 is installed on one side of the installation stand 9 through bolts; the feeding port 2 is arranged at one side of the liquid storage barrel 3; the stirring device 4 is connected with the liquid storage barrel 3 through a flange and is connected with the controller 7 through a lead; the filtering mechanism 5 is arranged at the bottom of the liquid storage barrel 3 through a flange; the pressure gauge 6 is arranged at one side of the liquid storage barrel 3; the controller 7 is arranged outside the liquid storage barrel 3 through a bolt; the pneumatic control cabinet 8 is arranged on one side of the liquid storage barrel 3 through a bolt and is respectively connected with the compressed air source and the liquid storage barrel 3 through an air pipe; the mounting stand 9 is clamped outside the liquid storage barrel 3; the embedded plate 10 is embedded outside the filtering mechanism 5; the number of the cylinders 11 is 4, the cylinders are respectively arranged at four corners of the embedded plate 10, connected with the mounting stand 9 through bolts and connected with the pneumatic control cabinet 8 through air pipes.
The stirring device 4 comprises a top cover 41, a sealing ring 42 and a magnetic stirring rod 43, wherein the top cover 41 is buckled at the top of the liquid storage barrel 3 and is fixedly reinforced with the liquid storage barrel 3 through a flange welded at the bottom of the top cover; the sealing ring 42 is arranged between the top cover 41 and the liquid storage barrel 3; the magnetic stirring rod 43 is of a FLUKO type, is arranged at the upper end of the top cover 41, penetrates into the liquid storage barrel 3 and is hermetically connected with the top cover 41 through a sealing ring 42.
The filtering mechanism 5 comprises a bottom tank 51, a liquid outlet 52, an embedded block 53, a membrane placing disc 54, a filtering membrane 55 and an O-shaped ring 56, wherein the bottom tank 51 is arranged at the bottom of the liquid storage barrel 3 through a flange; the liquid outlet 52 is arranged at the bottom of the bottom tank 51; 2-4 embedded blocks 53 are arranged at the upper end inside the bottom tank 51 through bolts; the film placing disc 54 is embedded on the embedding block 53; the filter membrane 55 is attached to the membrane placing disc 54; the O-shaped ring 56 is arranged at the joint of the bottom tank 51 and the liquid storage barrel 3.
The membrane placing disc 54 is disc-shaped, and is internally supported by a plurality of transverse strips and a plurality of longitudinal strips made of acrylic materials in a staggered manner.
The pressure gauge 6 is Y-100 type; the controller 7 specifically adopts an IVC1-1410 type PLC controller; the cylinder 11 is particularly of an SC100X25 type.
Principle of operation
The utility model discloses in, when using, at first put into stock solution bucket 3 with inactivator and animal cell through pan feeding mouth 2 in, carry out breakage and stirring to the cell through magnetism stirring rod 43, cell and virus after the breakage combine, the inactivator has reduced the toxicity in the cell liquid, gas accuse cabinet 8 discharges compressed air to stock solution bucket 3 in through the trachea, cell liquid after the breakage begins to be extruded under the pressure of atmospheric pressure, cell liquid filters through filter membrane 55, then flow to in bottom can 51, cell liquid after having filtered passes through leakage fluid dram 52 and discharges, loosen the bolt between filter mechanism 5 and the stock solution bucket 3, cylinder 11 drives filter mechanism 5 downstream through mounting plate 10, the convenience is to the clearance of cell piece on the filter membrane 55 or to the change of filter membrane 55, effectual realization equipment integration sets up, and production cost is reduced.
Utilize technical scheme, or technical personnel in the field are in the utility model discloses under technical scheme's the inspiration, design similar technical scheme, and reach above-mentioned technological effect, all fall into the utility model discloses a protection scope.
Claims (5)
1. The utility model provides a concentrated purification device of high-efficient bacterin which characterized in that: the automatic feeding device comprises a crawling ladder (1), a feeding opening (2), a liquid storage barrel (3), a stirring device (4), a filtering mechanism (5), a pressure gauge (6), a controller (7), a pneumatic control cabinet (8), an installation stand (9), an embedded plate (10) and a cylinder (11), wherein the crawling ladder (1) is installed on one side of the installation stand (9) through bolts; the feeding port (2) is arranged on one side of the liquid storage barrel (3); the stirring device (4) is connected with the liquid storage barrel (3) through a flange and is connected with the controller (7) through a lead; the filtering mechanism (5) is arranged at the bottom of the liquid storage barrel (3) through a flange; the pressure gauge (6) is arranged on one side of the liquid storage barrel (3); the controller (7) is arranged outside the liquid storage barrel (3) through a bolt; the pneumatic control cabinet (8) is arranged on one side of the liquid storage barrel (3) through a bolt and is respectively connected with the compressed air source and the liquid storage barrel (3) through an air pipe; the mounting stand (9) is clamped outside the liquid storage barrel (3); the embedded plate (10) is embedded outside the filtering mechanism (5); the number of the cylinders (11) is 4, the cylinders are respectively arranged at four corners of the embedded plate (10), connected with the mounting stand (9) through bolts and connected with the pneumatic control cabinet (8) through air pipes.
2. The high-efficiency vaccine concentration and purification device according to claim 1, wherein: the stirring device (4) comprises a top cover (41), a sealing ring (42) and a magnetic stirring rod (43), wherein the top cover (41) is fastened at the top of the liquid storage barrel (3) and is fixedly reinforced with the liquid storage barrel (3) through a flange welded at the bottom of the top cover; the sealing ring (42) is arranged between the top cover (41) and the liquid storage barrel (3); the magnetic stirring rod (43) is of a FLUKO type, is arranged at the upper end of the top cover (41), penetrates into the liquid storage barrel (3), and is connected with the top cover (41) in a sealing mode through a sealing ring (42).
3. The high-efficiency vaccine concentration and purification device according to claim 1, wherein: the filtering mechanism (5) comprises a bottom tank (51), a liquid outlet (52), an embedded block (53), a membrane disc (54), a filtering membrane (55) and an O-shaped ring (56), wherein the bottom tank (51) is arranged at the bottom of the liquid storage barrel (3) through a flange; the liquid outlet (52) is arranged at the bottom of the bottom tank (51); 2-4 embedded blocks (53) are arranged at the upper end of the inner part of the bottom tank (51) through bolts; the film placing disc (54) is embedded on the embedded block (53); the filter membrane (55) is attached to the membrane placing disc (54); the O-shaped ring (56) is arranged at the joint of the bottom tank (51) and the liquid storage barrel (3).
4. The high-efficiency vaccine concentration and purification device according to claim 3, wherein: the membrane placing disc (54) is disc-shaped, and is internally supported by a plurality of transverse strips and a plurality of longitudinal strips made of acrylic materials in a staggered manner.
5. The high-efficiency vaccine concentration and purification device according to claim 1, wherein: the pressure gauge (6) is Y-100 type; the controller (7) is an IVC1-1410 type PLC controller; the cylinder (11) is particularly of an SC100X25 type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920678647.8U CN210409034U (en) | 2019-05-13 | 2019-05-13 | Concentrated purification device of high-efficient bacterin |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920678647.8U CN210409034U (en) | 2019-05-13 | 2019-05-13 | Concentrated purification device of high-efficient bacterin |
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| CN210409034U true CN210409034U (en) | 2020-04-28 |
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| CN201920678647.8U Active CN210409034U (en) | 2019-05-13 | 2019-05-13 | Concentrated purification device of high-efficient bacterin |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116200244A (en) * | 2023-05-04 | 2023-06-02 | 翔鹏佑康(北京)科技有限公司 | Separation and purification equipment and purification method for cell culture virus liquid |
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2019
- 2019-05-13 CN CN201920678647.8U patent/CN210409034U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116200244A (en) * | 2023-05-04 | 2023-06-02 | 翔鹏佑康(北京)科技有限公司 | Separation and purification equipment and purification method for cell culture virus liquid |
| CN116200244B (en) * | 2023-05-04 | 2023-09-15 | 赛奥斯博生物科技(北京)有限公司 | Separation and purification equipment and purification method for cell culture virus liquid |
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