CN210251323U - Device for improving silica gel column chromatography efficiency - Google Patents
Device for improving silica gel column chromatography efficiency Download PDFInfo
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- CN210251323U CN210251323U CN201920285159.0U CN201920285159U CN210251323U CN 210251323 U CN210251323 U CN 210251323U CN 201920285159 U CN201920285159 U CN 201920285159U CN 210251323 U CN210251323 U CN 210251323U
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Abstract
The utility model discloses an improve device of silica gel column chromatography efficiency, including booster pump, chromatography column pipe and support, booster pump gas vent one side is connected with the forcing pipe, be provided with rotatory gas plug switch on the forcing pipe, the opening on chromatography column pipe top is connected to the forcing pipe opposite side, chromatography column pipe one side is provided with the eluant and throws the mouth, eluant is thrown mouth one side and is connected with the eluant input pipe, eluant is thrown mouth below one side and is provided with the entry of throwing of waiting to separate thing, wait to separate thing and throw mouth one side and be connected with the entry of waiting to separate thing, it is provided with silica gel and throws the mouth to wait to separate thing input mouth below one side, silica gel is thrown entry one side and is connected with the silica gel input pipe, chromatography column pipe bottom is provided with. The utility model discloses a set up the pressurization air pump and carry out the pressure boost to the chromatography case, improve the eluent velocity of flow, improved chromatography efficiency, improved production efficiency, safe and reliable, the practicality is strong.
Description
Technical Field
The utility model relates to a chemical production technical field particularly, relates to an improve device of silica gel column chromatography efficiency.
Background
Silica gel chromatography is to separate substances according to different adsorption forces of the substances on silica gel, generally, substances with larger polarity are easy to be adsorbed by the silica gel, substances with weaker polarity are not easy to be adsorbed by the silica gel, and the whole chromatography process is an adsorption, desorption, re-adsorption and re-desorption process. Silica gel chromatography is mainly used for refining petroleum products, removing aromatic hydrocarbon substances or separating and purifying effective components of Chinese herbal medicines, preparing high-purity substances and the like. Pressure can increase the eluent flow rate, reduce product collection time, but reduce the number of columns. So the atmospheric column is the most efficient but the longest time, like the separation of natural compounds, even a few months in a column, under otherwise identical conditions.
The reduced pressure column can reduce the amount of silica gel used, and can save half or even more, but because a large amount of air passes through the silica gel, the solvent is volatilized (sometimes, water vapor is condensed outside the column), and some easily decomposed substances can not be obtained, and a water pump must be used for pumping air at the same time (the noise is high, and the time is long). A pressurized column is a preferred method, similar to a normal pressure column, except that the applied pressure causes the eluent to move faster. The pressure can be provided by compressed air, a double-connected ball or a small air pump (just for supplying air to the fish tank). Particularly in the separation of easily decomposable samples. The pressure must not be too great, otherwise the solvent running too quickly would reduce the separation effect. The pressurized column is perceived by individuals as being suitable for use in the separation of common organic compounds.
The traditional silica gel chromatography usually consumes a long time and has low production efficiency, and the incomplete chromatography phenomenon easily occurs in the chromatography process of substances which are difficult to treat.
An effective solution to the problems in the related art has not been proposed yet.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide an improve silica gel column chromatography efficiency's device to solve the problem that proposes among the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme:
the utility model relates to a device for improving the chromatographic efficiency of a silica gel column, which comprises a booster pump, a chromatographic column tube and a bracket, wherein one side of the booster pump is provided with a rotary air plug, one side of the rotary air plug is connected with a pressure pipe, one side of the pressure pipe is connected with a duplex ball, one side of the lower part of the booster pump is provided with the chromatographic column tube, one side of the chromatographic column tube is provided with an eluent inlet, one side of the eluent inlet is connected with an eluent inlet tube, one side of the lower part of the eluent inlet is provided with a to-be-separated object inlet, one side of the to-be-separated object inlet is connected with the to-be-separated object inlet tube, one side of the lower part of the to-be-separated object inlet is provided with a silica gel inlet, one side of the silica gel inlet tube is connected with a silica gel inlet tube, the collecting device is characterized in that a fixing groove is formed in one side of the collecting base, a collecting bottle is arranged on one side of the fixing groove, a fixing frame is arranged on one side of the collecting base, a first fixing rod is arranged on one side of the fixing frame, and a second fixing rod is arranged on one side of the first fixing rod.
Furthermore, first fixed link one side is connected with first circular solid fixed ring, first circular solid fixed ring one side is provided with first rotatory fixed screw.
Furthermore, first dead lever one side is connected with the circular solid fixed ring of second, the circular solid fixed ring one side of second is provided with the rotatory fixed screw of second.
Furthermore, the collecting base is made of corrosion-resistant alloy material, and a fixing frame arranged on one side of the collecting base is made of steel alloy material.
Furthermore, the surface shell of the chromatographic column tube is made of a silicon metal transparent material.
Furthermore, a discharge control bolt is arranged on one side of the discharge pipe.
Compared with the prior art, the utility model discloses following beneficial effect has:
(1) the utility model discloses a set up the booster pump and carry out the pressure boost to the chromatography case, improve the eluent velocity of flow, improved chromatography efficiency, improved production efficiency, safe and reliable, the practicality is strong.
(2) The utility model discloses a set up the eluant respectively inside the chromatography column pipe and throw in the mouth, wait that the separator throws in the mouth and silica gel and throw in the mouth, make and wait that separator and eluant can the intensive mixing and with the silica gel separation, it is better to pass through booster pump pressurization back chromatography separation effect, has improved work efficiency, safe and reliable, the practicality is high.
(3) The utility model discloses a set up ejection of compact control bolt in discharging pipe department, control the load of chromatography column pipe downside discharging pipe, prevent that unnecessary silica gel and other impurity from flowing the material that the pollution has already finished by the chromatography, improved chromatography efficiency, improved chromatography intensity, avoided the material extravagant simultaneously.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic front view of an apparatus for improving silica gel column chromatography efficiency according to an embodiment of the present invention;
fig. 2 is a schematic diagram of a partial structure of an apparatus for improving silica gel column chromatography efficiency according to an embodiment of the present invention;
reference numerals: 1. a booster pump; 2. a chromatography column tube; 3. a support; 4. rotating the air plug; 5. a pressurizing pipe; 6. a duplex ball; 7. an eluent is put into the inlet; 8. an eluent is put into the tube; 9. throwing the object to be separated into the inlet; 10. putting the object to be separated into a pipe; 11. a silica gel input port; 12. a silica gel input tube; 13. a discharge pipe; 14. a collecting base; 15. fixing the groove; 16. a collection bottle; 17. a fixed mount; 18. a first fixing lever; 19. a second fixing bar; 20. a first circular retaining ring; 21. a first rotary set screw; 22. a second circular retaining ring; 23. a second rotary set screw; 24. and (4) a discharge control plug.
Detailed Description
The following, with reference to the drawings and the detailed description, further description of the present invention is made:
referring to fig. 1-2, a device for improving silica gel column chromatography efficiency according to an embodiment of the present invention includes a booster pump 1, a chromatography column tube 2 and a bracket 3, wherein a rotary air plug 4 is disposed on one side of the booster pump 1, a pressure tube 5 is connected to one side of the rotary air plug 4, a duplex ball 6 is connected to one side of the pressure tube 5, the chromatography column tube 2 is disposed on one side of the booster pump 1, an eluent inlet 7 is disposed on one side of the chromatography column tube 2, an eluent inlet tube 8 is connected to one side of the eluent inlet 7, an object inlet 9 is disposed on one side of the eluent inlet 7, an object inlet 10 is connected to one side of the object inlet 9, an silica gel inlet 11 is disposed on one side of the object inlet 9, a silica gel inlet 12 is connected to one side of the silica gel inlet 11, the bottom of chromatography column 2 is provided with discharging pipe 13, discharging pipe 13 below one side is provided with support 3, 3 bottom one side of support are provided with collects base 14, it is provided with fixed recess 15 to collect base 14 one side, fixed recess 15 one side is provided with receiving flask 16, it is provided with mount 17 to collect base 14 one side, mount 17 one side is provided with first dead lever 18, first dead lever 18 one side is provided with second dead lever 19. First fixed rod 18 one side is connected with first circular solid fixed ring 20, first circular solid fixed ring 20 one side is provided with rotatory set screw 21. The second fixing rod 19 is connected with a second circular fixing ring 22 on one side, and a second rotary fixing screw 23 is arranged on one side of the second circular fixing ring 22. The collecting base 14 is made of corrosion-resistant alloy material, and a fixing frame 17 arranged on one side of the collecting base is made of steel alloy material. The surface shell of the chromatographic column tube 2 is made of a silicon metal transparent material. One side of the discharge pipe 13 is provided with a discharge control plug 24.
In specific application, the chromatography column tube 2 is fixed by twisting a first rotary fixing screw 21 and a second rotary fixing screw 23 which are respectively arranged on a first circular fixing ring 20 and a second circular fixing ring 22 which are respectively arranged on a first fixing rod 18 and a second fixing rod 19, eluent, a substance to be separated and silica gel are respectively put into the chromatography column tube 2 from an eluent input tube 8, a substance to be separated input tube 10 and a silica gel input tube 12 through an eluent input opening 7, a substance to be separated input opening 9 and a silica gel input opening 11, a discharge control bolt 24 which is arranged on a discharge tube 13 is closed in a spiral way, air blowing is carried out into a pressurizing tube 5 through a duplex ball 6, the chromatography column tube 2 is pressurized, when the pressurization reaches a certain degree, the rotary air plug 4 is twisted in a spiral way to prevent the gas in the chromatography column tube from escaping, internal chromatography is waited, the chromatography column tube 2 is made of a transparent silicon metal material, the inside chromatography condition of accessible naked eye follow outside direct observation, when the chromatography finishes, places collecting flask 16 in the fixed recess 15 department of support 3 bottom, opens ejection of compact control bolt 24 on discharging pipe 13, collects the ejection of compact.
To sum up, the utility model discloses a set up the booster pump and carry out the pressure boost to the chromatography case, improve the eluent velocity of flow, improved chromatography efficiency, improved production efficiency, safe and reliable, the practicality is strong. The utility model discloses a set up the eluant respectively inside the chromatography column pipe and throw in the mouth, wait that the separator throws in the mouth and silica gel throw in the mouth, make and wait that separator and eluant can the intensive mixing and with the silica gel separation, it is better to pass through booster pump pressurization back chromatography separation effect, has improved work efficiency, safe and reliable, the practicality is high. The utility model discloses a set up ejection of compact control bolt in discharging pipe department, control the load of chromatography column pipe downside discharging pipe, prevent that unnecessary silica gel and other impurity from flowing the material that the pollution has already finished by the chromatography, improved chromatography efficiency, improved chromatography intensity, avoided the material extravagant simultaneously.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The device for improving the chromatographic efficiency of the silica gel column comprises a booster pump (1), a chromatographic column tube (2) and a bracket (3), and is characterized in that a rotary air plug (4) is arranged on one side of the booster pump (1), a pressurizing tube (5) is connected on one side of the rotary air plug (4), a duplex ball (6) is connected on one side of the pressurizing tube (5), the chromatographic column tube (2) is arranged on one side of the lower part of the booster pump (1), an eluent inlet (7) is arranged on one side of the chromatographic column tube (2), an eluent inlet (8) is connected on one side of the eluent inlet (7), a to-be-separated object inlet (9) is arranged on one side of the lower part of the eluent inlet (7), a to-be-separated object inlet (10) is connected on one side of the to-be-separated object inlet (9), a silica gel inlet (11) is arranged on one side of the lower, silica gel input mouth (11) one side is connected with silica gel input tube (12), chromatography column tube (2) bottom is provided with discharging pipe (13), discharging pipe (13) below one side is provided with support (3), support (3) bottom one side is provided with collects base (14), it is provided with fixed recess (15) to collect base (14) one side, fixed recess (15) one side is provided with receiving flask (16), it is provided with mount (17) to collect base (14) one side, mount (17) one side is provided with first dead lever (18), first dead lever (18) one side is provided with second dead lever (19).
2. The device for improving the efficiency of silica gel column chromatography according to claim 1, wherein a first circular fixing ring (20) is connected to one side of the first fixing rod (18), and a first rotary fixing screw (21) is arranged on one side of the first circular fixing ring (20).
3. The device for improving the efficiency of silica gel column chromatography according to claim 1, wherein a second circular fixing ring (22) is connected to one side of the second fixing rod (19), and a second rotary fixing screw (23) is arranged on one side of the second circular fixing ring (22).
4. The device for improving the efficiency of silica gel column chromatography as claimed in claim 1, wherein the collecting base (14) is made of a corrosion-resistant alloy material, and the fixing frame (17) provided at one side thereof is made of a steel alloy material.
5. The device for improving the chromatography efficiency of the silica gel column as claimed in claim 1, wherein the surface shell of the chromatography column tube (2) is made of a silicon metal transparent material.
6. The device for improving the efficiency of silica gel column chromatography according to claim 1, wherein the outlet pipe (13) is provided with an outlet control plug (24) on one side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920285159.0U CN210251323U (en) | 2019-03-07 | 2019-03-07 | Device for improving silica gel column chromatography efficiency |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920285159.0U CN210251323U (en) | 2019-03-07 | 2019-03-07 | Device for improving silica gel column chromatography efficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210251323U true CN210251323U (en) | 2020-04-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920285159.0U Active CN210251323U (en) | 2019-03-07 | 2019-03-07 | Device for improving silica gel column chromatography efficiency |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210251323U (en) |
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2019
- 2019-03-07 CN CN201920285159.0U patent/CN210251323U/en active Active
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