CN210205530U

CN210205530U - Needle for puncturing and inhaling powder aerosol capsule and administration device thereof

Info

Publication number: CN210205530U
Application number: CN201920242994.6U
Authority: CN
Inventors: Yuewei Zheng; 郑跃伟; Liping Yuan; 袁利平; Xikun Dai; 代希坤; Xuping Zhang; 章旭平; Rong Li; 李�荣
Original assignee: Zhejiang Bai'an Medical Technology Co Ltd
Current assignee: Zhejiang Bai'an Medical Technology Co Ltd
Priority date: 2019-02-27
Filing date: 2019-02-27
Publication date: 2020-03-31
Anticipated expiration: 2029-02-27

Abstract

The utility model discloses a needle and device of dosing for puncturing inhales dry powder aerosol capsule, the needle includes the needle point, the needle point includes at least one main inclined plane and sets up the sharp portion inclined plane in main inclined plane both sides, wherein, main inclined plane is prepared on the needle point according to first plane angle, sharp portion inclined plane is prepared on the needle point according to second plane angle, and, contained angle between the central axis of main inclined plane and needle point is first rotation angle, contained angle between the central axis of sharp portion inclined plane and needle point is the second rotation angle, two sharp portion inclined planes are crossing in the outermost end of needle point. The needle with the main inclined plane and the tip inclined plane has the advantages that the needle point is sharper, meanwhile, the contact surface of the needle point and the capsule is smaller than that of the existing wedge-shaped needle or pencil-shaped needle, the cutting edge is longer, the capsule is gradually cut along the tip inclined plane and the main inclined plane, and a larger area of regular puncture holes can be gradually formed.

Description

Needle for puncturing and inhaling powder aerosol capsule and administration device thereof

Technical Field

The utility model relates to the technical field of medical equipment, especially, relate to a needle and device of dosing for puncturing and inhaling dry powder inhalation capsule.

Background

Respiratory diseases are common diseases, the incidence rate of the respiratory diseases is higher and higher along with the deterioration of air quality, and particularly, chronic respiratory diseases can bring great pain to patients. The most important and effective modes for treating chronic respiratory diseases in hospitals at present are quantitative inhalation aerosol, dry powder inhalation, aerosol inhalation and the like. Dry powder inhalers, also known as aerosols, are generally administered by use of an inhaler.

Powder mist inhalers are known in the art and generally comprise a base and a cover, and after placing a capsule in a capsule holder, the patient can press an actuator, which is movable from a rest position, thereby cooperating with at least one needle pressable into the capsule holder, piercing the capsule through the needle or needles and releasing the medicament.

In medicine, needles are known for use in various applications, whether for diagnosis (biopsy), treatment (injection) or for piercing or cutting capsules for inhalers. When puncturing or cutting the capsule, it is often particularly important to form a large precision puncture hole to release the powder from the capsule as completely as possible, as compared to puncturing the skin of a human or animal, while the broken capsule cannot form fragments that are too small to avoid inhalation of the fragments by the patient, causing breathing problems. This requires that the needle must be very sharp to pierce or cut the capsule accurately and quickly, while avoiding crushing of the capsule while forming a large puncture.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defects of the prior art, the utility model aims to provide a needle for puncturing and sucking a powder inhalation capsule and a drug delivery device provided with the needle, which have the advantages of high puncturing efficiency, large puncturing surface and difficult capsule breakage.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a needle for puncturing and inhaling a dry powder inhalation capsule comprises a needle point, wherein the needle point comprises at least one main inclined plane and tip inclined planes arranged at two sides of the main inclined plane,

wherein, main inclined plane is prepared according to first plane angle on the needle point, the point inclined plane is prepared according to second plane angle on the needle point, just, main inclined plane with contained angle between the central axis of needle point is first rotation angle, point inclined plane with contained angle between the central axis of needle point is the second rotation angle, two point inclined plane in the outmost looks of needle point intersects.

Further, the needle is a solid needle.

Further, the diameter of the needle is 0.8 mm-1.2 mm.

Further, the needle is made of impact-resistant plastic or medical stainless steel.

In order to achieve the above object, the present invention further adopts another technical solution as follows:

a powder fog administration device comprises a medicine bin internally provided with a powder fog capsule and an actuator which can move from a rest position, wherein the actuator is provided with a needle, the actuator drives the needle to penetrate through the medicine bin to puncture the powder fog capsule, the medicine bin enables the powder fog capsule to be vertically placed, the actuator is provided with at least two needles, at least one needle is arranged corresponding to the upper end part of the powder fog capsule, and at least one other needle is arranged corresponding to the lower end part of the powder fog capsule.

Further, the number of the actuators is two, and the actuators are respectively arranged on two sides of the medicine cabin.

Further, the needles on the two actuators are arranged in the same manner, and the needle at the upper end is arranged opposite to the needle at the lower end.

Furthermore, the medicine bin comprises a cavity body enabling the powder aerosol capsule to be vertically arranged, at least two through air inlet holes are formed in the side wall of the cavity body, the at least two air inlet holes are symmetrically arranged relative to the center of the medicine bin, and the air inlet holes are tangent to the inner wall of the medicine bin.

Further, the air inlet hole is positioned at the lower end of the cavity.

Further, a suction nozzle is arranged above the medicine bin, a powder suction channel corresponding to the cavity is arranged in the suction nozzle, a filter screen is arranged between the powder suction channel and the cavity, and the aperture of a filter hole in the filter screen is 0.7mm-1 mm.

The above and other objects, features and advantages of the present invention will be further apparent from the following detailed description and the accompanying drawings.

Drawings

FIG. 1 is a schematic view of a needle according to an embodiment of the present invention;

FIG. 2 is a schematic side view of a needle according to an embodiment of the present invention;

FIG. 3 is a schematic diagram of an exploded structure of a powder aerosol drug delivery device according to an embodiment of the present invention;

FIG. 4 is a schematic diagram of an alternative angle of the powder aerosol delivery device according to the embodiment of the present invention;

fig. 5 is a schematic sectional structure view of the medicine bin according to the embodiment of the present invention;

in the figure: 1. a base; 2. an upper cover; 3. a medicine bin; 31. a cavity; 32. an air inlet; 33. a through hole; 4. a suction nozzle; 41. a powder suction channel; 42. filtering with a screen; 5. an actuator; 51. an elastic member; 6. a needle; 61. a needle tip; 62. a primary bevel; 63. a tip bevel; 7. and (4) making capsules.

Detailed Description

The present invention will be further described with reference to the accompanying drawings and the detailed description, and it should be noted that the embodiments or technical features described below can be arbitrarily combined to form a new embodiment without conflict.

In the description of the present invention, it should be noted that, for the orientation words, if there are terms such as "center", "lateral", "longitudinal", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., the orientation and positional relationship indicated are based on the orientation or positional relationship shown in the drawings, and only for the convenience of describing the present invention and simplifying the description, it is not intended to indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and not be construed as limiting the specific scope of the present invention.

Furthermore, if the terms "first" and "second" are used for descriptive purposes only, they are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features. Thus, the definition of "a first" or "a second" feature may explicitly or implicitly include one or more of the features, and in the description of the invention, "a plurality" means two or more unless specifically defined otherwise.

In the present invention, unless otherwise expressly specified or limited, the terms "assembled", "connected", and "connected", if any, are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally connected; or may be a mechanical connection; the two elements can be directly connected or connected through an intermediate medium, and the two elements can be communicated with each other. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to specific situations.

Referring to fig. 1 to 5 of the drawings, a needle for piercing an inhalation powder capsule and a drug delivery device thereof according to an embodiment of the present invention will be explained in the following description, in which a needle point 61 of a needle 6 having a main inclined surface 62 and a tip inclined surface 63 is more sharp, solving the problem of piercing efficiency, and at the same time, since the contact surface of the needle point 61 and a capsule 7 is smaller and has a longer cutting edge than that of a conventional wedge-shaped needle or pencil-shaped needle, the capsule 7 is gradually cut along the tip inclined surface 63 and the main inclined surface 62, a larger area of a more regular piercing hole can be formed, and it is prevented that the contact surface of the capsule 7 and the needle is torn like a wedge-shaped needle or pencil-shaped needle, and even if both ends of the capsule 7 are separated from the middle section of the capsule 7, only larger broken pieces are formed, and will.

As shown in fig. 1 and 2, a needle 6 for piercing an inhalation aerosol capsule comprises a needle tip 61, the needle tip 61 comprising at least one main bevel 62 and tip bevels 63 disposed at both sides of the main bevel 62,

wherein the main bevel 62 is formed on the needle tip 61 at a first planar angle, the tip bevel 63 is formed on the needle tip 61 at a second planar angle, an included angle between the main bevel 62 and a central axis of the needle tip 61 is a first rotational angle, an included angle between the tip bevel 63 and the central axis of the needle tip 61 is a second rotational angle, and the two tip bevels 63 intersect at an outermost end of the needle tip 61. The first plane angle and the second plane angle in the present embodiment are each set based on an angle defined between the central axis of the drug cartridge 3 and a reference plane, and the first rotational angle and the second rotational angle are set based on rotational angles around the central axis.

During processing, the main inclined surface 62 is generally processed, the main inclined surface 62 can be in a rhombus shape, a triangular shape or a fan-like shape, the tip inclined surface 63 is preferably in a rhombus shape, then the tip inclined surfaces 63 are processed on the edge lines of two sides of the main inclined surface 62, the tip inclined surfaces 63 and the main inclined surface 62 have a certain included angle, the two tip inclined surfaces 63 are symmetrically arranged, and then the two tip inclined surfaces intersect at the outermost end of the needle point 61, so that the sharper needle point 61 is obtained. The first plane angle and the first rotation angle of the main bevel 62 and the second plane angle and the second rotation angle of the tip bevel 63 vary depending on the material used for the needle, and the strength of the needle tip 61 is secured while the needle tip 61 is made sharper. Preferably, the needle is made of impact-resistant plastic or medical stainless steel, and is sanitary and safe.

Meanwhile, in order to enhance the strength of the needle tip 61 and prevent the dry powder aerosol from entering the needle tube, the needle 6 of the present embodiment is a solid needle.

In order to improve the piercing efficiency and to completely remove the powder aerosol in the capsule 7, the number of the needles 6 of the present embodiment is at least two, at least one needle 6 is provided corresponding to the upper end of the powder aerosol capsule 7, and at least another needle 6 is provided corresponding to the lower end of the powder aerosol capsule 7. Preferably, the number of the needles 6 in this embodiment is four, two needles 6 are arranged on two sides of the medicine bin 3, two needles 6 are located on the same side, the main inclined planes 62 of the needle points 61 are arranged oppositely, and the diameter of the needles is 0.8 mm-1.2 mm, so that the capsules 7 are prevented from being shredded by a plurality of needles, and the broken pieces of the capsules 7 with a larger area are reserved.

As shown in fig. 3 to 5, there is also provided an embodiment of a powder aerosol delivery device, comprising a cartridge 3 containing a powder aerosol capsule 7 and an actuator 5 movable from a rest position, wherein the actuator 5 is provided with a needle as described above, and the actuator 5 drives the needle 6 to penetrate through the cartridge 3 to pierce the powder aerosol capsule 7, wherein the cartridge 3 allows the powder aerosol capsule 7 to stand upright, the actuator 5 is provided with at least two needles 6, at least one needle 6 is disposed corresponding to an upper end of the powder aerosol capsule 7, and at least another needle 6 is disposed corresponding to a lower end of the powder aerosol capsule 7. The number of the actuators 5 is two, and the actuators are respectively arranged on two sides of the medicine bin 3. The needles 6 of the two actuators 5 are arranged in a manner such that the needle 6 at the upper end is located opposite the needle 6 at the lower end. The main structure of the actuator 5 is the same as the prior art, the elastic part 51 is arranged between the actuator 5 and the outer wall of the medicine bin 3, so that the use of a patient is more labor-saving, meanwhile, the medicine bin 3 is provided with through holes 33 for the needles 6 to pass through, so that the needles 6 can directly puncture the capsules 7, and the number and the positions of the through holes 33 correspond to the needles 6.

The medicine bin 3 comprises a cavity 31 enabling the aerosol capsule 7 to be vertically arranged, at least two through air inlets 32 are arranged on the side wall of the cavity 31, the at least two air inlets 32 are symmetrically arranged relative to the center of the medicine bin 3, and the air inlets 32 are tangent to the inner wall of the medicine bin 3. A suction nozzle 4 is arranged above the medicine bin 3, a powder suction channel 41 corresponding to the cavity 31 is arranged in the suction nozzle 4, a filter screen 42 is arranged between the powder suction channel 41 and the cavity 31, and the aperture of a filter hole on the filter screen 42 is 0.7mm-1 mm. The patient inserts the suction nozzle 4 into the mouth and nose, and sucks air forcibly, at this time, because the capsule 7 is pierced by the needle 6 and stands upright in the cavity 31, the air enters the cavity 31 from the air inlet 32 at the bottom of the cavity 31, the air forms a rotating airflow in the cavity 31 through the centrally symmetrical air inlet 32, the capsule 7 is driven to rotate, the powder mist is quickly separated from the capsule 7, and then is sucked into the powder suction channel 41 to enter the body of the patient; the capsule 7 is broken to form a broken block with a larger volume, and the broken block is blocked by the filter screen 42 due to the smaller filter holes on the filter screen 42, so that the broken block is prevented from being sucked out by a patient.

The following data are a comparison of the evacuation ratios of inhalers of different tip shapes, where the main bevel and tip bevel of the needle in this example constitute the tip of a triangular rhombus:

	existing inhaler 1	Existing inhaler 2	Inhaler of the present embodiment
				Needle tip shape	Wedge type	Pencil shape	Triangular rhombus
Number of needles	2	2	4
				Pore diameter/mm of filter pores	1	1.3	0.8
The direction of puncturing the capsule 7	Capsule 7 side wall	Capsule 7 side wall	Capsule 7 side wall
				Air flow rate of 60 + -5L/min	99.6	98.5	99.7
Emptying rate at air flow rate of 40 +/-5 liters/minute	83.4	/	99.7
				Emptying rate at air flow rate of 20 +/-5 liters/minute	/	/	29.2

Compared with the existing inhaler 1 and the existing inhaler 2, the inhaler of the embodiment has the advantages that the capsule 7 has a good puncturing effect and a high powder mist emptying rate, and the air inlet holes 32 are formed in the bottom of the cavity 31, so that the capsule 7 can be effectively driven to rotate, a good emptying rate can be obtained when the air flow is high, and the inhaler is more suitable for patients.

Meanwhile, the powder inhalation drug delivery device of the embodiment further comprises a base 1 and an upper cover 2, a drug bin 3 and an actuator 5 are positioned in the base 1, the drug bin 3 is fixedly connected with the base 1, a suction nozzle 4 is positioned in the upper cover 2 and is detachably connected with the drug bin 3, more specifically, the lower part of the suction nozzle 4 is clamped with the upper part of the drug bin 3, when a capsule 7 needs to be placed, the suction nozzle 4 is pulled out to expose a cavity 31 in the drug bin 3, and then the capsule 7 is placed into the capsule 7 to restore the suction nozzle 4 and the drug bin 3. When the powder aerosol drug delivery device is not used, the upper cover 2 is generally buckled on the suction nozzle 4, so as to keep the suction nozzle 4 clean and sanitary.

The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention cannot be limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are all within the protection scope of the present invention.

Claims

1. The utility model provides a needle for puncturing and inhaleing dry powder inhalation capsule which characterized in that, includes the needle point, the needle point includes at least one main inclined plane and sets up the point inclined plane in main inclined plane both sides, wherein, main inclined plane is prepared according to first plane angle on the needle point, point inclined plane is prepared according to second plane angle on the needle point, just, main inclined plane with contained angle between the central axis of needle point is first rotation angle, point inclined plane with contained angle between the central axis of needle point is the second rotation angle, two point inclined plane in the outmost of needle point intersects.

2. The needle of claim 1 for piercing a dry aerosol capsule for inhalation, wherein the needle is a solid needle.

3. The needle for piercing an inhaled dry aerosol capsule according to claim 1, wherein the needle has a diameter of 0.8mm to 1.2 mm.

4. A needle for piercing an inhaled powder aerosol capsule according to claim 1, 2 or 3 wherein said needle is made of impact resistant plastic or medical grade stainless steel.

5. A delivery device comprising a cartridge containing a powder aerosol capsule and an actuator movable from a rest position, wherein the actuator is provided with a needle according to any one of claims 1 to 4, the actuator driving the needle through the cartridge to pierce the powder aerosol capsule, wherein the cartridge holds the powder aerosol capsule upright, the actuator is provided with at least two needles, at least one needle is disposed in correspondence with an upper end of the powder aerosol capsule, and at least one other needle is disposed in correspondence with a lower end of the powder aerosol capsule.

6. The drug delivery device of claim 5, wherein the number of actuators is two, one on each side of the cartridge.

7. The drug delivery device of claim 6, wherein the needles on both actuators are arranged in a manner such that the needle at the upper end is disposed opposite the needle at the lower end.

8. The drug delivery device according to claim 5, wherein the drug bin comprises a cavity for the powder aerosol capsule to stand upright, the side wall of the cavity is provided with at least two air inlet holes which are communicated, the at least two air inlet holes are symmetrically arranged about the center of the drug bin, and the air inlet holes are tangential to the inner wall of the drug bin.

9. The drug delivery device of claim 8, wherein the air inlet hole is located at a lower end of the cavity.

10. The drug delivery device according to claim 8, wherein a suction nozzle is arranged above the drug bin, a powder suction channel corresponding to the cavity is arranged in the suction nozzle, a filter screen is arranged between the powder suction channel and the cavity, and the aperture of a filter hole on the filter screen is 0.7mm-1 mm.