CN210145539U - Simple DMSO (dimethyl sulfoxide) recrystallization system - Google Patents

Abstract

The utility model discloses a simple and easy DMSO recrystallization system, including recrystallization device, crystallization container, collection container and hoist device, recrystallization device is connected with hoist device, recrystallization device includes hollow core plate and (mixing) shaft, the central point of hollow core plate puts and (mixing) shaft fixed connection, hollow core plate and horizontal plane form an contained angle, the contained angle is 3 to 5, be provided with the coil pipe in the hollow core plate, the first port of coil pipe is in hollow core plate upper portion, the second port of coil pipe is in hollow core plate lower part, the medium entering pipeline with the first port of coil pipe is connected, the second port of coil pipe with medium discharge tube coupling; the lower parts of the crystallization container and the collection container are respectively provided with a lifting device, and the lifting devices are arranged on the same slide rail; the utility model solves the problem of difficult separation of the DMSO crystal from the liquid.

Description

Simple DMSO (dimethyl sulfoxide) recrystallization system

Technical Field

The utility model relates to a simple and easy DMSO recrystallization system.

Background

The domestic industrial grade DMSO has good chemical purity which can reach 99.9 percent, can be used as a medical auxiliary material after being adsorbed by active carbon and primarily refined, but only reaches the requirement of being used as an external auxiliary material, can cause great side reaction when being injected into a human body, and trace impurities causing the side reaction of the human body cannot be removed by the active carbon. At present, the cell cryopreservation technology is developed very rapidly, DMSO is used as an essential component of cell cryopreservation liquid, when cells are returned to a human body, the DMSO is often input into the human body together, and the requirement of an injection-grade pharmaceutic adjuvant cannot be met by the domestic pharmaceutic adjuvant-grade DMSO at present. More efficient purification of technical grade DMSO is required and recrystallization is a very effective method to remove trace impurities that cause side reactions in humans. However, DMSO crystals are difficult to obtain like common chemicals, crystals are very soft, liquid without crystals is difficult to remove cleanly, and solid-liquid separation is very difficult.

Disclosure of Invention

The utility model aims to provide a simple and easy DMSO recrystallization system to prior art not enough, the device realizes the solid-liquid separation of DMSO crystal very easily, and is efficient, low in manufacturing cost.

A simple DMSO (dimethyl sulfoxide) recrystallization system comprises a recrystallization device, a crystallization container, a collection container and a hoisting device, wherein the recrystallization device is connected with the hoisting device and comprises a hollow plate and a stirring shaft, the center of the hollow plate is fixedly connected with the stirring shaft, an included angle is formed between the hollow plate and the horizontal plane and is 3-5 degrees, a coil is arranged in the hollow plate, a first port of the coil is arranged at the upper part of the hollow plate, a second port of the coil is arranged at the lower part of the hollow plate, a medium inlet pipeline is connected with the first port of the coil, and the second port of the coil is connected with a medium outlet pipeline; and the lower parts of the crystallization container and the collection container are respectively provided with a lifting device, and the lifting devices are arranged on the same slide rail.

Furthermore, a temperature detector for detecting the medium is arranged outside the medium inlet pipeline.

Further, the hollow core slab is two at least, the quantity of hollow core slab is the even number, hollow core slab is from last to establishing ties on the (mixing) shaft down in proper order, hollow core slab and adjacent hollow core slab are about horizontal plane symmetry, and the coil pipe of adjacent hollow core slab passes through the pipe connection.

Furthermore, a liquid outlet is arranged at the bottom of the crystallization container, and a liquid outlet valve is arranged on the liquid outlet.

Furthermore, the bottom of the collecting container is gradually tightened to form a conical structure, and a liquid discharge valve is arranged at the conical bottom.

Further, the first port of coil pipe with the second port of coil pipe is close to the (mixing) shaft, be close to the (mixing) shaft on the hollow core plate and be equipped with a through-hole, medium discharge pipe runs through the through-hole.

Further, the hollow plate is circular.

Furthermore, a lifting device at the lower part of the crystallization container is provided with a rotating mechanism which enables the crystallization container to rotate, and the rotating mechanism comprises a driving motor and a transmission part.

Has the advantages that: (1) the design of the crystallization container and the collection container and the included angle of 3-5 degrees formed between the hollow plate and the horizontal plane of the utility model facilitate the separation of DMSO crystal from liquid, and solve the problem that the existing DMSO crystal is difficult to separate from liquid; (2) the design of hollow core plate increases the adhesive surface of the crystallization, and improves the crystallization efficiency.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic structural view of the hollow core slab of the present invention when the number is two.

Wherein, 1, a crystallization container; 2. hoisting the device; 3. a collection container; 4. a hollow slab; 5. a stirring shaft; 6. a medium inlet pipe; 7. a medium discharge pipe; 8. a first port of the coiled tubing; 9. a second end of the coil.

Detailed Description

The technical solution of the present invention is described in detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the embodiments.

As shown in fig. 1, a simple DMSO recrystallization system comprises a recrystallization device, a crystallization container 1, a collection container 3, and a hoisting device 2, the recrystallization device is connected to the hoisting device 2, the recrystallization device comprises a hollow slab 4 and a stirring shaft 5, the center of the hollow slab 4 is fixedly connected to the stirring shaft 5, the hollow slab 4 forms an included angle with the horizontal plane, the included angle is 3 ° to 5 °, a coil is disposed in the hollow slab 4, a first port 8 of the coil is disposed on the upper portion of the hollow slab 4, a second port 9 of the coil is disposed on the lower portion of the hollow slab 4, a medium inlet pipe 6 is connected to the first port 8 of the coil, a second port 9 of the coil is connected to a medium outlet pipe 7, a temperature detector for detecting the medium is disposed outside the medium inlet pipe 6, the first port 8 of the coil and the second port 9 of the coil are close to the stirring shaft 5, a through hole is formed in the hollow plate 4 close to the stirring shaft 5, and a medium discharge pipeline 7 penetrates through the through hole; and the lower parts of the crystallization container 1 and the collection container 3 are respectively provided with a lifting device, and the lifting devices are arranged on the same slide rail.

And a liquid outlet is formed in the bottom of the crystallization container 1, and a liquid outlet valve is arranged on the liquid outlet.

The bottom of the collecting container 3 is gradually tightened to be in a conical structure, and a drain valve is arranged at the conical bottom.

The hollow plate 4 is circular.

And a lifting device at the lower part of the crystallization container 1 is provided with a rotating mechanism which enables the crystallization container 1 to rotate, and the rotating mechanism comprises a driving motor and a transmission part.

As shown in fig. 2, the number of the hollow plates 4 is two, the hollow plates 4 are sequentially connected in series on the stirring shaft 5 from top to bottom, two adjacent hollow plates 4 are symmetrical about a horizontal plane, and are adjacent to each other the coil pipe of the hollow plate 4 is connected through a pipeline, the medium inlet pipeline 6 is connected with the first port 8 of the coil pipe of the hollow plate at the uppermost end, and the second port 9 of the coil pipe of the hollow plate 4 at the lowermost end is connected with the medium outlet pipeline 7.

Pouring the unpurified DMSO solution into a crystallization container 1, moving the crystallization container 1 to the lower part of a recrystallization device, and raising the crystallization vessel 1 to immerse the hollow plate 4 of the recrystallization apparatus in the DMSO solution, introducing a cooling medium of less than 18 ℃ into the medium inlet pipe 6, introducing the cooling medium into the coil of the hollow plate 4 to lower the temperature of the liquid around the hollow plate 4, so that DMSO crystals are precipitated and attached to the hollow plate 4, the driving motor is started to rotate the crystallization container 1, the crystallization efficiency is improved, when DMSO crystals are attached to the hollow plate 4 to reach a certain thickness, the crystallization container 1 is moved away by using a lifting device, because the hollow plate 4 has an included angle of 3 degrees to 5 degrees with the horizontal plane, the hollow plate 4 is in an inclined state, in the proposed process, the liquid flows out along the inclined surface and remains in the crystallization vessel 1, thereby allowing the DMSO crystals to be easily separated from the liquid. Moving the collection container 3 to the lower part of the recrystallization device, lifting the collection container 3 to enable the hollow plate of the recrystallization device to be arranged in the collection container 3, introducing a heating medium with the temperature higher than 50 ℃ into the medium inlet pipeline 6, enabling crystallized DMSO to become liquid due to temperature rise, enabling liquefied DMSO to flow into the collection container 3, and opening a valve at the bottom of the collection container 3 to take out the liquefied DMSO.

As mentioned above, although the present invention has been shown and described with reference to certain preferred embodiments, it should not be construed as limiting the invention itself. Various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (9)

1. A DMSO recrystallization system comprises a recrystallization device, a crystallization container (1), a collection container (3) and a hoisting device (2), wherein the recrystallization device is connected with the hoisting device (2), it is characterized in that the recrystallization device comprises a hollow plate (4) and a stirring shaft (5), the center of the hollow plate (4) is fixedly connected with the stirring shaft (5), the hollow plate (4) forms an included angle with the horizontal plane, the included angle is 3-5 degrees, a coil pipe is arranged in the hollow plate (4), a first end opening (8) of the coil pipe is arranged at the upper part of the hollow plate (4), the second end (9) of the coil is arranged at the lower part of the hollow plate (4), a medium inlet pipeline (6) is connected with the first end (8) of the coil, the second end (9) of the coil is connected to a medium discharge conduit (7).

2. A DMSO recrystallization system as claimed in claim 1, wherein the lower parts of the crystallization vessel (1) and the collection vessel (3) are respectively provided with a lifting device, and the lifting devices are installed on the same slide rail.

3. A DMSO recrystallization system as claimed in claim 1, wherein the medium inlet conduit (6) is externally provided with a temperature detector for detecting the medium.

4. A DMSO recrystallization system according to claim 1, wherein there are at least two hollow plates (4), the number of hollow plates is even, the hollow plates (4) are connected in series on the stirring shaft (5) from top to bottom, the hollow plates (4) are symmetrical with the adjacent hollow plates (4) with respect to the horizontal plane, and the coils of the adjacent hollow plates (4) are connected by pipes.

5. The DMSO recrystallization system according to claim 1, wherein a liquid outlet is arranged at the bottom of the crystallization container (1), and a liquid outlet valve is arranged on the liquid outlet.

6. A DMSO recrystallisation system according to claim 1, characterised in that the bottom of the collection vessel (3) is gradually narrowed in a conical configuration, the conical bottom being provided with a drain valve.

7. A DMSO re-crystallization system according to claim 1, characterized in that said hollow plate (4) is circular.

8. A DMSO recrystallization system as claimed in claim 1, wherein the first end (8) of the coiled tube and the second end (9) of the coiled tube are close to the stirring shaft (5), and the hollow plate (4) is provided with a through hole close to the stirring shaft (5), and the medium discharge pipe (7) penetrates through the through hole.

9. A DMSO recrystallization system as claimed in claim 1, wherein the lifting device at the lower part of the crystallization container (1) is provided with a rotation mechanism for rotating the crystallization container (1), and the rotation mechanism comprises a driving motor and a transmission component.

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