CN210019798U

CN210019798U - Porous artificial eye seat

Info

Publication number: CN210019798U
Application number: CN201821413231.5U
Authority: CN
Inventors: 胡可辉; 万力; 成明
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-08-30
Filing date: 2018-08-30
Publication date: 2020-02-07
Anticipated expiration: 2028-08-30

Abstract

The utility model relates to a porous artificial eye seat. The porous artificial eye seat is made of biological ceramics and is a 10-30mm spheroid, the spherical crown on one side of the porous artificial eye seat is a dense thin shell with the thickness of 0.2-3mm, the interior and the rest surfaces of the porous artificial eye seat are provided with uniformly distributed macroscopic pores with the thickness of 0.1-1 mm, more preferably 0.3-1 mm, the surface and the interior macroscopic pores are communicated with each other, the artificial eye seat further comprises uniformly distributed secondary pores and final pores, the size of the secondary pores is 1-100 mu m, the size of the final pores is smaller than 1 mu m, and the porosity of the artificial eye seat is 60-95%. The porous artificial eye seat of the utility model is favorable for the infiltration of new blood vessels and tissues into the porous artificial eye seat.

Description

Porous artificial eye seat

Technical Field

The utility model relates to a ceramic ball artificial eye seat. More particularly, the present invention relates to a porous prosthetic eye holder.

Background

The implantation of the artificial eye seat is a commonly used restoration treatment scheme for restoring the appearance after the removal of the eyeball, and after the implantation of the artificial eye seat, a patient can install an artificial eye piece on the artificial eye seat to restore the appearance to the maximum extent.

The prior art intraocular lens holders can be classified into several categories depending on the material. One is a solid sphere made of a silica gel material; one is porous artificial eye holder made of coral hydroxyapatite; there are also porous prosthetic eye sockets made of polymers.

However, the silica gel artificial eye holder can form a fibrous membrane package around the silica gel artificial eye holder after being implanted, so that the silica gel artificial eye holder is easy to displace and has the problem of immunological rejection. After the porous prosthetic eye seat is implanted, the new blood capillaries and fibrous connective tissues grow slowly to the center of the prosthetic eye seat along the pores of the prosthetic eye seat, so that the displacement of the prosthetic eye seat can be better prevented.

However, although porous prosthetic eye sockets of different materials have such advantages, they are all manufactured through a template method, which has a complicated process, a long process flow, and difficulty in manufacturing due to post-treatment involving a template agent. Furthermore, the large volume of templating agent required for the porous prosthetic eye socket to allow neogenetic tissue infiltration is generally expensive. In addition, when the template method is used, a doctor cannot design a micropore structure, so that the vascularization process after implantation is not controllable, and the quality stability of the eyeball is difficult to ensure. Moreover, the whole shape of the artificial eye holder manufactured by the die can be formed only by cutting, carving or polishing after the die is manufactured, the die opening time is long, the cost is high, and customized manufacturing of different patients cannot be realized.

Therefore, there is still a need for new configurations of prosthetic sockets.

SUMMERY OF THE UTILITY MODEL

The inventor designs a porous artificial eye holder gap structure according to the simulation of the vascularization process in the artificial eye holder after implantation and the mechanical analysis in vivo, and completes the utility model based on the design.

The utility model aims at providing a hierarchical pore biological ceramic ball false eye seat.

According to an embodiment of the present invention, there is provided a porous artificial eye seat, characterized in that: the artificial eye seat is prepared by biological ceramics and is a 10-30mm spheroid, the spherical crown at one side of the artificial eye seat is a compact thin shell with the thickness of 0.2-3mm, the interior and the rest surfaces of the artificial eye seat are provided with evenly distributed macroscopic holes with the thickness of 0.1 mm-1 mm, more preferably 0.3 mm-1 mm, wherein the macroscopic holes at the surface and the interior are communicated with each other,

wherein the artificial eye seat further comprises secondary holes and final-stage holes which are uniformly distributed, the size of the secondary holes is 1-100 μm, the size of the final-stage holes is less than 1 μm, and the porosity of the artificial eye seat is 60-95%.

Preferably, the secondary and final stage apertures are in communication with the macro-apertures.

Preferably, the bioceramic is a material prepared from one or more selected from hydroxyapatite, calcium phosphate, bioglass, calcium sulphate.

Preferably, the dense thin shell may occupy 1/3 to 1/2 of the entire spherical area.

Preferably, small holes or groove lines which are not communicated with the macroscopic holes, the secondary holes and the final stage holes are also arranged on the surface of the compact thin shell. The small hole or groove line is used for helping the adhesiveness between the artificial eye seat and the artificial eye sheet.

Preferably, the spheroid may be a regular sphere, an ellipsoid, a rugby sphere.

The biological ceramic material can increase the biocompatibility of the prosthetic eye seat and reduce inflammation, infection or rejection.

The porous artificial eye seat of the utility model is prepared by the following method:

1) carrying out eye socket CT scanning on a patient with eyeball loss to obtain an eye socket three-dimensional data model;

2) forming a blank of the artificial eye seat by adopting the biological ceramic slurry through 3d printing equipment; wherein, the blank is a near-spherical body of the three-dimensional data model obtained in the step 1), a spherical crown at one side of the blank is arranged into a compact thin shell with the thickness of 0.2-3mm, the inner part and the rest surfaces of the blank are arranged into macroscopic holes with the uniform distribution of 0.1 mm-1 mm, more preferably 0.3 mm-1 mm, and the surface and the internal macroscopic holes are communicated with each other;

3) calcining the artificial eye holder blank with the macroscopic hole at 600 ℃ for 1-4h, thereby removing the pore-forming agent;

4) sintering the artificial eye holder blank calcined in the step 3) at the temperature of 1000-1500 ℃ for 0.5-4h to obtain the required porous artificial eye holder.

Preferably, the bioceramic slurry is a photo-cured bioceramic slurry, and at this time, in the step 2), the bioceramic slurry at the hole forming position is not cured when the blank is formed, and is removed by ultrasonic vibration cleaning and pressure spray gun flushing under the action of a high-solubility solvent, so that a macroscopic hole structure is obtained.

Preferably, the biological ceramic slurry comprises 50-100 parts of biological ceramic, 10-40 parts of nontoxic photosensitive resin, 5-20 parts of pore-forming agent, 1-10 parts of dispersing agent and 0.5-5 parts of sintering aid.

Preferably, the bioceramic comprises a mixture of one or more of hydroxyapatite, calcium phosphate, bioglass, calcium sulphate; the pore-forming agent is one or a mixture of more of PMMA, ammonium bicarbonate, PVA, PVB, carbon powder, graphite powder, graphene and organic fibers.

Preferably, the high-solubility solvent comprises one or more of ethanol, water and a surfactant.

According to porous artificial eye seat adopt the mode that 3D printed to form designable interconnect's hole, moreover, the hole is bigger than the size that adopts the hole-creating agent (template agent promptly) to generate, is favorable to neogenesis blood vessel and the porous artificial eye seat of tissue infiltration. The utility model discloses a secondary hole and final stage hole size in the artificial eye seat are less, can be used to the required nutrient of blood vessel and the tissue transmission that form in the macroscopic hole etc..

In addition, the utility model discloses a porous prosthetic eye seat is based on patient's eye socket data takes shape, and its size is fit for each patient more.

Drawings

Fig. 1 is a model of an artificial eye seat according to an embodiment of the present invention.

Detailed Description

The present invention will be described in detail below with reference to examples, but the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention.

Example 1

Adopting hydroxyapatite: tricalcium phosphate: mixing 20nm-500nm powder with bioglass of 4:2:1 to obtain 50 parts of biological ceramic material, mixing 40 parts of acrylic resin monomer to obtain photosensitive resin binder, 5 parts of PMMA to obtain pore-forming agent, 2 parts of polymethyl cellulose to obtain dispersing agent, and 1 part of MgO to obtain sintering aid, uniformly mixing by using a mixer, and defoaming to obtain biological ceramic slurry for 3D printing.

Modeling of the artificial eye base is carried out by using the data of the eye socket scanned by the patient, wherein the model of the artificial eye base is a regular sphere with the diameter of 25mm, the spherical cap with the height of 10mm on one side is a compact thin shell with the thickness of 1mm, and the inner part and the rest surface are provided with uniformly distributed holes with the thickness of 0.3mm to 1mm, and the holes are communicated with each other. The model is shown in fig. 1.

The prepared biological ceramic slurry is used for printing the artificial eye holder by adopting an Autocera type 3D printer which is manufactured by Beijing ten-dimensional science and technology Limited liability company and can be used for photocuring forming. And obtaining a 3D printing blank after printing, photocuring and ultrasonic cleaning.

And calcining the blank at the temperature of 600 ℃ for 3h, and then sintering at the temperature of 1300 ℃ for 2h to obtain the finally prepared artificial eye seat.

Example 2

An ellipsoid with a polar radius larger than the equatorial radius is used as the model of the artificial eye socket, and the spherical cap with a height of 6mm from one pole is a compact thin shell with a thickness of 2mm, and the inner part and the rest of the surface have uniformly distributed holes of 0.1mm to 0.8mm, which are interconnected.

Except for the differences of these models, the prosthetic eye seat was prepared in the same manner as described in example 1.

Example 3

The prosthetic eye socket was prepared in the same manner as described in example 1, using a 1:1 mixed powder of bioglass and calcium sulfate as a raw material of bioceramic powder. And keeping the final sintering temperature at 1200 ℃ for 1 h.

Claims

1. A porous prosthetic eye mount, comprising: the artificial eye seat is prepared by biological ceramics and is a 10-30mm spheroid, the spherical crown at one side of the artificial eye seat is a compact thin shell with the thickness of 0.2-3mm, macroscopic holes with the thickness of 0.1 mm-1 mm are uniformly distributed in the artificial eye seat and on the other surfaces of the artificial eye seat, the macroscopic holes on the surfaces and the insides are communicated with each other,

the artificial eye seat also comprises secondary holes and final-stage holes which are uniformly distributed, the size of the secondary holes is 1-100 mu m, the size of the final-stage holes is less than 1 mu m, and the porosity of the artificial eye seat is 60-95%.

2. The porous prosthetic eye socket according to claim 1, wherein the macroscopic pores have a size of 0.3mm to 1 mm.

3. The multi-aperture prosthetic eye socket according to claim 1, wherein the secondary and final apertures are in communication with the macro-apertures.

4. The porous prosthetic eye seat according to claim 1, wherein the bioceramic is a material prepared from one or more selected from hydroxyapatite, calcium phosphate, bioglass, calcium sulphate.

5. The porous prosthetic eye seat according to claim 1, wherein the thin dense shell can occupy 1/3 to 1/2 of the total spherical area.

6. The porous prosthetic eye seat according to claim 1, wherein a fine hole or groove pattern not communicating with the macro, secondary and final stage holes is further present on the dense shell surface.

7. The porous prosthetic eye socket according to claim 1, wherein the spheroid is a regular sphere, an ellipsoid, a rugby sphere.