CN209968133U - Concentration equipment is used in antibody production - Google Patents
Concentration equipment is used in antibody production Download PDFInfo
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- CN209968133U CN209968133U CN201920598647.7U CN201920598647U CN209968133U CN 209968133 U CN209968133 U CN 209968133U CN 201920598647 U CN201920598647 U CN 201920598647U CN 209968133 U CN209968133 U CN 209968133U
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Abstract
The utility model discloses a concentrator is used in antibody production, including box, concentrated section of thick bamboo, booster pump, motor, transmission shaft, its characterized in that: the box setting on the support to be provided with row's miscellaneous pipe in the bottom half, concentrate the section of thick bamboo embedding box in, the booster pump setting on the box outer wall, the motor setting at concentrate a top, be provided with the power cord on the motor, the vertical setting of transmission shaft in concentrate the section of thick bamboo. The utility model discloses be connected booster pipe and concentrated bobbin top on the booster pump, can carry out the pressure boost in the concentrated bobbin, be the impurity of mixing in the antibody, water flows through the milipore filter on the concentrated bobbin side wall to the miscellaneous tub of row through the bottom half discharges, has realized carrying out the purpose of concentrated processing to the antibody, is provided with on the transmission shaft of motor and stirs the board, constantly stirs the antibody at the concentrated in-process of antibody, makes the antibody fully separate with water, and then improves the concentrated efficiency and the concentrated quality of antibody.
Description
Technical Field
The utility model relates to an antibody production technical field specifically is a concentrator is used in antibody production.
Background
Antibodies are a class of immunoglobulins that specifically bind to an antigen. Antibodies are classified by their reactive forms into lectins, sinkers, antitoxins, lysins, opsonins, neutralizing antibodies, complement-binding antibodies, and the like. When present antibody is in the production process, need to have certain requirement to the concentration of antibody, and the antibody is often too slow at concentrated in-process at present stage, and produces some waste liquids easily after the concentration, and the inconvenience is collected the waste liquid, can not carry out the intensive mixing in the antibody concentration process simultaneously, leads to the antibody concentration after the concentration can not guarantee to reach the demand.
Disclosure of Invention
The utility model aims at overcoming the inconvenience that current antibody concentrator exists and collecting the waste liquid, the concentrated in-process of antibody can not carry out intensive mixing, the not good problem of antibody concentration quality, provide a structural design reasonable, can collect the waste liquid, the concentrated in-process of antibody can carry out intensive mixing, the concentrated for antibody production concentrator of high quality of antibody.
The utility model provides a technical scheme that technical problem taken does:
the utility model provides an antibody production is with concentrator, includes box, concentrated section of thick bamboo, booster pump, motor, transmission shaft, its characterized in that: the box body is arranged on the bracket, the bottom of the box body is provided with the impurity discharging pipe, impurities and water generated by antibody concentration can be discharged from the box body through the impurity discharging pipe, the purity of the concentrated antibody is improved, the concentration cylinder is embedded into the box body, the top of the concentration cylinder is arranged outside the box body, the top of the concentration cylinder is provided with the feeding pipe, the bottom of the concentration cylinder is provided with the discharging pipe, the discharging pipe penetrates out of the bottom of the box body, the booster pump is arranged on the outer wall of the box body, the booster pump is provided with the power line and the booster pipe, the booster pipe is connected with the top of the concentration cylinder, the booster pump and the booster pipe can input air flow into the concentration cylinder, the pressure intensity in the concentration cylinder is improved, the water and the impurities mixed in the antibody are discharged into the box body through the ultrafiltration membrane on the side wall of the concentration cylinder and are discharged through the impurity discharging pipe, the concentrated antibody is discharged from the discharging pipe, and the concentrated, the waste of raw materials has been reduced, the motor setting at concentrated section of thick bamboo top, be provided with the power cord on the motor, the vertical setting of transmission shaft in concentrated section of thick bamboo, be connected transmission shaft top and motor to be provided with on the transmission shaft and stir the board, the motor drives transmission shaft and epaxial stirring board rotation, constantly stirs the antibody at the concentrated in-process of antibody, makes the antibody abundant and separation of water, and then improves the concentration efficiency and the concentrated quality of antibody, the antibody after the concentration is discharged from the discharging pipe fast, has improved the discharge efficiency of antibody.
Preferably, a sealing ring is arranged between the bottom of the box body and the discharge pipe, a valve is arranged on the discharge pipe, the sealing performance between the bottom of the box body and the discharge pipe is improved through the sealing ring, impurities discharged into the box body are prevented from flowing out from the bottom of the box body and the discharge pipe, and then the purity of the concentrated antibody is improved.
Preferably, the concentration cylinder is of a conical structure, the ultrafiltration membrane is arranged on the side wall of the concentration cylinder, the ultrafiltration membrane is of a polypropylene (PP) or Polyethylene (PE) material, the concentration cylinder is of a conical structure, the antibody in the concentration process flows upwards along the inner wall of the concentration cylinder, impurities in the antibody concentration process can be discharged into the box body through the filtration membrane, the impurities are discharged through the impurity discharge pipe, the concentrated antibody is discharged from the discharge pipe, the concentrated antibody and the impurities are conveniently subjected to classification treatment, waste of raw materials is reduced, the concentration efficiency of the antibody is improved, and waste of the antibody is reduced.
Preferably, the top of the concentration cylinder is provided with a pressure gauge, the pressure condition in the concentration cylinder can be reflected in real time through the pressure gauge, so that the worker can conveniently control the rhythm of antibody concentration, the working efficiency is improved, and the labor intensity of the operator is reduced.
Preferably, stir the board setting and be big in the upper end, the little helical structure of lower extreme, the motor drives transmission shaft and the epaxial rotation of stirring board of transmission, constantly stir the antibody at antibody concentration in-process, make the antibody fully separate with water, and then improve the concentration efficiency and the concentrated quality of antibody, the antibody after the concentration is discharged from the discharging pipe fast, the discharge efficiency of antibody has been improved, will stir the board and set up to big in the upper end, the little helical structure of lower extreme, make to stir the board and can fully stir the antibody in the concentration section of thick bamboo, be convenient for the antibody fully separate with water, the concentration efficiency and the concentrated quality of antibody are improved.
The working principle is as follows: with the booster pump, power cord on the motor is connected with external power source respectively, the antibody that will need concentrated processing adds concentrated section of thick bamboo in through the inlet pipe, start the booster pump, including a motor, an end cap, a controller, and a cover plate, the booster pump, the booster pipe can be with air current input to concentrated section of thick bamboo in, improve the pressure in the concentrated section of thick bamboo, can reflect the pressure condition in the concentrated section of thick bamboo in real time through the manometer, the concentrated rhythm of the staff's control antibody of being convenient for, the motor drives the transmission shaft and the epaxial stirring board of transmission is rotatory, constantly stir the antibody at the concentrated in-process of antibody, make the antibody fully with the separation of water, impurity in the concentrated in-process of antibody can discharge to the box through filtration membrane, and discharge through the impurity discharge pipe.
Has the advantages that: the utility model discloses be connected booster pipe and concentrated bobbin top on the booster pump, can carry out the pressure boost in the concentrated bobbin, be the impurity of mixing in the antibody, water flows through the milipore filter on the concentrated bobbin side wall, and the miscellaneous tub of row through the bottom half discharges, the purpose of carrying out concentrated processing to the antibody has been realized, be provided with on the transmission shaft of motor and stir the board, constantly stir the antibody at the concentrated in-process of antibody, make the antibody abundant with the separation of water, and then improve the concentration efficiency and the concentrated quality of antibody, the antibody after the concentration is discharged from the discharging pipe fast, the discharge efficiency of antibody has been improved.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic view of a part of the structure of the present invention, illustrating the connection structure of the concentration cylinder and the ultrafiltration membrane.
FIG. 3 is a schematic view of a part of the structure of the present invention, showing the connection structure of the box body and the discharge pipe.
Fig. 4 is a schematic diagram of another embodiment of the present invention.
In the figure: 1. the device comprises a box body, a concentration cylinder 2, a booster pump 3, a motor 4, a transmission shaft 5, a support 6, a impurity discharging pipe 7, a feeding pipe 8, a pressure gauge 9, a discharging pipe 10, an ultrafiltration membrane 11, a valve 12, a sealing ring 13, a power line 14, a booster pipe 15, a stirring plate 16 and a guide plate 17.
Detailed Description
The present invention will be described in more detail with reference to the accompanying drawings.
Example one
As shown in the attached figures 1-3, the concentration equipment for antibody production comprises a box body 1, a concentration cylinder 2, a booster pump 3, a motor 4 and a transmission shaft 5, and is characterized in that: the box body 1 is arranged on a bracket 6, the bottom of the box body 1 is provided with a trash discharging pipe 7, impurities and water generated by antibody concentration can be discharged from the box body 1 through the trash discharging pipe 7, the purity of the concentrated antibody is improved, the concentrating cylinder 2 is embedded into the box body 1, the top of the concentrating cylinder 2 is arranged outside the box body 1, the top of the concentrating cylinder 2 is provided with a feeding pipe 8, the bottom of the concentrating cylinder 2 is provided with a discharging pipe 10, the discharging pipe 10 penetrates out of the bottom of the box body 1, the booster pump 3 is arranged on the outer wall of the box body 1, the booster pump 3 is provided with a power line 14 and a booster pipe 15, the booster pipe 15 is connected with the top of the concentrating cylinder 2, the booster pump 3 and the booster pipe 15 can input air flow into the concentrating cylinder 2, the pressure in the concentrating cylinder 2 is improved, and the water and the impurities mixed in the antibody are discharged into the box body 1 through an ultrafiltration membrane 11 on the side, the concentrated antibody is discharged from the discharging pipe 10 through the impurity discharging pipe 7, the concentrated antibody and impurities are conveniently classified and processed, waste of raw materials is reduced, the motor 4 is arranged at the top of the concentration barrel 2, the power line 14 is arranged on the motor 4, the transmission shaft 5 is vertically arranged in the concentration barrel 2, the top end of the transmission shaft 5 is connected with the motor 4, the stirring plate 16 is arranged on the transmission shaft 5, the motor 4 drives the transmission shaft 5 and the stirring plate 16 on the transmission shaft 5 to rotate, the antibody is continuously stirred in the antibody concentration process, the antibody is fully separated from water, concentration efficiency and concentration quality of the antibody are improved, the concentrated antibody is rapidly discharged from the discharging pipe 10, and the antibody discharging efficiency is improved.
Preferably, a sealing ring 13 is arranged between the bottom of the box body 1 and the discharge pipe 10, a valve 12 is arranged on the discharge pipe 10, the sealing performance between the bottom of the box body 1 and the discharge pipe 10 is improved through the sealing ring 13, impurities discharged into the box body 1 are prevented from flowing out from the position between the bottom of the box body 1 and the discharge pipe 10, and the purity of the concentrated antibody is improved.
Preferably, the concentration cylinder 2 is of a conical structure, the ultrafiltration membrane 11 is arranged on the side wall of the concentration cylinder 2, the ultrafiltration membrane 11 is of a polypropylene (PP) or Polyethylene (PE) material, the concentration cylinder 2 is of a conical structure, and the antibody in the concentration process flows upwards along the inner wall of the concentration cylinder 2, so that the impurities in the antibody concentration process can be discharged into the box body 1 through the filtration membrane and discharged through the impurity discharge pipe 7, the concentrated antibody is discharged from the discharge pipe 10, the concentrated antibody and the impurities are conveniently classified and treated, the waste of raw materials is reduced, the concentration efficiency of the antibody is improved, and the waste of the antibody is reduced.
Preferably, the top of the concentration cylinder 2 is provided with a pressure gauge 9, the pressure condition in the concentration cylinder 2 can be reflected in real time through the pressure gauge 9, the worker can conveniently control the rhythm of antibody concentration, the working efficiency is improved, and the labor intensity of the operator is reduced.
Preferably, the stirring plate 16 is arranged in a spiral structure with a large upper end and a small lower end, the motor 4 drives the transmission shaft 5 and the stirring plate 16 on the transmission shaft 5 to rotate, the antibody is continuously stirred in the antibody concentration process, the antibody is fully separated from water, the concentration efficiency and the concentration quality of the antibody are further improved, the concentrated antibody is rapidly discharged from the discharge pipe 10, the antibody discharge efficiency is improved, the stirring plate 16 is arranged in a spiral structure with a large upper end and a small lower end, the stirring plate 16 can fully stir the antibody in the concentration barrel 2, the antibody is conveniently fully separated from water, and the concentration efficiency and the concentration quality of the antibody are improved.
Example two
As shown in the attached figure 4, the concentration equipment for antibody production comprises a box body 1, a concentration cylinder 2, a booster pump 3, a motor 4 and a transmission shaft 5, and is characterized in that: the box body 1 is arranged on a bracket 6, the bottom of the box body 1 is provided with a trash discharging pipe 7, impurities and water generated by antibody concentration can be discharged from the box body 1 through the trash discharging pipe 7, the purity of the concentrated antibody is improved, the concentrating cylinder 2 is embedded into the box body 1, the top of the concentrating cylinder 2 is arranged outside the box body 1, the top of the concentrating cylinder 2 is provided with a feeding pipe 8, the bottom of the concentrating cylinder 2 is provided with a discharging pipe 10, the discharging pipe 10 penetrates out of the bottom of the box body 1, the booster pump 3 is arranged on the outer wall of the box body 1, the booster pump 3 is provided with a power line 14 and a booster pipe 15, the booster pipe 15 is connected with the top of the concentrating cylinder 2, the booster pump 3 and the booster pipe 15 can input air flow into the concentrating cylinder 2, the pressure in the concentrating cylinder 2 is improved, and the water and the impurities mixed in the antibody are discharged into the box body 1 through an ultrafiltration membrane 11 on the side, the concentrated antibody is discharged from the discharging pipe 10 through the impurity discharging pipe 7, the concentrated antibody and impurities are conveniently classified and processed, waste of raw materials is reduced, the motor 4 is arranged at the top of the concentration barrel 2, the power line 14 is arranged on the motor 4, the transmission shaft 5 is vertically arranged in the concentration barrel 2, the top end of the transmission shaft 5 is connected with the motor 4, the stirring plate 16 is arranged on the transmission shaft 5, the motor 4 drives the transmission shaft 5 and the stirring plate 16 on the transmission shaft 5 to rotate, the antibody is continuously stirred in the antibody concentration process, the antibody is fully separated from water, concentration efficiency and concentration quality of the antibody are improved, the concentrated antibody is rapidly discharged from the discharging pipe 10, and the antibody discharging efficiency is improved.
Preferably, a sealing ring 13 is arranged between the bottom of the box body 1 and the discharge pipe 10, a valve 12 is arranged on the discharge pipe 10, the sealing performance between the bottom of the box body 1 and the discharge pipe 10 is improved through the sealing ring 13, impurities discharged into the box body 1 are prevented from flowing out from the position between the bottom of the box body 1 and the discharge pipe 10, and the purity of the concentrated antibody is improved.
Preferably, the concentration cylinder 2 is of a conical structure, the ultrafiltration membrane 11 is arranged on the side wall of the concentration cylinder 2, the ultrafiltration membrane 11 is of a polypropylene (PP) or Polyethylene (PE) material, the concentration cylinder 2 is of a conical structure, and the antibody in the concentration process flows upwards along the inner wall of the concentration cylinder 2, so that the impurities in the antibody concentration process can be discharged into the box body 1 through the filtration membrane and discharged through the impurity discharge pipe 7, the concentrated antibody is discharged from the discharge pipe 10, the concentrated antibody and the impurities are conveniently classified and treated, the waste of raw materials is reduced, the concentration efficiency of the antibody is improved, and the waste of the antibody is reduced.
Preferably, the top of the concentration cylinder 2 is provided with a pressure gauge 9, the pressure condition in the concentration cylinder 2 can be reflected in real time through the pressure gauge 9, the worker can conveniently control the rhythm of antibody concentration, the working efficiency is improved, and the labor intensity of the operator is reduced.
Preferably, the stirring plate 16 is arranged in a spiral structure with a large upper end and a small lower end, the motor 4 drives the transmission shaft 5 and the stirring plate 16 on the transmission shaft 5 to rotate, the antibody is continuously stirred in the antibody concentration process, the antibody is fully separated from water, the concentration efficiency and the concentration quality of the antibody are further improved, the concentrated antibody is rapidly discharged from the discharge pipe 10, the antibody discharge efficiency is improved, the stirring plate 16 is arranged in a spiral structure with a large upper end and a small lower end, the stirring plate 16 can fully stir the antibody in the concentration barrel 2, the antibody is conveniently fully separated from water, and the concentration efficiency and the concentration quality of the antibody are improved.
Preferably, the guide plate 17 is arranged on the outer wall of the discharge pipe 10 at the bottom in the box body 1, the guide plate 17 is arranged to be of an arc-shaped structure, impurities discharged through the ultrafiltration membrane 11 can be guided to the position near the impurity discharge pipe 7 of the box body 1 through the guide plate 17, and the impurities are rapidly discharged through the impurity discharge pipe 7, so that the impurities are prevented from being remained in the box body 1, and the impurities can be recycled conveniently.
The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
In the description of the present invention, it is to be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present invention and for simplicity in description, and are not intended to indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention.
The utility model discloses the part that does not relate to all is the same with prior art or can adopt prior art to realize.
Claims (5)
1. The utility model provides an antibody production is with concentrator, includes box, concentrated section of thick bamboo, booster pump, motor, transmission shaft, its characterized in that: the box setting on the support to be provided with the row's of miscellaneous pipe at the bottom half, concentrated section of thick bamboo embedding box in, set up the concentrated section of thick bamboo top outside the box, be provided with the inlet pipe at concentrated bobbin top, be provided with the discharging pipe at concentrated bobbin bottom to wear out the discharging pipe from the bottom half, the booster pump setting on the box outer wall, be provided with power cord, booster pipe on the booster pump to be connected booster pipe and concentrated bobbin top, the motor setting at concentrated bobbin top, be provided with the power cord on the motor, the vertical setting of transmission shaft in concentrated section of thick bamboo, be connected transmission shaft top and motor to be provided with on the transmission shaft and stir the board.
2. The antibody-producing concentration device according to claim 1, wherein: and a sealing ring is arranged between the bottom of the box body and the discharge pipe, and a valve is arranged on the discharge pipe.
3. The antibody-producing concentration device according to claim 1, wherein: the concentrating cylinder is of a conical structure, the ultrafiltration membrane is arranged on the side wall of the concentrating cylinder, and the ultrafiltration membrane is made of polypropylene (PP) or Polyethylene (PE).
4. The antibody-producing concentration device according to claim 1, wherein: the top of the concentration cylinder is provided with a pressure gauge.
5. The antibody-producing concentration device according to claim 1, wherein: the stirring plate is arranged in a spiral structure with a large upper end and a small lower end.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920598647.7U CN209968133U (en) | 2019-04-28 | 2019-04-28 | Concentration equipment is used in antibody production |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920598647.7U CN209968133U (en) | 2019-04-28 | 2019-04-28 | Concentration equipment is used in antibody production |
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| CN209968133U true CN209968133U (en) | 2020-01-21 |
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| CN201920598647.7U Active CN209968133U (en) | 2019-04-28 | 2019-04-28 | Concentration equipment is used in antibody production |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110981954A (en) * | 2020-01-23 | 2020-04-10 | 中科宝承生物医学科技有限公司 | Antibody purification equipment and operation method thereof |
| CN111116739A (en) * | 2020-01-23 | 2020-05-08 | 中科宝承生物医学科技有限公司 | Antibody concentration equipment and operation method thereof |
-
2019
- 2019-04-28 CN CN201920598647.7U patent/CN209968133U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110981954A (en) * | 2020-01-23 | 2020-04-10 | 中科宝承生物医学科技有限公司 | Antibody purification equipment and operation method thereof |
| CN111116739A (en) * | 2020-01-23 | 2020-05-08 | 中科宝承生物医学科技有限公司 | Antibody concentration equipment and operation method thereof |
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Address after: No.280-1, Tongyang Road, Nanchang District, Wuxi City, Jiangsu Province, 214000 Patentee after: Wuxi shengherui Biotechnology Co.,Ltd. Address before: Room 1008, Wuxing building, 280-1 Tongyang Road, Wuxi, Jiangsu, 214021 Patentee before: Wuxi Meirui Biotechnology Co.,Ltd. |