CN209952857U - High-position mixing and dropwise adding synthesis device for drug intermediate reaction tank - Google Patents

Abstract

The utility model discloses a high-position mixing and dripping synthesizer of a drug intermediate reaction tank, which comprises a dripping tank and a synthesizing tank, wherein the top of the dripping tank is connected with a feed pipe of a preparation dripping kettle, the middle part of the dripping tank is connected with a motor of the preparation dripping kettle, and the upper part of the dripping tank is provided with a thermometer of the preparation dripping kettle; a preparation dropwise adding kettle jacket is arranged on the outer side of the dropwise adding tank, a preparation dropwise adding kettle discharge pipe is connected to the bottom of the dropwise adding tank, a dropwise adding control valve is installed on the preparation dropwise adding kettle discharge pipe, and a preparation dropwise adding kettle jacket water inlet and a preparation dropwise adding kettle jacket water outlet are installed on the preparation dropwise adding kettle jacket; synthetic reation kettle inlet pipe is installed at synthetic tank deck portion, and synthetic reation kettle inlet pipe links to each other with preparing dropwise add cauldron discharging pipe, and synthetic reation kettle thermometer is installed at synthetic tank deck portion, and synthetic jar mid-portion is connected with synthetic reation kettle motor, and synthetic reation kettle manometer is installed on synthetic jar upper portion. The synthesis device has wide application and convenient and efficient use.

Description

High-position mixing and dropwise adding synthesis device for drug intermediate reaction tank

Technical Field

The utility model belongs to medicine midbody production facility field, concretely relates to medicine midbody retort high-order mixes dropwise add synthesizer.

Background

The medical intermediate is actually some chemical raw materials or chemical products used in the process of synthesizing the medicine. The chemical product can be produced in a common chemical plant without the production license of the medicine, and can be used for synthesizing the medicine as long as the chemical product reaches a certain grade. The production of medicines needs a large amount of special chemicals, most of the chemicals are originally produced by the pharmaceutical industry, but with the deepening of division of labor and the progress of production technology in the society, the pharmaceutical industry transfers some pharmaceutical intermediates to the production of chemical enterprises. The medical intermediate belongs to fine chemical products, and the production of the medical intermediate becomes a large industry of the international chemical industry.

The drug intermediate often needs to be subjected to dropwise addition reaction during reaction, and is generally carried out in a high-position dropwise addition tank mode, but a simple high-position dropwise addition tank is not suitable for low-temperature dropwise addition stirring reaction or high-temperature dissolution dropwise addition reaction which needs temperature control. If a reaction requires mixing of other materials at low temperature and addition, or requires high temperature dissolution and addition, the conventional overhead tank for this reaction is not suitable.

SUMMERY OF THE UTILITY MODEL

The utility model provides a medicine midbody retort high-order dropwise add synthesizer that mixes, the use of this equipment can make dropwise add reaction convenient and fast more, and a system realizes two kinds of reactions.

In order to achieve the above object, the utility model provides a following technical scheme: a high-position mixing and dropwise adding synthesis device for a drug intermediate reaction tank comprises a dropwise adding tank and a synthesis tank, wherein the top of the dropwise adding tank is connected with a feeding pipe of a preparation dropwise adding kettle, the middle of the dropwise adding tank is connected with a motor of the preparation dropwise adding kettle, and the upper part of the dropwise adding tank is provided with a thermometer of the preparation dropwise adding kettle; a preparation dropwise adding kettle jacket is arranged on the outer side of the dropwise adding tank, a preparation dropwise adding kettle discharge pipe is connected to the bottom of the dropwise adding tank, a dropwise adding control valve is installed on the preparation dropwise adding kettle discharge pipe, and a preparation dropwise adding kettle jacket water inlet and a preparation dropwise adding kettle jacket water outlet are installed on the preparation dropwise adding kettle jacket; synthetic reation kettle inlet pipe is installed at synthetic tank top, and synthetic reation kettle inlet pipe links to each other with preparing the dropwise add cauldron discharging pipe, and synthetic reation kettle thermometer is installed at synthetic tank top, and synthetic jar mid-connection has the synthetic reation kettle motor, and synthetic reation kettle pressure table is installed on synthetic jar upper portion, and the synthetic jar outside is provided with synthetic reation kettle and presss from both sides the cover, and synthetic reation kettle presss from both sides the cover water inlet and synthetic reation kettle presss from both sides the cover delivery port of installing synthetic reation kettle on pressing from both sides the cover, and synthetic reation kettle bottom valve is installed to synthetic tank bottom.

Preferably, a preparation dropwise adding kettle heat-insulating layer is further arranged on the outer side of the preparation dropwise adding kettle jacket on the outer side of the dropwise adding tank.

Preferably, a synthetic reaction kettle heat-insulating layer is further installed on the outer side of the synthetic reaction kettle jacket on the outer side of the synthetic tank.

Compared with the prior art, the beneficial effects of the utility model are that: be equipped with the dropwise add cauldron with reation kettle and carry out high-order use, the dropwise add material can be through pressing from both sides the cover cooling dropwise add, also can heat up through pressing from both sides the cover and dissolve the dropwise add, and is easy and simple to handle, and two kinds of functions of one set of device have just guaranteed going on smoothly of reaction.

Other features of the present disclosure and advantages thereof will become apparent from the following detailed description of exemplary embodiments thereof, which proceeds with reference to the accompanying drawings.

Drawings

In order to more clearly illustrate the embodiments of the present disclosure or technical solutions in related arts, the drawings used in the description of the embodiments or related arts will be briefly introduced below, it is obvious that the drawings in the following description are only embodiments of the present disclosure, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

FIG. 1 is an overall view of the synthesizer of the present invention;

in the figure: 1. a dropping tank, 2, a synthesis tank, 11, a dropping kettle feeding pipe is prepared, 12, a dropping kettle motor is prepared, 13, a dropping kettle thermometer is prepared, 14, a dropping kettle jacket is prepared, 15, a dropping control valve, 16, a dropping kettle jacket water inlet is prepared, 17, a dropping kettle jacket water outlet is prepared, 18, a dropping kettle discharging pipe is prepared, 19, a dropping kettle heat preservation layer is prepared, 21, a synthesis reaction kettle feeding pipe, 22, a synthesis reaction kettle thermometer, 23, a synthesis reaction kettle motor, 24, a synthesis reaction kettle pressure gauge, 25, a synthesis reaction kettle jacket, 26, a synthesis reaction kettle jacket water inlet, 27, a synthesis reaction kettle jacket water outlet, 28, a synthesis reaction kettle bottom valve, 29, a synthesis reaction kettle heat preservation layer.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

Unless specifically stated otherwise, the relative arrangement of the components and steps, the numerical expressions, and numerical values set forth in these embodiments do not limit the scope of the present invention. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

Referring to fig. 1, the present invention provides a technical solution: a high-order mixing and dropwise adding synthesis device of a drug intermediate reaction tank comprises a dropwise adding tank 1 and a synthesis tank 2, wherein the top of the dropwise adding tank 1 is connected with a preparation dropwise adding kettle feeding pipe 11, the middle part of the dropwise adding tank is connected with a preparation dropwise adding kettle motor 12, and the upper part of the dropwise adding tank is provided with a preparation dropwise adding kettle thermometer 13; a preparation dropwise adding kettle jacket 14 is arranged on the outer side of the dropwise adding tank, a preparation dropwise adding kettle discharge pipe 18 is connected to the bottom of the dropwise adding tank, a dropwise adding control valve 15 is installed on the preparation dropwise adding kettle discharge pipe, and a preparation dropwise adding kettle jacket water inlet 16 and a preparation dropwise adding kettle jacket water outlet 17 are installed on the preparation dropwise adding kettle jacket; synthetic reation kettle inlet pipe 21 is installed at 2 tops of synthetic jar, synthetic reation kettle inlet pipe links to each other with preparing dropwise add cauldron discharging pipe 18, synthetic reation kettle thermometer 22 is installed at synthetic tank top, synthetic jar mid-portion is connected with synthetic reation kettle motor 23, synthetic reation kettle pressure table 24 is installed on synthetic jar upper portion, the synthetic jar outside is provided with synthetic reation kettle and presss from both sides the cover 25, synthetic reation kettle presss from both sides to overlap and is installed synthetic reation kettle on the cover and presss from both sides cover water inlet 26 and synthetic reation kettle and presss from both sides cover delivery port 27, synthetic reation kettle bottom valve 28 is installed to the synthetic jar bottom. A preparation dropwise adding kettle heat-insulating layer 19 is also arranged on the outer side of the preparation dropwise adding kettle jacket 14 on the outer side of the dropwise adding tank 1. And a synthesis reaction kettle heat-insulating layer 29 is also arranged on the outer side of the synthesis reaction kettle jacket 25 on the outer side of the synthesis tank 2.

The material is fed into the dripping tank 1 through the feeding pipe 11 of the preparation dripping kettle, the material is cooled or dissolved at high temperature under the action of the jacket 14 of the preparation dripping kettle, the dripping control valve 15 is opened after the reaction temperature condition is reached, the material is controlled to reach the material adding speed, the material is fed into the synthesis tank 2 through flow rate control, wherein the reaction condition of the synthesis tank can be subjected to temperature control through the jacket 25 of the synthesis reaction kettle, the temperature rise or the temperature decrease of the synthesis reaction kettle can be controlled, and after the dripping reaction is completed, the reaction product is discharged through the bottom valve 28 of the synthesis reaction kettle at the.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (3)

1. The utility model provides a medicine midbody retort high-order mixture dropwise add synthesizer, includes dropwise add jar (1) and synthesis jar (2), its characterized in that: the top of the dripping tank (1) is connected with a preparation dripping kettle feeding pipe (11), the middle of the dripping tank is connected with a preparation dripping kettle motor (12), and the upper part of the dripping tank is provided with a preparation dripping kettle thermometer (13); a preparation dropwise adding kettle jacket (14) is arranged on the outer side of the dropwise adding tank, a preparation dropwise adding kettle discharge pipe (18) is connected to the bottom of the dropwise adding tank, a dropwise adding control valve (15) is installed on the preparation dropwise adding kettle discharge pipe, and a preparation dropwise adding kettle jacket water inlet (16) and a preparation dropwise adding kettle jacket water outlet (17) are installed on the preparation dropwise adding kettle jacket; synthetic reation kettle inlet pipe (21) is installed at synthetic jar (2) top, synthetic reation kettle inlet pipe links to each other with preparing dropwise add cauldron discharging pipe (18), synthetic reation kettle thermometer (22) are installed at synthetic tank top, synthetic jar mid-portion is connected with synthetic reation kettle motor (23), synthetic reation kettle pressure table (24) are installed on synthetic jar upper portion, the synthetic jar outside is provided with synthetic reation kettle and presss from both sides cover (25), synthetic reation kettle presss from both sides the cover and installs synthetic reation kettle on pressing from both sides the cover and presss from both sides cover water inlet (26) and synthetic reation kettle and press from both sides cover delivery port (27), synthetic reation kettle bottom valve (28) are installed to synthetic tank bottom.

2. The high-position mixing and dropwise adding synthesis device for the drug intermediate reaction tank as claimed in claim 1, wherein: and a preparation dropwise adding kettle heat-insulating layer (19) is also arranged on the outer side of the preparation dropwise adding kettle jacket (14) on the outer side of the dropwise adding tank (1).

3. The high-position mixing and dropwise adding synthesis device for the drug intermediate reaction tank as claimed in claim 1, wherein: and a synthetic reaction kettle heat-insulating layer (29) is also arranged on the outer side of the synthetic reaction kettle jacket (25) on the outer side of the synthetic tank (2).

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