CN209927866U

CN209927866U - Interleukin-6 detection kit

Info

Publication number: CN209927866U
Application number: CN201920435305.3U
Authority: CN
Inventors: 王晓波; 朱雪姣; 朱海峰
Original assignee: Wuhu Sen Sen Chi Biological Technology Co Ltd
Current assignee: Wuhu Sen Sen Chi Biological Technology Co Ltd
Priority date: 2019-04-01
Filing date: 2019-04-01
Publication date: 2020-01-10
Anticipated expiration: 2029-04-01

Abstract

The utility model belongs to the technical field of detection kits, in particular to an interleukin-6 detection kit, which comprises a needle cylinder, a detachable gun head arranged at the head part of the needle cylinder and a core cylinder arranged in the needle cylinder, wherein a sleeve is arranged between the core cylinder and the needle cylinder; the outer wall of the sleeve is attached to the inner wall of the needle cylinder, a gap is formed between the inner wall of the sleeve and the outer wall of the core cylinder, two elastic push-pull sheets which are arranged at intervals from left to right are arranged at the lower end of the core cylinder, a semi-circular sheet is arranged at the lower end of each elastic push-pull sheet, and the semi-circular sheets at the lower ends of the two elastic push-pull sheets are adjacently arranged from left to right; the utility model provides an accurate control of detect reagent box has inhaled the volume of the liquid that awaits measuring in the rifle head to have better adaptability, can be applicable to the demand of different detection demands to the liquid volume that awaits measuring.

Description

Interleukin-6 detection kit

Technical Field

The utility model belongs to the technical field of detect reagent box, concretely relates to interleukin-6 detect reagent box.

Background

Interleukin-6 (IL-6) is a core member of cytokines, was discovered in 1980 and was uniformly named as IL-6 in 1986, has a relative molecular weight of Mr26000, is a multifunctional glycoprotein consisting of 212 amino acids and mainly synthesized by monocyte-macrophages, T lymphocytes and fibroblasts, and can promote the liver to synthesize acute-phase proteins, activate T lymphocytes and induce the terminal differentiation of B lymphocytes to become immunocompetent cells with the function of secreting immunoglobulin. IL-6 has many biological functions, in infection resistance, tumor, immune disease and immune regulation of many aspects play an important role. In abnormal cases, elevation of IL-6 may have adverse effects on the body, causing tissue damage and exacerbating disease. With the continuous and intensive medical research, IL-6 has become increasingly important in clinical diagnosis.

The current application of IL-6 in clinical diagnosis is mainly as follows: the inflammatory response, IL-6, is an important proinflammatory cytokine, and abnormal release can cause the metabolic disorders and functional impairment of multiple organ cells of the body. 2. In tumor immunity, dysregulation of IL-6 may lead to tumorigenesis. In recent years, the research finds that the concentration of IL-6 in Bile Duct Cancer (BDC) patients, hepatocellular carcinoma patients, gastric cancer patients, colon cancer patients, breast cancer patients and ovarian cancer patients is higher than that in normal human bodies, and the experiments show that the conventional tumor diagnosis and combined measurement of the IL-6 level have important significance in the diagnosis and prognosis of tumors. 3. In addition, some studies also show that IL-6 is also related to the occurrence and development of diseases such as cerebral infarction, type 2 diabetes, chronic renal failure and the like.

At present, when the IL-6 is clinically detected, the detection kit needs to be immersed in a sample to be detected, the suction amount of the detection kit to the sample to be detected cannot be accurately controlled, the detection accuracy cannot be determined, the operation process is complicated, errors caused by artificial factors of experimental results are increased, the detection accuracy is limited, and further application of the method is limited.

SUMMERY OF THE UTILITY MODEL

The utility model aims to overcome the defects in the prior art, provide an interleukin-6 detection kit with simple use, and improve the detection accuracy of interleukin-6.

In order to achieve the above purpose, the utility model adopts the following technical scheme to realize:

an interleukin-6 detection kit comprises a needle cylinder, a detachable gun head arranged at the head of the needle cylinder and a core cylinder arranged in the needle cylinder, wherein a sleeve is arranged between the core cylinder and the needle cylinder;

the outer wall of the sleeve is attached to the inner wall of the needle cylinder, a gap is formed between the inner wall of the sleeve and the outer wall of the core cylinder, two elastic push-pull sheets which are arranged at intervals from left to right are arranged at the lower end of the core cylinder, a semi-circular sheet is arranged at the lower end of each elastic push-pull sheet, and the semi-circular sheets at the lower ends of the two elastic push-pull sheets are adjacently arranged from left to right;

a spring is sleeved in the middle of the core barrel, the lower end of the spring is in abutting fit with a first annular convex part which protrudes inwards on the inner wall of the sleeve, and the elasticity of the spring provides a tendency for the core barrel to move upwards;

the test paper is placed in the core barrel, and when the core barrel is pushed down, the test paper falls into the gun head from between the two semi-circular sheets, and when the sleeve is pulled up, the gun head sucks liquid to be tested to contact with the test paper.

Under the optimal condition, a second annular convex part is arranged on the outer cylinder wall of the core cylinder, is positioned above the first annular convex part and is abutted and matched with the upper end of the spring.

Preferably, a first annular push handle is arranged above the core barrel.

Preferably, a second annular push handle is arranged above the sleeve.

Under the optimal condition, a connecting pipe is arranged at the bottom of the needle cylinder, the upper end part of the connecting pipe is detachably connected with the needle cylinder, and the lower end part of the connecting pipe is detachably connected with the gun head.

Under the preferred condition, be equipped with the stopper on the upper end inner wall of connecting pipe, the whole type of test paper be T, and in the test paper fell into the rifle head, the upper end of test paper leaned on with this stopper and cooperatees.

Under the preferred condition, be equipped with on the lateral wall of connecting pipe and move back the first sleeve pipe, the up end of cylinder still is equipped with one and moves back the first pole, the lower tip that moves back the first pole with move back a head pipe fixed connection.

Preferably, the lance head and/or the connecting tube are transparent tubular.

Compared with the prior art, the utility model discloses following technological effect has:

the utility model provides a detection kit, with test paper place in advance in the core section of thick bamboo, when the core section of thick bamboo pushes down, push two halves disc through two lamella elasticity push-and-pull pieces, because the existence and the cooperation of this sleeve, two halves disc upwards deflect and make the clearance produce between the two and enlarge the clearance gradually, thereby make the test paper in the core section of thick bamboo fall into the rifle head, when removing the lower thrust of core section of thick bamboo, the spring provides the restoring force, make two halves disc resume left and right sides adjacent original state; the automatic placement of the test paper in the reagent box is realized;

the volume of the liquid to be detected sucked into the gun head is a certain value through the drawing action of the piston rod, so that the suction quantity of the liquid to be detected is effectively controlled, the defect that the liquid to be detected is excessively submerged due to excessive suction quantity or cannot be detected due to too little suction quantity is avoided, and the accurate detection of the liquid to be detected is ensured;

after detection is finished, the head withdrawing sleeve is driven to move downwards by pressing the head withdrawing rod, so that the gun heads fall off from the connecting pipe, the gun heads are detached and discarded, another gun head is assembled on the needle cylinder, and another liquid to be detected is sucked, so that detection can be carried out; moreover, the detection method is simple and convenient, and the detection accuracy is improved.

The utility model provides an accurate control of detect reagent box has inhaled the volume of the liquid that awaits measuring in the rifle head to have better adaptability, can be applicable to the demand of different detection demands to the liquid volume that awaits measuring.

Drawings

FIG. 1 is a schematic view of an interleukin-6 detection kit according to an embodiment of the present invention;

FIG. 2 is a partially enlarged schematic view of an interleukin-6 detection kit according to an embodiment of the present invention.

Description of the reference numerals

1 test paper 10 syringe

20 rifle head 21 stopper

30 core cylinder 40 sleeve

31 elastic push-pull piece 32 semi-circle piece

33 second annular projection 34 first annular push handle

41 first annular projection 42 second annular push handle

50 spring 60 connecting pipe

7 retreat head sleeve pipe 8 retreat head pole

Detailed Description

The following detailed description of the embodiments of the present invention will be made with reference to the accompanying drawings. It is to be understood that the description of the embodiments herein is for purposes of illustration and explanation only and is not intended to limit the invention.

FIG. 1 is a schematic view of an interleukin-6 detection kit according to an embodiment of the present invention; FIG. 2 is a partially enlarged schematic view of an interleukin-6 detection kit according to an embodiment of the present invention. As shown in fig. 1 and 2, an interleukin-6 detection kit comprises a syringe 10, a gun head 20 detachably disposed at the head of the syringe 10, and a core barrel 30 disposed in the syringe 10, wherein a sleeve 40 is disposed between the core barrel 30 and the syringe 10;

the outer wall of the sleeve 40 is attached to the inner wall of the needle cylinder 10, a gap is formed between the inner wall of the sleeve 40 and the outer wall of the core cylinder 30, the lower end of the core cylinder 30 is provided with two elastic push-pull sheets 31 which are arranged at intervals from left to right, the lower end of each elastic push-pull sheet 31 is provided with a semi-circular sheet 32, and the semi-circular sheets 32 at the lower ends of the two elastic push-pull sheets 31 are arranged adjacently from left to right;

a spring 50 is sleeved in the middle of the core barrel 30, the lower end of the spring 50 is in abutting fit with a first annular convex part 41 which protrudes inwards from the inner wall of the sleeve 40, and the elasticity of the spring 50 provides a tendency that the core barrel 30 moves upwards;

the test paper 1 is placed in the core cylinder 30, when the core cylinder 30 is pushed down, the test paper 1 falls into the gun head 20 from between the two semi-circular sheets 32, and when the sleeve 40 is pulled up, the gun head 20 sucks liquid to be tested to contact with the test paper 1.

The utility model provides an interleukin-6 detect reagent box's working process does:

the test paper 1 for detection is put into the core barrel 30, when the core barrel 30 is pushed downwards, the two half discs 32 are pushed by the two elastic push-pull sheets 31, due to the existence and the matching of the sleeve 40, the two half discs 32 deflect upwards to generate a gap between the two and gradually enlarge the gap, so that the test paper 1 in the core barrel 30 falls into the gun head 20, and when the pushing force of the core barrel 30 is removed, the spring 50 provides restoring force to restore the two half discs 32 to the original shapes which are adjacent left and right (at the moment, the two half discs 32 are tightly connected together);

when the sleeve 40 is pulled upwards, the two half round sheets 32 are always kept in a left-right adjacent closed state under the action of the elastic push-pull sheet 31, so that a sufficient negative pressure condition is ensured to be formed between the bottom end of the sleeve 40 and the head of the needle cylinder 10, and the liquid to be detected is sucked into the gun head 20 by the gun head 20 to be contacted with the detection test paper 1, so that the detection is completed.

In the utility model, the two half wafers 32 are made of rubber to ensure the air tightness of the needle cylinder.

Preferably, a second annular protrusion 33 is disposed on the outer wall of the core barrel 30, and the second annular protrusion 33 is located above the first annular protrusion 41 and is in abutting engagement with the upper end of the spring 50.

Preferably, a first annular push handle 34 is arranged above the core barrel 30, and the first annular push handle 34 is pushed to move downwards, so that the spring 50 can be driven to compress downwards, and the core barrel 30 is driven to push downwards; in a preferred embodiment of the present invention, the first annular pushing handle 34 is detachably mounted above the core barrel 30, so as to facilitate the taking and placing of the test strip 1.

Preferably, a second annular pushing handle 42 is arranged above the sleeve 40, and the second annular pushing handle 42 is driven to move upwards, so that the whole sleeve 40 and the core barrel 30 in the sleeve move upwards together, negative pressure is formed in the tube cavity, and liquid to be measured is sucked.

Under the preferable conditions, a connecting pipe 60 is arranged at the bottom of the needle cylinder 10, the upper end of the connecting pipe 60 is detachably connected with the needle cylinder 10, and the lower end of the connecting pipe 60 is detachably connected with the gun head 20.

Under the preferable condition, the inner wall of the upper end of the connecting pipe 60 is provided with a limiting block 21, the whole detection test paper 1 is T-shaped, the detection test paper 1 falls into the gun head, the upper end of the detection test paper 1 is matched with the limiting block 21 in an overlapping manner, and the limiting block can be an annular bulge or a block-shaped bulge arranged at intervals on the inner wall of the connecting pipe 60.

Under the preferable condition, the outer side wall of the connecting pipe is provided with a head withdrawing sleeve 7, the upper end surface of the needle cylinder 10 is also provided with a head withdrawing rod 8, and the lower end part of the head withdrawing rod 8 is fixedly connected with the head withdrawing sleeve 7. The head withdrawing sleeve 7 is used for separating the gun head 20 from the needle cylinder 10; after detection is finished, the head withdrawing rod 8 is pressed to drive the head withdrawing sleeve 7 to move downwards, so that the gun head 20 falls off from the connecting pipe 60 or the needle cylinder 10, the gun head is detached and discarded, another gun head is assembled on the needle cylinder, and then another liquid to be detected is sucked, so that detection can be carried out; moreover, the detection method is simple and convenient, and the detection accuracy is improved.

Preferably, in order to facilitate observation of the detection result of the test strip, the lance tip 20 and/or the connecting tube 60 are transparent tubes.

The preferred embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited thereto. The technical idea of the utility model within the scope, can be right the utility model discloses a technical scheme carries out multiple simple variant, makes up with any suitable mode including each concrete technical feature. In order to avoid unnecessary repetition, the present invention does not separately describe various possible combinations. These simple variations and combinations should also be considered as disclosed in the present invention, all falling within the scope of protection of the present invention.

Claims

1. The interleukin-6 detection kit is characterized by comprising a needle cylinder (10), a gun head (20) detachably arranged at the head of the needle cylinder (10), and a core cylinder (30) arranged in the needle cylinder (10), wherein a sleeve (40) is arranged between the core cylinder (30) and the needle cylinder (10);

the outer wall of the sleeve (40) is attached to the inner wall of the needle cylinder (10), a gap is reserved between the inner wall of the sleeve (40) and the outer wall of the core cylinder (30), two elastic push-pull sheets (31) which are arranged at intervals from left to right are arranged at the lower end of the core cylinder (30), a semi-circular sheet (32) is arranged at the lower end of each elastic push-pull sheet (31), and the semi-circular sheets (32) at the lower ends of the two elastic push-pull sheets (31) are adjacently arranged from left to right;

a spring (50) is sleeved in the middle of the core barrel (30), the lower end of the spring (50) is abutted and matched with a first annular convex part (41) which protrudes inwards from the inner wall of the sleeve (40), and the elasticity of the spring (50) provides a tendency that the core barrel (30) moves upwards;

the test paper (1) is placed in the core barrel (30), when the core barrel (30) is pushed down, the test paper (1) falls into the gun head (20) from between the two half wafers (32), and when the sleeve (40) is pulled up, the gun head (20) sucks liquid to be tested to be in contact with the test paper (1).

2. The interleukin-6 detection kit according to claim 1, wherein a second annular protrusion (33) is disposed on an outer wall of the cartridge (30), and the second annular protrusion (33) is located above the first annular protrusion (41) and is in abutting engagement with an upper end of the spring (50).

3. The interleukin-6 detection kit according to claim 1, wherein a first annular push handle (34) is arranged above the core barrel (30).

4. The interleukin-6 detection kit according to claim 1, wherein a second annular push handle (42) is arranged above the sleeve (40).

5. The interleukin-6 detection kit according to claim 1 or 4, wherein a connecting tube (60) is arranged at the bottom of the needle cylinder (10), the upper end of the connecting tube (60) is detachably connected with the needle cylinder (10), and the lower end of the connecting tube (60) is detachably connected with the gun head (20).

6. The interleukin-6 detection kit according to claim 5, wherein a limit block (21) is arranged on the inner wall of the upper end of the connecting pipe (60), the whole detection test paper (1) is T-shaped, and when the detection test paper (1) falls into the gun head, the upper end of the detection test paper (1) is matched with the limit block (21).

7. The interleukin-6 detection kit according to claim 6, wherein a head-withdrawing sleeve (7) is arranged on the outer side wall of the connecting tube, a head-withdrawing rod (8) is further arranged on the upper end surface of the needle cylinder (10), and the lower end of the head-withdrawing rod (8) is fixedly connected with the head-withdrawing sleeve (7).

8. The interleukin-6 detection kit according to claim 7, wherein the lance tip (20) and/or the connecting tube (60) is/are transparent and tubular.