CN209894704U - SERS capillary - Google Patents
SERS capillary Download PDFInfo
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- CN209894704U CN209894704U CN201920318173.6U CN201920318173U CN209894704U CN 209894704 U CN209894704 U CN 209894704U CN 201920318173 U CN201920318173 U CN 201920318173U CN 209894704 U CN209894704 U CN 209894704U
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- capillary
- sers
- capillary tube
- tube body
- wall
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Abstract
The utility model provides a SERS capillary tube, which comprises a capillary tube body, wherein the capillary tube body is of a polygonal structure, the inner wall of the capillary tube body is provided with a light transmission surface, and a metal nano particle attachment layer is arranged on one side surface opposite to the light transmission surface; the utility model discloses SERS capillary exciting light arouses evenly, improves measuring result's repeatability, reduces the interference, improves the signal excitation and collects efficiency, easy location sample, easily experiment operation.
Description
[ technical field ] A method for producing a semiconductor device
The utility model particularly relates to a SERS capillary.
[ background of the invention ]
Surface Enhanced Raman Spectroscopy (SERS) is widely used in various research and analysis fields, with one of the most interesting applications of SERS being the detection of unlabeled biomolecules. SERS has been successfully used to detect various biomolecules (e.g., proteins, nucleic acids, and biological metabolites, etc.), as well as interactions between biomolecules; in addition, detection of various body fluids (such as plasma serum, urine and saliva) by the Raman or SERS spectroscopy technology is combined with an efficient statistical analysis method, and a new method is hopefully provided for early nondestructive diagnosis of diseases.
However, conventional SERS detection is performed in a substantially dry state, easily causes photothermal damage to substance molecules, and fails to obtain structural and functional information reflecting the state of physiological aqueous solutions of biomolecules (particularly proteins). The SERS detection substrate based on the capillary has the advantage of small sample requirement (a few microliters), and is particularly suitable for detection and analysis of trace samples.
The conventional SERS capillary is a conventional capillary with a circular structure, and the circular structure easily causes nonuniform focusing of excitation light during signal acquisition, so that the interference of background signals of a substrate is increased; in addition, when the nano particles with a certain thickness are deposited on the inner wall of the capillary, the effective penetration and excitation of exciting light are easily blocked, and further the SERS detection effect is reduced.
[ Utility model ] content
In order to overcome the defects of the prior device, the utility model provides a SERS capillary.
The utility model discloses a realize like this: the SERS capillary comprises a capillary body, wherein the capillary body is of a polygonal structure, the inner wall of the capillary body is provided with a light transmitting surface, and one side surface opposite to the light transmitting surface is provided with a metal nano particle attachment layer.
Preferably, the capillary body is rectangular in cross-section.
Preferably, the capillary body cross-section is a regular hexagon.
Preferably, the remaining sides of the inner wall of the capillary body are free of metal nanoparticle adhesion layers.
Preferably, the remaining side surface of the inner wall of the capillary body is also provided with a metal nanoparticle adhesion layer.
Preferably, the metal nanoparticle attachment layer is a silver nanoparticle attachment layer.
The utility model has the advantages that: SERS capillary exciting light arouses evenly, improves measuring result's repeatability, reduces the interference, improves signal excitation and collects efficiency, easy location sample, easily experimental operation.
[ description of the drawings ]
The invention will be further described with reference to the following examples with reference to the accompanying drawings.
Fig. 1 is a cross-sectional view of the SERS capillary of the present invention.
[ detailed description ] embodiments
Referring to fig. 1, a SERS capillary 100 includes a capillary body 1, the capillary body 1 is a polygonal structure, the inner wall of the capillary body 1 has a light-transmitting surface 3, and a metal nanoparticle adhesion layer 2 is disposed on a side surface opposite to the light-transmitting surface 3. The capillary body 1 is preferably rectangular or regular hexagonal in cross-section.
The other side surfaces of the inner wall of the capillary tube body 1 can be free of the metal nanoparticle adhesion layer 2, or the other side surfaces of the inner wall of the capillary tube body 1 can be provided with the metal nanoparticle adhesion layer 2; the metal nanoparticle adhesion layer 2 is a silver nanoparticle adhesion layer.
A method for preparing a SERS capillary 100, comprising the steps of:
(1) adding 1mL of isopropanol solution with the mass fraction of 70% into the metal nanoparticle conductive slurry, and carrying out ultrasonic treatment for 15min under the condition of a darkroom to obtain a metal nanoparticle ink mother solution; the metal nanoparticle conductive slurry is preferably a silver nanoparticle conductive slurry; the volume ratio of the metal nanoparticle conductive slurry to the isopropanol is 1: 1.
(2) diluting the metal nanoparticle ink mother liquor by using 70% isopropanol solution to obtain nanoparticle precursor ink; the volume ratio of the metal nanoparticle conductive slurry to the isopropanol is 1: 1-1: 32.
(3) soaking the polygonal capillary in the nanoparticle precursor ink, keeping the soaking for 5-30min, absorbing and removing the residual nanoparticle precursor ink in the polygonal capillary, quickly placing one side surface of the polygonal capillary on a preheated heating platform at 135 ℃, keeping the side surface in contact with the heating platform, and cooling to obtain the SERS capillary 100.
The utility model overcomes current circular structure SERS capillary 100 leads to the inhomogeneous shortcoming of exciting light focus easily when measuring, adopts polygonal structure's capillary can obtain smooth laser irradiation, obtains the signal acquisition of focus and homogeneous more effectively. One side surface of the inner wall of the capillary is modified with metal nanoparticles, the side surface opposite to the side surface is a light transmitting surface, and the other side surfaces can be modified with metal nanoparticles or without metal nanoparticles, so that the capillary has higher excitation efficiency, and the problem that the excitation light is blocked from effectively penetrating due to deposition and enrichment of the metal nanoparticles at all positions of the inner wall of the existing capillary is solved, and the SERS detection effect is reduced. The utility model discloses a SERS capillary 100 arouses evenly, improves measuring result's repetitive stability, reduces the interference, improves the signal and arouses and collect efficiency, fixes a position the sample easily, easily experiment operation.
Claims (6)
1. A SERS capillary, comprising: the capillary tube comprises a capillary tube body, wherein the capillary tube body is of a polygonal structure, the inner wall of the capillary tube body is provided with a light transmitting surface, and a metal nano particle attachment layer is arranged on one side surface opposite to the light transmitting surface.
2. The SERS capillary as recited in claim 1, wherein: the cross section of the capillary tube body is rectangular.
3. The SERS capillary as recited in claim 1, wherein: the cross section of the capillary tube body is in a regular hexagon shape.
4. A SERS capillary as claimed in claim 2 or 3, wherein: the other side surfaces of the inner wall of the capillary tube body are not provided with metal nano particle adhesion layers.
5. A SERS capillary as claimed in claim 2 or 3, wherein: the other side surfaces of the inner wall of the capillary tube body are also provided with a metal nano particle adhesion layer.
6. The SERS capillary as recited in claim 1, wherein: the metal nanoparticle adhesion layer is a silver nanoparticle adhesion layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920318173.6U CN209894704U (en) | 2019-03-13 | 2019-03-13 | SERS capillary |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920318173.6U CN209894704U (en) | 2019-03-13 | 2019-03-13 | SERS capillary |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209894704U true CN209894704U (en) | 2020-01-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920318173.6U Expired - Fee Related CN209894704U (en) | 2019-03-13 | 2019-03-13 | SERS capillary |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209894704U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109781708A (en) * | 2019-03-13 | 2019-05-21 | 福建师范大学 | A kind of preparation method and SERS capillary of capillary SERS substrate |
-
2019
- 2019-03-13 CN CN201920318173.6U patent/CN209894704U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109781708A (en) * | 2019-03-13 | 2019-05-21 | 福建师范大学 | A kind of preparation method and SERS capillary of capillary SERS substrate |
| CN109781708B (en) * | 2019-03-13 | 2024-05-14 | 福建师范大学 | Preparation method of capillary SERS substrate and SERS capillary |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200103 Termination date: 20210313 |