CN209827116U - Recyclable medicine support - Google Patents
Recyclable medicine support Download PDFInfo
- Publication number
- CN209827116U CN209827116U CN201920008833.0U CN201920008833U CN209827116U CN 209827116 U CN209827116 U CN 209827116U CN 201920008833 U CN201920008833 U CN 201920008833U CN 209827116 U CN209827116 U CN 209827116U
- Authority
- CN
- China
- Prior art keywords
- recyclable
- support
- medicine
- stent
- drug carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 239000003814 drug Substances 0.000 title claims abstract description 51
- 210000002808 connective tissue Anatomy 0.000 claims abstract description 10
- 239000011248 coating agent Substances 0.000 claims abstract description 3
- 238000000576 coating method Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 12
- 239000003937 drug carrier Substances 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims 4
- 239000012528 membrane Substances 0.000 description 48
- 229940079593 drug Drugs 0.000 description 24
- 238000011084 recovery Methods 0.000 description 15
- 229930012538 Paclitaxel Natural products 0.000 description 8
- 229960001592 paclitaxel Drugs 0.000 description 8
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 8
- 210000004204 blood vessel Anatomy 0.000 description 7
- 210000005077 saccule Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 208000037803 restenosis Diseases 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical class [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 229910001000 nickel titanium Inorganic materials 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 238000013146 percutaneous coronary intervention Methods 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000916 dilatatory effect Effects 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000007769 metal material Substances 0.000 description 2
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010057469 Vascular stenosis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 210000004026 tunica intima Anatomy 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Abstract
The utility model discloses a recoverable medicine support, including tubulose support main part, inner membrance, adventitia, the inner membrance sets up the inboard of support main part, the adventitia sets up the outside of support main part, the inner membrance is close to coating has the medicine on one side of adventitia, the millipore technical scheme has been seted up on the adventitia, the utility model discloses can be used to medicine support.
Description
Technical Field
The utility model relates to a recoverable medicine support.
Background
Percutaneous Coronary Intervention (PCI) refers to a treatment method for improving the perfusion of the blood flow of the cardiac muscle by opening the narrow or even occluded coronary artery lumen through the cardiac catheter technique. The common interventional instruments for dilating stenoses include naked saccule, medicinal saccule, naked stent, medicinal stent, etc. These are the most common clinical instruments at present, and have respective indication advantages and own defects. The naked saccule is one of the earliest instruments in the PCI operation, and opens the way of coronary intervention. But because the resilience of the blood vessel and the tearing of the intima of the blood vessel after expansion can lead to higher restenosis rate, a naked stent appears, the restenosis rate of pure naked balloon expansion is greatly reduced to a certain extent by the appearance of the naked stent, but the restenosis rate is still higher, and the stent is permanently left in a human body as a foreign body, and the later-stage risk is also higher. The appearance of the drug stent further improves the effect of stent treatment and further reduces the restenosis rate. However, the drug stent has its limitations, such as local chronic inflammatory reaction caused by the polymer of the drug carrier, long-term administration of antiplatelet drugs for treatment, risk of thrombus in the later stage of stent, and the like. And it is not advisable to implant a stent again if restenosis occurs after stent implantation.
Drug balloons and degradable drug scaffolds have then emerged. The medicine saccule is one improved saccule blood vessel dilating operation, and has medicine coated to the saccule and the saccule is conveyed to the pathological change part via the duct for dilation. However, DEB also has problems in practical use, and it is difficult for the drug balloon to ensure sufficient binding force between the drug and the balloon to ensure loss during delivery, and also to ensure that the balloon can release sufficient drug in a short time to be absorbed by the blood supply tube when the lesion site is expanded, thereby exerting therapeutic effect.
Although research on the degradable stent is always carried out at present, the degradable stent generally has the problems of insufficient supporting force, easiness in fracture, nonuniform degradation, severe inflammation caused by degradation products and the like, and still waits to be solved. If the drug balloon is combined with the recoverability of the drug balloon, the support of the drug stent and good drug release and absorption effects, unexpected effects can be obtained.
For example, a recyclable drug stent is designed in chinese patent CN106073942A, and the drug-loading and therapeutic effects are achieved by carving micropores or microgrooves on stent rods, or coating a layer of absorbable drug-coated film. However, the problem that the stent is directly washed by blood in the process of conveying the stent cannot be well solved by loading the drug on the micropores and the thin film of the stent, so that the drug loss in practical application is still a problem.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide a recoverable medicine support, it can effectively slow down the loss of medicine in the use of medicine support.
In order to solve the technical problem, the utility model discloses a technical scheme as follows: the recyclable medicine support comprises a tubular support main body, an inner membrane and an outer membrane, wherein the inner membrane is arranged on the inner side of the support main body, the outer membrane is arranged on the outer side of the support main body, a medicine is coated on one side, close to the outer membrane, of the inner membrane, and micropores are formed in the outer membrane.
Further, preferably, the stent main body comprises a plurality of support rods which are annularly distributed, and two adjacent support rods are connected through a plurality of silk threads.
More preferably, one end of each support rod is connected with the recovery hook through a connecting rod.
More preferably, the recovery hook comprises a connecting rod, one end of the connecting rod is bent to form a hook shape, and the other end of the connecting rod is connected with all the connecting rods.
More preferably, the outer membrane is made of a silica gel material, the thickness of the outer membrane is 0.01-0.2 mm, and the hardness of the outer membrane is 20 a-60 a.
More preferably, the support rod, the connection rod, the wire, and the recovery hook are integrally formed.
More preferably, the recovery hook comprises a hollow tube, and the hollow tube is provided with an inclined opening.
More preferably, the outer film is a TPU material, and the hardness is 20 a-60 a.
Preferably, the inner film is made of PE material and has a thickness of 0.01-0.5 mm.
Preferably, the diameter of the micropores is 10-500 um, and when the stent main body is propped open, the micropores are enlarged by 5-20 times.
The utility model has the advantages that: the utility model discloses a support subject is as the support piece of inner membrance and adventitia, bears the medicine through the inner membrance, combines support subject to cover the medicine on the inner membrance through the adventitia to avoided support subject in transportation process, the medicine directly exposes in blood and flick the medicine when support subject struts, thereby effectively reduced the loss of medicine.
Drawings
Fig. 1 is a schematic structural diagram of a recyclable drug carrier according to the present invention;
fig. 2 is a schematic structural diagram of a recyclable drug rack of the present invention.
Detailed Description
The present invention is further described with reference to the following drawings and specific embodiments so that those skilled in the art can better understand the present invention and can implement the present invention, but the embodiments are not to be construed as limiting the present invention.
The first embodiment is as follows:
the embodiment discloses a recyclable drug stent, which comprises a tubular stent main body 2, an inner membrane 5 and an outer membrane 3, wherein the stent main body 2 is used as a supporting component of a blood vessel and is also used as a supporting main body of the inner membrane 5 and the outer membrane 3, the stent main body 2 is woven by a metal material such as stainless steel, cobalt-chromium alloy, nickel-titanium memory alloy and the like, the inner membrane 5 is bonded or thermally sealed on the inner side of the stent main body 2, the inner membrane 5 is connected with the stent main body 2 through a thermal sealing method, the inner membrane 5 is made of a PE material, and is non-porous and 0.01-0.5 mm in thickness;
the outer membrane 3 is arranged on the outer side of the stent main body 2, the outer membrane 3 is made of an elastic material, such as silica gel, TPU, TPE and other recoverable materials, and has good ductility and elasticity, preferably made of a silica gel material, the thickness is 0.01-0.2 mm, the hardness is 20 a-60 a, the loss of the medicine 4 is reduced when the stent main body 2 is expanded through the outer membrane 3, the medicine 4 is coated on one side of the inner membrane 5 close to the outer membrane 3, the medicine 4 comprises paclitaxel or rapamycin derivatives, the hyperplasia of the vascular intima can be inhibited, and the vascular stenosis is effectively inhibited, micropores are formed in the outer membrane 3, the diameter of each micropore is 10-500 micrometers, and when the stent main body 2 is expanded, the micropores are expanded by 5-20 times;
paclitaxel with a certain concentration is coated on the inner membrane 5, after the paclitaxel is fully dried, the outer membrane 3 with micropores is connected to the outer side of the stent main body 2 in a bonding or heat sealing mode, the stent main body 2 is compressed and placed in a special conveying appliance before use, the paclitaxel is pushed to a pathological change position by the special conveying appliance and then is pushed out and released, the recovery needs a special recovery tool for recovery, a large number of micropores are distributed on the surface of the outer membrane 3, when the stent main body 2 is not expanded, the micropores are small in size, blood cannot wash out the drugs 4 on the inner membrane 5, the protection effect is achieved, when the stent main body 2 is expanded, the outer membrane 3 is also expanded along with the expanded micropores, the surface of the outer membrane 3 is also expanded, and under the condition, the drugs can be fully contacted with the blood vessel wall, so that the use rate of the drugs is improved;
support main part 2 is including being many spinal branchs vaulting pole 21 of cyclic annular distribution, adjacent two all connect through many silk threads 22 between the bracing piece 21, and the size that many spinal branchs vaulting pole 210 strutted has been restricted to silk thread 22's length, every bracing piece 21 one end all is connected with retrieving hook 1 through connecting rod 23, retrieves hook 1 and is the metal class material, like stainless steel, cobalt chromium alloy, nickel titanium alloy etc. retrieves hook 1 and connecting rod 23 and forms through the welding, retrieves hook 1 and regard as the adapting unit of support main part 2 recovery, retrieve hook 1 and include connecting rod 11, connecting rod 11 one end is bent and is formed like, the other end and all connecting rod 23 is connected.
Example two:
the embodiment discloses a recyclable drug stent, which comprises a tubular stent main body 20, an inner membrane 50 and an outer membrane 30, wherein the stent main body 20 is used as a supporting component of a blood vessel and is also used as a supporting main body of the inner membrane 50 and the outer membrane 30, the stent main body 20 is made of a metal material, such as stainless steel, cobalt-chromium alloy, nickel-titanium memory alloy and the like, the inner membrane 50 is bonded or thermally sealed on the inner side of the stent main body 20, the inner membrane 50 is connected with the stent main body 20 through a thermal sealing method, the inner membrane 50 is made of a PE material and is non-porous, and the thickness is 0.01-0.5 mm;
the outer membrane 30 is arranged on the outer side of the stent main body 20, the outer membrane 30 is made of an elastic material, such as silica gel, TPU, TPE and other recoverable materials, and has good ductility and elasticity, preferably made of a TPU material, the thickness is 0.01-0.2 mm, the hardness is 20 a-60 a, the loss of the medicine 40 is reduced when the stent main body 20 is expanded through the outer membrane 30, the medicine 40 is coated on one side of the inner membrane 50 close to the outer membrane 30, the medicine 40 comprises paclitaxel or rapamycin derivatives, micropores are formed in the outer membrane 30, the diameter of each micropore is 10-500 um, and the micropores are expanded by 5-20 times when the stent main body is expanded;
paclitaxel with a certain concentration is coated on the inner membrane 50, after the paclitaxel is sufficiently dried, the outer membrane 30 with micropores is connected to the outer side of the stent main body 20 in a bonding or heat sealing mode, the stent main body 20 is compressed and placed in a special conveying appliance before use, the paclitaxel is pushed to a pathological change position by the special conveying appliance and then is pushed out and released, the recovery needs a special recovery tool for recovery, a large number of micropores are distributed on the surface of the outer membrane 30, when the stent main body 20 is not expanded, the micropores are small in size, blood cannot wash out the drugs 40 on the inner membrane 50, the protection effect is achieved, when the stent main body 20 is expanded, the outer membrane 30 is also expanded along with the expanded micropores, the surface of the outer membrane 30 is also expanded, and under the condition, the drugs can be fully contacted with the blood vessel wall, so that the use rate of the drugs is improved;
the bracket main body 20 comprises a plurality of support rods 210 which are distributed in an annular shape, two adjacent support rods 210 are connected through a plurality of silk threads 220, the length of the silk threads 220 limits the opening size of the plurality of support rods 210, and one end of each support rod 210 is connected with the recovery hook 10 through a connecting rod 230;
the support rod 210, the connection rod 230, the thread 220 and the recovery hook 10 are integrally formed by tube cutting or 3D printing, the recovery hook 10 includes a hollow tube 101, an inclined opening 102 is formed on the hollow tube 101 to form a hook shape, and the recovery hook 10 is used as a connection part for recovering the stent body 20.
The above embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. Equivalent substitutes or changes made by the technical personnel in the technical field on the basis of the utility model are all within the protection scope of the utility model. The protection scope of the present invention is subject to the claims.
Claims (10)
1. A recyclable drug carrier, comprising: including tubulose support main part, intima, adventitia, the intima sets up the inboard of support main part, the adventitia sets up the outside of support main part, the intima is close to coating has the medicine on one side of adventitia, the micropore has been seted up on the adventitia.
2. The recyclable drug carrier as described in claim 1, wherein the carrier body comprises a plurality of support rods distributed in a ring shape, and two adjacent support rods are connected by a plurality of wires.
3. The recyclable drug carrier as described in claim 2, wherein each of the support rods is connected at one end to a recycling hook by a connecting rod.
4. The recyclable medicine carrier as described in claim 3, wherein the recycling hook comprises a connecting rod, one end of the connecting rod is bent to form a hook shape, and the other end of the connecting rod is connected with all the connecting rods.
5. The recyclable medicine carrier as claimed in claim 4, wherein the outer film is made of silica gel material, the thickness is 0.01-0.2 mm, and the hardness is 20 a-60 a.
6. The recyclable drug carrier as described in claim 3, wherein the support rod, the connecting rod, the thread and the recycling hook are integrally formed.
7. The recyclable drug carrier as described in claim 6, wherein the recycling hook comprises a hollow tube with an oblique opening.
8. The recyclable drug carrier as described in claim 7, wherein the outer film is a TPU material with a hardness of 20a to 60 a.
9. The recyclable drug carrier as described in claim 1, wherein the inner film is made of PE and has a thickness of 0.01-0.5 mm.
10. The recyclable drug carrier as described in claim 1, wherein the micropores have a diameter of 10 to 500 μm, and the micropores are enlarged 5 to 20 times when the carrier body is expanded.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920008833.0U CN209827116U (en) | 2019-01-03 | 2019-01-03 | Recyclable medicine support |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920008833.0U CN209827116U (en) | 2019-01-03 | 2019-01-03 | Recyclable medicine support |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209827116U true CN209827116U (en) | 2019-12-24 |
Family
ID=68901646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920008833.0U Withdrawn - After Issue CN209827116U (en) | 2019-01-03 | 2019-01-03 | Recyclable medicine support |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209827116U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602523A (en) * | 2019-01-03 | 2019-04-12 | 科塞尔医疗科技（苏州）有限公司 | A kind of recyclable drug stent |
-
2019
- 2019-01-03 CN CN201920008833.0U patent/CN209827116U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109602523A (en) * | 2019-01-03 | 2019-04-12 | 科塞尔医疗科技（苏州）有限公司 | A kind of recyclable drug stent |
| CN109602523B (en) * | 2019-01-03 | 2024-02-09 | 科塞尔医疗科技（苏州）有限公司 | Recoverable medicine support |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20191224 Effective date of abandoning: 20240209 |
|
| AV01 | Patent right actively abandoned |
Granted publication date: 20191224 Effective date of abandoning: 20240209 |
|
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |