CN209826741U - Non-invasive oral saliva glucose concentration continuous detection device - Google Patents
Non-invasive oral saliva glucose concentration continuous detection device Download PDFInfo
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- CN209826741U CN209826741U CN201920362937.1U CN201920362937U CN209826741U CN 209826741 U CN209826741 U CN 209826741U CN 201920362937 U CN201920362937 U CN 201920362937U CN 209826741 U CN209826741 U CN 209826741U
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Abstract
The utility model relates to a non-invasive oral saliva glucose concentration continuous detection device. The invisible tooth socket comprises an invisible tooth socket 1 and an external signal receiver 2, wherein the invisible tooth socket 1 comprises a graphene seal 3, sensitive gel 4, a comb-shaped capacitor 5, a planar coil 6 and a substrate 7, and the invisible tooth socket is characterized in that a homogenous material square cavity is integrated in the middle of a tooth socket of the invisible tooth socket, the height of the cavity is not higher than that of the tooth socket, the top end of the cavity is opened, the graphene is placed on the opening and sealed to form a seal, nano-scale pores are uniformly distributed on the graphene seal, the area occupation rate of the pores on the graphene seal is 60%, the sensitive gel is located right below the graphene seal, the substrate is located right below the sensitive gel, a layer of the square planar coil is prepared on the upper surface of the substrate, the center of the square planar coil is provided with the comb-shaped capacitor, and the sensitive gel covers the comb-shaped capacitor. The utility model discloses can realize when realizing that there is not invasive glucose to detect, realize passive wireless long-time incessant real-time detection in succession.
Description
Technical Field
The utility model belongs to micro-mechanical technology makes the field, especially relates to a non-invasive oral cavity saliva glucose concentration continuous detection device.
Background
With the change of living habits and life rhythms of people, diabetes mellitus becomes a common endocrine disease seriously threatening the health of people. Diabetes affects more than nine thousand and two million Chinese patients, and its complications are the main causes of blindness, end-stage renal disease and amputation. Close monitoring and regulation of blood glucose concentration can greatly (more than 50%) reduce the incidence of diabetic complications. Continuous Glucose Monitoring (CGM), which measures glucose concentration continuously at high frequency, is the most effective method for monitoring blood glucose. At present, most of glucose concentration detection methods and detection devices cannot continuously detect the glucose concentration, and have the problems of human body damage, long measurement period, incapability of detecting at any time and the like.
The application number is CN201210364484.9, the patent name is 'continuous high-precision detecting instrument for human blood sugar concentration based on micro blood sampling', a continuous high-precision detecting instrument for human blood sugar concentration based on micro blood sampling is provided, a continuous blood sampling pipeline for micro blood sampling is adopted, the human blood sugar concentration is continuously detected, the continuous high-precision detecting instrument has the advantages that the fluctuation of blood glucose concentration caused by micro continuous blood sampling is avoided, the uninterrupted and interference-free blood sampling in the glucose detection process is realized, however, the continuous high-precision detecting instrument has the defects that long-time micro blood sampling is needed, the operation is very inconvenient, the injury to a human body can be caused, and the measuring period is longer.
The application number is CN201010153400.8, the patent name is human glucose concentration continuous monitoring device based on optical fiber surface plasma resonance, a human glucose concentration continuous monitoring device based on optical fiber surface plasma resonance is provided, the human glucose concentration continuous monitoring is realized by measuring the glucose concentration in human tissue fluid, the device has the advantages of high measurement precision and good stability, the human glucose concentration 24-hour continuous monitoring can be realized, however, the device has the defect that the human body can be injured by implanting a light probe and has invasiveness.
The invention discloses a transmission-type noninvasive blood sugar detection device and a transmission-type noninvasive blood sugar detection method, which are CN201410205838.4 and have the patent name of 'a transmission-type noninvasive blood sugar detection device'.
The patent application No. CN201310751879.9, entitled blood sugar detection device and preparation method thereof, provides a blood sugar detection device based on color test paper, which takes blood through a needle, tests the blood through the color test paper, and judges the concentration of blood sugar according to the color development condition of the test paper.
Disclosure of Invention
To the problem that exists among the above-mentioned glucose detection, the utility model aims to provide a non-invasive oral cavity saliva glucose concentration continuous detection device, with its integrated alveolus middle part at right lower jaw second molar facing, its aim at can non-invasive carry out human glucose concentration and detect, avoid causing the injury to the human body, can continuous detection whole day without intermission, measuring cycle is short, do not need the external power that additionally provides, passive wireless transmission can be realized to the signal, and convenient the dismantlement when having needs.
For solving the above problem, the utility model adopts the following technical scheme:
a non-invasive oral saliva glucose concentration continuous detection device comprises an invisible tooth socket (1) and an external signal receiver (2), wherein the invisible tooth socket (1) comprises a graphene seal (3), a sensitive gel (4), a comb-shaped capacitor (5), a planar coil (6) and a substrate (7), and is characterized in that a homogenous material square cavity is integrated in the middle of a tooth socket of the invisible tooth socket, the cavity is not higher than the tooth socket in height, the top end of the cavity is provided with an opening, the graphene is arranged on the opening and seals the opening to form a seal, small holes with nanometer magnitude are uniformly distributed on the graphene seal, the area occupation rate of the small holes on the graphene seal is 60%, the sensitive gel is positioned under the graphene seal, the substrate is positioned under the sensitive gel, a layer of the comb-shaped planar coil is arranged on the upper surface of the substrate, the center of the comb-shaped planar coil is provided with the comb-shaped capacitor, the sensitive gel covers the comb-shaped capacitor.
The length, width and height of the chamber are 1.5mm 1.0 mm.
The length and width of the opening are 1.0mm x 0.8 mm.
The length and width of the graphene seal is 1.0mm x 0.8 mm.
The small holes are formed by bombarding graphene with boron trifluoride atomic groups, the aperture size is 1.0nm, and the spacing between the holes is 1.0nm ~ 1.5.5 nm.
The sensitive gel is poly-3-acrylamide phenylboronic acid-acrylamide.
The comb-shaped capacitor is provided with two electrodes, the left electrode is provided with 9 teeth, the right electrode is provided with 10 teeth, the space between the teeth is 0.02mm, and the length of the teeth is 0.5 mm.
The number of turns of the square-wave planar coil is 3, the line width is 0.01mm, the line spacing is 0.005mm, the distance between the coil and the edge of the substrate is 0.055mm, and the coil is made of gold.
The specification of the substrate is 1.1mm 0.6mm 0.1mm, and the material is monocrystalline silicon.
The invention has the beneficial effects that:
1. the glucose detection device is used for non-invasive detection, and does not cause harm to human bodies;
2. the glucose detection device has the advantages of being passive and wireless, and can continuously and uninterruptedly detect glucose;
3. the glucose detection device has the advantages of easy assembly and disassembly, and is more convenient for the life of people.
Drawings
The invention is further described with reference to the accompanying drawings and specific embodiments;
FIG. 1 is a schematic sectional view of the overall structure of the detecting unit;
FIG. 2 is a top view of the comb-shaped capacitor and the planar coil of the detecting device;
FIG. 3 is a schematic representation of the reaction of the inside of the sensing gel of the device with glucose.
Detailed Description
Fig. 1 is a non-invasive oral saliva glucose concentration continuous detection device, which includes an invisible mouthpiece 1 and an external signal receiver 7, wherein the invisible mouthpiece 1 includes a graphene seal 2, a sensitive gel 3, a comb-shaped capacitor 4, a square planar coil 5 and a substrate 6, a cavity made of a same material is arranged at the bottom of a dental socket of the invisible mouthpiece 1, the cavity is not higher than the top of the dental socket, the top of the cavity is open, the graphene is placed on the opening and seals the opening to form the graphene seal 2, the substrate 6 is located at the bottom of the cavity, the upper surface of the substrate 6 is provided with three circles of square planar coils 5, the center of the square planar coil 5 is the comb-shaped capacitor 4, the comb-shaped capacitor 4 is also on the surface of the substrate 6, the sensitive gel 3 covers the comb-shaped capacitor 4, and the graphene seal 2 is located above the comb-shaped capacitor 4.
In FIG. 3, poly-3-acrylamidophenylboronic acid-acrylamide 8 and glucose molecule 9 undergo a gel-chain reaction, the left side of the figure shows the reaction is a thin poly-3-acrylamidophenylboronic acid-acrylamide 8 before reaction, and the right side shows the reaction product after the reaction of poly-3-acrylamidophenylboronic acid-acrylamide 8 and glucose molecule 9.
Claims (9)
1. A non-invasive oral saliva glucose concentration continuous detection device comprises an invisible tooth socket (1) and an external signal receiver (2), wherein the invisible tooth socket (1) comprises a graphene seal (3), a sensitive gel (4), a comb-shaped capacitor (5), a clip-shaped planar coil (6) and a substrate (7), and is characterized in that a square cavity made of a same material is integrated in the middle of a tooth socket of the invisible tooth socket, the height of the cavity is not higher than that of the tooth socket, the top end of the cavity is provided with an opening, the graphene is arranged on the opening to seal the opening to form a seal, small holes with nanometer magnitude are uniformly distributed on the graphene seal, the area occupation rate of the small holes on the graphene seal is 60%, the sensitive gel is positioned under the graphene seal, the substrate is positioned under the sensitive gel, the upper surface of the substrate is provided with a layer of the clip-shaped planar coil, the center of the clip-shaped planar coil is provided with the comb-shaped capacitor, the sensitive gel covers the comb-shaped capacitor.
2. The device of claim 1, wherein the chamber has a length and a width of 1.5mm by 1.0 mm.
3. The device of claim 1, wherein the opening has a length and a width of 1.0mm by 0.8 mm.
4. The device of claim 1, wherein the graphene seal has a length and a width of 1.0mm x 0.8 mm.
5. The apparatus of claim 1, wherein the pores are formed by bombarding graphene with boron trifluoride atomic groups, and have a pore size of 1.0nm, and the distance between pores is 1.0nm ~ 1.5.5 nm.
6. The apparatus of claim 1, wherein the sensitive gel is poly-3-acrylamidophenylboronic acid-acrylamide.
7. The device as claimed in claim 1, wherein the comb-shaped capacitor has two electrodes, 9 teeth on the left electrode and 10 teeth on the right electrode, the teeth are spaced apart by 0.02mm, and the teeth are 0.5mm long.
8. The device of claim 1, wherein the number of turns of the planar coil is 3, the line width is 0.01mm, the line spacing is 0.005mm, the coil is 0.055mm from the edge of the substrate, and the coil is made of gold.
9. The device of claim 1, wherein the substrate is 1.1mm by 0.6mm by 0.1mm and is made of single crystal silicon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920362937.1U CN209826741U (en) | 2019-03-21 | 2019-03-21 | Non-invasive oral saliva glucose concentration continuous detection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920362937.1U CN209826741U (en) | 2019-03-21 | 2019-03-21 | Non-invasive oral saliva glucose concentration continuous detection device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209826741U true CN209826741U (en) | 2019-12-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920362937.1U Expired - Fee Related CN209826741U (en) | 2019-03-21 | 2019-03-21 | Non-invasive oral saliva glucose concentration continuous detection device |
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| Country | Link |
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| CN (1) | CN209826741U (en) |
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2019
- 2019-03-21 CN CN201920362937.1U patent/CN209826741U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191224 Termination date: 20210321 |
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| CF01 | Termination of patent right due to non-payment of annual fee |