CN209685654U - Multi-channel pipeline device used in a kind of monoclonal antibody chromatography - Google Patents

Abstract

The utility model discloses multi-channel pipeline devices used in a kind of monoclonal antibody chromatography, including main pipeline, by the way that eight drain pipes are arranged in the lower surface of main pipeline, to eight chromatographic columns of connection, and then improve production efficiency, it improves and is fixedly connected with inlet tube in the left end of upper surface and right end, the upper end of two inlet tubes is fixedly connected to vacuum pump, connecting tube is rotatablely connected in the lower end of drain pipe, the inner wall of connecting tube is fixedly connected with flight, the bottom end of connecting tube is fixedly connected with enclosed globe shade, the outer wall of enclosed globe shade is fixedly connected with becket, the outer end of becket is sequentially connected metal hose and spray head, when two vacuum pumps work alternatively, liquid flow in main pipeline alternate cycles to the left and right, consequently facilitating rinsing endpoint and the turning of the inner cavity of main pipeline, when two vacuum pumps work at the same time, metal hose and spray head in hydro-flow thrust and It is stretched under the effect of itself centrifugal force, to wash away the inner wall of chromatographic column.

Description

Multi-channel pipeline device used in a kind of monoclonal antibody chromatography

Technical field

The utility model relates to technical field of motors, multi-channel pipeline device used in specially a kind of monoclonal antibody chromatography.

Background technique

Monoclonal antibody is a kind of antibody for antigenic determinant of monoclonal cell synthesis, and monoclonal antibody drug is It is proved to be extremely successful a kind for the treatment of product, when batch production, usually large-scale chromatographic purifying is made, existing layer The inlet pipe of analysis system, leakage fluid dram negligible amounts, connected chromatographic column is less, causes batch production efficiency lower, while medicine Liquid and cleaning solution share same pipeline, and there are multiple bendings in pipeline, the unimodal current generated only with single pump is difficult to clean, and And pipeline drain directly down, it is difficult to chromatography column wall be cleaned, therefore, spy proposes the utility model.

Utility model content

It is above-mentioned to solve the purpose of this utility model is to provide multi-channel pipeline device used in a kind of monoclonal antibody chromatography The problem of being proposed in background technique.

To achieve the above object, the utility model provides the following technical solutions: multichannel used in a kind of monoclonal antibody chromatography Piping installation, including main pipeline, the left end of the upper surface of the main pipeline and right end are fixedly connected to inlet tube, described in two The upper end of inlet tube is fixedly connected to vacuum pump, and the lower surface of the main pipeline is fixedly connected with drain pipe, and drain pipe is equal Even to be provided with eight, the outer wall of the drain pipe is fixedly connected with chromatographic column, and the inner wall of the drain pipe is rotatably connected to hydrojet The bottom surface of device, the drain pipe is fixedly connected with limiting device.

Preferably, the liquid-jet device includes connecting tube, under the external wall of upper portion rotation connection drain pipe of the connecting tube Portion's inner wall, the inner wall of the connecting tube are fixedly connected with flight, and the bottom end of the connecting tube is fixedly connected with enclosed globe shade, described The outer wall of enclosed globe shade is fixedly connected with becket, and the outer end of the becket is fixedly connected with metal hose, the metal hose Outer end be fixedly connected with spray head.

Preferably, the limiting device includes fixed ring, and the inner wall of the fixed ring offers slot, the slot it is interior Wall is plugged with insertion tube, and the outer end inner wall of insertion tube inner end inner wall and slot is respectively fixedly connected with the both ends of spring, the connection The outer wall of pipe offers limiting slot, the outer wall of the inner end outer wall grafting limiting slot of the insertion tube.

Preferably, it is fixedly connected with drug liquid tube in the middle part of the inlet tube, is fixedly installed in the middle part of the drug liquid tube One valve body.

Preferably, the middle part of two inlet tubes is fixedly installed with the second valve body.

Preferably, the lower end of the chromatographic column is fixedly connected with drain line.

Compared with prior art, the utility model has the beneficial effects that the utility model passes through in the lower surface of main pipeline Eight drain pipes are set, thus eight chromatographic columns of connection, and then production efficiency is improved, it improves equal in the left end of upper surface and right end It is fixedly connected with inlet tube, the upper end of two inlet tubes is fixedly connected to vacuum pump, is rotatablely connected connection in the lower end of drain pipe Pipe, the inner wall of connecting tube are fixedly connected with flight, and the bottom end of connecting tube is fixedly connected with enclosed globe shade, and the outer wall of enclosed globe shade is fixedly connected Have becket, the outer end of becket is fixedly connected with metal hose, and the outer end of metal hose is fixedly connected with spray head, when two it is true When sky pump works alternatively, liquid flow in main pipeline alternate cycles to the left and right, consequently facilitating rinsing the endpoint of the inner cavity of main pipeline And turning, cleaning effect is improved, avoids remaining, when two vacuum pumps work at the same time, the flow rate of liquid in connecting tube increases, and pushes away Dynamic flight drives connecting tube rotation, to make enclosed globe shade, becket, metal hose and sprinkler rotation, makes metal hose and spray Head stretches under hydro-flow thrust and the effect of itself centrifugal force, to wash away the inner wall of chromatographic column.

Detailed description of the invention

FIG. 1 is a schematic structural view of the utility model；

Fig. 2 is the utility model pumping equipment structural schematic diagram；

Fig. 3 is the detail view a of the utility model pumping equipment.

In figure: 1 main pipeline, 2 inlet tubes, 3 vacuum pumps, 4 drain pipes, 5 chromatographic columns, 6 liquid-jet devices, 7 limiting devices, 8 connect Adapter tube, 9 flights, 10 enclosed globe shades, 11 beckets, 12 metal hoses, 13 spray heads, 14 fixed rings, 15 slots, 16 insertion tubes, 17 bullets Spring, 18 limiting slots, 19 drug liquid tubes, 20 first valve bodies, 21 second valve bodies, 22 drain lines.

Specific embodiment

The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work Every other embodiment obtained, fall within the protection scope of the utility model.

Fig. 1-3 is please referred to, the utility model provides a kind of technical solution: multi-channel pipeline used in a kind of monoclonal antibody chromatography Device, including main pipeline 1, the left end of the upper surface of main pipeline 1 and right end are fixedly connected to inlet tube 2, two inlet tubes 2 Upper end is fixedly connected to vacuum pump 3, and 3 model 2XZ-2 of vacuum pump, two vacuum pumps 3 can be either simultaneously or alternately into main pipeline 1 Cleaning solution is injected, consequently facilitating the both ends of flushing main pipeline 1 and pipeline junction avoid remaining, main pipeline by cleaning effect 1 lower surface is fixedly connected with drain pipe 4, and drain pipe 4 is evenly arranged with eight, and the top of drain pipe 4 is equipped with valve body, drain The outer wall of pipe 4 is fixedly connected with chromatographic column 5, to improve the quantity of chromatographic column 5, and then improves production efficiency, chromatographic column 5 is existing Cylinder made of some glass tubes or lucite tube, the inner wall of drain pipe 4 are rotatably connected to liquid-jet device 6, and liquid-jet device 6 In the inside of chromatographic column 5, consequently facilitating cleaning to the inner wall of chromatographic column 5, the bottom surface of drain pipe 4 is fixedly connected with limit dress Set 7.

Specifically, for the ease of cleaning the inner wall of chromatographic column 5, liquid-jet device 6 includes connecting tube 8, the top of connecting tube 8 Outer wall is rotatablely connected the lower inner wall of drain pipe 4, and the inner wall of connecting tube 8 is fixedly connected with flight 9, and the bottom end of connecting tube 8 is solid Surely it is connected with enclosed globe shade 10, the outer wall of enclosed globe shade 10 is fixedly connected with becket 11, and the outer end of becket 11 is fixedly connected with gold Belong to hose 12, the outer end of metal hose 12 is fixedly connected with spray head 13, and becket 11, metal hose 12 and spray head 13 form hydrojet Mechanism, the outer wall of enclosed globe shade 10 is provided with multiple hydrojet mechanisms, and in nature, spray head 13 and metal hose 12 are by itself weight Power effect, spray head 13 is downward, metal hose 12 is bent, and when two vacuum pumps 3 work, the cleaning solution of larger flow velocity pushes spiral Piece 9 rotates metal hose 12 and spray head 13, makes metal hose 12 in the centrifugal force and cleaning solution of metal hose 12 and spray head 13 Impact force under the action of stretch, make spray head 13 be lifted, to rinse the upper inside wall of chromatographic column 5.

Specifically, the fashionable connecting tube 8 of liquid medicine injection rotates in order to prevent, limiting device 7 includes fixed ring 14, fixed ring 14 Inner wall offer slot 15, the inner wall of slot 15 is plugged with insertion tube 16, the outer end inner wall of insertion tube 16 inner end inner wall and slot 15 The both ends of spring 17 are respectively fixedly connected with, the extension end of insertion tube 16 is spherical surface, and insertion tube 16 can be fully inserted into slot 15, connection The outer wall of pipe 8 offers limiting slot 18, and the outer wall of the inner end outer wall grafting limiting slot 18 of insertion tube 16, above-mentioned is one group of limit knot Structure, the inner wall of fixed ring 14 are at least evenly arranged with 3 groups, and when normally injecting medical fluid into chromatographic column 5, medical fluid flow velocity is slower, Connecting tube 8 cannot be pushed to rotate by flight 9, when two vacuum pumps 3 inject cleaning solution into chromatographic column 5 simultaneously, connection 8 cleaning liquid inside flow velocity of pipe is larger, pushes flight 9 to rotate, is fully inserted into insertion tube 16 inside slot 15.

Specifically, the middle part of inlet tube 2 is fixedly connected with drug liquid tube 19, drug liquid tube 19 for the ease of injecting medical fluid Middle part is fixedly installed with the first valve body 20.

Specifically, the middle part of two inlet tubes 2 is fixedly installed with the second valve body 21 for the ease of using.

Specifically, the lower end of chromatographic column 5 is fixedly connected with drain line 22 for the ease of drain.

Working principle: when using the utility model, connecting external medicine liquid tank for drug liquid tube 19, by spray pump to eight layers It analyses and injects medical fluid in column 5, purified, improve production efficiency, after use, medical fluid is discharged, opens drain line 22, empties medicine Liquid alternately opens vacuum pump 3, and make 1 cleaning liquid inside of main pipeline flows to left and right alternate cycles, consequently facilitating rinsing main pipeline 1 End angle and corner avoid remaining by cleaning effect, while two vacuum pumps 3 of opener, make the cleaning solution in drain pipe 4 Flow velocity increases, and increases cleaning solution to the thrust of flight 9, to make connecting tube 8, enclosed globe shade 10, metal hose 12 and spray head 13 Rotation, stretches metal hose 12, and spray head 13 is lifted upwards, and the cleaning solution for spraying spray head 13 washes away in the top of chromatographic column 5 Wall, to clean to chromatographic column 5, the utility model is designed reasonably is easy to use, can connect multiple chromatographic columns 5, pass through life Efficiency is produced, and is worked alternatively by two vacuum pumps 3, the cleaning effect to the inlet pipe in tomographic system can be improved, also, When two vacuum pumps 3 work at the same time, the inner wall of chromatographic column 5 can be cleaned, there is stronger practicability.

While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art, It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.

Claims (6)

1. multi-channel pipeline device used in a kind of monoclonal antibody chromatography, including main pipeline (1), it is characterised in that: the main pipeline (1) left end of upper surface and right end are fixedly connected to inlet tube (2), and the upper end of two inlet tubes (2) is fixed to be connected It is connected to vacuum pump (3), the lower surface of the main pipeline (1) is fixedly connected with drain pipe (4), and drain pipe (4) is evenly arranged with Eight, the outer wall of the drain pipe (4) is fixedly connected with chromatographic column (5), and the inner wall of the drain pipe (4) is rotatably connected to hydrojet The bottom surface of device (6), the drain pipe (4) is fixedly connected with limiting device (7).

2. multi-channel pipeline device used in a kind of monoclonal antibody chromatography according to claim 1, it is characterised in that: the spray Liquid device (6) includes connecting tube (8), the lower inner wall of external wall of upper portion rotation connection drain pipe (4) of the connecting tube (8), institute The inner wall for stating connecting tube (8) is fixedly connected with flight (9), and the bottom end of the connecting tube (8) is fixedly connected with enclosed globe shade (10), The outer wall of the enclosed globe shade (10) is fixedly connected with becket (11), and it is soft that the outer end of the becket (11) is fixedly connected with metal It manages (12), the outer end of the metal hose (12) is fixedly connected with spray head (13).

3. multi-channel pipeline device used in a kind of monoclonal antibody chromatography according to claim 2, it is characterised in that: the limit Position device (7) includes fixed ring (14), and the inner wall of the fixed ring (14) offers slot (15), the inner wall of the slot (15) It is plugged with insertion tube (16), the outer end inner wall of insertion tube (16) the inner end inner wall and slot (15) is respectively fixedly connected with spring (17) The outer wall at both ends, the connecting tube (8) offers limiting slot (18), the inner end outer wall grafting limiting slot (18) of the insertion tube (16) Outer wall.

4. multi-channel pipeline device used in a kind of monoclonal antibody chromatography according to claim 1, it is characterised in that: it is described into It is fixedly connected in the middle part of liquid pipe (2) drug liquid tube (19), is fixedly installed with the first valve body (20) in the middle part of the drug liquid tube (19).

5. multi-channel pipeline device used in a kind of monoclonal antibody chromatography according to claim 1, it is characterised in that: two institutes The middle part for stating inlet tube (2) is fixedly installed with the second valve body (21).

6. multi-channel pipeline device used in a kind of monoclonal antibody chromatography according to claim 1, it is characterised in that: the layer The lower end of analysis column (5) is fixedly connected with drain line (22).