CN209645141U - It is a kind of for correcting the cornea implanted eyeglass of presbyopia - Google Patents
It is a kind of for correcting the cornea implanted eyeglass of presbyopia Download PDFInfo
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- CN209645141U CN209645141U CN201920078138.1U CN201920078138U CN209645141U CN 209645141 U CN209645141 U CN 209645141U CN 201920078138 U CN201920078138 U CN 201920078138U CN 209645141 U CN209645141 U CN 209645141U
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- eyeglass
- main body
- dermal matrix
- presbyopia
- correcting
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Abstract
The utility model relates to a kind of for correcting the cornea implanted eyeglass of presbyopia, including acellular dermal matrix main body and the multiple fixed brackets being arranged in around acellular dermal matrix main body, the fixation bracket is an integral molding structure with acellular dermal matrix main body, it is provided with clearance space between fixed bracket and acellular dermal matrix main body, the support bracket fastened bottom surface is provided with adhesive preparation.The cornea implanted eyeglass can show good biocompatibility, translucency, and good mechanical property is able to achieve preferable dioptric performance, and realizes dioptric plasticity after implantation is intraocular.In addition the cornea implanted eyeglass can also steadily indwelling after the implantation, will not be extruded come.
Description
Technical field
It is the utility model relates to medical biotechnology Material Field, in particular to a kind of for correcting the cornea implanted mirror of presbyopia
Piece.
Background technique
Presbyopia is the physiological process for the near vision decline for increasing with the age and gradually occurring.With age, crystal
Core gradually hardens, and the plasticity and elasticity of crystal gradually weaken, therefore regulatory function gradually weakens, about in 40-45 or so, low coverage
From work or just generation difficulty is read, this physiological due to caused by the age, which is adjusted, to be weakened, referred to as presbyopia.In aging society
Middle presbyopia is particularly problematic, therefore emerges the various supplementary means for increasing near vision, such as wear presbyopia glasses, presbyopia angle
Film contact lense, crystal pouch are implanted into adjustable artificial crystal, corneal laser surgery etc..
Cornea implant is recently emerging technology, it causes anterior corneal surface Curvature varying after being implanted into cornea, and then changes
Refractive power.Multiple material subject is used to prepare cornea implant, but is synthetic material.After this kind of material implantation cornea all
The problems such as biological compatibility is bad, and the opacity of the cornea causes light transmittance to decline, ulcer of the cornea may be faced, once occur above-mentioned
Problem needs to take out eyeglass, and more serious damage is caused to cornea.In addition, cornea implant in the prior art there is also
It is easy to be extruded the problem come.This is because cornea implant in the prior art has certain rigidity, Young's modulus exists
1800 between 3000MPa, and this cornea implant can rub with cornea tissue during blink, and then cornea is caused to be planted
Enter object and is extruded.
Acellular dermal matrix be by Animal Skin or people's cadaver skin, through a series of physical, chemical method, remove epidermis and
Cell component in corium retains a kind of biomaterial obtained by the dermal matrix ingredient of extremely low immunogenicity.The nineteen ninety-five U.S.
Lifecell Corp. first reported the preparation method of acellular dermal matrix.Meanwhile its work in clinical application is carried out
With, earliest as a kind of dermal substitute for burning, the substitution of Dermal defect caused by wound repair, but research discovery thereafter is de-
Acellular dermal matrix is except can be used for burning, in addition to wound and wound surface, it may also be used for the repairing of mucous membrane and soft tissue augmentation.
In the prior art, there are no the reports for using acellular dermal matrix to prepare cornea implanted eyeglass.
Summary of the invention
The utility model is intended to provide a kind of for correcting the cornea implanted eyeglass of presbyopia, technical problem to be solved
Including at least biocompatibility, the translucency for how improving cornea implanted eyeglass, the power of cornea implanted eyeglass how is improved
Property is learned, is extruded after avoiding implantation.
In order to achieve the goal above, the utility model provide it is a kind of for correcting the cornea implanted eyeglass of presbyopia, including
Acellular dermal matrix main body and the multiple fixed brackets being arranged in around acellular dermal matrix main body, the fixation bracket
It is an integral molding structure with acellular dermal matrix main body, is provided with interval between fixed bracket and acellular dermal matrix main body
Space, the support bracket fastened bottom surface are provided with adhesive preparation.
Multiple fixed brackets include that the first fixed bracket, the second fixed bracket and third fix bracket, described
First fixed bracket, the second fixed bracket and the fixed bracket of third are evenly distributed on the peripheral wall of acellular dermal matrix main body.
The first clearance space is provided between the fixed bracket of described first and acellular dermal matrix main body；Second is fixed
The second clearance space is provided between bracket and acellular dermal matrix main body；The fixed bracket of third and acellular dermal matrix master
Third clearance space is provided between body.
The fixed bracket of described first includes the first linking arm, the second linking arm and arc linking arm, and the arc connects
Arm is connect to be connected between the first linking arm and the second linking arm.
Second fixed bracket and the support bracket fastened structure of third are identical as the structure of the first fixed branch.
The adhesive preparation includes polylysine or poly- D-Lys.
The adhesive preparation further includes methotrexate (MTX), daunorubicin or adriamycin.
The acellular dermal matrix main body with a thickness of 30~100 μm, and have refractive power.
Preferably, the acellular dermal matrix main body is circle.
It is highly preferred that the diameter of the acellular dermal matrix main body is 3~5mm.
Beneficial effect
Compared with prior art, the utility model has the beneficial effects that described in the utility model for correcting presbyopia
Cornea implanted eyeglass can show good biocompatibility, translucency, and good mechanical property is able to achieve preferable dioptric
Performance, and dioptric plasticity is realized after implantation is intraocular.In addition the cornea implanted eyeglass can also be stayed steadily after the implantation
It sets, will not be extruded and.
Other features and advantages of the utility model will illustrate in the following description, also, partly from specification
In become apparent, or understood and implementing the utility model.The purpose of this utility model and other advantages can pass through
Specifically noted structure is achieved and obtained in the specification, claims and drawings.
Detailed description of the invention
Attached drawing is used to provide to further understand technical solutions of the utility model, and constitutes part of specification,
It is used to explain the technical solution of the utility model together with the specific embodiment of the application, not constitute to the utility model skill
The limitation of art scheme.
Fig. 1 is the structure chart of the cornea implanted eyeglass for correcting presbyopia of the utility model.
Fig. 2 is the implantation schematic diagram of cornea implanted eyeglass.
Specific embodiment
The utility model is described below in more detail to facilitate the understanding to the utility model.
As shown in Figure 1, described in the utility model for correct the cornea implanted eyeglass of presbyopia to include acellular dermal
Matrix body 1 and the multiple fixed brackets being arranged in around acellular dermal matrix main body, the fixation bracket and de- cell
Dermal matrix main body is an integral molding structure, and is provided with clearance space between fixed bracket and acellular dermal matrix main body, institute
The support bracket fastened bottom surface stated is provided with adhesive preparation.
Multiple fixed brackets include that the first fixed bracket 2, second fixes bracket 3 and the fixed bracket 4 of third, described
The fixed bracket 3 of the first fixed bracket 2, second and the fixed bracket 4 of third be evenly distributed on week of acellular dermal matrix main body
On wall.
The first clearance space 5 is provided between the fixed bracket 2 of described first and acellular dermal matrix main body；Second is solid
The second clearance space 6 is provided between fixed rack 3 and acellular dermal matrix main body；The fixed bracket 4 of third and acellular dermal
Third clearance space 7 is provided between matrix body.
The fixed bracket 2 of described first includes the first linking arm 21, the second linking arm 22 and arc linking arm 23, described
Arc linking arm is connected between the first linking arm 21 and the second linking arm 22.
The structure of second fixed bracket 3 and the fixed bracket 4 of third is identical as the first fixed structure of bracket 2.
The adhesive preparation includes polylysine or poly- D-Lys.
The adhesive preparation further includes methotrexate (MTX), daunorubicin or adriamycin.
The acellular dermal matrix main body with a thickness of 30~100 μm, and have refractive power.
Preferably, the acellular dermal matrix main body is circle.
It is highly preferred that the diameter of the acellular dermal matrix main body is 3~5mm.
As exemplary embodiment, the acellular dermal matrix main body is prepared by papillary layer of corium, specifically
Steps are as follows for preparation method:
1) skin is taken, the partial thickness skin including epidermis and skin corium is taken；
2) partial thickness skin that step 1) obtains handle as freeze-drying tablet, then the epidermis of 50-200 μm of removal, under exposed
Square papillaris pars cuts 100-800 μm of papillaris pars, obtains dermal matrix；
Preferably, -15 to -80 DEG C at a temperature of the partial thickness skin handled as freeze-drying tablet, it is highly preferred that -27
The partial thickness skin is handled as freeze-drying tablet at a temperature of DEG C；
3) use fixative fixing step 2) obtained dermal matrix, the set time is 1-3 hour, it is fixed after using distilling
Water washing；The fixative is the sodium phosphate buffer of the 0.01M containing 1.5g/100ml glutaraldehyde；
Preferably, the set time is 2 hours；
4) using the cell component in the obtained dermal matrix of alkaline solution removal step 3), the reaction time is 10 hours-
60 hours, obtain acellular dermal matrix；
Preferably, the reaction time is 20-30 hours；
Preferably, the alkaline solution be selected from alkali metal hydroxide, alkali carbonate, alkali metal hydrogencarbonate,
One of or mixtures thereof ammonium hydroxide, alkali alcoholate, organic amine or a variety of aqueous solutions；It is highly preferred that the alkali
Property solution equivalent concentration be 1.5-2.0N；It is further preferred that the alkaline solution is the NaOH of equivalent concentration 1.5-2.0N
Or KOH；
5) using buffer or distill water wash step 4) obtain acellular dermal matrix 10-50 minutes；Preferably, it washes
Washing the time is 30 minutes；Preferably, the buffer is 0.01M sodium phosphate aqueous solution；
6) acellular dermal matrix for obtaining step 5) is incubated for 10-30 hours in Incubating Solution；The Incubating Solution is
Asparagine aqueous acid, the glutamic acid aqueous solution of 0.5g/ml or the glycine solution of 0.1M of 0.5g/ml, preferably
The asparagine aqueous acid of 0.5g/ml or the glycine solution of 0.1M；Preferably, the pH value of the Incubating Solution is 7.4；
7) acellular dermal matrix for obtaining step 6) is cut, and makes it with a thickness of 30~100 μm, and has refractive power；
Preferably, the cutting is carried out using femtosecond laser cutting technique；
Alternatively, the preparation method of the acellular dermal matrix main body the following steps are included:
1) skin is taken, the partial thickness skin including epidermis and skin corium is taken；
Preferably, the partial thickness skin is obtained from corpse；
2) use fixative fixing step 1) partial thickness skin that obtains, the set time is 1-3 hour, it is fixed after using distilling
Water washing；The fixative is the sodium phosphate buffer of the 0.01M containing 1.5g/100mL glutaraldehyde；
Preferably, the set time is 2 hours；
3) using the cell component in the obtained skin of alkaline solution removal step 2), the reaction time is 10 hours -60 small
When, obtain cell free partial thickness skin；
Preferably, the reaction time is 20-30 hours；
Preferably, the alkaline solution be selected from alkali metal hydroxide, alkali carbonate, alkali metal hydrogencarbonate,
One of or mixtures thereof ammonium hydroxide, alkali alcoholate, organic amine or a variety of aqueous solutions；It is highly preferred that the alkali
Property solution equivalent concentration be 1.5-2.0N；It is further preferred that the alkaline solution is the NaOH of equivalent concentration 1.5-2.0N
Or KOH；
4) using buffer or distill water wash step 3) obtain cell free partial thickness skin 10-50 minutes；
Preferably, wash time is 30 minutes；Preferably, the buffer is the sodium phosphate aqueous solution of 0.01M；
5) the cell free partial thickness skin that step 4) obtains handle as freeze-drying tablet, then the epidermis of 50-200 μm of removal
Layer, exposure lower section papillaris pars, cuts 100-800 μm of papillaris pars, obtains acellular dermal matrix；
Preferably, -15 to -80 DEG C at a temperature of the partial thickness skin handled as freeze-drying tablet, it is highly preferred that temperature
It is -27 DEG C；
6) acellular dermal matrix for obtaining step 5) is incubated for 10-30 hours in Incubating Solution；The Incubating Solution is
Asparagine aqueous acid, the glutamic acid aqueous solution of 0.5g/ml or the glycine solution of 0.1M of 0.5g/ml, it is preferable that institute
State the asparagine aqueous acid or 0.1M glycine solution that Incubating Solution is 0.5g/ml；
Preferably, the pH value of the Incubating Solution is 7.4
7) obtained acellular dermal matrix is cut, makes it with a thickness of 30~100 μm, and there is refractive power；
Preferably, the cutting is carried out using femtosecond laser cutting technique.
First clearance space 5, the second clearance space 6 and the third clearance space 7 is same to be cut by femtosecond laser
Technology cuts to obtain.
As shown in Fig. 2, the method for implantation of the cornea implanted eyeglass described in the utility model for correcting presbyopia includes
Following steps:
1) corneal stroma pouch is prepared in the implanted region of quasi- implantation person's eyes, depth is about the half of corneal thickness, capsule
5~6mm of bag diameter；Preferably, the corneal stroma pouch is prepared using femtosecond laser；
2) support bracket fastened lock chamber is accommodated in the bottom sides preparation of corneal stroma pouch, which is whole annulus
Decline small notch；
3) the cornea implanted eyeglass is implanted into the corneal stroma pouch, so that acellular dermal matrix main body 1
Positioned at the center of corneal stroma pouch, the first fixed bracket 2, second is fixed into bracket 3 and the fixed bracket 4 of third buries respectively
Enter lock chamber；Alternatively, it can suture or not suture pouch notch, covering cornea bandage mirror protects notch；
4) after implant wearer, the refractive power of eyeglass implanted region and the near vision of implantation person's eyes are inspected periodically.
After completing implantation, the refractive status of cornea implanted eyeglass is adjusted:
1) implant wearer cornea refractive power is measured, the depth and range cut needed for reaching target refraction power are calculated；
2) femtosecond laser cuts eyeglass implanted region, makes it up to target refraction power；
3) cornea bandage mirror covering operative region protects notch；
4) operative region refractive status is inspected periodically.
Cornea implanted eyeglass described in the utility model for correcting presbyopia compared with prior art, can be according in the wrong
The variation of luminous power further cuts eyeglass implanted region using femtosecond laser, refractive status is adjusted, without taking eyeglass
Out.
Corneal stroma implantation common in the art have the shortcomings that it is obvious, outstanding behaviours be needing to adjust dioptric
When state, intrastromal corneal ring needs to take out, that is to say, that intrastromal corneal ring in the prior art be cannot by laser come
Refractive power is adjusted, and the cornea implanted eyeglass described in the utility model for correcting presbyopia can be adjusted by laser,
It does not need to take out on cornea implanted eyeglass.
Since the fixed bracket 3 of the first fixation bracket 2, second and the fixed bracket 4 of third are embedded to lock chamber respectively, stationary phase is worked as
Securely, and the first clearance space 5, the second clearance space 6 and third clearance space 7 are not complete cavity, complete to plant
After entering, the substances such as mucus of naturally secret can be filled with these clearance spaces automatically in human eye, further improve eyeglass
Fixing intensity so that eyeglass will not be squeezed away.
Above-described embodiment is the explanation to the utility model, is not the restriction to the utility model, the utility model institute
The parameter area of restriction is referring to claim, and without prejudice to the spirit of the utility model, the utility model can be made
Any type of modification.
Claims (10)
1. a kind of for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that including acellular dermal matrix main body and set
Multiple fixed brackets around acellular dermal matrix main body are set, the fixation bracket is with acellular dermal matrix main body
Integrated formed structure is provided with clearance space between fixed bracket and acellular dermal matrix main body, and described is support bracket fastened
Bottom surface is provided with adhesive preparation.
2. according to claim 1 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that described is multiple solid
Fixed rack includes the first fixed bracket, the second fixed bracket and the fixed bracket of third, and the described first fixed bracket, second are fixed
Bracket and the fixed bracket of third are evenly distributed on the peripheral wall of acellular dermal matrix main body.
3. according to claim 2 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that described first is solid
The first clearance space is provided between fixed rack and acellular dermal matrix main body；Second fixed bracket and acellular dermal matrix
The second clearance space is provided between main body；Third interval is provided between the fixed bracket of third and acellular dermal matrix main body
Space.
4. according to claim 3 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that described first is solid
Fixed rack includes the first linking arm, the second linking arm and arc linking arm, and the arc linking arm is connected to the first linking arm
And second between linking arm.
5. according to claim 4 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that the second fixed bracket
It is identical as the first support bracket fastened structure with the support bracket fastened structure of third.
6. according to claim 5 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that the adhesive preparation
Including polylysine or poly- D-Lys.
7. according to claim 6 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that the adhesive preparation
It further include methotrexate (MTX), daunorubicin or adriamycin.
8. according to claim 1 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that the de- cell is true
Skin matrix body with a thickness of 30~100 μm, and have refractive power.
9. according to claim 1 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that the de- cell is true
Skin matrix body is circle.
10. according to claim 9 for correcting the cornea implanted eyeglass of presbyopia, which is characterized in that the de- cell
The diameter of dermal matrix main body is 3~5mm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920078138.1U CN209645141U (en) | 2019-01-17 | 2019-01-17 | It is a kind of for correcting the cornea implanted eyeglass of presbyopia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920078138.1U CN209645141U (en) | 2019-01-17 | 2019-01-17 | It is a kind of for correcting the cornea implanted eyeglass of presbyopia |
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| CN209645141U true CN209645141U (en) | 2019-11-19 |
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