CN209596410U - A kind of noninvasive neuromodulation device that physics acoustic-electric coupling stimulation is intervened - Google Patents

A kind of noninvasive neuromodulation device that physics acoustic-electric coupling stimulation is intervened Download PDF

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CN209596410U
CN209596410U CN201821926020.1U CN201821926020U CN209596410U CN 209596410 U CN209596410 U CN 209596410U CN 201821926020 U CN201821926020 U CN 201821926020U CN 209596410 U CN209596410 U CN 209596410U
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module
acoustic
electric
stimulation
signal
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赵勇
赵金萍
陈俊仁
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JIANGSU BEITAIFU MEDICAL INSTRUMENT CO Ltd
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JIANGSU BEITAIFU MEDICAL INSTRUMENT CO Ltd
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Abstract

The utility model discloses a kind of physics acoustic-electrics to couple the noninvasive neuromodulation device that stimulation is intervened, it include: system management operation module, acoustic signal generation module, electric impulse signal generation module, acoustic-electric control module, acoustic stimulation module and electric pulse stimulation module, respectively module occurs with acoustic signal for the system management operation module, electric impulse signal occurs module, acoustic stimulation module, electric pulse stimulation module and acoustic-electric control module and is attached and controls its work.Through the above way, the noninvasive neuromodulation device that physics acoustic-electric coupling stimulation described in the utility model is intervened, it can make the melody of special acoustic signal and the width and amplitude of intensity automatic adjustment electric pulse, the width of pulse and amplitude can also be made to automatically adjust the melody and intensity of special acoustic signal, implementation synchronize follow, the physical interventions nerve electric stimulation of asynchronous whole Parameter adjustables, can be used for the treatment and rehabilitation of nervus retrogression and functional disorder disease.

Description

A kind of noninvasive neuromodulation device that physics acoustic-electric coupling stimulation is intervened
Technical field
The utility model relates to medical instruments fields, couple the noninvasive mind that stimulation is intervened more particularly to a kind of physics acoustic-electric Regulated device.
Background technique
Due to the job and life stress of today's society is larger, living environment is poor and diet is irregular etc., modern is very Various chronic forms dysfunction diseases are easy to appear, for example, the diseases such as similar tinnitus, insomnia, depression, self-closing and anxiety The disease of shape can seriously injure the health safety of people if these diseases are not treated in time.Also, these chronic diseases Disease incidence is higher, with greater need for timely treatment and long-term rehabilitation.Traditional treatment has drug therapy and surgical operation therapy, but long Phase takes drugs side effect mostly and is difficult to avoid that, and performs the operation with unpredictable pernicious consequence.
Now in the art, it does not see and is combined about the stimulation of deep EEG signals with the interaction of shallow brain (body surface) electric pulse stimulation Compound noninvasive neuromodulation technology report and document.For example, application No. is 201420311215.0 utility model patents A kind of electroacoustic stimulator for treating tinnitus is disclosed, there is the electric pulse parameter for the treatment of tinnitus using computer stored, it can be according to trouble The selected mode of person generates the electric pulse of different wave, and exports electro photoluminescence, the computer by electroacupuncture stimulation device Pure tone of the frequency within the scope of 0~20KH Z can also be generated at random, and can be unordered at random by above-mentioned pure tone stimulating apparatus It plays, it is seen then that electric pulse and pure tone stimulation and onrelevant.
The product of the additional common music of electric pulse currently on the market is discrete mostly or single direction closes Connection, and music is the purpose loosened of releiving for body;Directly addition or the associated technology of single direction all do not reach In conjunction with effect is followed, personalized stimulation regulation and control scheme, while electric pulse on the market are not more manufactured according to patient test data It is all made of single one group or two groups of electric pulses, function is too single, and regulating effect is bad, is not able to satisfy the need of user It asks.
Utility model content
The utility model is mainly solving the technical problems that provide a kind of noninvasive nerve that physics acoustic-electric coupling stimulation is intervened Electric pulse and acoustic signal are generated bi-directional association by regulation device, are stimulated using deep EEG signals mutual with shallow brain electric pulse stimulation It is dynamic in conjunction with nerve stimulation regulation is carried out, promote therapeutic effect.
In order to solve the above technical problems, the technical solution that the utility model uses is: providing a kind of physics acoustic-electric coupling Close the noninvasive neuromodulation device that stimulation is intervened, comprising: module, electric pulse letter occur for system management operation module, acoustic signal Number module, acoustic-electric control module, acoustic stimulation module and electric pulse stimulation module, the system management operation module difference occurs Module occurs with acoustic signal, electric impulse signal occurs module, acoustic stimulation module, electric pulse stimulation module and acoustic-electric and controls Module is attached and controls its work, and the acoustic signal occurs module and is connected with acoustic stimulation module to send signal, The acoustic stimulation module is connected with acoustic-electric control module to be interacted, and module occurs for the electric impulse signal and electric pulse pierces Sharp module is connected to send signal, and the electric pulse stimulation module is connected with acoustic-electric control module mutually to be acted.
In one preferred embodiment of the utility model, the acoustic-electric control module includes that acoustic signal follows electric pulse to believe Number variation control module and electric impulse signal follow acoustic signal change control module.
In one preferred embodiment of the utility model, the system management operation module follows electricity with acoustic signal respectively Pulse signal variation control module follows acoustic signal variation control module to be connected and is controlled with electric impulse signal.
In one preferred embodiment of the utility model, the acoustic signal follows electric impulse signal variation control module to connect It connects between electric pulse stimulation module and acoustics stimulating module, is controlled according to the variation that electric impulse signal carries out acoustic signal.
In one preferred embodiment of the utility model, the electric impulse signal follows acoustic signal variation control module to connect It connects between acoustic stimulation module and electric pulse stimulation module, is controlled according to the variation that acoustic signal carries out electric impulse signal.
In one preferred embodiment of the utility model, the acoustic stimulation module be placed in the outside of human body, ear canal or Cochlea is stimulated eventually by ear canal in auricle, head or the body surface of human body is arranged in the electric pulse stimulation module.
The beneficial effects of the utility model are: a kind of physics acoustic-electric coupling stimulation intervention that the utility model is pointed out is noninvasive Neuromodulation device realizes that deep EEG signals stimulation is combined with the interaction of shallow brain electric pulse stimulation, makes the melody of special acoustic signal With the width and amplitude of intensity automatic adjustment electric pulse, the width of pulse and amplitude can also be made to automatically adjust special acoustic signal Melody and intensity, then respectively by being placed on the Sound stimulat earphone of ear canal inside/outside or external loudspeaker and being attached to scalp or body surface On electric pulse stimulation electrode implementation synchronize follow, the physical interventions nerve electric stimulation of asynchronous whole Parameter adjustables, Ke Yiyong In the treatment and rehabilitation of nervus retrogression and functional disorder disease.
Detailed description of the invention
It, below will be to required in embodiment description in order to illustrate more clearly of the technical scheme in the embodiment of the utility model Attached drawing to be used is briefly described, it should be apparent that, the accompanying drawings in the following description is only some realities of the utility model Example is applied, it for those of ordinary skill in the art, without creative efforts, can also be according to these attached drawings Obtain other attached drawings, in which:
Fig. 1 is a kind of noninvasive one preferred embodiment of neuromodulation device that physics acoustic-electric coupling stimulation is intervened of the utility model Structural schematic diagram;
Fig. 2 is the circuit diagram of acoustic stimulation module in Fig. 1;
Fig. 3 is the operation schematic diagram of acoustic stimulation module in Fig. 1;
Fig. 4 is the circuit diagram that acoustic signal follows electric impulse signal variation control module in Fig. 1;
Fig. 5 is the circuit diagram that electric impulse signal follows acoustic signal variation control module in Fig. 1;
Fig. 6 is the circuit diagram of electric pulse stimulation module in Fig. 1;
Fig. 7 is the operation schematic diagram of electric pulse stimulation module in Fig. 1.
Specific embodiment
Below by the technical scheme in the utility model embodiment is clearly and completely described, it is clear that described Embodiment is only a part of the embodiment of the utility model, instead of all the embodiments.Based on the implementation in the utility model Example, all other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to The range of the utility model protection.
Fig. 1 ~ Fig. 7 is please referred to, the utility model embodiment includes:
A kind of noninvasive neuromodulation device that physics acoustic-electric coupling stimulation is intervened, comprising: system management operation module, acoustics Module, acoustic-electric control module, acoustic stimulation module and electric pulse stimulation module, institute occur for signal generating module, electric impulse signal Stating acoustic-electric control module includes that acoustic signal follows electric impulse signal variation control module and electric impulse signal to follow acoustic signal Change control module.
Respectively module occurs with acoustic signal for the system management operation module, module occurs for electric impulse signal, acoustics pierces Swashing module, electric pulse stimulation module, acoustic signal follows electric impulse signal variation control module and electric impulse signal to follow acoustics Signal intensity control module is attached and controls its work, as shown in Figure 1, system management operation module is used to carry out the present apparatus Operation, include is the function set being configured to system function and parameter, its effect be exactly according to everyone not With detection and treatment results value, system operation does different algorithms and obtains different treatment data output valves, reaches system operation Preparation, be the basis that other functions of modules operate normally, each functional module commanded to work, be by embedding operation software, management Unite software, hard disk, storage, USB interface, keyboard, button, the composition such as power supply, can manually or automatically operating system, do not With algorithm, different accurate treatment data output valves is obtained, to commander and ensure the correct of other functions of modules and system Operation;
Module occurs for acoustic signal, is a kind of energy for generating frequency as waveforms basis signals such as the sines of 0~20kHz The module of various frequencies, waveform and output level electric signal is provided;
Acoustic stimulation module, the acoustic signal occurs module and is connected with acoustic stimulation module to send signal, described Acoustic stimulation module follows electric impulse signal variation control module and electric impulse signal to follow acoustic signal with acoustic signal respectively Variation control module, which is connected, to be interacted, and by software algorithm or is combined the feedback data acquired, is obtained suitable output Data segment automatically controls the output of various wavy curves, can generate multiple waveforms, including but not limited to triangular wave, sawtooth wave, Rectangular wave (containing square wave), sine wave signal, pass through the single waveform of the above waveform, the stack combinations of two waveforms, three waveforms Stack combinations, wait the stack combinations of multiple waveforms, exactly special acoustic signal stimulation cochlea is converted into special electric signal, telecommunications While number being transferred to nerve center and perimeter systems along auditory nerve, that activates on nerve fibre a large amount of has a point excitability Neuron, when stimulation be more than its threshold value when, neuron depolarising generate action potential, formed electric signal one from nerve fibre End flows to the other end, the electric signal that these neuron action potentials are formed, and will rush existing hash in random nervous system, makes Its desynchronization, so that the normal function for reducing or removing hash, restoring nervous centralis, i.e. maincenter are remolded again, reach and control The purpose of the neurological dysfunctions such as tinnitus, sleep disturbance, melancholy and anxiety function is treated, schematic diagram is shown in that Fig. 2, schematic diagram are shown in Fig. 3;
U1 in Fig. 2 is a kind of hardware realizing sound wave digital signal and mutually converting, and internal DAC and ADC support 8~96 KHz sample rate possesses more filter capacitors and power tube, the signal amplification by grade for several times, Dolby circuit, so that output The signal accuracy of audio is promoted, and balanced device is integrated, to compensate the frequency response of earphone, so sound quality output effect is more preferable;
Acoustic signal follows electric impulse signal to change control module (see figure 4), when having electric pulse output, AD detection circuit pair The amplitude size of electric pulse output is detected (peak value), and the data feedback after detection to cpu circuit is obtained by software algorithm Data automatically control the loudness of special acoustic signal output, and the loudness of output follows electric pulse to change and change, this is designed It can more targetedly be treated to patient, more fully effect is experienced;
U2 in Fig. 4 realizes detection and operation, and there are double computing circuits of independent, high-gain, internal frequency compensation in inside, The peak values in real time amplitude of electric pulse is detected by peak-detector circuit using audio amplitude acquiring unit, and exports corresponding voltage Value, master control obtain the voltage by ADC to obtain the power of electric pulse, and strong and weak by electrical pulse amplitudes controls the big of sound Small, electrical pulse amplitudes are stronger, then sound is bigger, conversely, sound is smaller;
Electric impulse signal follows acoustic signal to change control module, when having the output of special acoustic signal, detects electricity using AD The amplitude size that special acoustic signal exports is detected on road, and the data after detection are sent to cpu circuit, is obtained by software algorithm Data automatically control the width and amplitude of electric pulse out, and electric pulse follows sound to change and change, pass through physics electric pulse stimulation The more acupuncture points of epidermis, dredging the channel, and combine and micro- electricity is converted out by physics sound, stimulated and adjusted the excitement and inhibition of nerve Performance, this design can bring more good stimulation or treatment to user, experience with more fully effect;
Module occurs for electric pulse, and the electric impulse signal occurs module and is connected with electric pulse stimulation module to send letter Number, the electric pulse stimulation module follows electric impulse signal variation control module and electric impulse signal to follow with acoustic signal respectively Acoustic signal variation control module, which is connected, mutually to be acted, and it is bent to automatically control various waveforms to obtain data by software algorithm Line can indicate that module, which occurs, for electric pulse to generate a variety of waves using function signal generator with trigonometric function equation Shape, including but not limited to triangular wave, sawtooth wave, rectangular wave (containing square wave) and sine wave;
The circuit of electric pulse stimulation module, electric pulse stimulation module is made of multiple groups independence electrical pulse circuit, including but not It is limited to 1-10 group electric pulse, electric pulse simulates massage great master's gimmick and massages, while including but not limited to 10-128 group is only Vertical electric pulse, can be massaged to physical feelings such as head, neck, shoulder, back, hand leg and foots by pulse, can be stimulated Shallow cranial nerve relaxs one's muscles and mitigates the movement pain of injury, and help restores physical function, and the vigor of activated cell accelerates disease sites Healing or the state of an illness restore, improve body immunity, fast quick-recovery physical function, schematic diagram is shown in that Fig. 6, schematic diagram are shown in Fig. 7;
L1 in Fig. 6 is inductance, and after control signal is controlled (switch periods repeatedly) work to Q1, L1 will be generated The voltage of stored current, output capacitance increases, so that output voltage is higher than input voltage, when there is voltage output, (micro- electricity Stream) pulse to physical feelings such as head or body surfaces carries out stimulation massage, and Q2 and Q3 form multiplex output circuit.
Each acupuncture point of human body surface can correctly correspond to human health Pathological Information, these information feedback is arrived in turn Inside of human body gives the stimulation (forming external electrical) of its electric impulse signal, passes through human body ear in combination with special acoustic signal Snail carries out acoustic stimulation, and the electric signal of cochlea conversion carries out electro photoluminescence to the sense of hearing and maincenter, and special acoustic signal is turned by cochlea It is changed to special electric signal (forming internal electricity).If sound amplitude is 0 ~ 30 grade, when the output amplitude for adjusting special acoustic signal is At 20 grades, i.e. the output analog electrical signal that is certain numerical value, by detection circuit to the analog electrical signal amplitude size of output into Row detection, the data after detection are sent to cpu circuit, obtain numerical value by a series of algorithm of software, then automatically control electric pulse Output width and output amplitude so that electric pulse follows acoustic signal to change and change generate the knot of internal electricity and external electrical It closes, potential difference is automatically formed in conjunction with after, to make electric signal one end from nerve fibre flow to the other end, when stimulation is more than threshold value When, the electric signal that these neuron action potentials are formed will rush existing hash in random nervous system, allow nervous centralis function Energy desynchronization allows the nerve remolded by dysfunction to realize and remolds again, reach and control to restore the normal function of nervous centralis Treat sleep disturbance, the purpose of melancholy and anxiety function.
Conversely, when the amplitude output amplitude for adjusting electric pulse is 6 grades, that is, being exported if the amplitude of electric pulse is 0 ~ 10 grade For the voltage of certain numerical value, detected by voltage amplitude size of the detection circuit to output, the data after detection are sent to CPU Circuit obtains numerical value, then the output amplitude of the special acoustic signal of automatic control and adjustment by a series of algorithm of software, so that sound Learning signal follows electric pulse to change and change, and generates the combination of external electrical and internal electricity.External electrical and inside are automatic after being electrically coupled Potential difference is formed, so that electric signal one end from nerve fibre is made to flow to the other end, when stimulation is more than threshold value, these neurons The electric signal that action potential is formed will rush existing hash in random nervous system, allow central functions desynchronization, from And restore the normal function of nervous centralis, it allows the nerve remolded by dysfunction to realize and remolds again, reach treatment sleep disturbance, control Treat melancholy and anxiety function purpose.
Wherein, internal electricity: putting on earphone, and special acoustic signal is incoming from external auditory canal, and eardrum is caused to shake, and drives auditory ossicular chain Movement, causes i-coch lymph vibration cycles, i-coch hair cell is made to do cutting movement, by acoustics (mechanical oscillation) Signal is converted to electric signal, forms internal electric signal;
External electrical: by conductor wire and 10 groups of conductive sheets, conductive sheet is circular ring shape, and the edge of circular ring shape is inside at 60 degree, Circular ring shape protrusion is formed, to embody and human epidermal or head comprehensive engagement, 10 groups of conduction electric pulse cycle operations, using frequency arteries and veins Electricity is rushed, deep layer stimulates human body cell and related acupuncture point, conducts new biological electrical pulse energy rapidly, forms external electrical arteries and veins Punching.
Internal electric signal carries out deep EEG signals stimulation, and external electric pulse carries out shallow brain (body surface) electric pulse stimulation, formed The compound noninvasive neuromodulation technology that deep EEG signals stimulation and the interaction of shallow brain (body surface) electric pulse stimulation combine.Believed by acoustics It number controls to adjust the parameter of electric pulse and controls to adjust the parameter of acoustic signal by electric pulse, special acoustic signal passes through cochlea Being converted into special electric signal (micro- electricity) and physics electric pulse and forming electrical pulse and follow mutually with interior electric signal is stimulated, and is provided A kind of brand-new accurate treatment or method of rehabilitation, are not necessarily to drug and operation, avoid the side effect of prolonged administration of drugs with And the operation unpredictable pernicious consequence of bring, it is applied widely.
The above description is only the embodiments of the present invention, and therefore it does not limit the scope of the patent of the utility model, all Using equivalent structure or equivalent flow shift made by the utility model description, it is applied directly or indirectly in other phases The technical field of pass, is also included in the patent protection scope of the utility model.

Claims (6)

1. a kind of noninvasive neuromodulation device that physics acoustic-electric coupling stimulation is intervened characterized by comprising system management operation Module occurs for module, acoustic signal, electric impulse signal occurs module, acoustic-electric control module, acoustic stimulation module and electric pulse and pierces Swash module, respectively module occurs with acoustic signal for the system management operation module, module, acoustic stimulation occur for electric impulse signal Module, electric pulse stimulation module and acoustic-electric control module are attached and control its work, and module occurs for the acoustic signal It is connected with acoustic stimulation module to send signal, the acoustic stimulation module is connected with acoustic-electric control module to be interacted, The electric impulse signal occurs module and is connected with electric pulse stimulation module to send signal, the electric pulse stimulation module and sound Electric control module, which is connected, mutually to be acted.
2. the noninvasive neuromodulation device that physics acoustic-electric coupling stimulation according to claim 1 is intervened, which is characterized in that institute Stating acoustic-electric control module includes that acoustic signal follows electric impulse signal variation control module and electric impulse signal to follow acoustic signal Change control module.
3. the noninvasive neuromodulation device that physics acoustic-electric coupling stimulation according to claim 2 is intervened, which is characterized in that institute State system management operation module follows electric impulse signal variation control module and electric impulse signal to follow sound with acoustic signal respectively Signal intensity control module, which is connected, to be controlled.
4. the noninvasive neuromodulation device that physics acoustic-electric coupling stimulation according to claim 2 is intervened, which is characterized in that institute Stating acoustic signal follows electric impulse signal variation control module to be connected between electric pulse stimulation module and acoustics stimulating module, root The variation control of acoustic signal is carried out according to electric impulse signal.
5. the noninvasive neuromodulation device that physics acoustic-electric coupling stimulation according to claim 1 is intervened, which is characterized in that institute Stating electric impulse signal follows acoustic signal variation control module to be connected between acoustic stimulation module and electric pulse stimulation module, root The variation control of electric impulse signal is carried out according to acoustic signal.
6. the noninvasive neuromodulation device that physics acoustic-electric coupling stimulation according to claim 1 is intervened, which is characterized in that institute Acoustic stimulation module is stated to be placed in outside, ear canal or the auricle of human body eventually by ear canal stimulation cochlea, the electric pulse thorn Head or the body surface of human body is arranged in sharp module.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364370A (en) * 2018-11-22 2019-02-22 江苏贝泰福医疗科技有限公司 A kind of method and device that acoustic-electric regulates and controls mutually, coupling is followed to stimulate
CN113995667A (en) * 2021-11-04 2022-02-01 中国中医科学院中医基础理论研究所 APP-based multifunctional electronic acupuncture earphone

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364370A (en) * 2018-11-22 2019-02-22 江苏贝泰福医疗科技有限公司 A kind of method and device that acoustic-electric regulates and controls mutually, coupling is followed to stimulate
CN109364370B (en) * 2018-11-22 2024-02-13 江苏贝泰福医疗科技有限公司 Method and device for mutually regulating and controlling acoustoelectric and following coupling stimulation
CN113995667A (en) * 2021-11-04 2022-02-01 中国中医科学院中医基础理论研究所 APP-based multifunctional electronic acupuncture earphone
CN113995667B (en) * 2021-11-04 2023-09-22 中国中医科学院中医基础理论研究所 APP-based multifunctional electronic acupuncture earphone

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