CN209574954U - A kind of skull hole sealing-plug of intracranial hypertension animal model - Google Patents

Abstract

The utility model discloses a kind of skull hole sealing-plugs of intracranial hypertension animal model, belong to sealing device field, are especially used for the sealing of animal skull.In view of the above-mentioned problems, making ideal intracranial hypertension animal model needs to design a kind of novel skull hole sealing-plug, problem to be solved is as follows: 1. good watertightnesses；2. good biocompatibility；3. being not easy to slip after implantation；4. facilitating taking-up；5. can with converted steel needle cannula is closed is connected.According to above-mentioned summary, technical solutions of the utility model are a kind of skull hole sealing-plug of intracranial hypertension animal model, which includes: sealing bar and seal cap, and sealing bar is vertically fixed in seal cap, the sealing bar be it is cylindric, the material of the sealing-plug is soft elastic material.The utility model passes through specific experiment, has good watertightness, and good biocompatibility after implantation, is not easy to slip, facilitates taking-up, can with converted steel needle cannula is closed is connected.

Description

A kind of skull hole sealing-plug of intracranial hypertension animal model

Technical field

The utility model belongs to sealing device field, is especially used for the sealing of animal skull.

Background technique

Intracranial hypertension animal model establishes multiselect exterior dura water pocket compression method (document 1,2) at present, and it is big to open cranium pillow Cisternal puncture method (document 3), which is inserted into, is perfused syringe needle, the Inject into cerebellomedullary cistern physiology to animal after insertion needle again at regular time and quantity Salt water or artificial cerebrospinal fluid, having scholar is to establish stable animal model intracranial pressure also to have attempted using thermostatic bath heating perfusion Liquid, and (document 4,5) is perfused with constant pressure infusing instrument.Above method mostly uses out after cranium directly to Cistern magna or cerebellum oblongata General injection needle (document 1.2.4.5) is inserted directly into pond, after being inserted into sphenotresia and the ventricles of the brain, because of its syringe needle itself The reason of sclerotin caused by rigidity is rigid and in operation is worn, prevents syringe needle from fitting closely with connective tissue or bone tissue, Leakage occurs often.In order to solve the problems, such as leakage, there is scholar to close using venous catheter needle (document 3) or using self-curing denture acrylic Bone window (document 2), but two methods still cannot be completely closed sphenotresia, and venous cannula is easy to slip, and tooth shedding is sealed It is big to close irritation, histocompatbility is poor, slightly mobile after solidification to cause to leak.

1. Liu Yunsheng, Liu Shangming, Liu Zhixiong, Chen Ling, Jian Wang, in Zhu Jian female (2001) rabbit model of acute intracranial hypertension The variation Central South University journal (medicine) of somatosensory evoked potentials and auditory evoked potential, 26 (3), 197.

2. Wan Jingwen, Wu Gang, Lin Jiandong, Zheng increases building for animal model according to brave (2009) acute focal intracranial pressure Vertical and intracranial pressure increases the experimental study China Ultrasonic tomography magazine to transcranial Doppler spectral contributions, 18 (2), 163- 166.

3. thank to macro, Liu Yunsheng, Liu Shang bright (2008) rabbit Acute Diffuse intracranial hypertension model tcd parameter and intracranial pressure and Magazine, 12 (1), 1-5. are learned in the correlation research contemporary Chinese operation of cerebral perfusion pressure

4. Zhao's twilight, Xia Zuoli, bent an ancient unit of weight celebrating (1987) introduce a kind of new side for replicating acute intracranial hypertension animal model Method Taishan Hospital journal (2)

A kind of production method Weifang Medical College journal of intracranial hypertension animal model of Tang Kexin, Li Ning 5. (1994) (3),236-237.

Summary of the invention

In view of the above-mentioned problems, making ideal intracranial hypertension animal model needs to design a kind of novel skull hole sealing Plug, problem to be solved are as follows: 1. good watertightnesses；2. good biocompatibility；3. being not easy to slip after implantation； 4. facilitating taking-up；5. can with converted steel needle cannula is closed is connected.

According to above-mentioned summary, technical solutions of the utility model are a kind of skull hole sealing-plug of intracranial hypertension animal model, The sealing-plug includes: sealing bar and seal cap, and sealing bar is vertically fixed in seal cap, the sealing bar be it is cylindric, it is described The material of sealing-plug is soft elastic material.

Further, the sealing bar includes head section and endpiece, and endpiece is connect with seal cap；The head section body diameter from Top is linearly increasing to tail end；The diameter of the endpiece is fixed, equal with the diameter on head section top.

Further, the material of the sealing-plug is silicon rubber.

Further, the seal cap is round or polygon, and the side that seal cap is not connect with sealing bar is arranged cyclic annular Protrusion.The annular projection facilitates syringe needle positioning, and also aspect uses clip to extract seal cap.

Further, the long 0.5mm of sealing bar head section, the long 1mm of endpiece, diameter include three kinds of sizes: (1) pushing up in head section End diameter is 1.00mm, and tail end diameter is 1.25mm；(2) top end diameter is 1.25mm in head section, and tail end diameter is 1.50mm； (3) top end diameter is 1.50mm in head section, and tail end diameter is 1.75mm.

The present invention passes through specific experiment, has good watertightness, and good biocompatibility after implantation, is not easy to slip, Facilitate taking-up, can with converted steel needle cannula is closed is connected.

Detailed description of the invention

Fig. 1 is a kind of front view of the skull hole sealing-plug of intracranial hypertension animal model of the utility model；

Fig. 2 is a kind of stereoscopic schematic diagram of the skull hole sealing-plug of intracranial hypertension animal model of the utility model.

Specific embodiment

As a comparison: when establishing intracranial hypertension model, having developed vagina nervi optici internal pressure measuring cell using having designed It high-precision can measure tiny pressure change (precision has reached 1mm water column) and survey pressure, however, it was found that the pressure transient of measurement, is surveyed Magnitude is less than normal；Estimating may be sphenotresia leakage, then close bone window using with self-curing denture acrylic, but because of its histocompatbility Difference, the problem of stickiness difference, the phenomenon that leading to leakage, it is still undesirable to survey pressure result.And self-curing denture acrylic and denture fixing device liquid pair The irritation of animal and experimenter are too big, increase difficulty for experiment.

Preliminary experimental verification has been carried out using the utility model method, and rabbit head is first drilled in using cranium and drills through size 1.25mm Drilling, the sealing bar that then diameter is 1.50mm are inserted into sphenotresia, are inserted into syringe needle and carry out survey pressure, measured value is steady as the result is shown It is fixed and accurate.The above results show that good leakproofness can be obtained using sealing-plug.And it is to be taken off after avoiding, anticreep is added Fall design.The above results show this novel skull hole sealing-plug, can help to establish ideal intracranial hypertension model accurate Measure intracranial pressure.And the good biocompatibility used, it can sterilize, hardness and the good medical grade silicon rubber material of elasticity, more favorably In development zoopery.

Using medical grade silicon rubber material, based on the good biocompatibility that it is highlighted in clinical application, hardness is drawn Elongation and tearability, and it can be sterilized, and it is preferable to use it to production sealing-plug.The mouth size of sealing-plug is slightly larger compared with drill mouth, existing We use be by RWD Life Science Co., Ltd. Shenzhen production miniature cranium bore, specification be diameter The drill bit of 0.75mm, 1.00mm, 1.25mm, matched sealing-plug can be controlled in diameter and correspond to 1.00mm, 1.25mm, 1.50mm, it is slightly bigger than normal because finding that the size of drilling may be influenced by operator and external factor during the test.Hereafter its Model can carry out matching production according to drilling size.

Clinic is always the more difficult project captured for the research of intracranial hypertension, nowadays can accurately measurement experiment animal Intracranial pressure is for building animal model, and simulates clinically relevant intracranial hypertension complication and have great importance, for encephalic The Mechanism Study of every complication of high pressure, diagnoses and treatment help striking.Consult pertinent literature and newspapers and periodicals, the money such as network Source, discovery has no the comparable instrument of identical or function can use for experimenter, once exploitation, intracranial hypertension research will be solved Certainly related experiment project problem uses for other experimenters for constructing view intracranial hypertension model.During the experiment, avoid because Intracranial pressure can not accurately be controlled and caused by animal dead, the possible economic loss such as experimental result inaccuracy.

Claims (3)

1. a kind of skull hole sealing-plug of intracranial hypertension animal model, which includes: sealing bar and seal cap, and sealing bar is hung down Directly be fixed in seal cap, it is characterised in that the sealing bar be it is cylindric, the material of the sealing-plug is soft elastic material； The material of the sealing-plug is silicon rubber；The sealing bar includes head section and endpiece, and endpiece is connect with seal cap；The head section circle Column diameter is linearly increasing from top to tail end；The diameter of the endpiece is fixed, equal with the diameter on head section top.

2. a kind of skull hole sealing-plug of intracranial hypertension animal model as described in claim 1, it is characterised in that the sealing Cap is round or polygon, and annular projection is arranged in the side that seal cap is not connect with sealing bar；The annular projection facilitates syringe needle fixed Also aspect uses clip to extract seal cap for position.

3. a kind of skull hole sealing-plug of intracranial hypertension animal model as described in claim 1, it is characterised in that the sealing Head segment length 0.5mm, the long 1mm of endpiece, diameter are one of three kinds of sizes:

(1) top end diameter is 1.00mm in head section, and tail end diameter is 1.25mm；

(2) top end diameter is 1.25mm in head section, and tail end diameter is 1.50mm；

(3) top end diameter is 1.50mm in head section, and tail end diameter is 1.75mm.