CN209549440U - A kind of preparation facilities of uniform grading gelatin embolism agent - Google Patents
A kind of preparation facilities of uniform grading gelatin embolism agent Download PDFInfo
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- CN209549440U CN209549440U CN201821919526.XU CN201821919526U CN209549440U CN 209549440 U CN209549440 U CN 209549440U CN 201821919526 U CN201821919526 U CN 201821919526U CN 209549440 U CN209549440 U CN 209549440U
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Abstract
The utility model discloses a kind of preparation facilities of uniform grading gelatin embolism agent, which includes: dispersed phase syringe, continuous phase syringe, dispersed phase syringe pump, continuous phase syringe pump, micro passage reaction, radiation source device and collection vessel.Dispersed phase syringe pump, continuous phase syringe pump are respectively placed in dispersed phase syringe and continuous phase syringe, and the T-shape microchannel of micro passage reaction is connected for shearing gelatine microsphere, it shears the gelatine microsphere formed and is wound on radiation source device in microchannel with certain rate, it is collected in container after overshoot, then washed dehydration obtains gelatin microsphere embolization agent.Utility model device preparation gelatine microsphere roundness is good, uniform particle sizes and there is certain elasticity and dilatancy, microspherulite diameter to be distributed in any relatively narrow range of 50~1000um.
Description
Technical field
The utility model relates to interventional medicine field of material technology, particularly relate to a kind of for the bright of embolotherapy
The application of glue embolization agent preparation facilities.
Background technique
Minimally-invasive vascular intervenien therapy technology is gradually promoted at home in recent years as emerging medicine,
Therapeutic effect gains universal acceptance.Its general procedure be under the guiding of medical imaging device, it is selective to intervene Medical treatment device
Tool is sent to many vitals of human body and position through naturally occurring blood vessel access, such as: heart, liver, brain, kidney, digestive system
And reproductive system, it is the important technology and method for carrying out diagnosing and treating, has without operation, wound is small, medical expense is opposite
Cheap advantage.
Progress of the treatment and effect of interventional medicine highly dependent upon related equipment and material, Endovascular Embolization material, especially
It is that gelatin particle embolism materials play essential effect in the treatment of minimally invasive interventional medicine.Excellent embolism materials are in the blood vessels
In interventional procedure, with its good biocompatibility, controllable internal degradation rate, antigenic extremely faint, embolism materials
Grain size can select the characteristics of, in vascular malformation occlusion, body vessel rupture urgent quick-acting haemostatic powder, inhibit tumour production,
It blocks internal abnormal blood flow channel, tissue blood flow to redistribute again, carry curative drug or bioactive molecule (such as gene material
Material, stem cell, immune vaccine, anticancer drugs, tracer material etc.) etc. diagnosing and treating during play irreplaceable work
With.Novel embolism materials will further widen use scope and medical effect, make to intervene intravascular diagnosing and treating field
Application prospect is more wide.
Gelatin is a kind of natural high-molecular compound, has good biocompatibility, the spies such as cheap, water imbibition is strong
Point, is widely used in embolotherapy.It is domestic at present clinical mainly using absorbable gelatin sponge particle suppository or the gelatin shredded sea
Silk floss, there are no gelatin microsphere embolization agent listings.According to the literature, microballoon class suppository can more embolism to distal vessels,
Better than granular pattern suppository, it is therefore necessary to optimize microspheric gelatin embolism agent.
The raying that the preparation equipment and method of the prior art are dripped due to gelatine microsphere is uneven, it cannot be guaranteed that gelatine microsphere
The preparation effect of uniformity, therefore the prior art has much room for improvement.
Summary of the invention
Preparation facilities described in the utility model is a kind of preparation facilities of gelatine microsphere, and the microballoon of device preparation can be straight
It connects for blood vessel embolism, embolism can also be used for after attached medicine.
A kind of preparation facilities of uniform grading gelatin embolism agent, the device include: dispersed phase syringe, continuous phase injection
Device, dispersed phase syringe pump, continuous phase syringe pump, micro passage reaction, radiation source device and collection vessel.Dispersed phase syringe pump,
Continuous phase syringe pump is respectively placed in dispersed phase syringe and continuous phase syringe, and micro- by the T-shape of micro passage reaction
Channel part connection, another part of micro passage reaction are wound on radiation source device, and collection vessel is placed under radiation source device
Side.
Further, a kind of preparation facilities of uniform grading gelatin embolism agent, which is characterized in that the dispersed phase syringe pump
It is connect by stirring rod with dispersed phase syringe, stirring club head is screw thread rotation head.
Further, a kind of preparation facilities of uniform grading gelatin embolism agent, which is characterized in that the continuous phase syringe pump
It is connect by stirring rod with continuous phase syringe, stirring club head is screw thread rotation head.
Further, a kind of preparation facilities of uniform grading gelatin embolism agent, which is characterized in that the micro passage reaction
Including T-shape microchannel and winding radiation source microchannel two parts；The micro-pipe diameter of the micro passage reaction is in 0.2~2mm.
A kind of preparation facilities of uniform grading gelatin embolism agent, the device preparation process the following steps are included:
The injection of step 1, dispersed phase and continuous phase solution:
Dispersed phase: preparing dispersed phase solution, injects in dispersed phase syringe；
Continuous phase: preparing continuous phase solution, injects in continuous phase syringe；
Step 2, the formation of gelatine microsphere:
Dispersed phase and continuous phase described in step 1 are passed through into dispersed phase syringe pump and continuous phase syringe pump connecting T-shaped respectively
Microchannel flows through dispersed phase in micro passage reaction and is sheared by continuous phase, not medium well by controlling the flow velocity of two syringe pumps
At w/o type gelatin drop of uniform size, appearance rounding；
Step 3, the collection of gelatine microsphere:
The gelatin drop that step 2 shearing is generated is in microchannel by being collected in appearance after being wrapped in radiation source certain distance
In device；The radiation source is gamma-rays, and radiation source intensity is 10~80kGy, and radiation source is 5~30cm apart from gelatin drop；
Step 4, separation, the drying of gelatine microsphere:
Cured gelatine microsphere is sunken to container bottom, removes upper oil phase, uses isopropanol mode of washing after supplementing pure water
Gelatine microsphere by gelatine microsphere and residual separation of oil and after being dried.
Further, in step 1, the gelatin mass concentration in aqueous gelatin solution mixture is 10~30%, photoinitiator
Concentration be 0.1~1%, the photoinitiator include one of Irgacure2959 photoinitiator, 819 photoinitiators or
The solution of Irgacure2959 photoinitiator, 819 photoinitiators being mixed to form.
Further, in step 1, concentration containing surfactant qualities is 1~20% in continuous phase, the surface-active
Agent includes that one of span80 activating agent, span60 activating agent, tween20 activating agent or the combination of any two are formed, institute
State the oily mutually mixture including one of vegetable oil, mineral oil or vegetable oil, mineral oil.
Further, in step 2, the microchannel is the micro-pipe of T-shape structure, the diameter of the microchannel 0.2~
2mm；Gelatin drop forming process is completed in the T-shape structure of microchannel；The dispersed phase and the flow rate of continuous phase point
It Wei not 0.2~2mL/h, 4~15mL/h.
Further, in step 3, through microchannel, the required time into container is 1~20min to the gelatin solution drip.
The beneficial effects of the utility model are: the gelatine microsphere roundness of utility model device preparation is good, uniform particle sizes
And there is certain elasticity and dilatancy, microspherulite diameter to be distributed in any relatively narrow range of 50~1000um, compensate for the current country
The deficiencies in the prior art.
Detailed description of the invention
Fig. 1 is the preparation facilities schematic diagram of uniform grading gelatin embolism agent of the present invention.
Specific embodiment
Son is described further the utility model with reference to the accompanying drawings and examples.
Attached drawing 1 is please referred to, a kind of preparation facilities of uniform grading gelatin embolism agent, which includes: dispersed phase syringe
1, continuous phase syringe 7, dispersed phase syringe pump 2, continuous phase syringe pump 6, micro passage reaction 3, radiation source device 4, collection are held
Device 5.Dispersed phase syringe pump 2, continuous phase syringe pump 6 are respectively placed in dispersed phase syringe 1 and continuous phase syringe 7, and are passed through
The T-shape channel portion of micro passage reaction 3 connects, and another part of micro passage reaction 3 is wound on radiation source device 4,
Collection vessel 5 is placed in 4 lower section of radiation source device.
Further, the micro passage reaction 3 includes T-shape microchannel and winding radiation source microchannel two parts；Institute
The micro-pipe diameter of micro passage reaction 3 is stated in 0.2~2mm.
A kind of preparation facilities of uniform grading gelatin embolism agent, the device preparation process the following steps are included:
The injection of step 1, dispersed phase and continuous phase solution:
Dispersed phase: it prepares in dispersed phase solution injection dispersed phase syringe 1；
Continuous phase: it prepares in continuous phase solution injection continuous phase syringe 7；
Step 2, the formation of gelatine microsphere:
By dispersed phase syringe 1 described in step 1 and continuous phase syringe 7, the T-shape by micro passage reaction 3 is micro-
Channel connection is 1mL/h by the flow that dispersed phase syringe pump 2 adjusts dispersed phase solution, is adjusted and connected by continuous phase syringe pump 6
The flow of continuous phase solution is 10mL/h, flows through dispersed phase and is sheared in micro passage reaction 3 by continuous phase, it is equal to be continuously generated size
Even, appearance rounding w/o type gelatin drop；
Step 3, the collection of gelatine microsphere:
The gelatin drop that step 2 shearing generates is collected after microchannel passes through and is wrapped in radiation 4 certain distance of source device
In container 5, the radiation source is gamma-rays, and radiation intensity 30kGy, adjusting radiation source apart from gelatin drop is 20cm；
Step 4, gelatine microsphere separation, drying:
Microballoon is 2min by the microtubular time, obtains the microsphere particle that partial size is 150 μm, and cured gelatine microsphere is sunken to
5 bottom of container removes upper oil phase, uses isopropanol mode of washing for gelatine microsphere after supplementing pure water and remains separation of oil simultaneously
Freeze-drying, solidification.
Further, in step 1, the gelatin mass concentration in aqueous gelatin solution mixture is 10~30%, photoinitiator
Concentration be 0.1~1%, the photoinitiator include one of Irgacure2959 photoinitiator, 819 photoinitiators or
The solution of Irgacure2959 photoinitiator, 819 photoinitiators being mixed to form.
Further, in step 1, concentration containing surfactant qualities is 1~20% in continuous phase, the surface-active
Agent includes that one of span80 activating agent, span60 activating agent, tween20 activating agent or the combination of any two are formed, institute
State the oily mutually mixture including one of vegetable oil, mineral oil or vegetable oil, mineral oil.
Further, in step 2, the microchannel is the micro-pipe of T-shape structure, the diameter of the microchannel 0.2~
2mm；Gelatin drop forming process is completed in the T-shape structure of microchannel；The dispersed phase and the flow rate of continuous phase point
It Wei not 0.2~2mL/h, 4~15mL/h.
Further, in step 3, through microchannel, the required time into container is 1~20min to the gelatin solution drip.
The foregoing is merely one of specific embodiments of the present invention, but the protection scope of the utility model is not limited to
This, anyone skilled in the art can carry out the utility model under the premise of without departing from the utility model technical principle
It improves or replaces, but these are improved and replacement is encompassed by within the protection scope of the utility model.
Claims (4)
1. a kind of preparation facilities of uniform grading gelatin embolism agent, which is characterized in that the device include: dispersed phase syringe (1),
Continuous phase syringe (7), dispersed phase syringe pump (2), continuous phase syringe pump (6), micro passage reaction (3), radiation source device (4)
With collection vessel (5), dispersed phase syringe pump (2), continuous phase syringe pump are respectively placed in dispersed phase syringe (1) and continuous phase injection
In device (7), and connected by the T-shape channel portion of micro passage reaction (3), another part of micro passage reaction (3)
It is wound in radiation source device (4), collection vessel (5) is placed in below radiation source device (4).
2. a kind of preparation facilities of uniform grading gelatin embolism agent according to claim 1, which is characterized in that the dispersion
Phase syringe pump (2) is connect by stirring rod with dispersed phase syringe (1), and stirring club head is screw thread rotation head.
3. a kind of preparation facilities of uniform grading gelatin embolism agent according to claim 1, which is characterized in that described continuous
Phase syringe pump (6) is connect by stirring rod with continuous phase syringe (7), and stirring club head is screw thread rotation head.
4. a kind of preparation facilities of uniform grading gelatin embolism agent according to claim 1, which is characterized in that described micro- logical
Road reactor (3) includes T-shape microchannel and winding radiation source microchannel two parts；The micro-pipe of the micro passage reaction (3)
Diameter is in 0.2~2mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821919526.XU CN209549440U (en) | 2018-11-21 | 2018-11-21 | A kind of preparation facilities of uniform grading gelatin embolism agent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821919526.XU CN209549440U (en) | 2018-11-21 | 2018-11-21 | A kind of preparation facilities of uniform grading gelatin embolism agent |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021204280A1 (en) * | 2020-04-10 | 2021-10-14 | 百剂博递医药科技(上海)有限公司 | Reaction device, microsphere preparation device and extraction method and liposome drug loading method |
| CN114392384A (en) * | 2021-12-24 | 2022-04-26 | 河南驼人医疗器械研究院有限公司 | Method for preparing high drug-loading rate embolism microsphere and collecting device |
| CN115252882A (en) * | 2022-07-23 | 2022-11-01 | 深圳市联科翰微医疗科技有限公司 | Visible gelatin embolism microsphere manufacturing process |
-
2018
- 2018-11-21 CN CN201821919526.XU patent/CN209549440U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021204280A1 (en) * | 2020-04-10 | 2021-10-14 | 百剂博递医药科技(上海)有限公司 | Reaction device, microsphere preparation device and extraction method and liposome drug loading method |
| CN114392384A (en) * | 2021-12-24 | 2022-04-26 | 河南驼人医疗器械研究院有限公司 | Method for preparing high drug-loading rate embolism microsphere and collecting device |
| CN115252882A (en) * | 2022-07-23 | 2022-11-01 | 深圳市联科翰微医疗科技有限公司 | Visible gelatin embolism microsphere manufacturing process |
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