CN209508101U - A kind of preparation system of efficient and environment-friendly type quinolones sand star drug - Google Patents
A kind of preparation system of efficient and environment-friendly type quinolones sand star drug Download PDFInfo
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- CN209508101U CN209508101U CN201821649382.0U CN201821649382U CN209508101U CN 209508101 U CN209508101 U CN 209508101U CN 201821649382 U CN201821649382 U CN 201821649382U CN 209508101 U CN209508101 U CN 209508101U
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- tank
- reactor tank
- quinolone
- piperazine
- quinolones
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Abstract
The utility model provides a kind of preparation system of efficient and environment-friendly type quinolones sand star drug, it includes the synthesis basic ring reactor tank of quinolone, and the basic ring reactor tank of quinolone is connected with dicarbonyl compound tank, aniline tank and triethyl orthoformate tank simultaneously；The discharge port of the synthesis basic ring reactor tank of quinolone connects upper piperazine reactor tank, and the upper piperazine reactor tank is connected with acetonitrile tank and piperazine tank simultaneously；The liquid outlet connection hydrolysis ester group reactor tank of the upper piperazine reactor tank；The hydrolysis ester group reactor tank is connected with sodium hydroxide solution tank；The hydrolysis ester group reactor tank is connected with neutralizing tank；It is connected on the neutralizing tank and neutralizes liquid supply system and the first Ethanol tank；The liquid outlet of the neutralizing tank is connected with crystallizer, and the outlet of the crystallizer is connected with centrifugation apparatus, and the discharge port of the centrifugation apparatus is connected with methide holding vessel.This system is used for the preparation of quinolone xacin-series drug, improves efficiency, and saves energy, plays environmentally friendly purpose.
Description
Technical field
The utility model belongs to medicine preparation system and device field more particularly to quinolones sand star medicine preparation system.
Background technique
Quinolones sand star drug turns out to be a kind of reliable and safe drugs by clinic.Quinolone medicine is generally to thin
The selectivity of bacterium is high, big to the safety of people, thus the discovery and development of quinolone drugs, has started the new of synthetic antibacterial drug
Epoch.
During quinolones sand star pharmaceutical preparation, including construct quinolone female ring, piperazine, water in substitution reaction
Solve ester group, purification, crude product mother solution fractionation and fine work mother liquor fractionation processes.Quinolones sand star pharmaceutical preparation contains more
Operating process is walked, current preparation process efficiency is relatively low, and the energy ratio consumed in the process is larger, and raw material utilize
Rate is low；Waste residue produced during the preparation process is unable to get timely processing, in turn results in the pollution of environment, therefore, it is necessary to design one
The preparation system of kind efficient and environment-friendly type quinolones sand star drug.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation systems of efficient and environment-friendly type quinolones sand star drug.
The object of the present invention is achieved like this: a kind of preparation system of efficient and environment-friendly type quinolones sand star drug, it
Including synthesizing the basic ring reactor tank of quinolone, the basic ring reactor tank of synthesis quinolone is connected with dicarbonyl compound simultaneously
Tank, triethyl orthoformate tank, aniline tank；It is same that the discharge port of the synthesis basic ring reactor tank of quinolone connects upper piperazine reactor tank
When piperazine tank and acetonitrile tank；The liquid outlet connection hydrolysis hydrolysis ester group reactor tank of the upper piperazine reactor tank is connected with 10% hydrogen simultaneously
Aqueous solution of sodium oxide tank；The hydrolysis hydrolysis ester group reactor tank liquid outlet connects neutralizing tank；Neutralization is connected on the neutralizing tank
Liquid supply system and the first Ethanol tank；The liquid outlet of the neutralizing tank is connected with crystallizer, the outlet of the crystallizer with
Centrifugation apparatus is connected, and the discharge port of the centrifugation apparatus is connected with quinolones sand star drug holding vessel.
The slag notch of the filter is connected with waste residue holding vessel, and stores processing waste residue.
The distillation equipment is connected by exhaust pipe with Ethanol tank, the ethyl alcohol generated for recycling distillation.
The neutralization liquid supply system includes hydrochloric acid tank, and the first purifying water pot is connected in the hydrochloric acid tank.
The waste liquid discharge port of the centrifugation apparatus is connected with liquid waste processing pond.
The centrifugation apparatus is connected with the second purifying water pot simultaneously.
The neutralizing tank is internally provided with pH detector, and reacting liquid pH value is controlled in 7.0-7.5.
Temperatuer detector is equipped with inside the basic ring reactor tank of synthesis quinolone.
Compared with prior art, the invention has the following outstanding advantages:
(1) it can be used in environment-friendly type quinolones sand star medicine preparation by using above-mentioned preparation system, due to using
Optimizing process, preparation efficiency is high, and resource utilization is high, effectively reduces energy loss, has saved the energy, Er Qie
In preparation process, good processing is accomplished to waste liquid, waste residue and exhaust gas, has prevented it from causing environmental pollution, has played environmental protection
Purpose.
(2) by the way that distillation equipment is connected with Ethanol tank, the ethyl alcohol generated in distillation process can be re-started recycling
It uses again, and then has saved raw material.
(3) it is connected by the waste residue for generating filter with waste residue holding vessel, waste residue can be effectively handled, is risen
The purpose of environmental protection is arrived.
(4) it is connected by centrifugation apparatus with liquid waste processing pond, waste liquid can be reprocessed, be prevented the pollution of the environment.
Detailed description of the invention
The utility model is described in further detail with reference to the accompanying drawings and examples.
Fig. 1 is the preparation process schematic diagram of the utility model quinolones sand star drug.
R group is ring 4- fluorophenyl, cyclopropyl, ethyl etc. in figure
Fig. 2 is the utility model overall structure diagram.
In figure: the basic ring reactor tank 4 of dicarbonyl compound tank 1, triethyl orthoformate tank 2, aniline tank 3, quinolone, acetonitrile
Tank 5, piperazine tank 6, upper piperazine reactor tank 7, sodium hydroxide solution tank 8, hydrolysis ester group reactor tank 9, distillation equipment 10, neutralizing tank
11, the first purifying water pot 12, dilute hydrochloric acid solution tank 13, hydrochloric acid tank 14, Ethanol tank 15, crystallizer 16, centrifugation apparatus 17, waste liquid
Processing pond 18, second purifies water pot 19, quinolone sand star drug holding vessel 20.
Specific embodiment
The embodiments of the present invention is described further with reference to the accompanying drawing.Referring to Fig. 1,2.A kind of Efficient Ring
The preparation system of guarantor's type quinolones sand star drug, it includes the synthesis basic ring reactor tank 4 of quinolone, the synthesis quinolonyl
This ring reactor tank 4 is connected with dicarbonyl compound tank 1, triethyl orthoformate tank 2, aniline tank 3 simultaneously；The synthesis quinolonyl
The discharge port of this ring reactor tank 4 connects upper piperazine reactor tank 7, and upper piperazine reactor tank 7 connects acetonitrile tank 5 and piperazine tank 6 simultaneously；Institute
State the liquid outlet connection hydrolysis ester group reactor tank 9 of piperazine reactor tank 7；The hydrolysis ester group reactor tank 9 is connected with hydroxide simultaneously
Sodium solution tank 8；The hydrolysis hydrolysis ester group reactor tank 9 is connected with distillation equipment 10；The distillation equipment 10 and 11 phase of neutralizing tank
Even；It is connected on the neutralizing tank 11 and neutralizes liquid supply system and Ethanol tank 15；The liquid outlet of the neutralizing tank 11 is set with crystallization
Standby 16 are connected, and the outlet of the crystallizer 16 is connected with centrifugation apparatus 17, the discharge port and quinolone of the centrifugation apparatus 17
Husky star drug holding vessel 20 is connected.It can be used in the preparation of a variety of quinolone sand star drugs by using above-mentioned preparation system.
Further, dicarbonyl compound, triethyl orthoformate and aniline in the basic ring reactor tank of synthesis quinolone
It reacts and generates the basic ring of quinolone.Three component reactions reduce single step reaction process two-by-two, have saved production cost.
Further, substitution reaction occurs in the upper piperazine reactor tank 7 and generates quinolone sand star drug leads structure.
Further, hydrolysis occurs in the hydrolysis ester group reactor tank 9 and generates quinolone sand star medicines structure.
Further, reaction is generated the discharge of ethyl alcohol waste liquid by distillation equipment 10 and collected by the hydrolysis ester group reactor tank 9.
Play the purpose of environmental protection.
Further, the neutralization liquid supply system packet neutralizing tank 11, the neutralizing tank 11 is connected with alkene hydrochloric acid tank 13.It is logical
Neutralizer can be provided for neutralization reaction by crossing neutralization liquid supply system.
Further, the waste liquid discharge port of the centrifugation apparatus 17 is connected with liquid waste processing pond 18.Waste liquid can be carried out
Reprocessing, prevents the pollution of the environment.
Further, the centrifugation apparatus 17 is connected with the second purifying water pot 19 simultaneously.It is by the second purifying water pot 19
Centrifugal process provides raw water.
Further, the neutralizing tank 11 is internally provided with pH detector, and reacting liquid pH value is controlled in 7.0-7.5.
Further, in the basic ring reactor tank 4 of the synthesis quinolone, upper piperazine reactor tank 7 and hydrolysis ester group reactor tank 9
Portion is equipped with temperatuer detector.The temperature inside tank can be constantly detected by thermometer, it is made to meet respective reaction temperature requirement.
With reference to the accompanying drawing to the course of work of the utility model and working principle further instruction.Referring to fig. 2.
Utility model works process and working principle are as follows:
Firstly, dicarbonyl compound 1, triethyl orthoformate 2, aniline 3 successively is added into synthesis quinolone female ring tank 4,
It is heated to 130 DEG C, insulation reaction 24 hours；Make to generate the basic ring of quinolone while hot into upper piperazine reactor tank 7, passes through acetonitrile tank
5 and piperazine tank 6 acetonitrile and piperazine is added, be warming up to 100 DEG C, flowing back 3 hours；Hydrolysis ester group reactor tank 9 is flowed into while hot, is passed through
100 DEG C of 50% sodium hydroxide is added in sodium hydroxide solution tank 8, reacts 4 hours；Then, water receiving solution ester group reactor tank 9 is to neutralizing tank
11, it is incorporated to ethanol solution, stirring, cooling, addition alkene hydrochloric acid solution keep reaction temperature to be no more than 45 DEG C, when reaction also pH is
7.0-7.5, stops plus alkene hydrochloric acid, standing 1 hour are centrifuged, and is washed with deionized water and filters and make its pH 7.0, it is small to continue centrifugation 3
When, inspection obtains quinolone xacin-series drug, and is stored in quinolone sand star drug holding vessel 20.
The above embodiments are only the optimal technical scheme of the utility model, and are not construed as the limit for the utility model
System, the technical solution that the protection scope of the utility model should be recorded with claim, the technical solution recorded including claim
The equivalents of middle technical characteristic are protection scope.Equivalent replacement i.e. within this range is improved, also in the utility model
Protection scope within.
Claims (6)
1. a kind of preparation system of efficient and environment-friendly type quinolones sand star drug, it is characterised in that: it includes synthesis quinolonyl
This ring reactor tank (4), the basic ring reactor tank (4) of quinolone are connected with dicarbonyl compound tank (1), primitive nail triethylenetetraminehexaacetic acid simultaneously
Ester tank (2) and aniline tank (3)；The discharge port of the synthesis basic ring reactor tank (4) of quinolone connects upper piperazine reactor tank (7),
The upper piperazine reactor tank (7) is connected with acetonitrile tank (5) and piperazine tank (6) simultaneously；The liquid outlet of the upper piperazine reactor tank (7)
Connection hydrolysis ester group reactor tank (9)；The hydrolysis ester group reactor tank (9) is connected with sodium hydroxide solution tank (8)；The hydrolysis ester
Base reactor tank (9) is connected with distillation equipment (10)；The distillation equipment (10) is connected with neutralizing tank (11)；The neutralizing tank (11)
On be connected with and neutralize liquid supply system and the first Ethanol tank (15)；The liquid outlet of the neutralizing tank (11) and crystallizer (16) phase
Even, the outlet of the crystallizer (16) is connected with centrifugation apparatus (17), the discharge port and quinolone of the centrifugation apparatus (17)
Husky star drug holding vessel (20) is connected.
2. a kind of preparation system of efficient and environment-friendly type quinolones sand star drug according to claim 1, it is characterised in that: institute
It states the synthesis basic ring reactor tank (4) of quinolone and constructs the basic ring of quinolone, the upper piperazine reaction for executing three component reactions
Tank (7), for executing the substitution reaction of upper piperazine to the basic ring of quinolone, the hydrolysis ester group reactor tank (9) is for producing work
Hydrolysis is executed in skill.
3. a kind of preparation system of efficient and environment-friendly type quinolones sand star drug according to claim 1, it is characterised in that: institute
It states hydrolysis ester group reactor tank (9) and is collected reaction generation ethyl alcohol waste liquid discharge by distillation equipment (10).
4. a kind of preparation system of efficient and environment-friendly type quinolones sand star drug according to claim 1, it is characterised in that: institute
The waste liquid discharge port for stating centrifugation apparatus (17) is connected with liquid waste processing pond (18).
5. a kind of preparation system of efficient and environment-friendly type quinolones sand star drug according to claim 1, it is characterised in that: institute
It states neutralizing tank (11) and is internally provided with pH detector, reacting liquid pH value is controlled in 7.0-7.5.
6. a kind of preparation system of efficient and environment-friendly type quinolones sand star drug according to claim 1, it is characterised in that: institute
It states and is equipped with temperatuer detector inside the basic ring reactor tank (4) of quinolone, upper piperazine reactor tank (7) and hydrolysis ester group reactor tank (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821649382.0U CN209508101U (en) | 2018-10-11 | 2018-10-11 | A kind of preparation system of efficient and environment-friendly type quinolones sand star drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821649382.0U CN209508101U (en) | 2018-10-11 | 2018-10-11 | A kind of preparation system of efficient and environment-friendly type quinolones sand star drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209508101U true CN209508101U (en) | 2019-10-18 |
Family
ID=68192019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821649382.0U Expired - Fee Related CN209508101U (en) | 2018-10-11 | 2018-10-11 | A kind of preparation system of efficient and environment-friendly type quinolones sand star drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209508101U (en) |
-
2018
- 2018-10-11 CN CN201821649382.0U patent/CN209508101U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191018 Termination date: 20201011 |