CN209481521U - A kind of tubular reactor of 3- hydroxyl tetrahydrofuran - Google Patents
A kind of tubular reactor of 3- hydroxyl tetrahydrofuran Download PDFInfo
- Publication number
- CN209481521U CN209481521U CN201822212145.4U CN201822212145U CN209481521U CN 209481521 U CN209481521 U CN 209481521U CN 201822212145 U CN201822212145 U CN 201822212145U CN 209481521 U CN209481521 U CN 209481521U
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- Prior art keywords
- reaction
- sodium borohydride
- tank
- water bath
- tubular reactor
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- XDPCNPCKDGQBAN-UHFFFAOYSA-N 3-hydroxytetrahydrofuran Chemical compound OC1CCOC1 XDPCNPCKDGQBAN-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims abstract description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229910000033 sodium borohydride Inorganic materials 0.000 claims abstract description 30
- 239000012279 sodium borohydride Substances 0.000 claims abstract description 30
- 239000000463 material Substances 0.000 claims abstract description 26
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 238000009472 formulation Methods 0.000 claims abstract description 20
- 239000000725 suspension Substances 0.000 claims abstract description 20
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 19
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000011090 malic acid Nutrition 0.000 claims abstract description 19
- 239000001630 malic acid Substances 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000003860 storage Methods 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims description 22
- 238000005485 electric heating Methods 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract description 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 4
- 239000001257 hydrogen Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 description 4
- 229960001826 dimethylphthalate Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- ARXKVVRQIIOZGF-UHFFFAOYSA-N 1,2,4-butanetriol Chemical compound OCCC(O)CO ARXKVVRQIIOZGF-UHFFFAOYSA-N 0.000 description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- -1 it can be seen that Chemical compound 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 238000003892 spreading Methods 0.000 description 2
- 230000007480 spreading Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- XDPCNPCKDGQBAN-SCSAIBSYSA-N (3r)-oxolan-3-ol Chemical compound O[C@@H]1CCOC1 XDPCNPCKDGQBAN-SCSAIBSYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 description 1
- 229960001686 afatinib Drugs 0.000 description 1
- 239000003005 anticarcinogenic agent Substances 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- MLBVMOWEQCZNCC-OEMFJLHTSA-N fosamprenavir Chemical compound C([C@@H]([C@H](OP(O)(O)=O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 MLBVMOWEQCZNCC-OEMFJLHTSA-N 0.000 description 1
- 229960003142 fosamprenavir Drugs 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 238000006197 hydroboration reaction Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000036632 reaction speed Effects 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The utility model belongs to the production technical field of medicine intermediate, and in particular to a kind of tubular reactor of 3- hydroxyl tetrahydrofuran, comprising: storage device, the storage device include malic acid solution material-compound tank and sodium borohydride suspension formulations tank；Controllable type charging gear, the controllable type charging gear include PLC controller, rear pump and the flowmeter of signal connection, have signal input part and signal output end in the PLC controller；Controllable type charging gear is equipped on the output channel of malic acid solution material-compound tank and sodium borohydride suspension formulations tank, pass through the control to material rate and amount, it avoids using excessive sodium borohydride, to reduce the consumption of sodium borohydride, also hydrogen is avoided to cause security risk, it is placed in water bath, it is entered after material mixing in reaction helix tube, environment temperature is rapidly increased to reaction temperature, the fast reaction of material may be implemented, the variation for reducing integrated environment temperature guarantees that the safety and stability of reaction carries out.
Description
Technical field
The utility model belongs to the production technical field of medicine intermediate, and in particular to a kind of pipe of 3- hydroxyl tetrahydrofuran
Formula reactor.
Background technique
3- hydroxyl tetrahydrofuran is using more and more in medical product, and wherein S-3- hydroxyl tetrahydrofuran downstream is main
Product has fosamprenavir (treatment for AIDS), and En Gelie is net (treatment for diabetes), Afatinib (anticarcinogen),
R-3- hydroxyl tetrahydrofuran (treatment for pfize alzheimer's disease), it can be seen that, 3- hydroxyl tetrahydrofuran is a kind of
Multiduty intermediate, with the listing of these drugs, the demand to 3- hydroxyl tetrahydrofuran can also expand.
However there are impassable limiting factors in existing production technology, currently, from apple dimethyl phthalate through
It crosses NaBH4 and restores to obtain 1,2,4-butanetriol and autoclave intermittence is all used to react, to guarantee reaction thoroughly, used in technique big
Big excessive sodium borohydride, methanol as reaction dissolvent at normal temperature to the decomposition rate of sodium borohydride quickly, not only consumption of boron
Sodium hydride also decomposes a large amount of hydrogen of generation and causes security risk；Reaction solution is added in sodium borohydride using under low temperature in technique
It is mixed with apple dimethyl phthalate, then is warming up to reaction temperature, since reduction reaction is the reaction of very exothermic, keep reaction temperature anxious
Play increases, and temperature further speeds up reaction speed after increasing, to further release a large amount of heat, forms vicious circle, reaction
It faces out of control；However optimal reaction temperature of this reaction is at 60-65 DEG C, excessive temperature is more than methanol boiling point, at slug, very
To Fire explosion；Reaction temperature is too low, and reaction is not thorough, at waste material；So in order to control risk, reaction can only small lot it is more
Batch carries out, and greatly limits the performance of production capacity；Nevertheless, every batch reaction all enables operator soul-stirring.
Utility model content
To solve the problems mentioned above in the background art.The utility model provides a kind of pipe of 3- hydroxyl tetrahydrofuran
Formula reactor has the characteristics that small occupied area, continuous reaction, yield are big, safely controllable, fireballing.
To achieve the above object, the utility model provides the following technical solutions: a kind of tubular type of 3- hydroxyl tetrahydrofuran is anti-
Answer device, comprising: storage device, the storage device include malic acid solution material-compound tank and sodium borohydride suspension formulations tank；It can
Control formula charging gear, the controllable type charging gear include PLC controller, rear pump and the flowmeter of signal connection, the PLC
There is signal input part and signal output end, the rear pump and flowmeter are installed in the malic acid solution and match on controller
On the conveying pipeline of batch can and sodium borohydride suspension formulations tank, the output end of the flowmeter is connected to the signal input part
On, the output end of the rear pump is connected on the signal output end；Mixing arrangement, the mixing arrangement include material mixing
Device, the material mixer are connected to the end of the malic acid solution material-compound tank and sodium borohydride suspension formulations tank conveying pipeline
End；Reaction unit, the reaction unit include water bath and reaction helix tube, and the reaction helix tube is placed in the water bath
Inside, the output end of the material mixer are connected on the reaction helix tube；Collection device, the collection device are to receive
Kettle, the reaction helix tube are connected to the input port for receiving kettle.
In order to can control output flow, as a kind of optimal technical scheme of the utility model, the rear pump and stream
The quantity of meter is two, and a rear pump and flowmeter are connected in series in the conveying of the malic acid solution material-compound tank
Guan Shang, and cooperate the flow closed-loop control system of the PLC controller composition malic acid solution material-compound tank, another described output
Pump and flowmeter are connected in series on the conveying pipeline of the sodium borohydride suspension formulations tank, and cooperate the PLC controller group
At the flow closed-loop control system of sodium borohydride suspension formulations tank.
In order to enable control output revolution speed, as a kind of optimal technical scheme of the utility model, the rear pump
Input terminal is connected with frequency converter, and output signal is input in the frequency converter by the PLC controller by signal output end.
Putty in order to prevent, as a kind of optimal technical scheme of the utility model, the material mixer is mixed for SK type
Clutch.
In order to enable guaranteeing that water-bath is evenly heated, as a kind of optimal technical scheme of the utility model, the water bath
It is cylindrical in shape, the bottom middle position of the water bath has heating chamber, and the inner wall of the heating chamber is fixed with equally distributed
Heating element.
Bath temperature is carried out automatically controlling in order to realize, it is described as a kind of optimal technical scheme of the utility model
Heating element is heating wire group, is equipped with temperature sensor in the water bath, the temperature sensor electrically connects with heating wire group
It connects.
It is described as a kind of optimal technical scheme of the utility model for the ease of carrying out pressure control to bath temperature
The top of water bath has water inlet, and the bottom of the water bath has discharge outlet.
In order to provide good reaction temperature atmosphere, as a kind of optimal technical scheme of the utility model, the reaction
Helix tube is spirally distributed in the water bath, and is located at the outside of the heating chamber, the both ends of the reaction helix tube
With input pipe and efferent duct, the input pipe is connected to the output end of the material mixer, and the efferent duct is connected to institute
It states and receives on kettle.
Putty in order to prevent, as a kind of optimal technical scheme of the utility model, the inner wall light of the reaction helix tube
It is sliding.
Compared with prior art, the utility model has the beneficial effects that
1, the utility model is equipped on the output channel of malic acid solution material-compound tank and sodium borohydride suspension formulations tank
Controllable type charging gear is avoided by the control to material rate and amount using excessive sodium borohydride, to reduce hydroboration
The consumption of sodium, it is thus also avoided that generate a large amount of hydrogen and cause security risk.
2, the utility model is equipped with reaction helix tube, is placed in water bath, enters reaction helix tube after material mixing
In, environment temperature is rapidly increased to reaction temperature, the fast reaction of material may be implemented, and water has biggish specific heat capacity, can
To absorb to the heat of reaction, and Spreading and diffusion, reduce the variation of integrated environment temperature, guarantee the safety and stability of reaction into
Row.
Detailed description of the invention
Attached drawing is used to provide a further understanding of the present invention, and constitutes part of specification, practical with this
Novel embodiment is used to explain the utility model together, does not constitute limitations of the present invention.In the accompanying drawings:
Fig. 1 is the structural schematic diagram of the utility model；
Fig. 2 is the mass flow closed-loop control schematic diagram in the utility model；
Fig. 3 is the water bath structural schematic diagram in the utility model；
In figure: 1, malic acid solution material-compound tank；2, sodium borohydride suspension formulations tank；3, PLC controller；31, signal is defeated
Enter end；32, signal output end；4, rear pump；5, flowmeter；6, material mixer；7, water bath；701, heating chamber；71, electric heating
Element；72, water inlet；73, discharge outlet；8, helix tube is reacted；81, input pipe；82, efferent duct；9, kettle is received.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Embodiment
Fig. 1-3 is please referred to, the utility model provides a kind of technical solution: a kind of pipe reaction of 3- hydroxyl tetrahydrofuran
Device, comprising: storage device, storage device include malic acid solution material-compound tank 1 and sodium borohydride suspension formulations tank 2；Controllable type
Charging gear, controllable type charging gear includes PLC controller 3, rear pump 4 and the flowmeter 5 of signal connection, in PLC controller 3
With signal input part 31 and signal output end 32, rear pump 4 and flowmeter 5 are installed in malic acid solution material-compound tank 1 and boron
On the conveying pipeline of sodium hydride suspension formulations tank 2, the output end of flowmeter 5 is connected on signal input part 31, rear pump 4 it is defeated
Outlet is connected on signal output end 32；Mixing arrangement, mixing arrangement include material mixer 6, and material mixer 6 is connected to apple
The end of 2 conveying pipeline of tartaric acid solution material-compound tank 1 and sodium borohydride suspension formulations tank；Reaction unit, reaction unit include water-bath
Case 7 and reaction helix tube 8, reaction helix tube 8 are placed in the inside of water bath 7, and the output end of material mixer 6 is connected to reaction spiral shell
On coil 8；Collection device, collection device are to receive kettle 9, and reaction helix tube 8 is connected to the input port for receiving kettle 9.
Specifically, apple dimethyl phthalate material-compound tank 1, sodium borohydride material-compound tank 2 are controlled by the rear pump 4 of two sets of frequency control
Output flow processed, rear pump 4 are followed by flowmeter 5, and flow signal is sent in PLC controller 3, and PLC controller 3 becomes according to flow
Change the frequency converter of two rear pumps 4 of countercharge, adjust frequency stabilization flow, realizes closed-loop control；The material of two rear pumps 4 passes through
It carries out adequately being mixed into reaction helix tube 8 in the SK type mixer of setting after threeway, reaction helix tube 8 is placed in water bath
In 7 water-bath, temperature of charge is rapidly increased to reaction temperature, fast reaction；Reaction helix tube 8 is designed as disc coil pipe, inner wall
By polishing treatment, the resistance of ducting can be reduced, solid material is avoided to adhere to；Reaction liquid stops 1-5 minutes in pipeline, access
It receives in kettle 9.
Specifically, the quantity of rear pump 4 and flowmeter 5 is two, a rear pump 4 and flowmeter 5 are connected in series in
On the conveying pipeline of malic acid solution material-compound tank 1, and cooperate the flow closed loop control of the composition malic acid solution material-compound tank 1 of PLC controller 3
System processed, another rear pump 4 and flowmeter 5 are connected in series on the conveying pipeline of sodium borohydride suspension formulations tank 2, and are cooperated
PLC controller 3 forms the flow closed-loop control system of sodium borohydride suspension formulations tank 2, the conveying of malic acid solution material-compound tank 1
The closed-loop control system to flow control is separately configured on the conveying pipeline of pipe and sodium borohydride suspension formulations tank 2, passes through
Flowmeter 5 detects that the flow signal in pipeline is sent in PLC controller 3, and PLC controller 3 is according to changes in flow rate countercharge two
The frequency converter of platform rear pump 4 adjusts frequency stabilization flow, realizes closed-loop control.
Specifically, the input terminal of rear pump 4 is connected with frequency converter, PLC controller 3 is believed output by signal output end 32
It number is input in frequency converter, the revolving speed of the power control rear pump 4 by controlling frequency converter carries out uninterrupted to realize
Control.
Specifically, material mixer 6 is SK type mixer, SK type static mixer is suitable for requiring less high mixing
Journey can be used for augmentation of heat transfer, and SK type is least easy blocking in the static mixer of various models.
Specifically, water bath 7 is cylindrical in shape, the bottom middle position of water bath 7 has heating chamber 701, heating chamber 701
Inner wall is fixed with equally distributed heating element 71, may be implemented rapidly and uniformly to heat the water in water bath 7.
Specifically, heating element 71 is heating wire group, temperature sensor, temperature sensor and electric heating are equipped in water bath 7
Silk group is electrically connected, and is fed back by temperature sensor to the water temperature in water bath 7, and the heating function of heating element 71 is controlled
Rate, and then control water temperature.
Specifically, the top of water bath 7 has water inlet 72, the bottom of water bath 7 has discharge outlet 73, can be according to water
Water temperature in bath cabinet 7 by water inlet 72 and discharge outlet 73 forces that cooling water is added, is used for balanced reaction temp.
Specifically, reaction helix tube 8 is spirally distributed in water bath 7, and it is located at the outside of heating chamber 701, guarantees
8 thermally equivalent of helix tube is reacted, the both ends of reaction helix tube 8 have input pipe 81 and efferent duct 82, and input pipe 81 is connected to object
Expect the output end of mixer 6, efferent duct 82, which is connected to, to be received on kettle 9.
Specifically, the inner wall smooth of reaction helix tube 8, can reduce the resistance of ducting, solid material is avoided to adhere to.
The working principle and process for using of the utility model: after the utility model installs, apple dimethyl phthalate ingredient
Tank 1, sodium borohydride material-compound tank 2 control output flow by the rear pump 4 of two sets of frequency control, and rear pump 4 is followed by flowmeter 5,
Flow signal is sent in PLC controller 3, frequency converter of the PLC controller 3 according to changes in flow rate two rear pumps 4 of countercharge, adjustment
Frequency stabilization flow realizes closed-loop control；By the control to material rate and amount, avoid using excessive sodium borohydride, from
And reduce the consumption of sodium borohydride, it is thus also avoided that generate a large amount of hydrogen and cause security risk, the material warp of two rear pumps 4
It crosses and carries out after threeway being adequately mixed into reaction helix tube 8 in the SK type mixer of setting, reaction helix tube 8 is placed in water-bath
In the water-bath of case 7, environment temperature is rapidly increased to reaction temperature, the fast reaction of material may be implemented, and water is with biggish
Specific heat capacity can absorb the heat of reaction, and Spreading and diffusion, reduce the variation of integrated environment temperature, guarantee the peace of reaction
Complete stablize carries out, and reaction helix tube 8 is designed as disc coil pipe, and inner wall passes through polishing treatment, can reduce the resistance of ducting, avoids solid
The attachment of body material；Reaction liquid stops 1-5 minutes in pipeline, and access receives in kettle 9.
Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention, it is not limited to this
Utility model, although the utility model is described in detail with reference to the foregoing embodiments, for those skilled in the art
For, it is still possible to modify the technical solutions described in the foregoing embodiments, or to part of technical characteristic
It is equivalently replaced.Within the spirit and principle of the utility model, any modification, equivalent replacement, improvement and so on,
It should be included within the scope of protection of this utility model.
Claims (9)
1. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran, it is characterised in that: include:
Storage device, the storage device include malic acid solution material-compound tank (1) and sodium borohydride suspension formulations tank (2)；
Controllable type charging gear, the controllable type charging gear include PLC controller (3), rear pump (4) and the stream of signal connection
Meter (5), has signal input part (31) and signal output end (32) on the PLC controller (3), the rear pump (4) and
Flowmeter (5) is installed on the conveying pipeline of the malic acid solution material-compound tank (1) and sodium borohydride suspension formulations tank (2),
The output end of the flowmeter (5) is connected on the signal input part (31), and the output end of the rear pump (4) is connected to institute
It states on signal output end (32)；
Mixing arrangement, the mixing arrangement include material mixer (6), and the material mixer (6) is connected to the malic acid
The end of solution material-compound tank (1) and sodium borohydride suspension formulations tank (2) conveying pipeline；
Reaction unit, the reaction unit include water bath (7) and reaction helix tube (8), and the reaction helix tube (8) is placed in institute
The inside of water bath (7) is stated, the output end of the material mixer (6) is connected on the reaction helix tube (8)；
Collection device, the collection device are to receive kettle (9), and reaction helix tube (8) is connected to the defeated of reception kettle (9)
Entrance.
2. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 1, it is characterised in that: the rear pump
(4) and the quantity of flowmeter (5) is two, and a rear pump (4) and flowmeter (5) are connected in series in the malic acid
On the conveying pipeline of solution material-compound tank (1), and the flow of the PLC controller (3) composition malic acid solution material-compound tank (1) is cooperated to close
Ring control system, another described rear pump (4) and flowmeter (5) are connected in series in the sodium borohydride suspension formulations tank
(2) on conveying pipeline, and cooperate the flow closed-loop control of the PLC controller (3) composition sodium borohydride suspension formulations tank (2)
System.
3. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 1, it is characterised in that: the rear pump
(4) input terminal is connected with frequency converter, and output signal is input to institute by signal output end (32) by the PLC controller (3)
It states in frequency converter.
4. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 1, it is characterised in that: the material is mixed
Clutch (6) is SK type mixer.
5. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 1, it is characterised in that: the water bath
(7) it is cylindrical in shape, the bottom middle position of the water bath (7) has heating chamber (701), the inner wall of the heating chamber (701)
It is fixed with equally distributed heating element (71).
6. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 5, it is characterised in that: the electric heating member
Part (71) is heating wire group, is equipped with temperature sensor in the water bath (7), the temperature sensor electrically connects with heating wire group
It connects.
7. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 1, it is characterised in that: the water bath
(7) top has water inlet (72), and the bottom of the water bath (7) has discharge outlet (73).
8. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 6, it is characterised in that: the reaction spiral shell
Coil (8) is spirally distributed in the water bath (7), and is located at the outside of the heating chamber (701), the reaction spiral
The both ends for managing (8) have input pipe (81) and efferent duct (82), and the input pipe (81) is connected to the material mixer (6)
Output end, the efferent duct (82) are connected on the reception kettle (9).
9. a kind of tubular reactor of 3- hydroxyl tetrahydrofuran according to claim 1, it is characterised in that: the reaction spiral shell
The inner wall smooth of coil (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822212145.4U CN209481521U (en) | 2018-12-27 | 2018-12-27 | A kind of tubular reactor of 3- hydroxyl tetrahydrofuran |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822212145.4U CN209481521U (en) | 2018-12-27 | 2018-12-27 | A kind of tubular reactor of 3- hydroxyl tetrahydrofuran |
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| Publication Number | Publication Date |
|---|---|
| CN209481521U true CN209481521U (en) | 2019-10-11 |
Family
ID=68128582
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822212145.4U Expired - Fee Related CN209481521U (en) | 2018-12-27 | 2018-12-27 | A kind of tubular reactor of 3- hydroxyl tetrahydrofuran |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209481521U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109503522A (en) * | 2018-12-27 | 2019-03-22 | 江苏联昇化学有限公司 | A kind of tubular reactor of 3- hydroxyl tetrahydrofuran |
-
2018
- 2018-12-27 CN CN201822212145.4U patent/CN209481521U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109503522A (en) * | 2018-12-27 | 2019-03-22 | 江苏联昇化学有限公司 | A kind of tubular reactor of 3- hydroxyl tetrahydrofuran |
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Address after: 225400 No. 88 Qidong Road, Binjiang Town Economic Development Zone, Taixing City, Jiangsu Province Patentee after: Jiangsu airy Chemical Co.,Ltd. Address before: 225400 No. 88 Qidong Road, Binjiang Town Economic Development Zone, Taixing City, Jiangsu Province Patentee before: JIANGSU LIANSHENG CHEMICAL Co.,Ltd. |
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Granted publication date: 20191011 |