CN209450976U - A kind of hydrocortisone continuous sterilizing system - Google Patents
A kind of hydrocortisone continuous sterilizing system Download PDFInfo
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- CN209450976U CN209450976U CN201822086128.0U CN201822086128U CN209450976U CN 209450976 U CN209450976 U CN 209450976U CN 201822086128 U CN201822086128 U CN 201822086128U CN 209450976 U CN209450976 U CN 209450976U
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Abstract
The utility model proposes a kind of hydrocortisone continuous sterilizing systems, including cooling heat exchanger, preheating heat exchanger, company disappears device and the feed liquid flow path and vapor flow path that are formed therebetween, feed liquid flow path includes being inputted by low temperature material liquid flowing channel, it is sent after preheating to medium temperature material liquid flowing channel and is preheated again, it is heated again through high temperature feed liquid runner, high temperature feed liquid returns to cooling material liquid flowing channel, by the feed liquid cooling that do not sterilize, finally export the circuit of low temperature sterilization feed liquid, vapor flow path includes being inputted by the high-temperature steam runner of Lian Xiaoqi, condensed water output, tail vapour send the heat exchange into tail steam flow road, the circuit finally exported；The feed liquid flow path and vapor flow path of continuous sterilizing system setting can adequately utilize the thermal energy of steam, utilize the feed liquid that do not sterilize of tail vapour and high temperature feed liquid preheating low temperature, the feed liquid that do not sterilize is preheated, high temperature feed liquid is cooled down, it is energy saving, and shorten the time that the feed liquid that do not sterilize is warming up to sterilising temp in the device that even disappears, the efficiency of sterilization is improved, the usage amount of steam is reduced.
Description
Technical field
The utility model belongs to the process units of field of medicaments, particularly relates to a kind of hydrocortisone continuous sterilizing system.
Background technique
Fermentation is a process very very strict to high-temperature sterilizing process requirement, hydrocortisone needed before fermentation through
Sterilization is crossed, then is cooled to fermentation temperature, injects in fermentor and ferments, traditional high-temp sterilizing system uses high
Warm steam carries out heat sterilization, then is cooled down by cooling water, and therefore, high-temperature sterilization process can not only consume a large amount of water energys,
And cannot sufficiently recover energy, cause the waste of the energy.
Utility model content
To solve the above the deficiencies in the prior art, the utility model proposes a kind of hydrocortisone continuous sterilizing systems, utilize
High temperature feed liquid preheats the feed liquid that do not sterilize for the first time, and the steam after recycling high-temperature sterilization carries out secondary preheating, finally enters
Connect the heat exchanger that disappears and carries out heat sterilization.
The technical solution of the utility model is achieved in that a kind of hydrocortisone continuous sterilizing system, including is sequentially connected
Cooling heat exchanger, preheating heat exchanger and Lian Xiaoqi, cooling heat exchanger carries out heat exchange for do not sterilize feed liquid and high temperature feed liquid,
Including low temperature material liquid flowing channel and cooling material liquid flowing channel, preheating heat exchanger preheats the feed liquid that do not sterilize for tail vapour, including tail
Steam flow road and medium temperature material liquid flowing channel connect the device that disappears for high-temperature steam and carry out heat sterilization, including high-temperature steam to the feed liquid that do not sterilize
Runner and high temperature feed liquid runner form a feed liquid flow path and a steam stream between cooling heat exchanger, preheating heat exchanger and company disappear device
Road, feed liquid flow path include the feed liquid that do not sterilized by the input of low temperature material liquid flowing channel, are sent after being preheated to medium temperature material liquid flowing channel and are preheated again,
High temperature feed liquid runner heat sterilization is passed through, the high temperature feed liquid of output returns to cooling material liquid flowing channel, by low temperature material liquid flowing channel
The feed liquid that do not sterilize cooling, finally exports the circuit of low temperature sterilization feed liquid, vapor flow path includes the high-temperature steam runner by Lian Xiaoqi
High-temperature steam, the condensed water output of formation are inputted, and tail vapour send the heat exchange again into tail steam flow road, the circuit finally exported.
Preferably, cooling heat exchanger is spiral heat exchanger, and preheating heat exchanger and the device that even disappears are tubular heat exchanger.
Preferably, feed liquid flow path further includes a drop for cooling down again to the low temperature sterilization feed liquid of not up to temperature requirement
Temperature reflux branch, positioned at the cooling solenoid valve of cooling reflux branch road and positioned at the output solenoid valve of feed liquid flow path tail end, cool down
Reflux branch one end is connect with feed liquid flow path tail end, and junction is located at the front end of output solenoid valve, the other end and cooling material flow
The input terminal in road connects.
Preferably, even disappear and be additionally provided with maintainer between device and cooling heat exchanger, maintainer includes that two of inside are arranged side by side
The heat preservation sandwich layer outside tank and one is maintained, vapor flow path further includes a heat preservation branch, heat preservation branch one end and high-temperature steam runner
Input terminal connection, the other end connect with the output end of high-temperature steam runner, and feed liquid flow path further includes that parallel connection seals in high temperature feed liquid
First between runner and cooling material liquid flowing channel maintains runner and second to maintain runner, and two maintenance tanks are located at the first maintenance
Runner and second maintains on runner, is equipped on the pipeline of the input terminal and output end of the first maintenance runner and the second maintenance runner
Maintain solenoid valve.
Compared with prior art, the feed liquid flow path and vapor flow path of the hydrocortisone continuous sterilizing system setting of the utility model
The thermal energy that steam can adequately be utilized, using the feed liquid that do not sterilize of tail vapour and high temperature feed liquid preheating low temperature, the feed liquid that do not sterilize is obtained
To preheating, high temperature feed liquid is cooled down, energy saving, and shorten do not sterilize feed liquid even disappear be warming up in device sterilising temp when
Between, the efficiency of sterilization is improved, the usage amount of steam is reduced.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, before not making the creative labor property
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the structural schematic diagram of the utility model.
In figure: 1, cooling heat exchanger, 2, preheating heat exchanger, 3, Lian Xiaoqi, 4, maintainer, 5, feed liquid flow path, 51, cool down back
Flow branch, 6, vapor flow path, 61, heat preservation branch.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without creative efforts
Every other embodiment obtained, fall within the protection scope of the utility model.
As shown in Figure 1: the hydrocortisone continuous sterilizing system of the utility model include sequentially connected cooling heat exchanger 1, it is pre-
Heat exchanger 2 and the device 3 that even disappears；
Wherein, it is same to preheat the feed liquid that do not sterilize for feed liquid and the high temperature feed liquid progress heat exchange of not sterilizing for cooling heat exchanger 1
When, cool down to high temperature feed liquid, including low temperature material liquid flowing channel and cooling material liquid flowing channel, the preferred spiral plate type of cooling heat exchanger 1
The feed liquid contact area of heat exchanger, two kinds of heat exchange is big, and reverse flow can get bigger heat transfer efficiency, and its flow resistance is small,
It is more suitable for liquid-liquid heat exchange, wherein the helical duct of internal layer is passed through high temperature feed liquid, the preferential cooling for guaranteeing high temperature feed liquid；
Preheating heat exchanger 2 preheats the feed liquid that do not sterilize for tail vapour, including tail steam flow road and medium temperature material liquid flowing channel, high
Warm steam is even disappeared after the heat exchange of device 3, still there is many tail vapour, and tail vapour is made full use of to carry out secondary preheating to the feed liquid that do not sterilize；Company disappears
Device 3 carries out heat sterilization, including high-temperature steam runner and high temperature feed liquid runner to the feed liquid that do not sterilize for high-temperature steam, does not sterilize
Feed liquid have passed through two-stage preheating after, heat, can be brought rapidly up to 120 DEG C or so, reach a high temperature sterilizing through high-temperature steam
It is required that preheating heat exchanger 2 and the device 3 that even disappears are preferably tubular heat exchanger, the feed liquid that do not sterilize is flowed by its straight tube, and steam is by it
Effluent entrance flows into, and tubular heat exchanger is compared with the higher process of temperature requirement that even disappears is suitble to, and heat loss is small, and pipeline and heat preservation
The investment of measure is relatively inexpensive, can prevent well steam and the feed liquid back-mixing that do not sterilize；
A feed liquid flow path 5 and a vapor flow path 6, feed liquid are formed between cooling heat exchanger 1, preheating heat exchanger 2 and company disappear device 3
Flow path 5 includes the feed liquid that do not sterilized by the input of low temperature material liquid flowing channel, is sent after being preheated to medium temperature material liquid flowing channel and is preheated again through tail vapour,
High temperature feed liquid runner is passed through through high-temperature steam heat sterilization, the high temperature feed liquid of output returns to the cooling feed liquid of cooling heat exchanger 1
Runner finally exports the circuit of low temperature sterilization feed liquid, vapor flow path 6 wraps by the feed liquid cooling that do not sterilize in low temperature material liquid flowing channel
Include by the device 3 that even disappears high-temperature steam runner input high-temperature steam, the condensed water of formation under the effect of gravity rain steam separation and it is defeated
Out, and tail vapour rise and send the heat exchange again into tail steam flow road by separation, the circuit finally exported；
Therefore, feed liquid flow path 5 and vapor flow path 6 set by hydrocortisone continuous sterilizing system can adequately utilize steam
Thermal energy, for steam after carrying out high-temperature sterilization, the tail vapour of discharge still has a large amount of thermal energy, utilize its preheat low temperature the material that do not sterilize
Liquid, meanwhile, the high temperature feed liquid of sterilizing, which need to cool down, can just send to fermentor, and conventionally employed cold water cooling has lost this part heat
Amount is cooled down using the feed liquid that do not sterilize of low temperature by cooling heat exchanger 1, has dual advantage, the feed liquid that do not sterilize obtains pre-
Heat, high temperature feed liquid are cooled down, while eliminating cold water cooling circuit, energy saving；In addition, the feed liquid that do not sterilize have passed through two-stage
Preheating is warming up to the sterilising temp time in device 3 and greatly shortens, improves the efficiency of sterilization, and can reduce making for steam even disappearing
Dosage.
As further technical solution, feed liquid flow path 5 further includes one for the low temperature sterilization to not up to temperature requirement
Feed liquid cool down again cooling reflux branch 51, positioned at cooling reflux branch 51 on cooling solenoid valve and be located at feed liquid flow path 5
The output solenoid valve of tail end, cooling reflux 51 one end of branch are connect with 5 tail end of feed liquid flow path, and junction is located at output solenoid valve
Front end, the other end are connect with the input terminal of cooling material liquid flowing channel, temperature sensor are set in output solenoid valve, not up to preset temperature
It is automatically closed when spending, cooling solenoid valve automatically turns on, starting cooling reflux branch 51, so that low temperature sterilization feed liquid is again introduced into drop
Warm material liquid flowing channel carries out circulation temperature lowering, is influenced certainly by system balancing, preset temperature, which should not significantly deviate, once changes
Thermoae limit temperature, otherwise, system enters closed loop cycle, will affect the input for the feed liquid that do not sterilize, for consider system balancing because
Element, as further technical solution, company, which disappears, is additionally provided with maintainer 4 between device 3 and cooling heat exchanger 1, and maintainer 4 includes inside
Two heat preservation sandwich layers maintained outside tanks and one arranged side by side, maintain tank with enough spaces, may make that low temperature is unpasteurized
Imbalance between feed liquid input and the output of low temperature sterilization feed liquid is buffered, and vapor flow path 6 further includes a heat preservation branch 61, is protected
Warm 61 one end of branch is connect with the input terminal of high-temperature steam runner, and the other end is connect with the output end of high-temperature steam runner, feed liquid
Flow path 5 further includes that first sealed between high temperature feed liquid runner and the material liquid flowing channel that cools down in parallel maintains runner and second to maintain to flow
Road, two maintenance tanks are located at the first maintenance runner and second and maintain on runner, and first maintains runner and second to maintain runner
Input terminal and output end pipeline on be equipped with maintenance solenoid valve, all of above solenoid valve connects control system, and does not sterilize
The flowing of feed liquid and the flowing of high-temperature sterilization feed liquid are preferentially respectively adopted delivery pump and carry out power transmission, are convenient for coutroi velocity；Root
It according to experience, maintains the 1-5min time to can reach sterilizing and requires, two maintenance tank sequences open and receive high-temperature sterilization feed liquid, when one
Tank input terminal solenoid valve is maintained to open filling sterilizing high temperature feed liquid, filling reaches setting time, closes its input terminal and maintains electromagnetism
Valve maintains 1-5min, opens the maintenance solenoid valve of its output end, and an input terminal maintains the end of solenoid valve another maintenance tank when closing
Solenoid valve is maintained to open, successively sequential working, in section of holding time, output solenoid valve is automatically closed in control system, and opens
Cooling reflux branch 51 works.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection scope within.
Claims (4)
1. a kind of hydrocortisone continuous sterilizing system, which is characterized in that including sequentially connected cooling heat exchanger, preheating heat exchanger and
Connect the device that disappears, cooling heat exchanger is expected for feed liquid and the high temperature feed liquid progress heat exchange of not sterilizing, including low temperature material liquid flowing channel and cooling
Liquid stream road, preheating heat exchanger preheats the feed liquid that do not sterilize for tail vapour, including tail steam flow road and medium temperature material liquid flowing channel, and company disappears
Device carries out heat sterilization, including high-temperature steam runner and high temperature feed liquid runner to the feed liquid that do not sterilize for high-temperature steam, is cooling down
A feed liquid flow path and a vapor flow path are formed between heat exchanger, preheating heat exchanger and the device that even disappears, feed liquid flow path includes by low temperature feed liquid
Runner inputs the feed liquid that do not sterilize, is sent after being preheated to medium temperature material liquid flowing channel and is preheated again, passes through the heating of high temperature feed liquid runner and goes out
Bacterium, the high temperature feed liquid of output return to cooling material liquid flowing channel, by the feed liquid cooling that do not sterilize in low temperature material liquid flowing channel, finally export low
The circuit of temperature sterilizing feed liquid, vapor flow path include inputting high-temperature steam, the condensed water of formation by the high-temperature steam runner of Lian Xiaoqi
Output, and tail vapour send the heat exchange again into tail steam flow road, the circuit finally exported.
2. hydrocortisone continuous sterilizing system according to claim 1, it is characterised in that: the cooling heat exchanger is spiral plate
Formula heat exchanger, the preheating heat exchanger and the company disappear device as tubular heat exchanger.
3. hydrocortisone continuous sterilizing system according to claim 2, it is characterised in that: the feed liquid flow path further includes a use
In the branch, the drop positioned at cooling reflux branch road of flowing back that cool down that the low temperature sterilization feed liquid to not up to temperature requirement cools down again
Warm solenoid valve and output solenoid valve positioned at the feed liquid flow path tail end, cooling reflux branch one end and the feed liquid flow path tail end
Connection, junction are located at the front end of output solenoid valve, and the other end is connect with the input terminal of the cooling material liquid flowing channel.
4. hydrocortisone continuous sterilizing system according to claim 3, it is characterised in that: the company disappears device and cooling heat exchanger
Between be additionally provided with maintainer, maintainer includes two internal heat preservation sandwich layers maintained outside tanks and one arranged side by side, the steam
Flow path further includes a heat preservation branch, heat preservation branch one end connect with the input terminal of the high-temperature steam runner, the other end with it is described
The output end of high-temperature steam runner connects, and the feed liquid flow path further includes that parallel connection seals in the high temperature feed liquid runner and the cooling
First between material liquid flowing channel maintains runner and second to maintain runner, and two maintenance tanks are located at the first maintenance runner and second
It maintains on runner, is equipped with maintenance electromagnetism on the pipeline of the input terminal and output end of the first maintenance runner and the second maintenance runner
Valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822086128.0U CN209450976U (en) | 2018-12-12 | 2018-12-12 | A kind of hydrocortisone continuous sterilizing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822086128.0U CN209450976U (en) | 2018-12-12 | 2018-12-12 | A kind of hydrocortisone continuous sterilizing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209450976U true CN209450976U (en) | 2019-10-01 |
Family
ID=68040553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822086128.0U Active CN209450976U (en) | 2018-12-12 | 2018-12-12 | A kind of hydrocortisone continuous sterilizing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209450976U (en) |
-
2018
- 2018-12-12 CN CN201822086128.0U patent/CN209450976U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300380 Zhangjiawo Industrial Zone, Xiqing Economic Development Zone, Xiqing District, Tianjin Patentee after: Tianjin Xinyi Jinjin Pharmaceutical Co.,Ltd. Address before: 300380 Zhangjiawo Industrial Zone, Xiqing Economic Development Zone, Xiqing District, Tianjin Patentee before: TIANJIN JINJIN PHARMACEUTICAL Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder |