CN209450694U - A kind of Regeneration of Alveolar Bone material - Google Patents
A kind of Regeneration of Alveolar Bone material Download PDFInfo
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- CN209450694U CN209450694U CN201821708284.XU CN201821708284U CN209450694U CN 209450694 U CN209450694 U CN 209450694U CN 201821708284 U CN201821708284 U CN 201821708284U CN 209450694 U CN209450694 U CN 209450694U
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- alveolar bone
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- regeneration
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Abstract
The utility model discloses a kind of Regeneration of Alveolar Bone materials, and three layers including different materials composition, described three layers are respectively outermost layer, middle layer and innermost layer；Outermost layer is in elliposoidal, is coated on outside middle layer；The middle layer is according to alveolar bone level distribution gradient inside outermost layer, and each level of middle layer can combine closely；Innermost layer is enclosed by the imitative dentin layer in middle layer.The utility model can also can guarantee the firmness degree of implantation material, and be not easy to be washed out, be effectively reduced potential inflammatory reaction while guaranteeing gradient degradation.
Description
Technical field
The utility model relates to bone-regeneration material fields, and in particular to a kind of Regeneration of Alveolar Bone material.
Background technique
Alveolar Bone Defect is very common in clinic, not only influences beauty, chewing, pronunciation and the feed function of patient, and
And will affect further dentures repai, seriously endanger the physical and mental health of patient.Tooth-planting because of its Comfortable attractive, do not injure and face
The many advantages such as tooth are praised highly by many patients, have become one of the therapeutic regimen for repairing agomphosis.However, edentulous region
The factors such as width, height and the bone density of sclerotin will affect the combination effect of planting body and bone, seriously constrain oral cavity kind
It is implanted in clinical extensive development.Therefore, Regeneration and Repair is carried out to the alveolar bone of edentulous region, to make its height and the width can be full
The space needs planted enough, can obviously expand the indication range of plantation, and can promote the survival rate at a specified future date of planting body.
Although autologous bone transplanting is considered the goldstandard of bone defect healing by scholar, but still there are limited sources, donor site
The deficiencies of long pain, second operation increase Infective morbidity is not the Alveolar Bone Defect recovery technique that optimum is promoted.Cause
This, prepares novel artificial bone alternate material and has become the Critical policies for solving Alveolar bone insufficiency.In consideration of it, scholars grind
Various types of artificial bone renovating materials have been made, the biologically inert class (metals such as stainless steel, titanium alloy can be substantially divided into；Oxidation
The ceramic-likes such as aluminium, zirconium oxide) and bioactivity class (hydroxyapatite, bio-vitric, calcium phosphate etc.).Above-mentioned artificial bone substitutes material
Although material has certain clinical application effect, there is also many disadvantages.
Existing Regeneration of Alveolar Bone material is easy to be washed out, and weight bearing area application is difficult to realize reconstruction, bone after regeneration
The disadvantages of bone mass of substitute and itself mismatch.And the bionical characteristic of material is insufficient, and internal degradation process is often difficult to
Formation with alveolar bone reaches accurate matching, and there are potential inflammatory reactions.
Utility model content
In order to solve above-mentioned the technical problems existing in the prior art, the utility model provides a kind of Regeneration of Alveolar Bone material
Material.A kind of technical solution of Regeneration of Alveolar Bone material provided by the utility model is as follows:
A kind of Regeneration of Alveolar Bone material, shape can be used for being implanted into alveolar bone, and the Regeneration of Alveolar Bone material includes difference
Three layers of material composition, described three layers are respectively outermost layer, middle layer and innermost layer；Outermost layer is in elliposoidal, is coated on centre
Layer outside；The middle layer is according to alveolar bone level distribution gradient inside outermost layer, and each level of middle layer can be tight
Close combination；Innermost layer is enclosed by the imitative dentin layer in middle layer；
Outermost layer includes biodegradable polymer fiber, ceramic porous material and bioactive glass particle,
Middle ceramic porous material is filled by bioactive glass particle, and polymer fiber wraps up the two mixing material；It is described
Ceramic porous material forms the skeleton of implantable material shape, and implantable material frame configuration is elliptic cylindrical shape；
Middle layer is bone collection substituent material, and the middle layer includes imitative adamantine layer, imitative dentin layer, imitates enamel
Layer is made of hydroxyapatite and calcium carbonate, and imitative dentin layer is made of hydroxyapatite, phosphoric acid calcium and collagen, and
Imitative dentin layer is capable of forming an elliposoidal hollow cavity.
The innermost layer by odontoblast, fibroblast, histocyte and undifferentiated mesenchymal cell mix and
At.
Further, ceramic porous material is selected from TCP (tricalcium phosphate), HA (hydroxyapatite), CPC (calcium phosphate bone water
Mud) or three mixture.
Further, bioactive glass particle can be the silicon being made of bases such as SiO2, Na2O, CaO and P2O5
Silicate glass or strontium-reinforced bioactive glass.
Further, polymeric fibre material can also be substituted by natural polymeric material.
Further, fixed alveolar bone when setting facilitates implantation at the top of the outermost layer of the Regeneration of Alveolar Bone material
The protrusion of regrown material, the convex shape can be the shapes such as pentagonal prism, cuboid.
Further, innermost layer can also add growth factor, osteoblast, neuroblast to promote alveolus bone uptake.
Preferably, the thickness of outermost layer spheroid shape especially ceramic porous material is successively thinning from top to bottom, is arranged in this way
The degradation speed of innermost layer is enabled to successively to increase by the outermost of alveolar bone, the inflammation after reducing alveolar bone grafts is anti-
It answers.
Preferably, the imitative adamantine layer of the middle layer, imitative dentin layer are also successively thinning from top to bottom, more can in this way
It is consistent with alveolar bone perienchyma composition, it is easy to accomplish reconstruction.
Preferably, the most inner side that collagen contained by dentin layer is preferentially placed in middle layer is imitated.
Preferably, innermost layer forms framework by the imitative dentin layer inner wall of middle layer, and internal cavity is in elliposoidal, it is affiliated most
Growth factor and osteoblast and neuroblast in internal layer internal cavity are in preceding injection in implantation patient's alveolar bone
In the internal cavity.
Preferably, the bottom of the Regeneration of Alveolar Bone material has the aperture through outermost layer and middle layer, the aperture
For innermost layer packing material such as growth factor and osteoblast and neuroblast etc. to be injected innermost layer cavity；It is described
Aperture is covered and is filled by the polymer fiber in outermost layer, meanwhile, guarantee that the aperture is readily able to by sharp object such as needle
Pipe is disclosed into and being not easy to due to the presence of the polymer fiber the automatic of filler when extracting the sharp object and overflow
Out.
The application also proposed a kind of Regeneration of Alveolar Bone material fabrication process, and the method is suitable for above-mentioned Regeneration of Alveolar Bone
The preparation of material, includes the following steps:
Step 1: preparation middle layer: being sequentially prepared imitative adamantine layer and imitative dentin layer, take suitable hydroxyapatite, phosphorus
Collagen is laid with one layer on imitative dentine mold by sour calcium and collagen, and then hydroxyapatite, calcium phosphate mixing are equal
It is covered in after even on collagen and forms imitative dentin layer；Then hydroxyapatite and calcium carbonate mixing are placed on imitative tooth
Imitative adamantine layer is formed on adamantine layer mold；
Step 2: preparing outermost layer: by TCP (tricalcium phosphate), HA (hydroxyapatite), CPC (calcium phosphate bone cement)
Mixing material is shaped to the spheroid shape shape of upper opening, then using taking out after high-sintering process solidification, by bioactivity
Glass particle is filled into the hole of the ceramic porous material；Mixed ceramics finally are wrapped up into polymer fiber covering
Porous material and bioactive glass particle；
Step 3: the centre prepared is placed in outermost upper opening, filled out using bioactive glass particle
The gap between middle layer and outermost layer is filled, is then sealed outermost top layer notch using material identical with imitative adamantine layer
It is stifled, and protrusion is formed on the top layer, then wait consolidation；
Step 4: lower center position drilling run through middle layer and outermost layer, then using polymer fiber filling and
Covering；
Step 5: by odontoblast, fibroblast, histocyte and undifferentiated before clinic is implanted into alveolar bone
Mesenchymal cell is implanted sequentially the cavity of middle layer formation respectively, forms innermost layer.
Further, hydroxyapatite described in step 1, calcium phosphate and collagen volume ratio are preferred are as follows: 3:4:
2；The volume ratio column of the hydroxyapatite and calcium carbonate in step 1 are preferred are as follows: 2:5.
Further, it is long than imitative adamantine layer to form the time for the imitative dentin layer in step 1, preferably 30min with
20min。
Further, the imitative dentin layer in step 1 and imitative adamantine layer mold be all made of semiellipse column manner at
Type；
Further, the mold for being shaped to the spheroid shape shape in step 2 is also the spheroid shape using external opening
Module.
Further, in step 5 be injected separately into odontoblast, fibroblast, histocyte and it is undifferentiated between
It is required to be uniformly distributed in inner chamber body after mesenchymal cells, the mode that rotation can be used is realized.
The utility model proposes Regeneration of Alveolar Bone material and preparation method thereof, can while guaranteeing gradient degradation,
Also can guarantee the firmness degree of implantation material, the setting of polymer fiber guarantees that particle or ceramic material etc. are not easy to be washed out,
Bioactive glass particle is the composition for being easy to same dental structure adhesion, not only has good bonding to dentale tissue but also to soft tissue
The setting of function, middle layer does not have to handle again bone mass can be made to match with primary bone convenient for being implanted directly into yet, and effectively subtracts
Potential inflammatory reaction is lacked.
Detailed description of the invention
Fig. 1 is Regeneration of Alveolar Bone material structure figure；
Fig. 2 is the vertical cross section of Regeneration of Alveolar Bone material structure；
Fig. 3 is the horizontal sectional drawing of Regeneration of Alveolar Bone material structure；
Fig. 4 is Regeneration of Alveolar Bone material outermost layer structure；
Fig. 5 is Regeneration of Alveolar Bone intermediate layer of material structure；
Fig. 6 is the making step of Regeneration of Alveolar Bone material.
In figs. 1-5: 1 outermost layer, 2 middle layers, 3 innermost layers, 4 apertures, 5 protrusions, 6 polymer fibers, 7 ceramic porous
Material, 8 imitative adamantine layers, 9 imitative dentin layers.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment, the present embodiment only show the key technology means for solving the technical problem underlying of the utility model, and this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the utility model protection
Range.
As shown in Figs. 1-5, a kind of Regeneration of Alveolar Bone material, shape can be used for being implanted into alveolar bone, the Regeneration of Alveolar Bone
Material includes three layers of different materials composition, and described three layers are respectively outermost layer 1, middle layer 2 and innermost layer 3；Outermost layer 1 is in ellipse
Spherical shape is coated on 2 outside of middle layer；The middle layer 2 according to alveolar bone level distribution gradient inside outermost layer 1, and
Each level of middle layer 2 can combine closely；Innermost layer 3 is enclosed by the imitative dentin layer 9 in middle layer 2.
Shown outermost layer 1 includes biodegradable polymer fiber 6, ceramic porous material 7 and bioactivity glass
Particle, wherein ceramic porous material 7 is filled by bioactive glass particle, and polymer fiber 6 wraps up the two mixing
Material；The ceramic porous material 7 forms the skeleton of implantable material shape, and implantable material frame configuration is elliptical cylinder-shape
Shape.
Shown middle layer 2 is bone collection substituent material, and the middle layer 2 includes imitative adamantine layer 8, imitates dentin layer 9,
Imitative adamantine layer 8 is made of hydroxyapatite and calcium carbonate, imitates dentin layer 9 by hydroxyapatite, phosphoric acid calcium and collagen egg
White composition, and imitative dentin layer 9 is capable of forming an arc hollow cavity.
Innermost layer 3 then sets growth factor and osteoblast and neuroblast, innermost layer 3 by odontoblast,
Fibroblast, histocyte and undifferentiated mesenchymal cell mix.
According to the scheme that is preferably carried out, ceramic porous material 7 is selected from TCP (tricalcium phosphate), HA (hydroxyapatite), CPC
(calcium phosphate bone cement) or the mixture of three.
According to the scheme that is preferably carried out, bioactive glass particle can for by SiO2, Na2O, CaO and P2O5 etc. substantially at
The silicate glass or strontium-reinforced bioactive glass being grouped as.
According to the scheme that is preferably carried out, 6 material of polymer fiber can also be substituted by natural polymeric material.
According to scheme is preferably carried out, consolidate when setting facilitates implantation at the top of the outermost layer 1 of the Regeneration of Alveolar Bone material
The protrusion 5 of the fixed Regeneration of Alveolar Bone material, raised 5 shape can be the shapes such as pentagonal prism, cuboid；
According to the scheme that is preferably carried out, the thickness of 1 spheroid shape of outermost layer especially ceramic porous material 7 is from top to bottom successively
Thinning, setting in this way enables to the degradation speed of innermost layer 3 successively to increase by the outermost of alveolar bone, reduces alveolar bone
Inflammatory reaction after transplanting.
According to the scheme that is preferably carried out, the imitative adamantine layer 8 of the middle layer 2, imitative dentin layer 9 be also from top to bottom according to
It is secondary thinning, it so more can be consistent with alveolar bone perienchyma composition, it is easy to accomplish reconstruction.
Preferably, the most inner side that collagen contained by dentin layer 9 is preferentially placed in middle layer 2 is imitated.
Preferably, innermost layer 3 forms framework by 9 inner wall of imitative dentin layer of middle layer 2, and internal cavity is in elliposoidal, institute
Growth factor and osteoblast and neuroblast in category 3 internal cavity of innermost layer is before in implantation patient's alveolar bone
It injects in the internal cavity.
Preferably, the bottom of the Regeneration of Alveolar Bone material has the aperture 4 through outermost layer 1 and middle layer 2, described
Aperture 4 is used for the injection such as 3 packing material of innermost layer such as growth factor and osteoblast and neuroblast innermost layer 3 is empty
Chamber；The aperture is covered and is filled by the polymer fiber 6 in outermost layer 1, meanwhile, guarantee the aperture 4 be readily able to by
Sharp object such as needle tubing is disclosed into and being not easy to fill due to the presence of the polymer fiber 6 when extracting the sharp object
The automatic spilling of object.
As shown in fig. 6, the utility model also proposed a kind of Regeneration of Alveolar Bone material fabrication process, the method is suitable for
The preparation of above-mentioned Regeneration of Alveolar Bone material, includes the following steps:
Step 1: preparation middle layer 2: be sequentially prepared imitative adamantine layer 8 and imitative dentin layer 9, take suitable hydroxyapatite,
Collagen is laid with one layer on imitative dentine mold by calcium phosphate and collagen, and then hydroxyapatite, calcium phosphate mix
It is covered in after uniformly on collagen and forms imitative dentin layer 9；Then hydroxyapatite and calcium carbonate mixing are placed on
Imitative adamantine layer 8 is formed on imitative 8 mold of adamantine layer.
Step 2: preparing outermost layer 1: by TCP (tricalcium phosphate), HA (hydroxyapatite), CPC (calcium phosphate bone cement)
Mixing material be shaped to the spheroid shape shape of upper opening, then using being taken out after high-sintering process solidification, will biology it is living
Property glass particle is filled into the hole of the ceramic porous material 7；It is finally that the covering package of polymer fiber 6 is mixed
Ceramic porous material 7 and bioactive glass particle.
Step 3: the middle layer 2 prepared is placed in the upper opening of outermost layer 1, using bioactive glass particle
The gap between middle layer 2 and outermost layer 1 is filled, then uses material identical with imitative adamantine layer 8 by the top layer of outermost layer 1
Notch blocks, and protrusion 5 is formed on the top layer, then waits consolidation.
Step 4: aperture 4 is formed through middle layer 2 and outermost layer 1 in lower center position drilling, then using polymerization
The filling of fibres 6 and covering.
Step 5: by odontoblast, fibroblast, histocyte and undifferentiated before clinic is implanted into alveolar bone
Mesenchymal cell is implanted sequentially the cavity of the formation of middle layer 2 by aperture 4 respectively, forms innermost layer 3.
Preferably, hydroxyapatite described in step 1, calcium phosphate and collagen volume ratio are preferred are as follows: 3:4:2；
The volume ratio column of the hydroxyapatite and calcium carbonate in step 1 are preferred are as follows: 2:5.
Preferably, the imitative formation time of dentin layer 9 in step 1 is longer than imitative adamantine layer 8, preferably 30min
And 20min.
Preferably, the imitative dentin layer 9 in step 1 and 8 mold of imitative adamantine layer be all made of semiellipse column manner at
Type.
Preferably, the mold for being shaped to the spheroid shape shape in step 2 is also the ellipsoid pattern using external opening
Block.
Preferably, in step 5 be injected separately into odontoblast, fibroblast, histocyte and it is undifferentiated between fill
It is required to be uniformly distributed in inner chamber body after cell plastid, the mode that rotation or injection injection can be used is realized.
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (3)
1. a kind of Regeneration of Alveolar Bone material, three layers including different materials composition, described three layers be respectively outermost layer, middle layer and
Innermost layer；It is characterized by:
Outermost layer is in elliposoidal, coats the middle layer；
The middle layer is according to alveolar bone level distribution gradient inside outermost layer, and each level of middle layer is combined closely；
Innermost layer is enclosed by the imitative dentin layer in middle layer.
2. Regeneration of Alveolar Bone material according to claim 1, it is characterised in that: the outermost layer includes biodegradable
Polymer fiber, ceramic porous material and bioactive glass particle, the hole in the ceramic porous material are living by biology
Property glass particle filling, and polymer fiber is wrapped in the outside of ceramic porous material and bioactive glass particle；The pottery
Porcelain porous material forms the skeleton of implantable material shape, and implantable material skeleton is elliptic cylindrical shape.
3. Regeneration of Alveolar Bone material according to claim 1, it is characterised in that: each level of middle layer includes imitative tooth enamel
Matter layer and imitative dentin layer, and imitative dentin layer is capable of forming a hollow cavity.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821708284.XU CN209450694U (en) | 2018-10-22 | 2018-10-22 | A kind of Regeneration of Alveolar Bone material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821708284.XU CN209450694U (en) | 2018-10-22 | 2018-10-22 | A kind of Regeneration of Alveolar Bone material |
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| Publication Number | Publication Date |
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| CN209450694U true CN209450694U (en) | 2019-10-01 |
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| CN201821708284.XU Expired - Fee Related CN209450694U (en) | 2018-10-22 | 2018-10-22 | A kind of Regeneration of Alveolar Bone material |
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2018
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Granted publication date: 20191001 Termination date: 20201022 |