CN209412227U - A kind of heparin sodium efficient impurity removal enzymatic vessel - Google Patents

Abstract

The utility model relates to enzymatic vessel technical fields, specially a kind of heparin sodium efficient impurity removal enzymatic vessel, including stirring outer cylinder and stirring inner canister, it stirs outer cylinder lower end surface and base plate is welded by support column, the shaft upper end of the upper surface motor of base plate is welded with inner vessel support plate, it stirs outer cylinder outer right wall and is equipped with air inlet, it stirs outer wall on the left of outer cylinder and is equipped with exhaust outlet, it stirs outer barrel and is equipped with stirring inner canister, it stirs and is equipped with agitating device inside inner canister, agitating device includes teeter column, connecting rod and agitating plate, have the beneficial effect that the stirring inner canister that stirring outer barrel is arranged in the utility model can be rotated, the agitating device being arranged inside cooperation stirring inner canister can uniformly stir the extracting solution inside stirring inner canister, air inlet connects steam inlet duct simultaneously, steam enters stirring outer barrel and carries out to stirring inner canister Even heat conductivity heat-insulating, finally along the steam exhaust pipe discharge of exhaust outlet connection.

Description

A kind of heparin sodium efficient impurity removal enzymatic vessel

Technical field

The utility model relates to enzymatic vessel technical field, specially a kind of heparin sodium efficient impurity removal enzymatic vessel.

Background technique

Heparin sodium is a kind of clinically used anticoagulation medicine, is the glutinous polysaccharide material mainly extracted from intestinal mucosa Matter, with significant ground anticoagulation and the work for preventing thrombosis.Its main technique of zymohydrolysis extracting method is under alkaline environment, and enzyme will Protein digestion in small intestinal mucosa is separated heparin from caused excessive compound, is then handed over strong alkalinity anion Resin is changed from extracting solution by heparin Anion-adsorption, reusing certain density saline solution will be under the elution of heparin anion Come, heparin crude product can be obtained after ethanol precipitation, drying.

In order to guarantee to need heparin anion efficiency in enzymatic vessel in strong-base anion-exchange resin adsorbing and extracting liquid Inside carries out uniform stirring to extracting solution.Agitator tank inside commonly used in being stirred to extracting solution is equipped with one group of paddle, Rotation stirring is carried out to extracting solution, is easy to keep the stirring of extracting solution upper and lower level uneven；Guarantor to the extracting solution being stirred Temp effect is general, causes the reduction of heparin Anion separation effect.

Utility model content

The purpose of this utility model is to provide a kind of heparin sodium efficient impurity removal enzymatic vessels, to solve in above-mentioned background technique The problem of proposition.

To achieve the above object, the utility model provides the following technical solutions: a kind of heparin sodium efficient impurity removal enzymatic vessel, packet Stirring outer cylinder and stirring inner canister are included, the stirring outer cylinder is the cylinder-like body of opening upwards, the welding of stirring outer cylinder lower end surface edge There are four support columns, four support column bottom ends are welded on the upper surface of base plate, and the upper surface middle part of base plate passes through bolt Connect motor bottom, and the shaft of motor vertically upward and be perforated through stirring outer cylinder bottom end, the shaft of motor with The bottom surface contact position for stirring outer cylinder is equipped with bearing, and the shaft upper end of motor is welded with disk-shaped inner vessel support plate, inner canister branch The upper surface middle part of fagging is welded with the fixture block of rectangular strip, stirs and is welded with air inlet below outer cylinder outer right wall, stirs Exhaust outlet is welded on the left of outer cylinder above outer wall, air inlet and exhaust outlet are connected to the inside of stirring outer cylinder, stir outer cylinder Upper inside wall be arranged with Limit Bearing, the stirring outer barrel is equipped with stirring inner canister, and stirring inner canister is the circle of opening upwards Cylindrical body, stirring inner canister inside are equipped with agitating device, and agitating device includes teeter column, connecting rod and agitating plate, and teeter column is vertical Be welded on the middle part of stirring inner canister inner bottom surface, the outer wall uniform welding of teeter column has six pairs of connecting rods, each pair of connecting rod it is outer It holds while being welded with an agitating plate, the upper port outer wall for stirring inner canister is welded with circular snap ring, and snap ring upper surface is uniform It opens up the upper surface for being close to stir inner canister there are four jack and is covered with top cover, there are four vertically downward for the lower surface welding of top cover Inserting column, four inserting columns respectively correspond insertion four jacks inside.

Preferably, there are the spacing of 2-3mm between the lower surface of the inner vessel support plate and the inner bottom surface for stirring outer cylinder, There are the spacing of 10-20mm between the outer wall of stirring inner canister and the inner wall for stirring outer cylinder.

Preferably, the bottom of the stirring inner canister offers the card slot of rectangular strip, and card slot is set with fixture block cooperation card, is stirred The inner wall of the external wall of upper portion and Limit Bearing of mixing inner canister is in close contact.

Preferably, the connecting rod is made of interior bar and outer cylinder, and interior bar is welded on the outer wall of teeter column, and outer cylinder is in sleeve-shaped It is set in the outer end of interior bar, the spring connected between outer cylinder and stirring column outer wall.

Preferably, the inner wall of jack is equipped with the rubber pad of inverted cone shape, and rubber pad in snap ring at the stirring inner canister upper end It is close to be plugged in the outer wall of internal inserting column.

Compared with prior art, the utility model has the beneficial effects that

1. the stirring inner canister that stirring outer barrel is arranged in the utility model can be rotated, inside cooperation stirring inner canister The agitating device of setting can uniformly stir the extracting solution inside stirring inner canister；

2. the utility model stirs extracting solution, air inlet connects steam inlet duct, and it is outer that steam enters stirring Cylinder is internal to carry out uniform heat conductivity heat-insulating to stirring inner canister, finally along the steam exhaust pipe discharge of exhaust outlet connection.

Detailed description of the invention

FIG. 1 is a schematic structural view of the utility model；

Fig. 2 is the utility model structure sectional front view；

Fig. 3 is the sectional view in Fig. 2 at A.

In figure: stirring outer cylinder 1, stirring inner canister 2, base plate 3, inner vessel support plate 4, fixture block 5, air inlet 6, exhaust outlet 7, limit Position bearing 8, agitating device 9, teeter column 10, connecting rod 11, agitating plate 12, top cover 13, inserting column 14, interior bar 15, outer cylinder 16.

Specific embodiment

The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work Every other embodiment obtained, fall within the protection scope of the utility model.

It please refers to Fig.1 to Fig.3, the utility model provides a kind of technical solution: a kind of heparin sodium efficient impurity removal enzymatic vessel, packet Stirring outer cylinder 1 and stirring inner canister 2 are included, referring to figs. 1 and 2, stirring outer cylinder 1 is the cylinder-like body of opening upwards, and stirring is outer 1 lower end surface edge of cylinder is welded with four support columns, and four support column bottom ends are welded on the upper surface of base plate 3, base plate 3 Upper surface middle part is bolted the bottom of motor, and the shaft of motor vertically upward and is perforated through stirring outer cylinder 1 Bottom end, the shaft of motor and the bottom surface contact position of stirring outer cylinder 1 are equipped with bearing, and the shaft upper end of motor is welded with disk-shaped Inner vessel support plate 4, it is interior there are the spacing of 2-3mm between the lower surface of inner vessel support plate 4 and the inner bottom surface for stirring outer cylinder 1 There are the spacing of 2-3mm between the outer wall of tank support plate 4 and the inner wall for stirring outer cylinder 1, prevent inner vessel support plate 4 and stirring outer cylinder 1 inner wall is worn, and the upper surface middle part of inner vessel support plate 4 is welded with the fixture block 5 of rectangular strip.

As shown in Fig. 2, being welded with air inlet 6 below stirring 1 outer right wall of outer cylinder, the upper of 1 left side outer wall of outer cylinder is stirred Side is welded with exhaust outlet 7, and air inlet 6 and exhaust outlet 7 are connected to the inside of stirring outer cylinder 1, air inlet 6 for connect steam into Tracheae enters steam inside stirring outer cylinder 1 and carries out heat conductivity heat-insulating to stirring inner canister 2, and exhaust outlet 7 is for connecting steam exhaust-gas Pipe will stir the steam inside outer cylinder 1 and be discharged.

Referring to figs. 1 and 2, the upper inside wall for stirring outer cylinder 1 is arranged with Limit Bearing 8, stirs and is equipped with inside outer cylinder 1 Inner canister 2 is stirred, stirring inner canister 2 is the cylinder-like body of opening upwards, is stirred between the outer wall of inner canister 2 and the inner wall of stirring outer cylinder 1 There are the spacing of 10-20mm, for the circulation of steam, the bottom for stirring inner canister 2 offers the card slot of rectangular strip, and card slot with The cooperation card of fixture block 5 is set, and the inner wall of the external wall of upper portion and Limit Bearing 8 that stir inner canister 2 is in close contact, and Limit Bearing 8 can prevent The upper end of stirring inner canister 2 shifts shaking.

As shown in Figure 1, being equipped with agitating device 9 inside stirring inner canister 2, agitating device 9 includes teeter column 10,11 and of connecting rod Agitating plate 12, teeter column 10 are vertically welded in the middle part of stirring 2 inner bottom surface of inner canister, and the outer wall uniform welding of teeter column 10 has six To connecting rod 11, in conjunction with shown in Fig. 2 and Fig. 3, connecting rod 11 is made of interior bar 15 and outer cylinder 16, and interior bar 15 is welded on teeter column 10 Outer wall, outer cylinder 16 is set in the outer end of interior bar 15, the inner wall of outer cylinder 16 and the outer wall sliding contact of interior bar 15 in sleeve-shaped, outside The spring connected between cylinder 16 and 10 outer wall of teeter column, spring are close to be set in the outer wall of interior bar 15, each pair of 11 China and foreign countries of connecting rod The outer end of cylinder 16 is welded with an agitating plate 12 simultaneously.

Referring to figs. 1 and 2, the upper port outer wall for stirring inner canister 2 is welded with circular snap ring, and snap ring upper surface is equal The even upper surface for being close to stir inner canister 2 there are four jack that opens up is covered with top cover 13, and top cover 13 prevents inside stirring inner canister 2 Extracting solution is overflowed in stirring, and there are four inserting column 14 vertically downward, four inserting columns 14 are right respectively for the lower surface welding of top cover 13 It should be inserted into inside four jacks, the inner wall of jack is equipped with the rubber pad of inverted cone shape, and rubber pad is close to the outer wall of inserting column 14, to slotting Column 14 is gripped.

Working principle: when utility model works, extracting solution is poured into the inside of stirring inner canister 2, then inner canister 2 will be stirred It is put into inside stirring outer cylinder 1, the fixture block 5 for welding 4 upper surface of inner vessel support plate is caught in the card slot that stirring 2 bottom of inner canister is opened up In, top cover 13 is close to the upper surface that lid is located at stirring inner canister 2, so that the corresponding insertion stirring of the inserting column 14 of 13 lower weld of top cover It is fixed in the jack that 2 upper end snap ring of inner canister opens up, starts electric motor operation, the inner canister that the shaft upper end of motor is welded Support plate 4 drives stirring inner canister 2 to be rotated, the centrifugal action when stirring inner canister 2 and rotating, agitating plate 12 in agitating device 9 It throws away outward, controls the transformation of speed of motor, so that under the spring effect that agitating plate 12 is connected on outer cylinder 16 back and forth Stir, such agitating plate 12 can uniformly be stirred stirring inner canister 2 inside, while stirring, the connection steam of air inlet 6 into Tracheae, steam enter inside stirring outer cylinder 1 and carry out heat conductivity heat-insulating to stirring inner canister 2, the steam row finally connected along exhaust outlet 7 Tracheae discharge.

While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art, It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.

Claims (5)

1. a kind of heparin sodium efficient impurity removal enzymatic vessel, including stirring outer cylinder (1) and stirring inner canister (2), it is characterised in that: described to stir The cylinder-like body that outer cylinder (1) is opening upwards is mixed, stirring outer cylinder (1) lower end surface edge is welded with four support columns, four supports Column bottom end is welded on the upper surface of base plate (3), and the bottom of motor is bolted in the upper surface middle part of base plate (3) Portion, and the shaft of motor vertically upward and is perforated through the bottom end of stirring outer cylinder (1), the shaft of motor and stirring outer cylinder (1) Bottom surface contact position be equipped with bearing, the shaft upper end of motor is welded with disk-shaped inner vessel support plate (4), inner vessel support plate (4) upper surface middle part is welded with the fixture block (5) of rectangular strip, stirs and is welded with air inlet below outer cylinder (1) outer right wall (6), it is welded with exhaust outlet (7) above outer wall on the left of stirring outer cylinder (1), air inlet (6) and exhaust outlet (7) are connected to stirring The upper inside wall of the inside of outer cylinder (1), stirring outer cylinder (1) is arranged with Limit Bearing (8), is equipped with inside the stirring outer cylinder (1) It stirs inner canister (2), stirring inner canister (2) is the cylinder-like body of opening upwards, is equipped with agitating device (9) inside stirring inner canister (2), stirs Mixing device (9) includes teeter column (10), connecting rod (11) and agitating plate (12), and teeter column (10) is vertically welded in stirring inner canister (2) middle part of inner bottom surface, the outer wall uniform welding of teeter column (10) have six pairs of connecting rods (11), each pair of connecting rod (11) it is outer An agitating plate (12) is held while being welded with, the upper port outer wall of stirring inner canister (2) is welded with circular snap ring, table on snap ring Face is uniformly provided with four jacks, and the upper surface for being close to stirring inner canister (2) is covered with top cover (13), the lower surface weldering of top cover (13) It connects there are four inserting column (14) vertically downward, four inserting columns (14) respectively correspond inside four jacks of insertion.

2. a kind of heparin sodium efficient impurity removal enzymatic vessel according to claim 1, it is characterised in that: the inner vessel support plate (4) there are the spacing of 2-3mm between the inner bottom surface of lower surface and stirring outer cylinder (1), stir outer wall and the stirring of inner canister (2) There are the spacing of 10-20mm between the inner wall of outer cylinder (1).

3. a kind of heparin sodium efficient impurity removal enzymatic vessel according to claim 1, it is characterised in that: the stirring inner canister (2) Bottom offer the card slot of rectangular strip, and card slot is set with fixture block (5) cooperation card, stirs the external wall of upper portion and limit of inner canister (2) The inner wall of position bearing (8) is in close contact.

4. a kind of heparin sodium efficient impurity removal enzymatic vessel according to claim 1, it is characterised in that: the connecting rod (11) by Interior bar (15) and outer cylinder (16) are constituted, and interior bar (15) is welded on the outer wall of teeter column (10), and outer cylinder (16) is set in sleeve-shaped The outer end of interior bar (15), the spring connected between outer cylinder (16) and teeter column (10) outer wall.

5. a kind of heparin sodium efficient impurity removal enzymatic vessel according to claim 1, it is characterised in that: the stirring inner canister (2) The inner wall of jack is equipped with the rubber pad of inverted cone shape in snap ring at upper end, and rubber pad is close to be plugged in the outer of internal inserting column (14) Wall.