CN209356445U - A kind of sampling structure improving Ion transfer spectral sensitivity - Google Patents
A kind of sampling structure improving Ion transfer spectral sensitivity Download PDFInfo
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- CN209356445U CN209356445U CN201821948187.8U CN201821948187U CN209356445U CN 209356445 U CN209356445 U CN 209356445U CN 201821948187 U CN201821948187 U CN 201821948187U CN 209356445 U CN209356445 U CN 209356445U
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Abstract
The utility model discloses a kind of sampling structures for improving Ion transfer spectral sensitivity, the Inlet Position of reagent molecule and sample influences the sensitivity that gaseous sample detects very big in photo-ionisation, the reagent molecule and sample intake method of 4 kinds of different structures are devised thus, the detection to Propofol gaseous sample may be implemented, and therefrom optimal screening goes out a kind of optimal sampling structure, the sensitivity for improving ionic migration spectrum detection can be used for the highly sensitive detection of other gases.
Description
Technical field
The utility model relates to improve the different structure of Ion transfer spectral sensitivity, specifically a kind of ion mobility spectrometry
Input mode.
Background technique
Ion mobility spectrometry is the technology of a kind of difference according to sample products Ion transfer speed and separation detection, has knot
Structure is simple, high sensitivity, detects fireballing advantage.Ionization source is the important component of ion mobility spectrometry, effect be by
Reagent molecule ionization generates reagent ion, and reagent ion and example reaction generate product ion, effect of the product ion in electric field
Under migration area separate and successively reach detector, to realize the separation and detection of target compound.
Different input modes has the ionizing efficiency of sample very big difference, and one side reagent molecule is needed in light
Efficiently be converted into reagent ion under ionization, another aspect reagent ion needs and sample molecule sufficiently reacts, reagent molecule and
The Inlet Position of sample molecule, and reaction after gas outlet position all can strong influence sample detection sensitivity, so
Need to invent a kind of input mode for effectively improving ionic migration spectrum detection sample sensitivity.
Some gaseous samples are suitble to detect in the positive-ion mode, and examine and do not measure under some gaseous sample positive ion modes
Come, the utility model structure can work normally under negative ions mode, it may be achieved the detection of different samples.
Utility model content
The utility model devises a kind of input mode for improving Ion transfer spectral sensitivity, it is therefore an objective to improve gaseous sample
The sensitivity of detection.The sample feeding mode, is applicable not only to gaseous sample, be equally applicable to can by Thermal desorption or other
The solid and fluid sample of gas are evaporated or be converted into mode, can detect in positive or negative ion mode, and reagent molecule can be selected
The reagent molecule of be easy to ionize, signal strength height and energy and example reaction.
A kind of input mode improving Ion transfer spectral sensitivity, the reaction zone including ion mobility spectrometry, tubular reaction zone
Positioned at left and right two side end faces at be respectively equipped with vacuum UV lamp and ion gate, in reaction zone side wall surface be equipped with reagent molecule into
Sample mouth and sample feeding mouth, gas outlet；
Structure a, reagent molecule injection port and gas outlet be located at close to vacuum UV lamp reaction zone on the left of, reagent molecule into
Sample mouth and gas outlet are coaxially oppositely arranged；Sample feeding mouth is located on the right side of the reaction zone of ion gate, and sample feeding mouth is located at
In side wall surface below reaction zone；
Or, structure b, reagent molecule injection port and gas outlet are located on the left of the reaction zone of vacuum UV lamp, reagent point
Sub- injection port is located in the side wall surface below reaction zone, and gas outlet is located in the side wall surface above reaction zone, reagent molecule sample introduction
Mouth and gas outlet are coaxially oppositely arranged；Sample feeding mouth is located in the side wall surface below reaction zone；
Or, structure c, gas outlet is located on the left of the reaction zone of vacuum UV lamp, and gas outlet is located at below reaction zone
In side wall surface；Reagent molecule injection port and sample feeding mouth (3) are located on the right side of the reaction zone of ion gate；Reagent molecule into
Sample mouth is located in the side wall surface above reaction zone, and reagent molecule injection port and sample feeding mouth are coaxially oppositely arranged, sample feeding
Mouth is located in the side wall surface below reaction zone；
Or, structure d, gas outlet is located on the left of the reaction zone of vacuum UV lamp, and gas outlet is located above reaction zone
In side wall surface；Sample feeding mouth is located on the right side of the reaction zone of ion gate, and sample feeding mouth is located at the side wall below reaction zone
On face；Reagent molecule injection port is located in the side wall surface below reaction zone, the axis of reagent molecule injection port and sample feeding mouth
Parallel setting.
Sample molecule is 50-500ml/min in the sample introduction flow velocity of sample feeding mouth, and the flow rate of carrier gas of reagent molecule is 50-
500ml/min。
Sampling structure of the invention, sample feeding mode are applicable not only to gaseous sample, are equally applicable to that pyrolysis can be passed through
Be easy to ionize, letter can be selected in analysis or other modes evaporation or the solid and fluid sample that are converted into gas, reagent molecule
Number intensity it is high and can and example reaction reagent molecule.
Sampling structure of the invention, input mode are suitable for the positive or negative ion mode of ion mobility spectrometry, positive ion mode
It is lower to select the reagent molecule for being suitable for sample detection, the reagent molecule for being suitable for sample detection is selected under negative ion mode.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of four kinds of different ions migration spectrum input modes a, b, c, d,
Wherein (1) is vacuum UV lamp, and (2) are reagent molecule injection port, and (3) are sample feeding mouth, and (4) are gas outlet,
It (5) is ion gate；
Fig. 2 is the corresponding ion transfer spectrogram of detection Propofol under four kinds of different ions migration spectrum input modes a, b, c, d；
Fig. 3 is the corresponding response intensity of detection Propofol under four kinds of different ions migration spectrum input modes a, b, c, d.
Specific embodiment
A kind of input mode improving Ion transfer spectral sensitivity, the reaction zone including ion mobility spectrometry, tubular reaction zone
It is respectively equipped with vacuum UV lamp (1) and ion gate (5) at two side end faces of left and right, is equipped with examination in the side wall surface of reaction zone
Agent molecule injection port (2) and sample feeding mouth (3), gas outlet (4),
Structure a, reagent molecule injection port (2) and gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1),
Reagent molecule injection port (2) and gas outlet (4) are coaxially oppositely arranged；Sample feeding mouth (3) is located at the reaction close to ion gate (5)
On the right side of area, sample feeding mouth (3) is located in the side wall surface below reaction zone；
Or, structure b, reagent molecule injection port (2) and gas outlet (4) are located at close to the reaction zone left side of vacuum UV lamp (1)
Side, reagent molecule injection port (2) are located in the side wall surface below reaction zone, and gas outlet (4) are located at the side wall surface above reaction zone
On, reagent molecule injection port (2) and gas outlet (4) are coaxially oppositely arranged；Sample feeding mouth (3) is located at the side wall below reaction zone
On face；
Or, structure c, gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), and gas outlet (4) are located at reaction
In side wall surface below area；The reaction zone that reagent molecule injection port (2) and sample feeding mouth (3) are located at close to ion gate (5) is right
Side；Reagent molecule injection port (2) is located in the side wall surface above reaction zone, reagent molecule injection port (2) and sample feeding mouth
(3) it is coaxially oppositely arranged, sample feeding mouth (3) is located in the side wall surface below reaction zone；
Or, structure d, gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), and gas outlet (4) are located at reaction
In side wall surface above area；Sample feeding mouth (3) is located on the right side of the reaction zone of ion gate (5), sample feeding mouth (3) position
In side wall surface below the reaction zone；Reagent molecule injection port (2) is located in the side wall surface below reaction zone, reagent molecule sample introduction
The parallel setting of axis of mouth (2) and sample feeding mouth (3).
Sample molecule is 50-500ml/min in the sample introduction flow velocity of sample feeding mouth (3), and the flow rate of carrier gas of reagent molecule is
50-500ml/min。
Embodiment 1
As shown by figures 2 b and 3b, b structure, reagent molecule injection port (2) and gas outlet (4) are located at close to vacuum UV lamp
(1) on the left of reaction zone, reagent molecule injection port (2) is located in the side wall surface below reaction zone, and gas outlet (4) are located at reaction
In side wall surface above area, reagent molecule injection port (2) and gas outlet (4) are coaxially oppositely arranged, and sample feeding mouth (3) is located at anti-
It answers in the side wall surface below area.Reagent molecule injection port is close apart from lamp, and sample and reagent molecule injection port are ipsilateral, the letter of sample peak
Number intensity height, although reagent molecule is blown out from the preceding gas outlet of lamp cap, in the dense of the position reagent molecule close apart from optical window
Degree is high, and ionizing efficiency is high, and the reagent ion of generation is present in entire reaction zone, and injection port of the sample before ion gate is into can be with
It is sufficiently reacted with reagent ion, so the response intensity of Propofol is up to 0.13；
As shown by figures 2 a and 3, a structure, reagent molecule injection port (2) and gas outlet (4) are located at close to vacuum UV lamp
(1) on the left of reaction zone, reagent molecule injection port (2) and gas outlet (4) are coaxially oppositely arranged, and sample feeding mouth (3), which is located at, to be leaned on
On the right side of the reaction zone of nearly ion gate (5), sample feeding mouth (3) is located in the side wall surface below reaction zone.Reagent molecule and sample
Injection port heteropleural, possible sample distribution it is upper and b structure it is ipsilateral on have difference, without the reagent ion and sample in b structure
The probability of product collision is big, so response intensity 0.11 is more slightly lower than b structure；
Such as Fig. 2 d and with shown in 3d, d structure, gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), out
Port (4) is located in the side wall surface above reaction zone；Sample feeding mouth (3) is located on the right side of the reaction zone of ion gate (5), sample
Product injection port (3) is located in the side wall surface below reaction zone, and reagent molecule injection port (2) is located at the side wall surface below reaction zone
On, the parallel setting of axis of reagent molecule injection port (2) and sample feeding mouth (3).Reagent molecule and sample feeding mouth are same
Side, and reaction zone is advanced into ion gate, on the one hand concentration can be diluted, when another aspect concentration is maximum at ion gate
Wait, light intensity is weaker, but sample concentration maximum and reagent ion can with crash response, will not very by force will not be very weak, institute
With response intensity 0.06 between structure a and c；
As shown in Fig. 2 c and 3c, c structure, gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), outlet
Mouth (4) is located in the side wall surface below reaction zone；Reagent molecule injection port (2) and sample feeding mouth (3) are located at close to ion gate
(5) on the right side of reaction zone, reagent molecule injection port (2) is located in the side wall surface above reaction zone, reagent molecule injection port (2)
It is coaxially oppositely arranged with sample feeding mouth (3), sample feeding mouth (3) is located in the side wall surface below reaction zone.Reagent molecule and
Sample feeding mouth advances into reaction zone in different survey, in ion gate, and on the one hand concentration can be diluted, another aspect concentration is in ion
When maximum at door, light intensity is weaker, although reagent ion RIP intensity is high, different survey distribution, so that sample is in high concentration
Range there is no effective collision reaction, so response intensity 0.02 is most weak.
Claims (1)
1. a kind of sampling structure for improving Ion transfer spectral sensitivity, the reaction zone including ion mobility spectrometry, tubular react position
It is respectively equipped with vacuum UV lamp (1) and ion gate (5) at two side end faces of left and right, is divided in the side wall surface of reaction zone equipped with reagent
Sub- injection port (2) and sample feeding mouth (3), gas outlet (4), it is characterised in that:
Structure a, reagent molecule injection port (2) and gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), reagent
Molecule injection port (2) and gas outlet (4) are coaxially oppositely arranged；The reaction zone that sample feeding mouth (3) is located at close to ion gate (5) is right
Side, sample feeding mouth (3) are located in the side wall surface below reaction zone；
Or, structure b, reagent molecule injection port (2) and gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), examination
Agent molecule injection port (2) is located in the side wall surface below reaction zone, and gas outlet (4) are located in the side wall surface above reaction zone, examination
Agent molecule injection port (2) and gas outlet (4) are coaxially oppositely arranged；Sample feeding mouth (3) is located in the side wall surface below reaction zone；
Or, structure c, gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), and gas outlet (4) are located under reaction zone
In the side wall surface of side；Reagent molecule injection port (2) and sample feeding mouth (3) are located on the right side of the reaction zone of ion gate (5)；Examination
Agent molecule injection port (2) is located in the side wall surface above reaction zone, and reagent molecule injection port (2) and sample feeding mouth (3) are coaxial
It is oppositely arranged, sample feeding mouth (3) is located in the side wall surface below reaction zone；
Or, structure d, gas outlet (4) are located on the left of the reaction zone of vacuum UV lamp (1), and gas outlet (4) are located on reaction zone
In the side wall surface of side；Sample feeding mouth (3) is located on the right side of the reaction zone of ion gate (5), and sample feeding mouth (3) is located at reaction
In side wall surface below area；Reagent molecule injection port (2) is located in the side wall surface below reaction zone, reagent molecule injection port (2)
Setting parallel with the axis of sample feeding mouth (3).
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| CN201821948187.8U CN209356445U (en) | 2018-11-25 | 2018-11-25 | A kind of sampling structure improving Ion transfer spectral sensitivity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112986373A (en) * | 2019-12-12 | 2021-06-18 | 中国科学院大连化学物理研究所 | Ion mobility spectrometry and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112986373A (en) * | 2019-12-12 | 2021-06-18 | 中国科学院大连化学物理研究所 | Ion mobility spectrometry and application thereof |
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