CN209356444U - A kind of ionic migration spectrometer of real time on-line monitoring - Google Patents
A kind of ionic migration spectrometer of real time on-line monitoring Download PDFInfo
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- CN209356444U CN209356444U CN201821945973.2U CN201821945973U CN209356444U CN 209356444 U CN209356444 U CN 209356444U CN 201821945973 U CN201821945973 U CN 201821945973U CN 209356444 U CN209356444 U CN 209356444U
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- transference tube
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Abstract
The utility model discloses a kind of ionic migration spectrometers of real time on-line monitoring, it can work under positive ion mode or negative ion mode, the real-time sampling and on-line checking of gas with various sample can be achieved, and then the speed and sensitivity of ionic migration spectrum detection are improved, it can be used for the real time on-line monitoring of various samples.
Description
Technical field
The utility model relates to improve the analysis method of ion mobility spectrometry real time on-line monitoring, specifically a kind of ion
The input mode of migration spectrum.
Background technique
Ion mobility spectrometry is the technology of a kind of difference according to sample products Ion transfer speed and separation detection, has knot
Structure is simple, high sensitivity, detects fireballing advantage.
Ionization source is the important component of ion mobility spectrometry, and effect is to ionize reagent molecule to generate reagent ion,
Reagent ion and example reaction generate product ion, and product ion separates in migration area under the action of electric field and successively reaches inspection
Device is surveyed, to realize the separation and detection of target compound.
Humidity is an important factor for influencing ionizing efficiency, and the sensitivity that the input mode of sample detects actual sample seems
Increasingly important, negative pressure real-time online samples, and under one-way gas flow mode, drift gas can be realized simultaneously the work of the dilution to sample gas humidity
With to eliminate influence of the humidity to sample detection well, the sensitivity of raising actual sample detection, real-time online contracts simultaneously
The analysis time of short sample.
Utility model content
The utility model devises a kind of ionic migration spectrometer of real time on-line monitoring, it is therefore an objective to realize different analysis samples
Real-time online detection, real-time online input mode and ion mobility spectrometry ms magnitude detection time matching, shorten Ion transfer
The time of spectrum analysis actual sample.
A kind of ionic migration spectrometer of real time on-line monitoring, including ionization source and transference tube, transference tube include
The reaction zone and right side migration area in left side are equipped with vacuum UV lamp light ionization source in the reaction zone left end far from migration area, float gas
It is entered in transference tube through drift gas import by the migration area right end tail portion of the separate reaction zone of transference tube, is moved in ion
It moves and is equipped with ion gate between the migration area and reaction zone of pipe, exhalation sample gas is leaned on through sample gas inlet by the centre of transference tube
The reaction zone of nearly ion gate enters in transference tube, will by the gas outlet being arranged in ionic reaction area left end lower sidewalls
Sample gas is endlessly pumped into transference tube, gas flowmeter and sampling pump phase of the gas outlet through control sampling flow velocity
Even；
Mouth is added in the reagent molecule that side wall surface is equipped with carrier gas carrier band above ionic reaction area left end；
Vacuum UV lamp is placed on the left of cylindric transference tube, and vacuum UV lamp goes out the axis of light optical window and transference tube
Line is vertical and vacuum UV lamp along the axis of transference tube sends out emerging beam.
Under migration tube normal operating condition, under the action of sampling pump, sample gas is adopted the reaction into migration tube in real time
Area, meanwhile, reagent molecule also constantly enters in the reaction zone of transference tube, and by the vacuum UV lamp photoelectricity of reaction zone
From generating reaction reagent ion, sample and reaction reagent ionic reaction generate the product ion of sample in reaction zone, product from
Son periodically enters migration area by ion gate under reaction zone electric field action, and is divided under the electric field action of migration area
From successively arrival Faraday plate is detected, and finally obtains the ion mobility spectrometry of Propofol.
Migration tube can be detected in the positive-ion mode or under negative ion mode to Propofol progress real-time online detection；
In the positive-ion mode, apply positive 5kV high pressure on migration tube, reagent molecule can be toluene, ethylbenzene or benzene
With the first-class organic molecule being easily ionized in one of methyl ether or two；
In the negative ion mode, apply negative 5kV high pressure on migration tube, reagent molecule can be acetone, butanone, first
With the first-class organic molecule being easily ionized in one of benzene, ethylbenzene or methyl phenyl ethers anisole or two.
It include the reaction zone close to left side and the ion migration zone close to right side in transference tube, drift gas is moved by ion
The drift gas air inlet for moving pipe right end enters ion migration zone, and drift gas velocity range is 100-1000ml/min, and reagent molecule carries
Gas carries the reaction zone that reagent molecule enters close left side in transference tube, examination by pipeline through reagent molecule generating device
Close to lamp cap position in the transference tube side wall surface that agent molecule flow rate of carrier gas is 50ml/min and reagent molecule air inlet is opposite
Aspiration pump pumping, flowmeter control pumping flow velocity, sample gas is as the sample in the transference tube side wall surface where reaction zone
Product gas air inlet is pumped into reaction zone, and sampling flow rates are 100-500ml/min.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of the ionic migration spectrometer of real time on-line monitoring, and 1 is vacuum UV lamp, and 2 be reagent
Molecule generating device, 3 be reagent molecule carrier gas inlet, and 4 be sample gas inlet, and 5 be ion gate, and 6 be conducting ring, and 7 be aperture plate, 8
To float gas import, 9 be amplifier, and 10 be high voltage power supply, and 11 be mass flowmenter, and 12 be aspiration pump, and 13 be gas outlet；
Fig. 2 is the ion transfer spectrogram that expiratory air Propofol is detected under positive ion mode；
Fig. 3 is the ion transfer spectrogram that expiratory air Propofol is detected under negative ion mode.
Specific embodiment
A kind of ionic migration spectrometer of real time on-line monitoring, transference tube include reaction zone and the right side migration in left side
Area is equipped with vacuum UV lamp light ionization source in the reaction zone left end far from migration area, and drift gas is through drift gas import by transference tube
The migration area right end tail portion of separate reaction zone enter in transference tube, in the migration area and reaction zone of transference tube it
Between be equipped with ion gate, exhalation sample gas entered by the centre of transference tube close to the reaction zone of ion gate through sample gas inlet
In transference tube, sample gas is endlessly pumped by the gas outlet being arranged in ionic reaction area left end lower sidewalls
In transference tube, gas outlet is connected through the gas flowmeter of control sampling flow velocity with sampling pump；
Mouth is added in the reagent molecule that side wall surface is equipped with carrier gas carrier band above ionic reaction area left end；
Vacuum UV lamp is placed on the left of cylindric transference tube, and vacuum UV lamp goes out the axis of light optical window and transference tube
Line is vertical and vacuum UV lamp along the axis of transference tube sends out emerging beam.
Under migration tube normal operating condition, under the action of sampling pump, sample gas is adopted the reaction into migration tube in real time
Area, meanwhile, reagent molecule also constantly enters in the reaction zone of transference tube, and by the vacuum UV lamp photoelectricity of reaction zone
From generating reaction reagent ion, sample and reaction reagent ionic reaction generate the product ion of sample in reaction zone, product from
Son periodically enters migration area by ion gate under reaction zone electric field action, and is divided under the electric field action of migration area
From successively arrival Faraday plate is detected, and finally obtains the ion mobility spectrometry of Propofol.
Migration tube can be detected in the positive-ion mode or under negative ion mode to Propofol progress real-time online detection；
In the positive-ion mode, apply positive 5kV high pressure on migration tube, reagent molecule can be toluene, ethylbenzene or benzene
With the first-class organic molecule being easily ionized in one of methyl ether or two；
In the negative ion mode, apply negative 5kV high pressure on migration tube, reagent molecule can be acetone, butanone, first
With the first-class organic molecule being easily ionized in one of benzene, ethylbenzene or methyl phenyl ethers anisole or two.
It include the reaction zone close to left side and the ion migration zone close to right side in transference tube, drift gas is moved by ion
The drift gas air inlet for moving pipe right end enters ion migration zone, and drift gas velocity range is 100-1000ml/min, and reagent molecule carries
Gas carries the reaction zone that reagent molecule enters close left side in transference tube, examination by pipeline through reagent molecule generating device
Close to lamp cap position in the transference tube side wall surface that agent molecule flow rate of carrier gas is 50ml/min and reagent molecule air inlet is opposite
Aspiration pump pumping, flowmeter control pumping flow velocity, sample gas is as the sample in the transference tube side wall surface where reaction zone
Product gas air inlet is pumped into reaction zone, and sampling flow rates are 100-500ml/min.
Embodiment 1
A kind of ionic migration spectrometer of real time on-line monitoring, including ionization source and transference tube, ionization source are a vacuum
Ultraviolet lamp, vacuum UV lamp are placed on the left of cylindric transference tube, and vacuum UV lamp goes out light optical window towards transference tube
The radial line and radial line of vacuum UV lamp emerging beam and transference tube is perpendicular.
It include the reaction zone close to left side and the ion migration zone close to right side in transference tube, drift gas is moved by ion
The drift gas air inlet for moving pipe right end enters ion migration zone, and drift gas velocity range is 100-1000ml/min, and reagent molecule carries
Gas carries the reaction zone that reagent molecule enters close left side in transference tube, examination by pipeline through reagent molecule generating device
Close to lamp cap position in the transference tube side wall surface that agent molecule flow rate of carrier gas is 50ml/min and reagent molecule air inlet is opposite
Aspiration pump pumping, flowmeter control pumping flow velocity, sample gas is as the sample in the transference tube side wall surface where reaction zone
Product gas air inlet is pumped into reaction zone, and sampling flow rates are 100-500ml/min.
In the positive-ion mode, drift gas velocity range is 200ml/min, reagent molecule flow rate of carrier gas 50ml/min, sampling
Flow velocity 50ml/min, ion mobility spectrometry reagent ion M+, the reduction mobility of Propofol product ion is 1.50cm2V-1s-1, such as
Shown in Fig. 2.
Embodiment 2
A kind of ionic migration spectrometer of real time on-line monitoring, including ionization source and transference tube, ionization source are a vacuum
Ultraviolet lamp, vacuum UV lamp are placed on the left of cylindric transference tube, and vacuum UV lamp goes out light optical window towards transference tube
The radial line and radial line of vacuum UV lamp emerging beam and transference tube is perpendicular.
It include the reaction zone close to left side and the ion migration zone close to right side in transference tube, drift gas is moved by ion
The drift gas air inlet for moving pipe right end enters ion migration zone, and drift gas velocity range is 100-1000ml/min, and reagent molecule carries
Gas carries the reaction zone that reagent molecule enters close left side in transference tube, examination by pipeline through reagent molecule generating device
Close to lamp cap position in the transference tube side wall surface that agent molecule flow rate of carrier gas is 50ml/min and reagent molecule air inlet is opposite
Aspiration pump pumping, flowmeter control pumping flow velocity, sample gas is as the sample in the transference tube side wall surface where reaction zone
Product gas air inlet is pumped into reaction zone, and sampling flow rates are 100-500ml/min.
In the negative ion mode, when drift gas velocity is 200ml/min, reagent molecule flow rate of carrier gas 50ml/min, sample streams
Fast 50ml/min, ion mobility spectrometry reagent ion O2 -(H2O) nWhen, for expiratory air Propofol (100%RH) detect, third pool
There are two product ion peaks altogether for phenol, and product ion is respectively reduction mobility 1.47cm2V-1s-1And 1.38cm2V-1s-1(M-H)-
And MO2 -, as shown in Figure 3.
Claims (1)
1. a kind of ionic migration spectrometer of real time on-line monitoring, including ionization source and transference tube, transference tube includes a left side
The reaction zone and right side migration area of side are equipped with vacuum UV lamp (1) in the reaction zone left end far from migration area, it is characterised in that:
Drift gas import (8) be located at transference tube separate reaction zone migration area right end tail portion, in transference tube migration area with
Be equipped with ion gate (5) between reaction zone, sample gas inlet (4) be located at the centre of transference tube close to ion gate reaction zone into
Enter into transference tube, gas outlet (13) are located in ionic reaction area left end lower sidewalls, and gas outlet (13) are through gas flow
Meter (11) is connected with aspiration pump (12)；
Reagent molecule carrier gas inlet (3) is located above ionic reaction area left end in side wall surface；
Vacuum UV lamp (1) is placed on the left of cylindric transference tube, and vacuum UV lamp (1) goes out light optical window and transference tube
Axis is vertical and vacuum UV lamp (1) along the axis of transference tube sends out emerging beam.
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| CN201821945973.2U CN209356444U (en) | 2018-11-25 | 2018-11-25 | A kind of ionic migration spectrometer of real time on-line monitoring |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112924527A (en) * | 2019-12-06 | 2021-06-08 | 中国科学院大连化学物理研究所 | Method for improving detection sensitivity of exhaled propofol |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112924527A (en) * | 2019-12-06 | 2021-06-08 | 中国科学院大连化学物理研究所 | Method for improving detection sensitivity of exhaled propofol |
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