CN209333548U - A kind of liquid chromatogram geopressure gradient static mixer - Google Patents
A kind of liquid chromatogram geopressure gradient static mixer Download PDFInfo
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- CN209333548U CN209333548U CN201822067651.9U CN201822067651U CN209333548U CN 209333548 U CN209333548 U CN 209333548U CN 201822067651 U CN201822067651 U CN 201822067651U CN 209333548 U CN209333548 U CN 209333548U
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- mixing chamber
- premix
- main
- liquid chromatogram
- premixer
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Abstract
The utility model discloses a kind of liquid chromatogram geopressure gradient static mixers, including premixer, main mixer, it is characterized in that the outlet of premixer is connected with main mixer, main mixer includes main mixing chamber, several mixing chambers through main mixing chamber are offered on main mixing chamber, each mixing chamber both ends are provided with connector, sieve plate is provided in mixing chamber on the inside of each connector, the connector at each mixing chamber both ends is sequentially connected in series to form the main mixing chamber of mixing by tandem tube, main mixing chamber one end is connected by connecting tube with the outlet end mouth of premixer.The utility model be added the liquid chromatogram geopressure gradient static mixer being made of tee tube, premixer, main mixing chamber, have liquid phase good mixing effect, use cost it is low, improve gradient system utilization rate.
Description
Technical field
The utility model relates to the mixing arrangement technical field of high performance liquid chromatograph more particularly to a kind of liquid chromatogram are high
Press gradient static mixer.
Background technique
In traditional liquid chromatogram instrument, the configuration of typically isocratic or low pressure gradient, i.e., in entire analytic process,
The ratio of mobile phase keeps constant low pressure gradient system that is constant or first flowing into high-pressure pump again after proportioning valve mixes, in this way
Configuration it is enough for analyzing some simple samples, but for many complicated samples, cannot but be isolated well, this
Binary or quaternary gradient configuration are needed, that is, in the analysis process, the ratio of mobile phase is continuous with the progress of analysis
Change.
Traditional low pressure quaternary gradient configuration needs to configure a pump and a dedicated proportioning valve, and when mixing is also easy to produce
Bubble generally requires one online quaternary degasser of configuration, and the maintenance of this sampling instrument and use cost are very big, and general user is very
Hardly possible receives, and now designs a kind of liquid chromatogram geopressure gradient static mixer in view of the above problems.
Utility model content
The purpose of this utility model is to provide a kind of liquid chromatogram geopressure gradient static mixers, have liquid phase mixing effect
Fruit is good, use cost is low, improves the advantages of gradient system utilization rate, solves the problems, such as the defect of conventional low gradient mixing.
In order to achieve the above objectives, the utility model adopts the following technical solution: a kind of liquid chromatogram geopressure gradient static state is mixed
Clutch, including premixer, main mixer, it is characterised in that the outlet of premixer is connected with main mixer, main mixer
Including main mixing chamber, several mixing chambers through main mixing chamber are offered on main mixing chamber, each mixing chamber both ends are all provided with
It is equipped with connector, sieve plate is provided in the mixing chamber on the inside of each connector, the connector at each mixing chamber both ends passes through tandem tube
It is sequentially connected in series to form the main mixing chamber of mixing, main mixing chamber one end is connected by connecting tube with the outlet end mouth of premixer
It is logical.
Further, premixer includes filtering head, premix female, premix male connector, and the feed liquor port sleeve for premixing female is set
There is filtering head, is provided with filtering sieve plate between filtering head and premix female, the outlet end muzzle for premixing female is located at premix male connector
On, and premix and be provided with premix sieve plate between female and premix male connector, premix male connector is connected by connecting tube and main mixing chamber connection
It connects.
Further, it filters sieve plate, premix several premix holes offered on sieve plate, premix the aperture .0.22- in hole
0.45μm。
Further, several ceramic beads are provided between two sieve plates in each mixing chamber.
Further, several mix apertures offered on sieve plate .0.22-0.45 μm of the aperture of mix aperture.
Further, the diameter of porcelain bead is greater than the aperture of mix aperture.
Further, liquid chromatogram geopressure gradient static mixer further includes tee tube, the filtering on the premixer
The outlet end mouth connection of head import and tee tube connects.
The utility model has the beneficial effect that compared with prior art
1. the liquid chromatogram geopressure gradient static mixer being made of tee tube, premixer, main mixing chamber being added,
Have liquid phase good mixing effect, use cost it is low, improve gradient system utilization rate；
2. there are two types of effects for sieve plate: first is that 0.45 μm or more of granule foreign can be filtered, playing prevents main mixer stifled
The effect of plug；Second is that can be with the effect of premix flow phase；Main mixing chamber uses Multicarity tandem connection type, mixing
Cavity is divided into multistage, is connected using the connecting tube of small internal diameter；Sieve plate is designed in main mixing chamber at liquid inlet, and in the cavity
Corrosion resistant filler such as ceramic bead or ceramic powders etc. are added, mixing dead volume is reduced, increases mixed path to improve mixing
Effect.
Detailed description of the invention
Attached drawing is used to provide a further understanding of the present invention, and constitutes part of specification, practical with this
Novel embodiment is used to explain the utility model together, does not constitute limitations of the present invention.In the accompanying drawings:
Fig. 1 be the utility model proposes a kind of liquid chromatogram geopressure gradient static mixer structural schematic diagram.
In figure: 1- tee tube, 2- premixer, 3- cavity, the main mixing chamber of 4-, 5- connector, 6- sieve plate, 7- ceramics are small
Ball, 8- connecting tube, 9- filtering head, 10- filtering sieve plate, 11- premix female, 12- premix male connector, 13- premix sieve plate, 14- sealing
Pad 15- tandem tube, the main mixing chamber of 16-.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Referring to Fig.1, a kind of liquid chromatogram geopressure gradient static mixer, including premixer 2, main mixer, feature
It is that the outlet of premixer 2 is connected with main mixer, main mixer includes main mixing chamber 4, is opened up on main mixing chamber 4
There are several mixing chambers 3 through main mixing chamber 4, each 3 both ends of mixing chamber are provided with connector 5, and each 5 inside of connector is mixed
It closes and is provided with sieve plate 6 in chamber 3, the connector 5 at each 3 both ends of mixing chamber is sequentially connected in series to form mixing master by tandem tube 15
Mixing chamber 16, main 16 one end of mixing chamber are connected by connecting tube 8 with the outlet end mouth of premixer 2.
Premixer 2 includes filtering head 9, premix female 11, premix male connector 12, and the feed liquor port sleeve of premix female 11 is equipped with
Filtering head 9, is provided with filtering sieve plate 10 between filtering head 9 and premix female 11, the outlet end muzzle of premix female 11 is located at pre-
It in mixed male connector 12, and premixes and is provided with premix sieve plate 13 between female 11 and premix male connector 12, premix male connector 12 passes through connecting tube 8
It is connect with main 16 connection of mixing chamber；Several premix holes offered on filtering sieve plate 10, premix sieve plate 13, premix the aperture in hole
0.22-0.45μm；Several ceramic beads 7 are provided between two sieve plates 6 in each mixing chamber 3；If being offered on sieve plate 6
Dry-mixing hole, 0.22-0.45 μm of the aperture of mix aperture；The diameter of ceramic bead 7 is greater than the aperture of mix aperture；It further include tee tube
1,9 import of filtering head on premixer 2 is connect with the outlet end mouth connection of tee tube 1；3 both ends of mixing chamber offer fixation
Slot, sieve plate 6 are placed on fixing groove bottom, fix in groove sidewall and are provided with internal screw thread, attack and be equipped on the lateral wall of connector one end
External screw thread, and matched with internal screw thread on fixing groove inner sidewall, and sieve plate is fixed in fixing groove.
In use, liquid is entered by tee tube 1, when uneven liquid is entered by 2 inlet of premixer, by being pre-mixed
Device 2 is rapidly by liquid blending, after sieve plate 6 and ceramic bead 7 of the liquid by optimization design further cache mixing, finally from out
Liquid mouth flows out, and in whole process, various different viscosities and polar liquid phase can be mixed well, and gradient elution effect is good, and liquid phase is mixed
Conjunction effect is good, use cost is low, improves gradient system utilization rate, while the intensive setting of entire mixer, and volume is more traditional mixed
Clutch greatly reduces, and can more reduce the manufacturing cost of product.
Place is not described in detail for the utility model, is the well-known technique of those skilled in the art.
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (7)
1. a kind of liquid chromatogram geopressure gradient static mixer, including premixer (2), main mixer, it is characterised in that premix
The outlet of clutch (2) is connected with main mixer, and main mixer includes main mixing chamber (4), offers on main mixing chamber (4)
Several mixing chambers (3) through main mixing chamber (4), each mixing chamber (3) both ends are provided with connector (5), each connector (5)
It is provided with sieve plate (6) in the mixing chamber (3) of inside, the connector (5) at each mixing chamber (3) both ends passes through tandem tube (15) successively
It is connected in series to form the main mixing chamber (16) of mixing, main mixing chamber (16) one end goes out liquid by connecting tube (8) and premixer (2)
Port is connected.
2. liquid chromatogram geopressure gradient static mixer according to claim 1, it is characterised in that: premixer (2) packet
Filtering head (9), premix female (11), premix male connector (12) are included, the feed liquor port sleeve of premix female (11) is equipped with filtering head (9),
Filtering sieve plate (10) is provided between filtering head (9) and premix female (11), the outlet end muzzle of premix female (11) is located at pre-
It on mixed male connector (12), and premixes and is provided with premix sieve plate (13) between female (11) and premix male connector (12), premix male connector (12)
It is connect by connecting tube (8) with main mixing chamber (16) connection.
3. liquid chromatogram geopressure gradient static mixer according to claim 2, it is characterised in that: filtering sieve plate (10),
Several premix holes offered on premix sieve plate (13), premix 0.22-0.45 μm of the aperture in hole.
4. liquid chromatogram geopressure gradient static mixer according to claim 1, it is characterised in that: in each mixing chamber (3)
Two sieve plates (6) between be provided with several ceramic beads (7).
5. liquid chromatogram geopressure gradient static mixer according to claim 1, it is characterised in that: sieve plate is opened on (6)
Several mix apertures being equipped with, 0.22-0.45 μm of the aperture of mix aperture.
6. liquid chromatogram geopressure gradient static mixer according to claim 5, it is characterised in that: ceramic bead (7)
Diameter is greater than the aperture of mix aperture.
7. liquid chromatogram geopressure gradient static mixer according to claim 1 or 2, it is characterised in that: further include threeway
It manages (1), filtering head (9) import on the premixer (2) is connect with the outlet end mouth connection of tee tube (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822067651.9U CN209333548U (en) | 2018-12-10 | 2018-12-10 | A kind of liquid chromatogram geopressure gradient static mixer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822067651.9U CN209333548U (en) | 2018-12-10 | 2018-12-10 | A kind of liquid chromatogram geopressure gradient static mixer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209333548U true CN209333548U (en) | 2019-09-03 |
Family
ID=67756428
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822067651.9U Active CN209333548U (en) | 2018-12-10 | 2018-12-10 | A kind of liquid chromatogram geopressure gradient static mixer |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
| CN114733380A (en) * | 2022-03-04 | 2022-07-12 | 中国科学院大连化学物理研究所 | Standard gas generating device |
| US11555805B2 (en) | 2019-08-12 | 2023-01-17 | Waters Technologies Corporation | Mixer for chromatography system |
| US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
| US11898999B2 (en) | 2020-07-07 | 2024-02-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
-
2018
- 2018-12-10 CN CN201822067651.9U patent/CN209333548U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
| US11555805B2 (en) | 2019-08-12 | 2023-01-17 | Waters Technologies Corporation | Mixer for chromatography system |
| US11898999B2 (en) | 2020-07-07 | 2024-02-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
| US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
| CN114733380A (en) * | 2022-03-04 | 2022-07-12 | 中国科学院大连化学物理研究所 | Standard gas generating device |
| CN114733380B (en) * | 2022-03-04 | 2024-02-23 | 中国科学院大连化学物理研究所 | Standard gas generating device |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: Room 511, Block C, Building 2, No. 321 Jinpeng Street, Xihu District, Hangzhou City, Zhejiang Province, 310030 Patentee after: Hangzhou Tianzhao Technology Co.,Ltd. Address before: Room 403, Block A, Building 3, No. 8 Xiyuan 9th Road, Sandun Town, Xihu District, Hangzhou City, Zhejiang Province, 310030 Patentee before: HANGZHOU XUYU TECHNOLOGY Co.,Ltd. |
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| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230928 Address after: 337000 District A, Science and Technology Innovation City, West Renma Intelligent Industrial Park, Danjiang Street, Anyuan District, Pingxiang City, Jiangxi Province Patentee after: Jiangxi Tianzhao Chromatography Technology Co.,Ltd. Address before: Room 511, Block C, Building 2, No. 321 Jinpeng Street, Xihu District, Hangzhou City, Zhejiang Province, 310030 Patentee before: Hangzhou Tianzhao Technology Co.,Ltd. |