CN209302737U - Stirred autoclave is used in a kind of production of B- thymidine - Google Patents
Stirred autoclave is used in a kind of production of B- thymidine Download PDFInfo
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- CN209302737U CN209302737U CN201821648625.9U CN201821648625U CN209302737U CN 209302737 U CN209302737 U CN 209302737U CN 201821648625 U CN201821648625 U CN 201821648625U CN 209302737 U CN209302737 U CN 209302737U
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- main body
- kettle main
- heating pipe
- stirred autoclave
- agitating plate
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Abstract
The utility model relates to pharmaceutical production technical fields, and disclose a kind of B- thymidine production stirred autoclave, including kettle main body, heating pipe is fixedly connected to bottom at left and right sides of the kettle main body, the heat-generating pipe of heating pipe bottom is fixedly installed with through heating pipe and extended at the top of the heating pipe, and insulating layer is covered with outside the heating pipe；By being provided with variable frequency drive motors, the rotation of positive and negative both direction can be achieved, keep obtaining for stirring more uniform, by be provided with there are six stirring slurry and left and right be symmetrically parallel to each other, further through setting there are four agitating plate and left and right be symmetrically parallel to each other, make stirring it is more thorough, by offering stomata on agitating plate, energy consumption of the agitating plate in stirring is reduced, by the way that paddle as the radian of bottom, to be made to capable of being also sufficiently stirred for the raw material of bottom.
Description
Technical field
The utility model relates to pharmaceutical production technical field, stirred autoclave is used in specially a kind of B- thymidine production.
Background technique
The beta-thymidine of one of the important source material fixed as its husband of synthesis department is a kind of important medicine intermediate, has good
Good antivirus action has remarkable effect in cancer chemotherapy and anti-virus aspect, while it still synthesizes the fixed weight of Qi Duofu
Raw material is wanted, it is the abbreviation of thymidine that beta-thymidine, which is also referred to as thymidine, the entitled 1- (2 '-deoxidation-β-D- furans of chemistry
Ribose) -5-methyl-uridin, the entitled Thymidine of English, molecular formula is C10H14N2O5, molecular weight 242.2286.
It is needed in pharmacy, the industrial circles such as food using a large amount of stirred autoclave, it is in the prior art to be stirred to react
Agitating device in kettle is typically all single axle stirring structure, and the blade of this single axle stirring structure at work can only be single
Direction rotation, can only meet basic stirring requirement, cause mixing time long, and stirring energy consumption is high, can not optimize and be stirred
Effect, and the process for producing beta-thymidine is very strict, and stirred autoclave on the market is extremely difficult to require, therefore proposes a kind of B-
Thymidine production is solved the above problems with stirred autoclave.
Utility model content
(1) the technical issues of solving
In view of the deficiencies of the prior art, the utility model provides a kind of B- thymidine production stirred autoclave, has and stirs
It is good to mix effect, the advantages that Parameter adjustable, it is poor to solve mixing effect, the nonadjustable problem of parameter.
(2) technical solution
To realize that above-mentioned mixing effect is good, the purpose of Parameter adjustable, the utility model is provided the following technical solutions: a kind of B-
Thymidine production stirred autoclave, including kettle main body, the kettle main body left and right sides are fixedly connected to heating pipe with bottom,
The heat-generating pipe of heating pipe bottom, the heating tube are fixedly installed with through heating pipe and extended at the top of the heating pipe
Insulating layer is covered with outside road, two sides are fixedly installed with through kettle body top and extend to kettle master on the left of the kettle body top
The solids injection lances in internal portion, the kettle body top are movably installed with through kettle body top and extend to turning for kettle bottom part body
Axis, the kettle body top are fixedly connected with motor, the output end connection on the shaft top and motor, the kettle body top
Liquid jet through kettle body top is installed, is connected with liquid graded tube at the top of the liquid jet, it is right in the shaft
What is claimed is fixed with agitating paddle, agitating plate and paddle, and the agitating plate front offers stomata, and the kettle body top right side is solid
Dingan County is equipped with through kettle body top and extends to the soda acid induction tube of kettle bottom part body, fixed peace at the top of the soda acid induction tube
Equipped with soda acid graduation apparatus, the kettle bottom part body is fixedly connected with filtering cabin, and the filtering cabin bottom, which is movably installed with, to be penetrated through
Filter position bottom and the motion stops at the top of filter position are extended to the over, the motion stops bottom is fixedly installed with nanofiltration net, described to receive
Rice filtering sieve bottom is fixedly connected with the telescopic rod through filtering cabin bottom, and the telescopic rod external activity is equipped in rotation
Lock, the telescopic rod bottom are fixedly connected with bracket, and the heat-generating pipe is fixedly installed with temperature controller far from kettle main body one end,
It is fixedly connected on the right side of the temperature controller with bottom with bracket, the temperature controller front is fixedly installed with temperature scale table
And temperature control burtons, the temperature control burtons are located at temperature scale table bottom, the temperature controller respectively with heat-generating pipe
It is connected with temperature scale table.
Preferably, suit with inner wall at left and right sides of filtering cabin at left and right sides of the nanofiltration net.
Preferably, there are six the agitating paddles, the paddle blade is as the radian of bottom.
Preferably, there are four the agitating plates, ten stomatas are offered on each agitating plate, the agitating plate is located at
Between two agitating paddles at top, and agitating plate is parallel with agitating paddle.
Preferably, the liquid jet and solids injection lances all there are two and bilateral symmetry, the solids injection lances and kettle main body
Left and right sides inner wall is parallel.
It preferably, be partially trapezoidal lower on the filtering cabin point is rectangle, and bottom tilts down 45 degree, it is described
Trapezoid block at the top of motion stops is bonded with inner wall at left and right sides of filtering cabin.
Preferably, the soda acid induction tube is parallel with inner wall at left and right sides of kettle main body, and the heat-generating pipe and heating pipe are left
Right two sides inner wall is parallel.
(3) beneficial effect
Compared with prior art, the utility model provides a kind of B- thymidine production stirred autoclave, and having following has
Beneficial effect:
1, B- thymidine production stirred autoclave, by being provided with variable frequency drive motors, it can be achieved that positive and negative both direction
Rotation, make stirring it is more uniform, by be provided with there are six agitating paddle and left and right be symmetrically parallel to each other, further through
Setting is there are four agitating plate and left and right is symmetrically parallel to each other, and keeps stirring more thorough, by offering gas on agitating plate
Hole reduces energy consumption of the agitating plate in stirring, by the way that paddle as the radian of bottom, to be made to capable of also obtaining for the raw material of bottom
To being sufficiently stirred, by the way that multiple solids injection lances and liquid jet is arranged, make whole device that can add plurality of raw materials simultaneously, by setting
Set motion stops and motion stops bottom be connected with nanofiltration net, it can be achieved that when piston pushes up, reactant because gravity original
Because falling into filtering cabin, by the filtering of nanofiltration net, the reactant quality made is higher, by being provided with rotation internal lock,
Making telescopic rod that can lock telescopic rod when stretching to suitable position prevents telescopic rod from sliding, when whole device enhanced convenience.
2, B- thymidine production stirred autoclave is made anti-by being provided with liquid graded tube at the top of liquid jet
The reactant ratio parameter answered can freely regulate and control, by being provided with soda acid induction tube and parallel with inner wall at left and right sides of kettle main body,
Further through soda acid graduation apparatus is provided at the top of soda acid induction tube, the pH value of reaction system in reaction kettle is made to obtain real-time monitoring,
It is parallel with inner wall at left and right sides of heating pipe by setting heat-generating pipe, further through insulating layer is provided with, make the temperature in reaction kettle
It is heated evenly and temperature is not easy to scatter, temperature controller is fixedly installed with far from kettle main body one end by setting heat-generating pipe, and logical
Excess temperature controller front is fixedly installed with temperature scale table and temperature control burtons, makes the temperature parameter in reaction kettle can be real-time
Monitoring regulation.
Detailed description of the invention
FIG. 1 is a schematic structural view of the utility model.
In figure: 1 kettle main body, 2 agitating plates, 3 stomatas, 4 solids injection lances, 5 agitating paddles, 6 liquid jets, 7 liquid graded tubes, 8
Shaft, 9 motors, 10 soda acid graduation apparatus, 11 temperature scale tables, 12 temperature controllers, 13 temperature control burtons, the induction of 14 soda acids
Pipe, 15 insulating layers, 16 heating pipes, 17 heat-generating pipes, 18 nanofiltration nets, 19 rotation internal locks, 20 brackets, 21 telescopic rods, 22 are lived
Dynamic plug, 23 paddles, 24 filtering cabins.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
It is clear, it is fully described by, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Referring to Fig. 1, a kind of production of B- thymidine stirred autoclave, including kettle main body 1,1 left and right sides of kettle main body and bottom
Portion is fixedly connected to heating pipe 16, is fixedly installed at the top of heating pipe 16 through heating pipe 16 and extends to heating tube
The heat-generating pipe 17 of 16 bottom of road, heat-generating pipe 17 is parallel with 16 left and right sides inner wall of heating pipe, the left and right sides of heating pipe 16 with
Bottom is fixedly connected to insulating layer 15, and 1 top left side two sides of kettle main body are fixedly installed with through 1 top of kettle main body and extend
Solids injection lances 4 inside to kettle main body 1, there are two solids injection lances 4 and controls symmetrically, solids injection lances 4 and kettle main body 1 or so
Two sides inner wall is parallel, and 1 top movable of kettle main body is equipped with through 1 top of kettle main body and extends to the shaft 8 of 1 bottom of kettle main body,
It is fixedly connected with motor 9 at the top of kettle main body 1 and 8 top of shaft is fixedly connected with motor 9, motor 9 is variable frequency drive motors, and is turned
Speed is freely adjustable, and 1 top of kettle main body is fixedly installed with through 1 top of kettle main body on the left of motor 9 and extends to kettle main body 1
Internal liquid jet 6, there are two liquid jets 6 and controls symmetrically, and liquid scale is fixedly connected at the top of liquid jet 6
Pipe 7 is fixedly connected to agitating paddle 5, agitating plate 2 and paddle 23 at left and right sides of shaft 8, and there are three agitating paddles 5, and mutually flat
Row, for 23 blade of paddle as the radian of bottom, 2 front of agitating plate offers stomata 3, and there are four agitating plates 2 and bilateral symmetry
It being parallel to each other, ten stomatas 3 is offered on each agitating plate 2, agitating plate 2 is located between two agitating paddles 5 at top,
And agitating plate 2 is parallel with agitating paddle 5,1 top right side of kettle main body is fixedly installed with through 1 top of kettle main body and extends to kettle main body
The soda acid induction tube 14 of 1 bottom, soda acid induction tube 14 is parallel with 1 left and right sides inner wall of kettle main body, solid at the top of soda acid induction tube 14
Dingan County is equipped with soda acid graduation apparatus 10, and it is partially trapezoidal lower on filtering cabin 24 that 1 bottom of kettle main body, which is fixedly connected with filtering cabin 24,
Dividing is rectangle, and bottom tilts down 45 degree, and 24 bottom of filtering cabin is movably installed with through 24 bottom of filtering cabin and extension
To the motion stops 22 at 24 top of filtering cabin, it is partially trapezoidal in motion stops 22 and suits with 24 left and right sides inner wall of filtering cabin, it is living
22 bottoms of dynamic plug are fixedly installed with nanofiltration net 18,18 left and right sides of nanofiltration net with 24 left and right sides inner wall of filtering cabin
Suit, 18 bottom of nanofiltration net is fixedly connected with the telescopic rod 21 through 24 bottom of filtering cabin, 21 external activity of telescopic rod peace
Equipped with rotation internal lock 19,21 bottom of telescopic rod is fixedly connected with bracket 20, and heat-generating pipe 17 is fixedly installed with far from 1 one end of kettle main body
Temperature controller 12,12 right side of temperature controller are fixedly connected with bottom with bracket 20, and 12 front of temperature controller is fixedly mounted
There are temperature scale table 11 and temperature control burtons 13, temperature control burtons 13 are located at 11 bottom of temperature scale table.
In conclusion B- thymidine production stirred autoclave, by being provided with variable frequency drive motors 9, it can be achieved that positive and negative
The rotation of both direction, make stirring it is more uniform, by be provided with there are six agitating paddle 5 and left and right it is symmetrically mutually flat
Row, further through setting there are four agitating plate 2 and left and right be symmetrically parallel to each other, make stirring it is more thorough, pass through agitating plate 2
On offer stomata 3, reduce agitating plate 2 stirring when energy consumption, by the way that paddle 23 as the radian of bottom, is made bottom
The raw material in portion can be also sufficiently stirred, and by the way that multiple solids injection lances 4 and liquid jet 6 is arranged, make whole device can be simultaneously
Plurality of raw materials is added, by setting motion stops 22 and 22 bottom of motion stops is connected with nanofiltration net 18, it can be achieved that when activity 22
When plug pushes up, reactant is because of the reason of gravity, falls into filtering cabin 24, and by the filtering of nanofiltration net 18, what is made is anti-
It answers amount of substance higher, by being provided with rotation internal lock 19, makes telescopic rod 21 that can lock telescopic rod 21 when stretching to suitable position
Prevent telescopic rod 21 slide, when whole device enhanced convenience, by being provided with liquid graded tube 7 at the top of liquid jet 6,
Making the reactant ratio parameter of reaction can freely regulate and control, by be provided with soda acid induction tube 14 and in the left and right sides of kettle main body 1
Wall is parallel, further through soda acid graduation apparatus 10 is provided at the top of soda acid induction tube 14, obtains the pH value of reaction system in reaction kettle
It is parallel with 16 left and right sides inner wall of heating pipe by setting heat-generating pipe 17 to real-time monitoring, further through being provided with insulating layer 15,
Make that the temperature in reaction kettle is heated evenly and temperature is not easy to scatter, is pacified by setting heat-generating pipe 17 far from 1 one end of kettle main body is fixed
Equipped with temperature controller 12, temperature scale table 11 and temperature control burtons are fixedly installed with further through 12 front of temperature controller
13, make the temperature parameter in reaction kettle can real-time monitoring and regulating.
Also, by being provided with liquid graded tube 7 at the top of liquid jet 6, make the reactant ratio parameter of reaction can
Freely regulate and control, by being provided with soda acid induction tube 14 and parallel with 1 left and right sides inner wall of kettle main body, further through soda acid induction tube 14
Top is provided with soda acid graduation apparatus 10, and the pH value of reaction system in reaction kettle is made to obtain real-time monitoring, by the way that heat-generating pipe is arranged
17 is parallel with 16 left and right sides inner wall of heating pipe, further through insulating layer 15 is provided with, is heated evenly the temperature in reaction kettle
And temperature is not easy to scatter, and temperature controller 12 is fixedly installed with far from 1 one end of kettle main body by setting heat-generating pipe 17, further through temperature
Degree 12 front of controller is fixedly installed with temperature scale table 11 and temperature control burtons 13, makes the temperature parameter in reaction kettle can be real
When monitoring regulation.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that
There is also other identical elements in process, method, article or equipment including the element.
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (7)
1. a kind of production of B- thymidine stirred autoclave, including kettle main body (1), it is characterised in that: kettle main body (1) left and right two
Side and bottom are fixedly connected to heating pipe (16), are fixedly installed at the top of the heating pipe (16) through heating pipe
(16) and the heat-generating pipe (17) of heating pipe (16) bottom is extended to, is covered with insulating layer (15) outside the heating pipe (16),
Kettle main body (1) the top left side two sides are fixedly installed at the top of kettle main body (1) and extend to kettle main body (1) inside
Solids injection lances (4), kettle main body (1) top movable are equipped at the top of kettle main body (1) and extend to kettle main body (1) bottom
Shaft (8), be fixedly connected with motor (9) at the top of the kettle main body (1), the output end on shaft (8) top and motor (9)
Connection, kettle main body (1) top are equipped with the liquid jet (6) at the top of kettle main body (1), liquid jet (6) top
Portion is connected with liquid graded tube (7), and agitating paddle (5), agitating plate (2) and paddle are symmetrically fixed on the shaft (8)
(23), agitating plate (2) front offers stomata (3), and kettle main body (1) top right side is fixedly installed with through kettle main body
(1) top and the soda acid induction tube (14) of kettle main body (1) bottom is extended to, is fixedly installed at the top of the soda acid induction tube (14)
Soda acid graduation apparatus (10), kettle main body (1) bottom are fixedly connected with filtering cabin (24), filtering cabin (24) the bottom activity peace
Equipped with the motion stops (22) for running through filtering cabin (24) bottom and being extended to the at the top of filter position (24), motion stops (22) bottom is solid
Dingan County is equipped with nanofiltration net (18), and nanofiltration net (18) bottom is fixedly connected with stretching through filtering cabin (24) bottom
Contracting bar (21), telescopic rod (21) external activity are equipped with rotation internal lock (19), and telescopic rod (21) bottom is fixedly connected
Have bracket (20), the heat-generating pipe (17) is fixedly installed with temperature controller (12) far from kettle main body (1) one end, the temperature control
It is fixedly connected on the right side of instrument (12) processed with bottom with bracket (20), temperature controller (12) front is fixedly installed with temperature scale
Table (11) and temperature control burtons (13), the temperature control burtons (13) are located at temperature scale table (11) bottom, the temperature
Controller (12) is connect with heat-generating pipe (17) and temperature scale table respectively.
2. a kind of B- thymidine production stirred autoclave according to claim 1, it is characterised in that: the nanofiltration net
(18) left and right sides suits with inner wall at left and right sides of filtering cabin (24).
3. a kind of B- thymidine production stirred autoclave according to claim 1, it is characterised in that: the agitating paddle (5)
There are six, paddle (23) blade is as the radian of bottom.
4. a kind of B- thymidine production stirred autoclave according to claim 1, it is characterised in that: the agitating plate (2)
There are four, offer ten stomatas (3) on each agitating plate (2), the agitating plate (2) be located at close to top two stir
It mixes between paddle (5), and agitating plate (2) is parallel with agitating paddle (5).
5. a kind of B- thymidine production stirred autoclave according to claim 1, it is characterised in that: the liquid jet
(6) and solids injection lances (4) all there are two and bilateral symmetry, inner wall is flat at left and right sides of the solids injection lances (4) and kettle main body (1)
Row.
6. a kind of B- thymidine production stirred autoclave according to claim 1, it is characterised in that: the filtering cabin (24)
It point is rectangle that upper part, which is trapezoidal lower, and bottom tilts down 45 degree, the trapezoid block at the top of the motion stops (22) and
Inner wall fitting at left and right sides of filtering cabin (24).
7. a kind of B- thymidine production stirred autoclave according to claim 1, it is characterised in that: the soda acid induction tube
(14) parallel with inner wall at left and right sides of kettle main body (1), the heat-generating pipe (17) is parallel with inner wall at left and right sides of heating pipe (16).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821648625.9U CN209302737U (en) | 2018-10-11 | 2018-10-11 | Stirred autoclave is used in a kind of production of B- thymidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821648625.9U CN209302737U (en) | 2018-10-11 | 2018-10-11 | Stirred autoclave is used in a kind of production of B- thymidine |
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| Publication Number | Publication Date |
|---|---|
| CN209302737U true CN209302737U (en) | 2019-08-27 |
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ID=67670708
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821648625.9U Active CN209302737U (en) | 2018-10-11 | 2018-10-11 | Stirred autoclave is used in a kind of production of B- thymidine |
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| Country | Link |
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| CN (1) | CN209302737U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113731328A (en) * | 2021-08-06 | 2021-12-03 | 徐州恒世食品有限公司 | Food additive reaction device and production method |
-
2018
- 2018-10-11 CN CN201821648625.9U patent/CN209302737U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113731328A (en) * | 2021-08-06 | 2021-12-03 | 徐州恒世食品有限公司 | Food additive reaction device and production method |
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