CN209276535U - A kind of full-automatic enzymatic converting apparatus - Google Patents
A kind of full-automatic enzymatic converting apparatus Download PDFInfo
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- CN209276535U CN209276535U CN201821829109.6U CN201821829109U CN209276535U CN 209276535 U CN209276535 U CN 209276535U CN 201821829109 U CN201821829109 U CN 201821829109U CN 209276535 U CN209276535 U CN 209276535U
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Abstract
The utility model discloses a kind of full-automatic enzymatic converting apparatus, it include ingredient reaction unit, it is connected with ingredient reaction unit by pipeline and is used to that enzymatic reaction solution to be stirred to and be carried out the adjusting of pH value and the pretreatment unit of filtration treatment, the upper prop liquid device for formulating being connected to pretreatment unit output end by pipeline, the chromatographic column processing unit being connected to upper prop liquid device for formulating output end by pipeline is connected to by pipeline with chromatographic column processing unit output end and is used for the nanofiltration device that enzymatic reaction solution carries out thickening filtration；By realizing automation valve opening and closing control to mixed liquor feed-inputing branched pipe, pure water feed branch pipe, aqueous slkali feed-inputing branched pipe, the acid solution feed-inputing branched pipe in chromatographic column processing unit, and the flow by automatically controlling each pipe realizes the automatic control of chromatography process, when solution is too low in chromatographic column, realize that efficient automatic production is realized in the timely moisturizing to chromatographic column by Fork LIquid Level Switch.
Description
Technical field
The utility model relates to chemicals production equipment field more particularly to a kind of full-automatic enzymatic converting apparatus.
Background technique
Enzymatic converting apparatus is applied in chemical production industries, after the mixing by various raw materials, by hybrid technique, enzyme
Reaction process, pretreating process, chromatography technique and nanofiltration technique obtain the finished product needed, are widely applied in the industrial production.
It in existing enzymatic converting apparatus, needs to be mixed after manually adding various raw material proportionings, is in automatic production
It constantly mixes and the solution after delivery of filtered is into chromatographic column processing unit, chromatographic column processing unit will be molten after pretreatment filtration
Liquid is chromatographed (resin) processing, this stage is mainly to be separated with water with the elution that acid carries out product.In chromatographic column treatment process
Need to detect acid solution, aqueous slkali, the input quantity of material liquid and pure water, existing chromatography technique is all single step run, passes through hand
Dynamic control valve acid adding-water or salt-water, alkali-water cannot achieve automation control.
Therefore, the existing technology needs to be improved and developed.
Utility model content
In view of above-mentioned deficiencies of the prior art, the purpose of this utility model is to provide a kind of full-automatic enzymatic conversions to set
It is standby, it is intended to solve the problems, such as to cannot achieve automation control in existing chromatographic column processing unit.
The technical solution of the utility model is as follows:
A kind of full-automatic enzymatic converting apparatus includes for various ingredients to be mixed and adjust that filters after pH value to match
Expect reaction unit, is connected and is used to that enzymatic reaction solution to be stirred and be carried out the adjusting of pH value by pipeline with ingredient reaction unit
And the pretreatment unit of filtration treatment, it is connected to pretreatment unit output end by pipeline and is used to stir enzymatic reaction solution simultaneously
The upper prop liquid device for formulating weighed, it is right with water and acid to be connected to and be used for by pipeline with upper prop liquid device for formulating output end
Enzymatic reaction solution carries out eluting isolated chromatographic column processing unit, is connected to and is used in combination by pipeline with chromatographic column processing unit output end
The nanofiltration device of thickening filtration is carried out in enzymatic reaction solution；The chromatographic column processing unit is provided with several；
The chromatographic column processing unit includes chromatography feed pipe, the chromatographic column of chromatography charging pipe end is connected to, with layer
Analyse feed pipe front end connection pure water feed branch pipe, the water inlet control valve on pure water feed branch pipe, setting with chromatograph into
The aqueous slkali feed-inputing branched pipe of expects pipe front end connection, the alkali soluble hydraulic control valve controlled on aqueous slkali feed-inputing branched pipe and by PLC, with
The acid solution feed-inputing branched pipe for chromatographing the connection of feed pipe front end, the acid solution controlled on acid solution feed-inputing branched pipe and by PLC
Control valve, the mixed liquor feed-inputing branched pipe being connected to chromatography feed pipe front end, on mixed liquor feed-inputing branched pipe and by PLC control
Mixture control valve, positioned at chromatography feed pipe on and for control chromatograph feed pipe in flow charging autocontrol valve, position
It is communicated with moisturizing pipeline on chromatography feed pipe between charging autocontrol valve and chromatographic column, control is provided in moisturizing pipeline
The moisturizing control valve of moisturizing pipeline opening and closing is arranged in chromatographic column and incudes the too low rear control moisturizing control valve of liquid level in chromatographic column
The Fork LIquid Level Switch of unlatching is connected to the discharge nozzle of chromatographic column outlet end, is arranged on discharge nozzle and for controlling discharge nozzle
The discharging autocontrol valve of interior flow, the eluent cooling pipe being connected to discharging pipe end, is arranged in eluent cooling pipe
On the cooling valve of eluent, the eluent cooler being connected to the cooling valve of eluent by pipeline.
Further, ingredient reaction unit includes the diluted alkaline liquid bath for extracting after lye and diluting lye, with sig water
Slot discharge port is connected to by pipeline and is used to extract the sig water feed pump of lye, is connected with sig water feed pump by pipeline
And the batching kettle for mixing various raw materials, it is connected and is used to store the material liquid of prepared solution with batching kettle discharge port
Slot is connected to raw material liquid trough discharge port and the reactor feed pump for extracting solution in raw material liquid trough, pumps with reactor feed
The ingredient filter being connected to by pipeline, the material liquid heater being connected to ingredient filter outlet end by pipeline, with raw material
The first reactor that liquid heater outlet end is connected to by pipeline reacts cold by what pipeline was connected to first reactor outlet end
But device.
Further, there are two reactor feed pump is arranged in parallel, there are two the ingredient filter is arranged in parallel.
Further, further include having second reactor, the second reactor and the first reactor and react cooler
Between pipeline it is in parallel.
Further, pretreatment unit includes first reactor dump tank, passes through pipeline simultaneously with first reactor dump tank
The second reactor dump tank for joining connection, passes through pipeline with the liquid outlet of first reactor dump tank and second reactor dump tank
The reaction solution delivery pump of connection is connected to by pipeline with the liquid outlet of reaction solution delivery pump and is used for the pre- place of solution stir process
Kettle is managed, is connected to and is used to extract the filter press feed pump of the solution of pretreatment kettle by pipeline with the liquid outlet of pretreatment kettle, with
The liquid outlet of filter press feed pump is connected to by pipeline and is used for the filter press of filters pressing solution.
Further, the upper prop liquid device for formulating include to upper prop liquid kettle, be arranged on to upper prop liquid kettle and with it is described
The liquid inlet that pretreatment unit is connected is connect and is used for by pipeline with hydrochloric acid storage tank for storing the hydrochloric acid storage tank of hydrochloric acid
Extract solution in hydrochloric acid storage tank to the hydrochloric acid delivery pump in upper prop liquid kettle, pass through pipeline company with the liquid outlet to upper prop liquid kettle
Lead to and is used to extract several upper prop liquid pumps to the solution in upper prop liquid kettle；
The upper prop liquid pump quantity is correspondingly arranged with the chromatographic column processing unit quantity.
Further, the nanofiltration device includes several elutions being correspondingly arranged with the chromatographic column processing unit quantity
Liquid bath is connected to by pipeline with the liquid outlet of eluant groove and is used to extract the eluent transfering material pump of the solution in eluant groove,
It is connected to and is used to generate the NF slot of concentrate by pipeline with the liquid outlet of eluent transfering material pump, be connected to simultaneously with NF slot by pipeline
For making the nanofiltration component of solution circulation nanofiltration in NF slot, it is connected to the liquid outlet of NF slot by pipeline and is used to extract in NF slot
The concentrate transfering material pump of concentrate, the concentrate output channel being connected to the liquid outlet of concentrate transfering material pump by pipeline.
Further, there are two the upper prop liquid pump settings, there are two the settings of chromatographic column processing unit, and eluant groove is provided with
Two；Two upper prop liquid pumps are connected to the mixed liquor feed-inputing branched pipe of two chromatographic column processing units by pipeline respectively；Two layers
The eluent cooler output end of analysis column processing unit is connected with the input terminal of two eluant grooves by pipeline respectively.
Further, the nanofiltration component include be connected to the liquid outlet of NF slot by pipeline and be used to extract it is molten in NF slot
The RO low-lift pump of liquid is connected to by pipeline with the liquid outlet of RO low-lift pump and is used for the RO filter of filtering solution, filters with RO
The liquid outlet of device is connected to by pipeline and is used for several nanofiltration main filters of filtering solution, the liquid out with nanofiltration main filter
The RO heat exchanger that mouth is connected to by pipeline and is used to keep solution cooling；The discharge port of the RO heat exchanger is connected to NF slot.
Further, there are two the nanofiltration main filter is arranged in parallel by pipeline.
Compared with prior art, the utility model passes through to mixed liquor feed-inputing branched pipe, the pure water in chromatographic column processing unit
Feed-inputing branched pipe, aqueous slkali feed-inputing branched pipe, acid solution feed-inputing branched pipe realize automation valve opening and closing control, and each by automatically controlling
The flow of pipe realizes the automatic control of chromatography process, when solution is too low in chromatographic column, is realized by Fork LIquid Level Switch to layer
Analyse the timely moisturizing of column, setting can realize the chromatography of more solution there are two chromatographic column processing unit in nanofiltration process
Journey, it is more efficient in this way, realize efficient automatic production.
Detailed description of the invention
Fig. 1 is a kind of connection block diagram of the embodiment of full-automatic enzymatic converting apparatus of the utility model.
Fig. 2 is a kind of ingredient reaction unit connection signal of the embodiment of full-automatic enzymatic converting apparatus of the utility model
Figure.
Fig. 3 is a kind of connection signal of the pretreatment unit of the embodiment of full-automatic enzymatic converting apparatus of the utility model
Figure.
Fig. 4 is that a kind of connection of the upper prop liquid device for formulating of the embodiment of full-automatic enzymatic converting apparatus of the utility model is shown
It is intended to.
Fig. 5 is that a kind of connection of the chromatographic column processing unit of the embodiment of full-automatic enzymatic converting apparatus of the utility model is shown
It is intended to.
Fig. 6 is a kind of connection schematic diagram of the nanofiltration device of the embodiment of full-automatic enzymatic converting apparatus of the utility model.
In figure: 100, ingredient reaction unit；110, diluted alkaline liquid bath；120, sig water feed pump；130, batching kettle；140,
One PH detector；150, raw material liquid trough；160, the first liquid level alarm；170, reactor feed pumps；180, ingredient filter；
190, material liquid heater；1100, first reactor；1120, cooler is reacted；1130, second reactor；200, pretreatment dress
It sets；210, first reactor dump tank；220, second reactor dump tank；230, the second liquid level alarm；240, reaction solution is defeated
Send pump；250, kettle is pre-processed；260, the second PH detector；270, filter press feed pump；280, filter press；300, upper prop liquid is prepared
Device；310, to upper prop liquid kettle；320, hydrochloric acid storage tank；330, hydrochloric acid delivery pump；340, third PH detector；350, upper prop liquid
Pump；400, chromatographic column processing unit；410, feed pipe is chromatographed；420, chromatographic column；430, mixed liquor feed-inputing branched pipe；431, mixed liquor
Control valve；440, pure water feed branch pipe；441, pure water control valve；450, aqueous slkali feed-inputing branched pipe；451, alkali soluble hydraulic control valve；
460, acid solution feed-inputing branched pipe；461, acid solution control valve；470, autocontrol valve is fed；480, moisturizing pipeline；481, moisturizing
Control valve；490, Fork LIquid Level Switch；4100, discharge nozzle；4110, discharge autocontrol valve；4120, eluent cooling pipe；
4121, the cooling valve of eluent；4130, eluent cooler；4140, waste water conveyance conduit；4141, waste water transfer valve；500, it receives
Filter device；510, eluant groove；520, eluent transfering material pump；530, NF slot；540, nanofiltration component；541, RO low-lift pump；542,
RO filter；543, nanofiltration main filter；544, RO heat exchanger；545, RO high-pressure pump；550, concentrate transfering material pump；560, it is concentrated
Liquid output channel；600,PLC.
Specific embodiment
The utility model provides a kind of full-automatic enzymatic converting apparatus, to make the purpose of this utility model, technical solution
And effect is clearer, clear, referring to the drawings and gives an actual example to the utility model further description.It should be appreciated that
Specific embodiment described herein is only used to explain the utility model, is not used to limit the utility model.
As shown in Figure 1, indicating various equipment with block diagram, connecting pipe is indicated with line with the arrow, it is molten in specific embodiment
Liquid, mixed liquor, mixed solution refer both to enzymatic reaction solution, and a kind of full-automatic enzymatic converting apparatus, includes ingredient reaction unit
100, ingredient reaction unit 100 adjusts pH value for mixing various ingredients and add water and stir, will adjust the mixed liquor of pH value into
After row filtering, enzymic transformations are carried out with certain flow velocity and flow, and control temperature.It is logical with ingredient reaction unit 100
Piping, which is connected, is connected to pretreatment unit 200, and pretreatment unit 200 is used to enzymatic reaction solution carrying out the adjusting of pH value and stir
It mixes, stirring is conveyed after completing and carries out filtration treatment.The upper prop liquid being connect with 200 water outlet of pretreatment unit by pipeline is matched
Device 300 processed, upper prop liquid device for formulating 300 is for stirring and weighing mixed liquor.Upper prop liquid device for formulating 300 passes through pipe
The chromatographic column processing unit 400 of road connection, the solution after 400 pretreatment filtration of chromatographic column processing unit are chromatographed at (resin)
Reason, this device are mainly to be separated with water with the elution that acid carries out product, and chromatographic column processing unit 400 can be set to one,
It can be set to multiple.The nanofiltration device 500 being connect with chromatographic column processing unit 400 by pipeline, nanofiltration device 500 will chromatograph
Solution after elution carries out nanofiltration thickening filtration.
As shown in Figure 1 and Figure 2, ingredient reaction unit 100 includes the diluted alkaline liquid bath for extracting after lye and diluting lye
110, sig water feed pump 120 is communicated with by pipeline with 110 discharge port of diluted alkaline liquid bath, is electrically connected on sig water feed pump 120
It connects on PLC600, opening and closing and the flow velocity of sig water feed pump 120 is controlled according to PLC600, for controlling the speed for extracting lye
Degree, is connected by pipeline with sig water feed pump 120 and is connected with batching kettle 130, and batching kettle 130 has multiple feed inlets, facilitates throwing
Enter various raw materials, blender is had in batching kettle 130, for being stirred various raw materials.With product s-adenosyl-L-methionine pair
For toluenesulfonic acid sulfate, trinosin, L-Methionine, magnesium chloride hexahydrate, chlorination are added in batching kettle 130
Four kinds of raw materials such as potassium, and added water and stirred into material-compound tank.The first PH detector 140, the first PH inspection are provided on batching kettle 130
It surveys device 140 to connect with PLC600, when the first PH detector 140 detects the pH value of setting, sig water is controlled by PLC600
Feed pump 120 is out of service, realizes automatic pH value control.It is connected with 130 discharge port of batching kettle and is connected with raw material liquid trough 150, raw material
Liquid bath 150 is provided with the first liquid level alarm 160, for aobvious in real time for storing the material liquid modulated in raw material liquid trough 150
Show the liquid level in raw material liquid trough 150, the equal warning reminding operator when reaching the upper limit or lower limit.Raw material is connected to by pipeline
150 discharge port of liquid bath has reactor feed to pump 170, and reactor feed pump 170 may be configured as multiple, 170 use of reactor feed pump
In extracting solution in raw material liquid trough 150, ingredient filter 180, ingredient filtering are communicated with by pipeline with reactor feed pump 170
Device 180 may be configured as multiple, be communicated with material liquid heater 190 by pipeline with 180 outlet end of ingredient filter, material liquid adds
Hot device 190 is accelerated reaction and is carried out, be communicated with first by pipeline with 190 outlet end of material liquid heater for heating solution
Reactor 1100, first reactor 1100 carry out the reaction of certain time for solution, keep the biochemical reaction of solution abundant, with the
One reactor, 1100 outlet end is communicated with reaction cooler 1120 by pipeline, and reaction cooler 1120 makes after reaction there are also high temperature
Solution be cooled sufficiently to suitable temperature.It is two that reactor feed pump 170, which is arranged in parallel, in the present embodiment, the ingredient filtering
There are two device 180 is arranged in parallel, the setting of two reactor feeds pump 170 can after a failure (the most common are
Dregs block input port), another reactor feed pump 170 can start in time, will not when overhauling a bad pump
Production is impacted；The setting of two ingredient filters 180 is also same principle, is occurred in an ingredient filter 180
When problem, another can star, still ensure that normal production.The output end label of cooler 1120 is reacted in embodiment
For a1, pretreatment unit 200 is connected by output end.
Ingredient reaction unit 100 further includes having second reactor 1130, second reactor 1130 and the first reactor
Pipeline between 1100 and reaction cooler 1120 is in parallel, and in this way when solution will pass through secondary response, it is anti-can to first pass through first
It answers device 1100 to carry out primary first-order equation, carries out secondary response using second reactor 1130, applicable processing range is wider, when only
Need to solution carry out primary first-order equation make, solution can directly by first reactor 1100 with react the pipeline between cooler 1120
Cooling in reaction cooler 1120 is entered, solution after cooling enters pretreatment unit 200.
As shown in Figure 1, Figure 3, pretreatment unit 200 is connected by a1 pipeline with ingredient reaction unit 100, pretreatment dress
Setting 200 includes first reactor dump tank 210, passes through the second anti-of pipeline parallel communication with first reactor dump tank 210
Device dump tank 220 is answered, there is various feed inlets, the first reaction on first reactor dump tank 210 and second reactor dump tank 220
Device dump tank 210 and second reactor dump tank 220 can receive different soda acid ingredients respectively and carry out mixed configuration various concentration
Solution can also be configured same solution, increase the storage of solution, accelerate production efficiency.First reactor dump tank 210 and second
Reactor dump tank 220 is provided with the second liquid level alarm 230, and the second liquid level alarm 230 monitors interior liquid level and control height
Liquid level warning.It is communicated with and is reacted by pipeline with the liquid outlet of first reactor dump tank 210 and second reactor dump tank 220
Liquid delivery pump 240, reaction solution delivery pump 240 for extract out first reactor dump tank 210 or with second reactor dump tank 220
In solution, pretreatment kettle 250 is communicated with by pipeline with the liquid outlet of reaction solution delivery pump 240, pretreatment kettle 250 offers
Multiple feed openings, pretreatment kettle 250 are provided with the second PH detector 260, by the way that solution is added in feed opening, reach the PH of setting
Value pre-processes in kettle 250 and is provided with blender, is stirred sufficiently for solution, passes through pipe with the liquid outlet of pretreatment kettle 250
Road is communicated with filter press feed pump 270, and filter press feed pump 270 is used to extract the solution of pretreatment kettle 250, feeds with filter press
The liquid outlet of pump 270 is communicated with filter press 280 by pipeline, and filter press 280 is used for filters pressing solution, the delivery outlet of filter press 280
Pass through pipeline b1 connection upper prop liquid device for formulating 300.
As Figure 1 and Figure 4, upper prop liquid device for formulating 300 is connected by b1 pipeline with pretreatment unit 200, upper prop liquid
Device for formulating 300 includes to have upper prop liquid liquid inlet and the pretreatment to fill on to upper prop liquid kettle 310 to upper prop liquid kettle 310
It sets 200 to connect by pipeline b1, is additionally provided with the hydrochloric acid storage tank 320 for storing hydrochloric acid, connected with hydrochloric acid storage tank 320 by pipeline
It is connected to hydrochloric acid delivery pump 330, hydrochloric acid delivery pump 330 is used to extract that hydrochloric acid solution in hydrochloric acid storage tank 320 to arrive to upper prop liquid kettle 310
In, to be provided with third PH detector 340 in upper prop liquid kettle 310, do not reached requirement when to the solution pH value in upper prop liquid kettle 310
When, hydrochloric acid is pumped in upper prop liquid kettle 310 by the control starting of hydrochloric acid delivery pump 330, carries out solution PH adjusting, Zhi Daoda
To the pH value of setting, upper prop liquid pump 350 is communicated with by pipeline with the liquid outlet to upper prop liquid kettle 310, upper prop liquid pump 350 is used in combination
It in extraction to the solution in upper prop liquid kettle 310, and is transported in chromatographic column processing unit 400, upper prop liquid pump 350 may be configured as more
A, quantity is corresponding with 400 quantity of chromatographic column processing unit.
As shown in Figure 1, shown in Figure 5, chromatographic column processing unit 400 includes chromatography feed pipe 410, at 410 end of chromatography feed pipe
End is communicated with chromatographic column 420, and the head end of chromatography feed pipe 410 is connected with mixed liquor feed-inputing branched pipe 430, as shown in figure 4, mixed liquor
The output end for being connected to upper prop liquid pump 350 of the other end connection upper prop liquid device for formulating 300 of feed-inputing branched pipe 430, in mixed liquor
Mixture control valve 431 is provided on feed-inputing branched pipe 430, mixture control valve 431 connect with PLC600 and by PLC600 program
Automatically control, realize the automatic open close of mixture control valve 431 to automatically control solution in upper prop liquid device for formulating 300 into
Enter to chromatograph in feed pipe 410.It is also communicated with pure water feed branch pipe 440 in chromatography 410 front end of feed pipe, is located at pure water feed branch pipe
Pure water control valve 441 is provided on 440, pure water control valve 441 is controlled pure water and entered chromatography feed pipe by PLC600 process control
In 410.It is also communicated with aqueous slkali feed-inputing branched pipe 450 in chromatography 410 front end of feed pipe, is set on aqueous slkali feed-inputing branched pipe 450
It is equipped with alkali soluble hydraulic control valve 451, alkali soluble hydraulic control valve 451 is controlled aqueous slkali and entered chromatography feed pipe by PLC600 process control
In 410.It is communicated with acid solution feed-inputing branched pipe 460 with chromatography 410 front end of feed pipe, is arranged on acid solution feed-inputing branched pipe 460
There is acid solution control valve 461, acid solution control valve 461 is controlled acid solution and entered chromatography feed pipe 410 by PLC600 process control
In.Charging autocontrol valve 470 on chromatography feed pipe 410 and for controlling flow in chromatography feed pipe 410, is located at certainly
It is communicated with moisturizing pipeline 480 on chromatography feed pipe 410 between dynamic control valve and chromatographic column 420, is provided in moisturizing pipeline 480
Moisturizing control valve 481 is opened and closed by control moisturizing pipeline 480 after the water level in analysis chromatographic column 420, is arranged in chromatographic column 420
There is Fork LIquid Level Switch 490, Fork LIquid Level Switch 490 automatically turns on moisturizing control valve 481 in low liquid level warning, realizes to layer
Automatic water supplement in column 420 is analysed, is connected with discharge nozzle 4100 in 420 layers of outlet end of chromatographic column, setting is used in combination on discharge nozzle 4100
In the discharging autocontrol valve 4110 of flow in control discharge nozzle 4100, discharging autocontrol valve 4110 is controlled by PLC600 and is examined
The flow in expects pipe 4100 is measured, and according to the flow velocity and opening and closing set in flow control discharge nozzle 4100, in discharge nozzle 4100
End is connected with eluent cooling pipe 4120, the cooling valve 4121 of eluent is provided in the eluent cooling, with eluent
Cooling valve 4121 is connected with eluent cooler 4130 by pipeline, and 4130 output end of eluent cooler connects nanofiltration device
500；It is also connected with waste water conveyance conduit 4140 in 4100 end of discharge nozzle, is provided with waste water on the waste water conveyance conduit 4140
Transfer valve 4141,4140 transport wastewater of waste water conveyance conduit to wastewater disposal basin focus on.
420 processing unit 400 of chromatographic column can realize automatic running, pass through the sequence of 420 liquid of chromatographic column when automatic running
For mixture-water-sulfuric acid-water-alkali-water-hydrochloric acid-water.Step are as follows:
Feeding: the upper prop liquid pump 350 in upper prop liquid device for formulating 300 is opened, and is automatically turned on and is mixed by PLC600 program
Hydraulic control valve 431 is closed, the mixed liquor in upper prop liquid device for formulating 300 is made to enter chromatography charging by mixed liquor feed-inputing branched pipe 430
Pipe 410, and adjusting flow by charging autocontrol valve 470 is 2.88m3/h, so that mixed liquor is entered chromatography feed pipe 410 laggard
Row flow is adjusted, and is run 50 minutes by PLC600 timing, and mixed liquor is made to enter chromatographic column 420.
Water is crossed for the first time: mixture control valve 431 is automatically closed after the completion of feeding process, and automatically turns on pure water control
Valve 441, pure water enters chromatography feed pipe 410 by pure water feed branch pipe 440, and adjusts stream by charging autocontrol valve 470
Amount is 2.88m3/h, flow adjusting is carried out after so that pure water is entered chromatography feed pipe 410, and run 66 points by PLC600 timing
Clock makes pure water enter chromatographic column 420.
Persulfuric acid: pure water control valve 441 is just automatically closed when first time crosses the completion of water process, and automatically turns on acid solution control
Valve 461 processed, sulfuric acid solution enters chromatography feed pipe 410 by acid solution feed-inputing branched pipe 460, and passes through charging autocontrol valve
470 adjust flow as 2.88m3/h, carry out flow adjusting after so that sulfuric acid solution is entered chromatography feed pipe 410, and pass through PLC600
Timing is run 66 minutes, and sulfuric acid solution is made to enter chromatographic column 420.
Water is crossed for the second time: acid solution control valve 461 is automatically closed after the completion of persulfuric acid process, and automatically turns on pure water control
Valve 441, pure water enters chromatography feed pipe 410 by pure water feed branch pipe 440, and adjusts stream by charging autocontrol valve 470
Amount is 2.88m3/h, flow adjusting is carried out after so that pure water is entered chromatography feed pipe 410, and run 66 points by PLC600 timing
Clock makes pure water enter chromatographic column 420.
It crosses alkali: crossing after the completion of water process for the second time, pure water control valve 441 is just automatically closed, and automatically turn on alkali soluble hydraulic control
Valve 451 processed, aqueous slkali enters chromatography feed pipe 410 by aqueous slkali feed-inputing branched pipe 450, and passes through charging autocontrol valve 470
Adjusting flow is 2m3/h, carries out flow adjusting after so that alkali acid solution is entered chromatography feed pipe 410, and transport by PLC600 timing
Row 100 minutes, aqueous slkali is made to enter chromatographic column 420.
Third time crosses water: crossing alkali process and alkali soluble hydraulic control valve 451 is automatically closed after the completion, and automatically turn on pure water control valve
441, pure water enters chromatography feed pipe 410 by pure water feed branch pipe 440, and adjusts flow by charging autocontrol valve 470
For 2m3/h, flow adjusting is carried out after so that pure water is entered chromatography feed pipe 410, and is run 100 minutes by PLC600 timing, is made
Pure water enters chromatographic column 420.
Persalt: hydrochloric acid and sulfuric acid belong to acids, therefore use same acid solution feed-inputing branched pipe 460, when third time
It crosses the completion of water process and pure water control valve 441 is just automatically closed, and automatically turn on acid solution control valve 461, hydrochloric acid solution passes through acid
Solution feed branch pipe 460 enters chromatography feed pipe 410, and adjusting flow by charging autocontrol valve 470 is 2m3/h, makes salt
Acid solution carries out flow adjusting after entering chromatography feed pipe 410, and is run 100 minutes by PLC600 timing, makes hydrochloric acid solution
Into chromatographic column 420.
4th mistake water, acid solution control valve 461 is automatically closed after the completion in persalt process, and automatically turns on pure water control
Valve 441, pure water enters chromatography feed pipe 410 by pure water feed branch pipe 440, and adjusts stream by charging autocontrol valve 470
Amount is 2m3/h, flow adjusting is carried out after so that pure water is entered chromatography feed pipe 410, and run 100 minutes by PLC600 timing,
Pure water is set to enter chromatographic column 420.
Waste water conveyance conduit 4140 is open-minded in chromatography process, and for the waste water of chromatography to be discharged, discharge nozzle 4100 is open-minded, is used for
The product needed is set to enter next procedure.
When the case where appearance low liquid level in whole process in chromatographic column 420, Fork LIquid Level Switch 490 controls moisturizing control
Valve 481 processed opens moisturizing pipeline 480, and moisturizing pipeline 480 is automatically added water into chromatographic column 420, avoids the solution in chromatographic column 420
It is very few, cause to influence production efficiency.
Nanofiltration (Nanofiltration, abridge NF) is used for by the lesser substance of relative molecular mass, such as inorganic salts or Portugal
The small organic molecules such as grape sugar, sucrose are separated from solvent.Nanofiltration is also known as low pressure reverse osmosis, is the one of membrane separation technique
Kind emerging field, separating property between ultrafiltration, allow some inorganic salts and certain solvents through film between reverse osmosis, thus
Achieve the effect that separation.
As shown in Fig. 1, Fig. 6, nanofiltration device 500 includes eluant groove 510, and eluant groove 510 can be set to several
A, quantity is corresponding with the quantity of chromatographic column processing unit 400.As shown in figure 5, eluant groove 510 and chromatographic column 420 are handled
The output end of the eluent cooler 4130 of device 400 is connected, and is communicated with and is washed by pipeline with the liquid outlet of eluant groove 510
De- liquid transfering material pump 520.Eluent transfering material pump 520 is used to extract the solution in eluant groove 510, with eluent transfering material pump 520
Liquid outlet is communicated with NF slot 530 by pipeline, and NF slot 530 is connected to NF slot 530 by pipeline for generating and storing concentrate
There is nanofiltration component 540, nanofiltration component 540 is used to make solution in NF slot 530 to recycle the concentrate that nanofiltration ultimately forms needs, with NF
The liquid outlet of slot 530 is communicated with concentrate transfering material pump 550 by pipeline, and concentrate transfering material pump 550 is dense in NF slot 530 for extracting
Contracting liquid is communicated with concentrate output channel 560 by pipeline with the liquid outlet of concentrate transfering material pump 550, and output channel output is dense
Contracting liquid completes enzymatic conversion processes.
Nanofiltration component 540 includes to be connected to the liquid outlet of NF slot 530 by pipeline and be used to extract solution in NF slot 530
RO low-lift pump 541(reverse osmosis booster pump), it is anti-that RO filter 542(is communicated with by pipeline with the liquid outlet of RO low-lift pump 541
Percolating filter), RO filter 542 is used for filtering solution, is communicated with nanofiltration master by pipeline with the liquid outlet of RO filter 542
Filter 543, nanofiltration main filter 543 are used for further filtering solution, pass through pipeline with the liquid outlet of nanofiltration main filter 543
It is communicated with the reverse osmosis heat exchanger of RO heat exchanger 544(), the RO heat exchanger 544 that RO heat exchanger 544 is used to keep solution cooling；The RO
The discharge port of heat exchanger 544 is connected to NF slot 530, realizes the circulation nanofiltration to solution.Nanofiltration main filter 543 can pass through pipeline
It has been arranged in parallel multiple, it is two that the nanofiltration main filter 543 in the present embodiment, which is arranged in parallel, and solution is made to realize abundant nanofiltration；
Pass through pipeline on pipeline in the present embodiment between RO filter 542 and nanofiltration main filter 543 and is connected with RO high-pressure pump
545, RO high-pressure pumps 545 make nanofiltration solution in pipeline generate high pressure, improve conveying speed, accelerate production efficiency.
As shown in figure 4, in the present embodiment there are two the settings of upper prop liquid pump 350, as shown in Figure 1, chromatographic column processing unit 400
There are two settings, as shown in fig. 6, two upper prop liquid pumps 350 are respectively and at two chromatographic columns there are two the settings of eluant groove 510
The mixed liquor feed-inputing branched pipe 430 for managing device 400 is connected to by pipeline c1, c2；The elution liquid cooling of two chromatographic column processing units 400
But 4130 output end of device is connected with the input terminal of two eluant grooves 510 by pipeline d1, d2 respectively；When due to nanofiltration process
Between dean, the setting of two 420 processing units 400 of chromatographic column can realize the chromatography process of more solution in nanofiltration process,
It is more efficient in this way, realize efficient automatic production.
The utility model passes through to mixed liquor feed-inputing branched pipe, the pure water feed branch pipe, aqueous slkali in chromatographic column processing unit
Feed-inputing branched pipe, acid solution feed-inputing branched pipe realize automation valve opening and closing control, and the flow by automatically controlling each pipe realizes layer
The automatic control of analysis process realizes the timely moisturizing to chromatographic column by Fork LIquid Level Switch when solution is too low in chromatographic column,
There are two chromatographic column processing units for setting, and the chromatography process of more solution can be realized in nanofiltration process, more efficient in this way,
Realize efficient automatic production.
It should be understood that the application of the utility model is not limited to above-mentioned citing, those of ordinary skill in the art are come
It says, it can be modified or changed according to the above description, and all these modifications and variations all should belong to the appended power of the utility model
The protection scope that benefit requires.
Claims (10)
1. a kind of full-automatic enzymatic converting apparatus, which is characterized in that include for ingredient to be mixed and adjusts mistake after pH value
The ingredient reaction unit of filter is connected by pipeline with ingredient reaction unit and is used to stir enzymatic reaction solution and carries out pH value
Adjusting and filtration treatment pretreatment unit, be connected to and be used for enzymatic reaction solution by pipeline with pretreatment unit output end
The upper prop liquid device for formulating for stirring and weighing, with upper prop liquid device for formulating output end be connected to and be used for by pipeline water and
Acid carries out enzymatic reaction solution to elute isolated chromatographic column processing unit, is connected to chromatographic column processing unit output end by pipeline
And the nanofiltration device of thickening filtration is carried out for enzymatic reaction solution；
The chromatographic column processing unit is provided with several；
The chromatographic column processing unit includes chromatography feed pipe, be connected to chromatography charging pipe end chromatographic column, with chromatograph into
Expects pipe front end connection pure water feed branch pipe, the pure water control valve on pure water feed branch pipe, setting with chromatography feed pipe
The aqueous slkali feed-inputing branched pipe of front end connection, the alkali soluble hydraulic control valve controlled on aqueous slkali feed-inputing branched pipe and by PLC, with chromatography
The acid solution feed-inputing branched pipe of feed pipe front end connection, the acid solution control valve controlled on acid solution feed-inputing branched pipe and by PLC,
The mixed liquor feed-inputing branched pipe being connected to chromatography feed pipe front end, the mixed liquor controlled on mixed liquor feed-inputing branched pipe and by PLC
Control valve is located at charging certainly positioned at the charging autocontrol valve chromatographed on feed pipe and for controlling flow in chromatography feed pipe
It is communicated with moisturizing pipeline on chromatography feed pipe between dynamic control valve and chromatographic column, control moisturizing pipeline is provided in moisturizing pipeline
The moisturizing control valve of opening and closing is arranged in chromatographic column and incudes the sound that the too low rear control moisturizing control valve of liquid level in chromatographic column is opened
Liquid-level switch is pitched, the discharge nozzle of chromatographic column outlet end is connected to, is arranged on discharge nozzle and for controlling flow in discharge nozzle
Discharge autocontrol valve, and the elution on eluent cooling pipe is arranged in the eluent cooling pipe being connected to discharging pipe end
Liquid cooling but valve, the eluent cooler being connected to the cooling valve of eluent by pipeline.
2. full-automatic enzymatic converting apparatus according to claim 1, which is characterized in that ingredient reaction unit includes to be used for
It extracts after lye and dilutes the diluted alkaline liquid bath of lye, be connected to diluted alkaline liquid bath discharge port by pipeline and be used to extract the dilute of lye
Lye feed pump is connected by pipeline with sig water feed pump and is used for the batching kettle of mixed raw material, with batching kettle discharge port
It is connected and is used to store the raw material liquid trough of prepared solution, it is several to be connected to raw material liquid trough discharge port and for extracting raw material
The reactor feed pump of solution, several to pump the ingredient filter being connected to by pipeline with reactor feed in liquid bath, with ingredient mistake
The material liquid heater that filter outlets end is connected to by pipeline is connected to material liquid heater outlet end by pipeline first anti-
Device is answered, reacts cooler by what pipeline was connected to first reactor outlet end.
3. full-automatic enzymatic converting apparatus according to claim 2, which is characterized in that the reactor feed pump parallel connection is set
There are two setting, there are two the ingredient filter is arranged in parallel.
4. full-automatic enzymatic converting apparatus according to claim 3, which is characterized in that it further include having second reactor, institute
The pipeline stating second reactor and the first reactor and reacting between cooler is in parallel.
5. full-automatic enzymatic converting apparatus according to claim 2, which is characterized in that pretreatment unit includes first anti-
Device dump tank is answered, passes through the second reactor dump tank of pipeline parallel communication with first reactor dump tank, with first reactor
The reaction solution delivery pump that dump tank is connected to the liquid outlet of second reactor dump tank by pipeline, with going out for reaction solution delivery pump
Liquid mouth is connected to by pipeline and is used for the pretreatment kettle of solution stir process, is connected to simultaneously with the liquid outlet of pretreatment kettle by pipeline
For extracting the filter press feed pump of the solution of pretreatment kettle, it is connected to and is used for by pipeline with the liquid outlet of filter press feed pump
The filter press of filters pressing solution.
6. full-automatic enzymatic converting apparatus according to claim 5, which is characterized in that the upper prop liquid device for formulating includes
Need upper prop liquid kettle, for storing the hydrochloric acid storage tank of hydrochloric acid, connecting with hydrochloric acid storage tank by pipeline and being used to extract hydrochloric acid storage tank
Interior solution to the hydrochloric acid delivery pump in upper prop liquid kettle, be connected to the liquid outlet to upper prop liquid kettle by pipeline and be used to extract
Several upper prop liquid pumps to the solution in upper prop liquid kettle；
The upper prop liquid pump quantity is correspondingly arranged with the chromatographic column processing unit quantity.
7. full-automatic enzymatic converting apparatus according to claim 6, which is characterized in that the nanofiltration device includes and institute
Several eluant grooves that chromatographic column processing unit quantity is correspondingly arranged are stated, are connected to simultaneously with the liquid outlet of eluant groove by pipeline
For extracting the eluent transfering material pump of the solution in eluant groove, it is connected to and is used in combination by pipeline with the liquid outlet of eluent transfering material pump
In the NF slot for generating concentrate, it is connected to and is used to make the nanofiltration component of solution circulation nanofiltration in NF slot by pipeline with NF slot, with
The liquid outlet of NF slot is connected to by pipeline and is used to extract the concentrate transfering material pump of concentrate in NF slot, with concentrate transfering material pump
The concentrate output channel that liquid outlet is connected to by pipeline.
8. full-automatic enzymatic converting apparatus according to claim 7, which is characterized in that the upper prop liquid pump is provided with two
A, there are two the settings of chromatographic column processing unit, and there are two eluant groove settings；Two upper prop liquid pumps are respectively and at two chromatographic columns
The mixed liquor feed-inputing branched pipe for managing device is connected to by pipeline；The eluent cooler output end difference of two chromatographic column processing units
It is connected with the input terminal of two eluant grooves by pipeline.
9. full-automatic enzymatic converting apparatus according to claim 8, which is characterized in that the nanofiltration component includes and NF
The liquid outlet of slot is connected to by pipeline and is used to extract the RO low-lift pump of solution in NF slot, passes through pipe with the liquid outlet of RO low-lift pump
Road is connected to and is used for the RO filter of filtering solution, is connected to the liquid outlet of RO filter by pipeline and is used for filtering solution
Several nanofiltration main filters, the RO heat exchange for being connected to the liquid outlet of nanofiltration main filter by pipeline and being used to keep solution cooling
Device；The discharge port of the RO heat exchanger is connected to NF slot.
10. full-automatic enzymatic converting apparatus according to claim 9, which is characterized in that the nanofiltration main filter passes through
There are two pipeline is arranged in parallel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821829109.6U CN209276535U (en) | 2018-11-07 | 2018-11-07 | A kind of full-automatic enzymatic converting apparatus |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821829109.6U CN209276535U (en) | 2018-11-07 | 2018-11-07 | A kind of full-automatic enzymatic converting apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113444757A (en) * | 2021-06-23 | 2021-09-28 | 贵州卡本嘉泰生物科技产业发展有限公司 | Preparation method of 1, 4-butanedisulfonic acid adenosine methionine |
| CN113499608A (en) * | 2021-06-29 | 2021-10-15 | 贵州卡本嘉泰生物科技产业发展有限公司 | Chromatographic system for enzymatic reaction and control method thereof |
-
2018
- 2018-11-07 CN CN201821829109.6U patent/CN209276535U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113444757A (en) * | 2021-06-23 | 2021-09-28 | 贵州卡本嘉泰生物科技产业发展有限公司 | Preparation method of 1, 4-butanedisulfonic acid adenosine methionine |
| CN113499608A (en) * | 2021-06-29 | 2021-10-15 | 贵州卡本嘉泰生物科技产业发展有限公司 | Chromatographic system for enzymatic reaction and control method thereof |
| CN113499608B (en) * | 2021-06-29 | 2022-04-08 | 贵州卡本嘉泰生物科技产业发展有限公司 | Chromatographic system for enzymatic reaction and control method thereof |
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