CN209264661U - It is a kind of to prepare chromatographic column filling device - Google Patents
It is a kind of to prepare chromatographic column filling device Download PDFInfo
- Publication number
- CN209264661U CN209264661U CN201822214185.2U CN201822214185U CN209264661U CN 209264661 U CN209264661 U CN 209264661U CN 201822214185 U CN201822214185 U CN 201822214185U CN 209264661 U CN209264661 U CN 209264661U
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- CN
- China
- Prior art keywords
- chromatographic column
- rotating cylinder
- filling device
- retaining sleeve
- bracket
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Abstract
The utility model, which provides, a kind of prepares chromatographic column filling device, bracket including pedestal and above pedestal, it further include the rotation filling mechanism being mounted between pedestal and bracket, the feed hopper being mounted on the horizontal plate of bracket, the diversion pipe being connected to feed hopper bottom end and the controller being mounted on the outside of the perpendicular supporting plate of bracket, rotation filling mechanism includes containing rotating cylinder and by the rotary drive assembly of driving motor driving, with support plate and retaining sleeve stationary chromatographic column and the chromatographic column fixation kit containing spring, it is fixedly mounted on the vibrator of retaining sleeve upper surface and the sensor containing transmitting module and receiving module.Compared with prior art, the utility model has the following beneficial effects: accelerating the speed of filler filling by rotation filling mechanism, effectively increasing charging efficiency, the uniformity of filler filling is improved, and then improves the stability of chromatography post separation and purification effect.
Description
Technical field
The utility model relates to technical field of chromatography separation, and in particular to a kind of to prepare chromatographic column filling device.
Background technique
Chromatographic isolation is current pharmacy, a kind of highest method of separative efficiency in biological chemical field separating-purifying means,
It is one of the important means of separation and the preparation of other high purity substances of natural products.Wherein, preparation chromatographic column is to prepare
The key equipment of type liquid chromatogram separation plays a part of separating sample component, and component in chromatograph analyte detection process
Separating effect on a column depends primarily on the stationary phase used in chromatography column.The quality of stationary phase filling quality is straight
The column effect for influencing packed column is connect, therefore the fill method of chromatographic column fixed phase is also critically important.And existing preparation chromatographic column
Mostly manpower manual is filled, and there are human factors to influence the disadvantages of big, filling is uneven, dead volume is larger, and to stationary phase
Flow velocity can not freely manipulate, influence the stability and charging efficiency of chromatography post separation and purification effect.
Utility model content
In view of the deficiencies of the prior art, chromatographic column filling device is prepared the purpose of the utility model is to provide a kind of, with
It is mostly manpower manual filling that solution prepares chromatographic column in the prior art, and there are human factor influences greatly, filling is uneven, dead volume
The disadvantages of larger, and the flow velocity of stationary phase can not be manipulated freely, influence chromatography post separation and purification effect stability and
The problem of charging efficiency.
To achieve the above object, the utility model provides following technical scheme:
It is provided by the utility model it is a kind of prepare chromatographic column filling device, including pedestal and above the pedestal
Bracket, further include the rotation filling mechanism being mounted between the pedestal and bracket, be mounted on the horizontal plate of the bracket into
Hopper, the diversion pipe being connected to the feed hopper bottom end and the controller being mounted on the outside of the perpendicular supporting plate of the bracket, the rotation
Filling mechanism includes:
Rotary drive assembly, including support frame, driving motor and the column spinner being fixedly mounted in the middle part of the base top surface
Body, the driving motor are fixedly mounted in support frame as described above and are electrically connected with the controller, the driving motor output
End is connected behind support frame as described above top with one end of the rotating cylinder, the other end of the rotating cylinder and the cross
Rotation connection in the middle part of the bottom surface of plate；
Chromatographic column fixation kit is used for stationary chromatographic column, is mounted on the one side of the rotating cylinder, including lower part
The fixed block of support plate, the retaining sleeve at middle part and top, the support plate and fixed block are respectively and fixedly installed to the column spinner
The bottom and top of body side surface, the upper end face of support plate by through the retaining sleeve inner end guide rod and the fixation
Block lower end surface is connected, and the retaining sleeve is slidably matched with guide rod, and one end and the clamping are equipped on the guide rod
Put on, the spring that lower end surface is respectively connected with, the other end of the spring respectively with the upper surface of the support plate, the fixation
The lower end surface of block is connected, and the spring is in free state.
Vibrator is fixedly mounted on the upper surface of the retaining sleeve, and is electrically connected with the controller；
Sensor is electrically connected, the transmitting module including being separately mounted to the rotating cylinder top surface with the controller
And the receiving module of the horizontal planar bottom surface, the transmitting module and the column spinner side for being equipped with the chromatographic column fixation kit
Face is adjacent, the receiving module receiving side signal to it is opposite with the transmitting module signal direction of the launch and with the transmitting mould
Block rotational trajectory is overlapped.
Further, the rotating cylinder is the positive polygon prism of even number rib.
Further, the rotating cylinder is square prism.
Further, the upper end face of support plate is equipped with counterbore, and the counterbore internal diameter is greater than the outer of the chromatographic column bottom end
Diameter, and the rubber pad that longitudinal section is in " Qian " font is installed in the counterbore, the internal diameter of the rubber pad is equal to the chromatographic column
The outer diameter of bottom end.
Further, there is gap between the retaining sleeve inner side end and the rotating cylinder side.
Further, the retaining sleeve is made of elastic material, and middle part is equipped with through-hole, and the aperture of the through-hole is equal to institute
The diameter of chromatographic column is stated, and is equipped with the horn mouth being connected to the through-hole in the outboard end of the retaining sleeve.
Further, the feed hopper quantity is 2, is symmetrical with the rotary drive assembly arrangement, corresponding, institute
The quantity for stating chromatographic column fixation kit and vibrator is at least 2, and the chromatographic column fixation kit is mounted on the column spinner
On the opposite side of body.
Further, the guide rod quantity is 2.
Further, the diversion pipe is made of soft material, and pipe is equipped with control valve, the control valve and the control
Device processed is electrically connected.
Further, it is equipped in the bottom surface quadrangle of the pedestal and adjusts foot.
Compared with prior art, preparation chromatographic column provided by the utility model is had the advantages that with filling device
1, using chromatographic column fixation kit by chromatographic column it is fixed after, by controller control rotary drive assembly turn into
Under hopper, and by sensor realize with the filling of progress filler after the docking of diversion pipe, open vibrator, finally to tamp color
The filler in column is composed, the speed of filler filling is accelerated, effectively increases charging efficiency, improves the uniformity of filler filling,
And then improve the stability of chromatography post separation and purification effect；
2, the sensor being arranged, can incude the location information of chromatographic column in real time, and control driving motor stops operating in time,
Diversion pipe is facilitated accurately to carry out mating operation with chromatographic column；
3, by be arranged in retaining sleeve or more lateral spring stretching repeatedly and compress, good cushioning effect can be played,
Reduce the influence that vibrator generates rotary drive assembly, bracket and pedestal；
4, two feed hoppers are set, two chromatographic columns can be filled simultaneously, further improve the charging efficiency of chromatographic column；
5, be arranged control valve, can Effective Regulation fixed phase stuffing flow velocity, further improve filler filling it is uniform
Property.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model；
Fig. 2 is the top view of the utility model；
Fig. 3 is that the utility model rotary drive assembly rotates the top view after 90 °；
Fig. 4 is the structural schematic diagram of retaining sleeve；
Fig. 5 is the structural schematic diagram of rubber pad.
The reference numerals are as follows:
1: pedestal 11: adjusting foot
2: bracket 21: horizontal plate
22: perpendicular supporting plate 3: rotary drive assembly
31: support frame 32: driving motor
33: rotating cylinder 4: chromatographic column fixation kit
41: support plate 411: counterbore
412: rubber pad 42: retaining sleeve
421: through-hole 422: horn mouth
43: fixed block 44: guide rod
45: spring 5: vibrator
6: sensor 61: transmitting module
62: receiving module 7: feed hopper
8: diversion pipe 81: control valve
9: controller 10: chromatographic column.
Specific embodiment
The utility model is described in detail below with reference to attached drawing and in conjunction with the embodiments.It should be noted that not conflicting
In the case where, the feature in the embodiments of the present invention and embodiment can be combined with each other.For sake of convenience, hereinafter such as
There is "upper", "lower", "left", "right" printed words, only indicates consistent with the upper and lower, left and right direction of attached drawing itself, not to structure
Play restriction effect.
As shown in fig. 1~fig. 5, the utility model provide it is a kind of prepare chromatographic column filling device, including pedestal 1 and set
Bracket 2 above pedestal 1 further includes the rotation filling mechanism being mounted between pedestal 1 and bracket 2, to be mounted on bracket 2 horizontal flat
Feed hopper 7 on plate 21, the diversion pipe 8 being connected to 7 bottom end of feed hopper and it is mounted on the controller 9 that bracket 2 erects 22 outside of supporting plate,
Rotating filling mechanism includes:
Rotary drive assembly 3 is rotated for driving chromatographic column 10 to rotate around 3 middle line of rotary drive assembly, including fixed peace
Support frame 31, driving motor 32 and rotating cylinder 33, driving motor 32 in the middle part of 1 top surface of pedestal are fixedly mounted on support frame
It is electrically connected in 31 and with controller 9, the one end of 32 output end of driving motor behind 31 top of support frame with rotating cylinder 33
It is connected, is rotatablely connected in the middle part of the bottom surface of the other end of rotating cylinder 33 and horizontal plate 21；
Chromatographic column fixation kit 4 is used for stationary chromatographic column 10, is mounted on the one side of rotating cylinder 33, including lower part
The support plate 41 for being used to support 10 bottom of chromatographic column, middle part retaining sleeve 42 for clamping chromatographic column 10 shaft and top
Fixed block 43, support plate 41 and fixed block 43 are respectively and fixedly installed to the bottom and top of 33 side of rotating cylinder, support plate 41
Upper surface is connected by the guide rod 44 through 42 inner end of retaining sleeve with 43 lower end surface of fixed block, retaining sleeve 42 and guide rod
44 are slidably matched, and the spring 45 that one end and the upper and lower end face of retaining sleeve 42 are respectively connected with, spring 45 are equipped on guide rod 44
The other end be connected respectively with the lower end surface of the upper surface of support plate 41, fixed block 43, and spring 45 be in free state；
Vibrator 5 vibrates to tamp filler for generating to chromatographic column 10, is fixedly mounted on the upper surface of retaining sleeve 42,
And it is electrically connected with controller 9；
Sensor 6 is electrically connected with controller 9, and for incuding the location information of chromatographic column 10 in real time, and in time, control is driven
Dynamic motor 32 stops operating, and facilitates diversion pipe 8 accurately to carry out mating operation with chromatographic column 10, including be separately mounted to column spinner
The receiving module 62 of 21 bottom surface of transmitting module 61 and horizontal plate of 33 top surface of body, transmitting module 61 fix group with chromatographic column is equipped with
33 side of rotating cylinder of part 4 is adjacent, 62 receiving side signal of receiving module to opposite with the 61 signal direction of the launch of transmitting module and
It is overlapped with 61 rotational trajectory of transmitting module.
When work, entire filling device is in initial position as shown in Figure 3, by chromatographic column fixation kit 4 by chromatography
Column 10 is fixed, drives rotating cylinder 33 to rotate using the driving motor 32 that controller 9 controls rotary drive assembly 3, to drive
Chromatographic column 10 rotates, and when the transmitting module 61 of sensor 6 turns to the underface of receiving module 62 (after rotating 90 °), connects
The signal that module 62 receives the sending of transmitting module 61 is received, control driving motor 32 stops operating in time by controller 9, Jin Ershi
Existing chromatographic column 10 is docked with the accurate of diversion pipe 8, and chromatographic column 10, diversion pipe 8 and 7 three of feed hopper are coaxial at this time, start later
Chromatographic column 10 is fixed from the charging of feed hopper 7 and is mutually filled, and starts vibrator 5 simultaneously, to tamp filling out in chromatographic column 10
Material accelerates filling speed, effectively improves charging efficiency, improves the uniformity of filler filling, and then improves chromatography post separation and pure
Change the stability of effect；By the way that the stretching repeatedly of about 42 lateral spring 45 of retaining sleeve is arranged in and compresses, can play well
Cushioning effect reduces the influence that vibrator 5 generates rotary drive assembly 3, bracket 2 and pedestal 1.
Rotating cylinder 33 is the positive polygon prism of even number rib, and in the present embodiment, rotating cylinder 33 is preferably square prism.
In order to which preferably stationary chromatographic column 10,41 upper surface of support plate are equipped with counterbore 411,411 internal diameter of counterbore is greater than chromatography
The outer diameter of 10 bottom end of column, and the rubber pad 412 that longitudinal section is in " Qian " font, the internal diameter etc. of rubber pad 412 are installed in counterbore 411
Outer diameter in 10 bottom end of chromatographic column can further drop as shown in figure 5, rubber pad 412 completely wraps 10 bottom end of chromatographic column
Low vibration device 5 tamps the influence generated when the filler filled in chromatographic column 10 to rotary drive assembly 3.
There is certain gap between 33 side of 42 inner side end of retaining sleeve and rotating cylinder, such retaining sleeve 42 is along guide rod
44 resistances being subject to when sliding up and down can be smaller, and prevents vibrator 5 to transmit to rotating cylinder 33 and vibrate.
Retaining sleeve 42 is made of elastic material, and middle part is equipped with through-hole 421, and the aperture of through-hole 421 is equal to chromatographic column 10
Diameter, and the horn mouth 422 being connected to through-hole 421 is equipped in the outboard end of retaining sleeve 42.It, can be by chromatography by horn mouth 422
Column 10 is rapidly caught in through-hole 421, realizes that retaining sleeve 42 clamps chromatographic column 10, and reverse operating can rapidly remove color
Compose column 10.
In order to further increase the charging efficiency of chromatographic column 10,7 quantity of feed hopper is 2, is symmetrical with rotary drive assembly 3
Arrangement, corresponding, the quantity of chromatographic column fixation kit 4 and vibrator 5 is at least 2, and chromatographic column fixation kit 4 is installed
On the opposite side of rotating cylinder 33,2 chromatographic columns can be filled simultaneously in this way.
44 quantity of guide rod is 2, more preferable to the guide effect of retaining sleeve 42 in this way, and more firm.
Diversion pipe 8 is made of soft material, and pipe is equipped with control valve 81, and control valve 81 and controller 9 are electrically connected, use
In the flow velocity of regulation fixed phase stuffing, the uniformity of filler filling is also further improved.When chromatographic column 10 and 8 success of diversion pipe
After docking, control valve 81 is opened by controller 9, will be filled into uniform filling in chromatographic column 10 in feed hopper 7.
In order to adjust the levelness of entire filling device, it is equipped in the bottom surface quadrangle of pedestal 1 and adjusts foot 11.
The above description is only the embodiments of the present invention, and therefore it does not limit the scope of the patent of the utility model, all
Equivalent structure or equivalent flow shift made based on the specification and figures of the utility model, is applied directly or indirectly in
Other relevant technical fields, are also included in the patent protection scope of the utility model.
Claims (10)
1. a kind of prepare chromatographic column filling device, special including pedestal (1) and the bracket (2) being set to above the pedestal (1)
Sign is, further includes the rotation filling mechanism being mounted between the pedestal (1) and bracket (2), is mounted on the bracket (2) cross
Feed hopper (7) on plate (21), the diversion pipe (8) being connected to the feed hopper (7) bottom end and to be mounted on the bracket (2) perpendicular
Controller (9) on the outside of supporting plate (22), the rotation filling mechanism include:
Rotary drive assembly (3), including support frame (31), the driving motor being fixedly mounted in the middle part of the pedestal (1) top surface
(32) and rotating cylinder (33), the driving motor (32) be fixedly mounted in support frame as described above (31) and with the controller
(9) be electrically connected, driving motor (32) output end at the top of support frame as described above (31) after with the rotating cylinder (33)
One end be connected, be rotatablely connected in the middle part of the bottom surface of the other end of the rotating cylinder (33) and the horizontal plate (21)；
Chromatographic column fixation kit (4) is used for stationary chromatographic column (10), is mounted on the one side of the rotating cylinder (33), wraps
Include the fixed block (43) of the support plate (41) of lower part, the retaining sleeve (42) at middle part and top, the support plate (41) and fixed block
(43) it is respectively and fixedly installed to the bottom and top of the rotating cylinder (33) side, support plate (41) upper surface is by passing through
The guide rod (44) for wearing the retaining sleeve (42) inner end is connected with the fixed block (43) lower end surface, the retaining sleeve (42)
It is slidably matched with guide rod (44), one end and the retaining sleeve (42) upper and lower end face point is installed on the guide rod (44)
The spring (45) not being connected, the other end of the spring (45) respectively with the upper surface of the support plate (41), the fixation
The lower end surface of block (43) is connected, and the spring (45) is in free state；
Vibrator (5) is fixedly mounted on the upper surface of the retaining sleeve (42), and is electrically connected with the controller (9)；
Sensor (6) is electrically connected, the hair including being separately mounted to the rotating cylinder (33) top surface with the controller (9)
It penetrates the receiving module (62) of module (61) and the horizontal plate (21) bottom surface, the transmitting module (61) and the chromatography is installed
Rotating cylinder (33) side of column fixation kit (4) is adjacent, receiving module (62) receiving side signal to the transmitting mould
Block (61) signal direction of the launch is opposite and is overlapped with the transmitting module (61) rotational trajectory.
2. preparation chromatographic column filling device according to claim 1, which is characterized in that the rotating cylinder (33) is even
The positive polygon prism of number rib.
3. preparation chromatographic column filling device according to claim 2, which is characterized in that the rotating cylinder (33) is positive
Quadrangular.
4. preparation chromatographic column filling device according to any one of claims 1 to 3, which is characterized in that the branch
Fagging (41) upper surface is equipped with counterbore (411), and counterbore (411) internal diameter is greater than the outer diameter of the chromatographic column (10) bottom end, and
The rubber pad (412) that longitudinal section is in " Qian " font is installed, the internal diameter of the rubber pad (412) is equal in the counterbore (411)
The outer diameter of chromatographic column (10) bottom end.
5. preparation chromatographic column filling device according to any one of claims 1 to 3, which is characterized in that the folder
Holding between set (42) inner side end and the rotating cylinder (33) side has gap.
6. preparation chromatographic column filling device according to claim 5, which is characterized in that the retaining sleeve (42) is by elasticity
Material is made, and middle part is equipped with through-hole (421), and the aperture of the through-hole (421) is equal to the diameter of the chromatographic column (10), and
The outboard end of the retaining sleeve (42) is equipped with the horn mouth (422) being connected to the through-hole (421).
7. preparation chromatographic column filling device according to any one of claims 1 to 3, which is characterized in that it is described into
Hopper (7) quantity is 2, is symmetrical with the rotary drive assembly (3) arrangement, corresponding, the chromatographic column fixation kit
(4) and the quantity of vibrator (5) is at least 2, and the chromatographic column fixation kit (4) is mounted on the rotating cylinder (33) phase
Pair side on.
8. preparation chromatographic column filling device according to claim 1, which is characterized in that guide rod (44) quantity is
2.
9. preparation chromatographic column filling device according to claim 1, which is characterized in that the diversion pipe (8) is by soft
Material is made, and pipe is equipped with control valve (81), and the control valve (81) and the controller (9) are electrically connected.
10. preparation chromatographic column filling device according to claim 1, which is characterized in that in the bottom surface of the pedestal (1)
Quadrangle, which is equipped with, adjusts foot (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822214185.2U CN209264661U (en) | 2018-12-27 | 2018-12-27 | It is a kind of to prepare chromatographic column filling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822214185.2U CN209264661U (en) | 2018-12-27 | 2018-12-27 | It is a kind of to prepare chromatographic column filling device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209264661U true CN209264661U (en) | 2019-08-16 |
Family
ID=67565820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822214185.2U Expired - Fee Related CN209264661U (en) | 2018-12-27 | 2018-12-27 | It is a kind of to prepare chromatographic column filling device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209264661U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112403031A (en) * | 2020-12-21 | 2021-02-26 | 广东青云山药业有限公司 | Extraction device and extraction method of medical theaflavin |
-
2018
- 2018-12-27 CN CN201822214185.2U patent/CN209264661U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112403031A (en) * | 2020-12-21 | 2021-02-26 | 广东青云山药业有限公司 | Extraction device and extraction method of medical theaflavin |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190816 Termination date: 20191227 |