CN209243040U - Ceramic membrane filtration system for preparing ergothioneine by biological fermentation synthesis - Google Patents

Ceramic membrane filtration system for preparing ergothioneine by biological fermentation synthesis Download PDF

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Publication number
CN209243040U
CN209243040U CN201821629647.0U CN201821629647U CN209243040U CN 209243040 U CN209243040 U CN 209243040U CN 201821629647 U CN201821629647 U CN 201821629647U CN 209243040 U CN209243040 U CN 209243040U
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film component
ceramic film
valve
ceramic
dialyzate
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CN201821629647.0U
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李健
周子振
张进城
原晋波
石刚
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Tianjin Sinonocy Biological Technology Co ltd
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Tianjin Sinonocy Biological Technology Co ltd
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Abstract

The utility model discloses a biological fermentation synthesis preparation ergothioneine uses ceramic membrane filtration system, including circulating tank, conveying pump, cartridge filter, circulating pump, first ceramic membrane subassembly, second ceramic membrane subassembly and heat exchanger. The utility model discloses a biological fermentation synthesis preparation ergothioneine is used for preparing macromolecular impurities such as filter particle, protein, polysaccharide at the extraction in-process of ergothioneine at biological fermentation synthesis method preparation to have that the retention rate to impurity is high, the rate of recovery of ergothioneine is high, degree of automation is high, filter speed is fast, the feed liquid exposes the characteristics of the time weak point in the air, has reduced the risk that the feed liquid is polluted by miscellaneous fungus.

Description

A kind of biofermentation is synthetically prepared erythrothioneine ceramic membrane filter system
Technical field
The utility model belongs to biofermentation synthesis technical field, and in particular to a kind of biofermentation is synthetically prepared ergot sulphur Because with ceramic membrane filter system.
Background technique
Erythrothioneine is a kind of natural, is that a kind of can accumulate from plant and in animal natural Amino acid, tool have very much strong antioxidant activity, can scavenging capacity chalcogen, chelating divalent metal ions, activation antioxidant enzyme, Inhibit superoxide dismutase and inhibits various hemoproteins that oxidation reaction etc. occurs.Since these of erythrothioneine are special Property, it is extensive to determine that it has in medicine, food and drink, functional food, animal feed, cosmetics and biotechnology field Purposes and market prospects.
Biofermentation synthetic method with gill fungus bacterium mycelium submerged fermentation technology biosynthesis preparation erythrothioneine is existing at present There is a preparation method of common erythrothioneine in technology, this method can have by the fermentation processes means such as being metabolized and regulating and controlling Effect ground improves the yield of erythrothioneine, reduces production cost and guarantees the safety of product.
It is miscellaneous that the extraction process of biofermentation synthetic method preparation erythrothioneine needs to filter out the macromoleculars such as particle, albumen, polysaccharide Matter, existing filter device is low to the rejection of impurity, the rate of recovery of erythrothioneine is low, the degree of automation is low, the rate of filtration is slow, The feed liquid exposure aerial time is long, has by the risk of living contaminants.Therefore it needs a kind of biofermentation and is synthetically prepared wheat The rear end filter plant of angle thioneine.
Utility model content
The purpose of the utility model is to overcome the deficiencies in the prior art, a kind of biofermentation is provided and is synthetically prepared ergot sulphur Because with ceramic membrane filter system, for filtered out in the extraction process of biofermentation synthetic method preparation erythrothioneine particle, albumen, The big molecular impurities such as polysaccharide, and there is, the rate of recovery height of erythrothioneine, high degree of automation, mistake high to the rejection of impurity The feature that filtering velocity degree is fast, the feed liquid exposure aerial time is short, reduces risk of the feed liquid by living contaminants.
The utility model is achieved through the following technical solutions:
A kind of biofermentation is synthetically prepared erythrothioneine ceramic membrane filter system, including circulating tank, dehvery pump, ensures public security Filter, circulating pump, the first ceramic film component, the second ceramic film component and heat exchanger;
For holding mycelium mixed liquor and fermenting, bottom end is connect the circulating tank with the dehvery pump, described defeated The other end of material pump is connect with the cartridge filter, and the other end of the cartridge filter is connect with the circulating pump, described The other end of circulating pump is parallel with first ceramic film component and second ceramic film component, first ceramic film component It is commonly connected on the heat exchanger with the other end of second ceramic film component, the other end of the heat exchanger is followed with described The connection of ring pump so that the heat exchanger, the circulating pump and first ceramic film component and second ceramic film component it Between form circulation loop, the heat exchanger also passes through concentrate return pipe and connect with the circulating tank, described first pottery Porcelain membrane module and second ceramic film component also pass through dialyzate return pipe and connect with the circulating tank, the dialysis Liquid return pipe is connected with dialyzate discharge nozzle.
In the above-mentioned technical solutions, the connection is to pass through piping connection.
In the above-mentioned technical solutions, the circulation upper end is connected with for inputting mycelial feed pipe and for defeated Enter the water inlet pipe of purified water, inlet valve is provided on the feed pipe, is provided with inlet valve on the water inlet pipe.
In the above-mentioned technical solutions, feeding valve is provided on the pipeline that the bottom end of the circulating tank is connect with the dehvery pump With the first sewage pipe, the first blowdown valve is provided on first sewage pipe.
In the above-mentioned technical solutions, the bottom of first ceramic film component and the bottom of second ceramic film component are total With the second sewage pipe is connected with, close outlet end is provided with the second blowdown valve, close to described first on second sewage pipe The bottom of ceramic film component is provided with the first Membrane cleaning valve and the bottom of second ceramic film component is provided with second Membrane cleaning valve.
In the above-mentioned technical solutions, it is arranged on the dialyzate return pipe close to the position of first ceramic film component There are the first sampling valve and the first dialysis valve, is arranged on the dialyzate return pipe close to the position of second ceramic film component There are the second sampling valve and the second dialysis valve.
In the above-mentioned technical solutions, concentrate reflux is provided on the pipeline between the heat exchanger and the circulating pump Valve.
In the above-mentioned technical solutions, between the heat exchanger and first ceramic film component and the second ceramic film component Blow valve and pressure regulator valve are provided on pipeline.
In the above-mentioned technical solutions, one end on the dialyzate return pipe close to the circulating tank is provided with dialyzate Return valve, the dialyzate discharge nozzle are provided with dialyzate outlet valve close to the position of outlet end.
In the above-mentioned technical solutions, first pressure is provided on the pipeline between the dehvery pump and the cartridge filter Table is provided with second pressure gauge and the first thermometer on the pipeline between the cartridge filter and the circulating pump, described to follow Third pressure gauge and second temperature table, the heat exchanger are provided on pipeline between ring pump and first ceramic film component The 4th pressure gauge is provided on pipeline between first ceramic film component and the second ceramic film component, described first thoroughly The front tube road for analysing valve is provided with the 5th pressure gauge, and the front tube road of the second dialysis valve is provided with the 6th pressure gauge, It is provided with first-class scale on the concentrate return pipe, is provided with second scale on the dialyzate discharge nozzle.
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system when in use:
The mycelium mixed liquor after fermenting in the circulating tank is delivered to the cartridge filter by the dehvery pump Then filtering is delivered to first ceramic film component and the filtering of the second ceramic film component by the circulating pump, via the The concentrate that one ceramic film component and the second ceramic film component are obtained by filtration is joined via the circulating pump again by the heat exchanger With circulation, can be discharged by the dialyzate of the ceramic membrane aperture of the first ceramic film component and the second ceramic film component through dialyzate Pipe output, part of concentrate go successively to the circulating tank via concentrate return pipe and participate in circulation, part dialyzate warp The circulating tank is gone successively to by dialyzate return pipe and participates in circulation.
It the advantages of the utility model and has the beneficial effect that
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system for sending out in biology The big molecular impurities such as particle, albumen, polysaccharide are filtered out in the extraction process of ferment synthetic method preparation erythrothioneine, and are had to impurity Rejection height, the rate of recovery height of erythrothioneine, high degree of automation, the rate of filtration be fast, the feed liquid exposure aerial time Short feature reduces risk of the feed liquid by living contaminants.
Detailed description of the invention
Fig. 1 is that a kind of biofermentation of the utility model is synthetically prepared the structure of erythrothioneine ceramic membrane filter system and shows It is intended to.
Wherein, 1: circulating tank, 2: the first blowdown valves, 3: feeding valve, 4: dehvery pump, 5: cartridge filter, 6: circulating pump, 7: First ceramic film component, 8: the second ceramic film components, 9: the first sampling valves, 10: the second sampling valves, 11: the first Membrane cleaning valves, 12: the second Membrane cleaning valves, 13: the second blowdown valves, 14: the first dialysis valves, 15: the second dialysis valves, 16: blow valve, 17: pressure regulation Valve, 18: concentrate return valve, 19: heat exchanger, 20: dialyzate return valve, 21: dialyzate outlet valve, 22: inlet valve, 23: into Material valve, 24: first pressure gauge, 25: second pressure gauge, 26: the first thermometers, 27: third pressure gauge, 28: second temperature table, 29: the four pressure gauges, 30: the five pressure gauges, 31: the six pressure gauges, 32: first-class scale, 33: second scale, 34: concentration Liquid return pipe, 35: dialyzate discharge nozzle, 36: dialyzate return pipe, 37: water inlet pipe, 38: feed pipe, 39: the first sewage pipes, 40: the second sewage pipes.
It for those of ordinary skill in the art, without creative efforts, can be according to above attached Figure obtains other relevant drawings.
Specific embodiment
The utility model is described in further detail with specific embodiment with reference to the accompanying drawing.It should be understood that Following embodiments be it is illustrative, be not restrictive, the protection scope of the utility model cannot be limited with following embodiments. Following connections as described in the examples are to pass through piping connection.
Embodiment one
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system, including circulating tank, Dehvery pump, cartridge filter, circulating pump, the first ceramic film component, the second ceramic film component and heat exchanger;
For holding mycelium mixed liquor and fermenting, bottom end is connect the circulating tank with the dehvery pump, described defeated The other end of material pump is connect with the cartridge filter, and the other end of the cartridge filter is connect with the circulating pump, described The other end of circulating pump is parallel with first ceramic film component and second ceramic film component, first ceramic film component It is commonly connected on the heat exchanger with the other end of second ceramic film component, the other end of the heat exchanger is followed with described The connection of ring pump so that the heat exchanger, the circulating pump and first ceramic film component and second ceramic film component it Between form circulation loop, the heat exchanger also passes through concentrate return pipe and connect with the circulating tank, described first pottery Porcelain membrane module and second ceramic film component also pass through dialyzate return pipe and connect with the circulating tank, the dialysis Liquid return pipe is connected with dialyzate discharge nozzle.
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system when in use:
The mycelium mixed liquor after fermenting in the circulating tank is delivered to the cartridge filter by the dehvery pump Then filtering is delivered to first ceramic film component and the filtering of the second ceramic film component by the circulating pump, via the The concentrate that one ceramic film component and the second ceramic film component are obtained by filtration is joined via the circulating pump again by the heat exchanger With circulation, can be discharged by the dialyzate of the ceramic membrane aperture of the first ceramic film component and the second ceramic film component through dialyzate Pipe output, part of concentrate go successively to the circulating tank via concentrate return pipe and participate in circulation, part dialyzate warp The circulating tank is gone successively to by dialyzate return pipe and participates in circulation.
Embodiment two
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system, including circulating tank, Dehvery pump, cartridge filter, circulating pump, the first ceramic film component, the second ceramic film component and heat exchanger;
For holding mycelium mixed liquor and fermenting, the circulation upper end is connected with for inputting the circulating tank Mycelial feed pipe and water inlet pipe for inputting purified water are provided with inlet valve, the water inlet on the feed pipe Inlet valve is provided on pipe, the bottom end of the circulating tank is connect with the dehvery pump, the other end of the dehvery pump with it is described Cartridge filter connection, the other end of the cartridge filter are connect with the circulating pump, and the other end of the circulating pump is in parallel There are first ceramic film component and second ceramic film component, first ceramic film component and the second ceramic membrane group The other end of part is commonly connected on the heat exchanger, and the other end of the heat exchanger is connect with the circulating pump so that described change Circulation loop is formed between hot device, the circulating pump and first ceramic film component and second ceramic film component, institute The heat exchanger stated also passes through concentrate return pipe and connect with the circulating tank, first ceramic film component and described Two ceramic film components also pass through dialyzate return pipe and connect with the circulating tank, and the dialyzate return pipe is connected with dialysis Liquid discharge nozzle.
First pressure gauge, the cartridge filter are provided on pipeline between the dehvery pump and the cartridge filter Second pressure gauge and the first thermometer, the circulating pump and first ceramics are provided on pipeline between the circulating pump Third pressure gauge and second temperature table, the heat exchanger and first ceramic membrane are provided on pipeline between membrane module The 4th pressure gauge is provided on pipeline between component and the second ceramic film component, the front tube road of the first dialysis valve is set It is equipped with the 5th pressure gauge, the front tube road of the second dialysis valve is provided with the 6th pressure gauge, the concentrate return pipe On be provided with first-class scale, second scale is provided on the dialyzate discharge nozzle, various instrument are commercially available.
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system when in use:
The mycelium mixed liquor after fermenting in the circulating tank is delivered to the cartridge filter by the dehvery pump Then filtering is delivered to first ceramic film component and the filtering of the second ceramic film component by the circulating pump, via the The concentrate that one ceramic film component and the second ceramic film component are obtained by filtration is joined via the circulating pump again by the heat exchanger With circulation, can be discharged by the dialyzate of the ceramic membrane aperture of the first ceramic film component and the second ceramic film component through dialyzate Pipe output, part of concentrate go successively to the circulating tank via concentrate return pipe and participate in circulation, part dialyzate warp The circulating tank is gone successively to by dialyzate return pipe and participates in circulation.
Embodiment three
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system, including circulating tank, Dehvery pump, cartridge filter, circulating pump, the first ceramic film component, the second ceramic film component and heat exchanger;
For holding mycelium mixed liquor and fermenting, the circulation upper end is connected with for inputting the circulating tank Mycelial feed pipe and water inlet pipe for inputting purified water are provided with inlet valve, the water inlet on the feed pipe Inlet valve is provided on pipe, the bottom end of the circulating tank is connect with the dehvery pump, the bottom end of the circulating tank with it is described defeated It is provided with feeding valve and the first sewage pipe on the pipeline of material pump connection, is provided with the first blowdown valve on first sewage pipe; The other end of the dehvery pump is connect with the cartridge filter, and the other end of the cartridge filter and the circulating pump connect It connects, the other end of the circulating pump is parallel with first ceramic film component and second ceramic film component, wherein in parallel Second ceramic film component can play the role of pressure stabilizing, the bottom of first ceramic film component and second ceramic membrane The bottom of component is connected with the second sewage pipe jointly, on second sewage pipe close to outlet end be provided with the second blowdown valve, The bottom of first ceramic film component is provided with the first Membrane cleaning valve and close to the bottom of second ceramic film component Portion is provided with the second Membrane cleaning valve;The other end of first ceramic film component and second ceramic film component is commonly connected to On the heat exchanger, it is provided on the pipeline between the heat exchanger and first ceramic film component and the second ceramic film component Blow valve and pressure regulator valve;The other end of the heat exchanger is connect with the circulating pump so that the heat exchanger, the circulating pump with And circulation loop is formed between first ceramic film component and second ceramic film component, the heat exchanger also passes through dense Contracting liquid return pipe is connect with the circulating tank, and concentrate is provided on the pipeline between the heat exchanger and the circulating pump and is returned Valve is flowed, the dialyzate return pipe is connected with dialyzate discharge nozzle, makes pottery on the dialyzate return pipe close to described first The position of porcelain membrane module is provided with the first sampling valve and the first dialysis valve, makes pottery on the dialyzate return pipe close to described second The position of porcelain membrane module is provided with the second sampling valve and the second dialysis valve;Close to the circulating tank on the dialyzate return pipe One end be provided with dialyzate return valve, the dialyzate discharge nozzle is provided with dialyzate discharging close to the position of outlet end Valve.
First pressure gauge, the cartridge filter are provided on pipeline between the dehvery pump and the cartridge filter Second pressure gauge and the first thermometer, the circulating pump and first ceramics are provided on pipeline between the circulating pump Third pressure gauge and second temperature table, the heat exchanger and first ceramic membrane are provided on pipeline between membrane module The 4th pressure gauge is provided on pipeline between component and the second ceramic film component, the front tube road of the first dialysis valve is set It is equipped with the 5th pressure gauge, the front tube road of the second dialysis valve is provided with the 6th pressure gauge, the concentrate return pipe On be provided with first-class scale, second scale is provided on the dialyzate discharge nozzle, various instrument are commercially available.
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system when in use:
The mycelium mixed liquor after fermenting in the circulating tank is delivered to the cartridge filter by the dehvery pump Then filtering is delivered to first ceramic film component and the filtering of the second ceramic film component by the circulating pump, via the The concentrate that one ceramic film component and the second ceramic film component are obtained by filtration is joined via the circulating pump again by the heat exchanger With circulation, can be discharged by the dialyzate of the ceramic membrane aperture of the first ceramic film component and the second ceramic film component through dialyzate Pipe output, part of concentrate go successively to the circulating tank via concentrate return pipe and participate in circulation, part dialyzate warp The circulating tank is gone successively to by dialyzate return pipe and participates in circulation.
A kind of biofermentation of the utility model is synthetically prepared erythrothioneine ceramic membrane filter system for sending out in biology The big molecular impurities such as particle, albumen, polysaccharide are filtered out in the extraction process of ferment synthetic method preparation erythrothioneine, and are had to impurity Rejection height, the rate of recovery height of erythrothioneine, high degree of automation, the rate of filtration be fast, the feed liquid exposure aerial time Short feature reduces risk of the feed liquid by living contaminants.
The spatially relative terms such as "upper", "lower", "left", "right" have been used in embodiment for ease of explanation, have been used for Relationship of the elements or features relative to another elements or features shown in explanatory diagram.It should be understood that in addition to figure Shown in except orientation, spatial terminology is intended to include the different direction of device in use or operation.For example, if in figure Device be squeezed, the element for being stated as being located at other elements or feature "lower" will be located into other elements or feature "upper". Therefore, exemplary term "lower" may include both upper and lower orientation.Device, which can be positioned in other ways, (to be rotated by 90 ° or position In other orientation), it can be interpreted accordingly used herein of the opposite explanation in space.
Illustrative description has been done to the utility model above, it should explanation, in the core for not departing from the utility model In the case where the heart, it is any it is simple deformation, modification or other skilled in the art can not spend creative work etc. The protection scope of the utility model is each fallen with replacement.

Claims (10)

1. a kind of biofermentation is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that including circulating tank, conveying Pump, cartridge filter, circulating pump, the first ceramic film component, the second ceramic film component and heat exchanger;
The circulating tank is for holding mycelium mixed liquor and fermenting, and bottom end is connect with the dehvery pump, the dehvery pump The other end connect with the cartridge filter, the other end of the cartridge filter is connect with the circulating pump, the circulation The other end of pump is parallel with first ceramic film component and second ceramic film component, first ceramic film component and institute The other end for stating the second ceramic film component is commonly connected on the heat exchanger, the other end of the heat exchanger and the circulating pump Connection is so that shape between the heat exchanger, the circulating pump and first ceramic film component and second ceramic film component At circulation loop, the heat exchanger also passes through concentrate return pipe and connect with the circulating tank, first ceramic membrane Component and second ceramic film component also pass through dialyzate return pipe and connect with the circulating tank, and the dialyzate returns Flow tube is connected with dialyzate discharge nozzle.
2. biofermentation according to claim 1 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that The connection is to pass through piping connection.
3. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that The circulation upper end is connected with the water inlet pipe for inputting mycelial feed pipe and for inputting purified water, it is described into It is provided with inlet valve in expects pipe, is provided with inlet valve on the water inlet pipe.
4. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that Feeding valve and the first sewage pipe, the first row are provided on the pipeline that the bottom end of the circulating tank is connect with the dehvery pump The first blowdown valve is provided on dirty pipe.
5. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that The bottom of first ceramic film component and the bottom of second ceramic film component are connected with the second sewage pipe jointly, described Outlet end is provided with the second blowdown valve on second sewage pipe, the bottom of first ceramic film component is provided with first The bottom of Membrane cleaning valve and close second ceramic film component is provided with the second Membrane cleaning valve.
6. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that Position on the dialyzate return pipe close to first ceramic film component is provided with the first sampling valve and the first dialysis valve, Position on the dialyzate return pipe close to second ceramic film component is provided with the second sampling valve and the second dialysis valve.
7. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that Concentrate return valve is provided on pipeline between the heat exchanger and the circulating pump.
8. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that Blow valve and pressure regulation are provided on pipeline between the heat exchanger and first ceramic film component and the second ceramic film component Valve.
9. biofermentation according to claim 2 is synthetically prepared erythrothioneine ceramic membrane filter system, which is characterized in that One end on the dialyzate return pipe close to the circulating tank is provided with dialyzate return valve, the dialyzate discharge nozzle Position close to outlet end is provided with dialyzate outlet valve.
10. biofermentation according to claim 6 is synthetically prepared erythrothioneine ceramic membrane filter system, feature exists In being provided with first pressure gauge, the cartridge filter and institute on the pipeline between the dehvery pump and the cartridge filter It states and is provided with second pressure gauge and the first thermometer on the pipeline between circulating pump, the circulating pump and the first ceramic membrane group Third pressure gauge and second temperature table, the heat exchanger and first ceramic film component are provided on pipeline between part And the 4th pressure gauge is provided on the second pipeline between ceramic film component, the front tube road of the first dialysis valve is provided with The front tube road of 5th pressure gauge, the second dialysis valve is provided with the 6th pressure gauge, sets on the concentrate return pipe It is equipped with first-class scale, is provided with second scale on the dialyzate discharge nozzle.
CN201821629647.0U 2018-10-08 2018-10-08 Ceramic membrane filtration system for preparing ergothioneine by biological fermentation synthesis Active CN209243040U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111644097A (en) * 2020-06-24 2020-09-11 山东润德生物科技有限公司 Dialysis mixing process for glucosamine liquid ceramic membrane filtration

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111644097A (en) * 2020-06-24 2020-09-11 山东润德生物科技有限公司 Dialysis mixing process for glucosamine liquid ceramic membrane filtration

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