CN209215221U - Fluoremetry container and fluorescence determination device - Google Patents
Fluoremetry container and fluorescence determination device Download PDFInfo
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- CN209215221U CN209215221U CN201821539833.5U CN201821539833U CN209215221U CN 209215221 U CN209215221 U CN 209215221U CN 201821539833 U CN201821539833 U CN 201821539833U CN 209215221 U CN209215221 U CN 209215221U
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Abstract
A kind of fluoremetry container and fluorescence determination device, for carrying out fluoremetry to the cell acquired from the position to be detected of organism.Fluoremetry container is characterized in that having: accumulation unit, has opening portion, and the detection liquid containing above-mentioned cell can be internally accumulated from the opening portion, has bottom in the side opposite with above-mentioned opening portion；Determination part is connect with the above-mentioned bottom of above-mentioned accumulation unit, and the thickness of inner space is certain, and a face on the direction of above-mentioned thickness in two faces opposite each other is aspect of measure, and at least the above aspect of measure can be through the light released from above-mentioned cell.
Description
Technical field
The utility model relates to a kind of fluoremetry containers and fluorescence determination device as centrifuge separation container.
Background technique
In the past, when carrying out optical observation to the low detection liquid of the cell concentrations such as phlegm, arena, cervical smear, first
It is centrifuged using centrifuge tube and carrys out concentrating cells, later from light source to cell irradiation exciting light, and observed and being issued from cell
Fluorescence.
In general, the bottom of previous PCR (Polimerase Chain Reaction) pipe and centrifuge tube is in as shown in Figure 8
Coniform or hemispherical, cell and erythrocyte sedimentation are in the bottom of centrifuge tube after centrifugation, using lowest level as layer of red blood cells,
It is laminated thereon for the form of cellular layer.It, can only be from the lower section of centrifuge tube via red blood cell when carrying out optical observation to cellular layer
Layer observes cellular layer to observe the fluorescence that cellular layer issues, or from side of the side of centrifuge tube to cellular layer.From centrifugation
In the case that cellular layer is observed via layer of red blood cells in the lower section of pipe, layer of red blood cells can interfere to observe.In the side from centrifuge tube
It, can not since the distance from the side of cellular layer to the other side is big in the case where observing cellular layer to the side of cellular layer
The case where observing the other side of cellular layer.Accordingly, it is difficult to be integrally observed to cellular layer.
Therefore, the cellular layer for being deposited in the bottom of centrifuge tube must be transferred in other containers and see by operator
It surveys, observation process is caused to become many and diverse.
Utility model content
The utility model is completed in view of background above, its main purpose is, providing a kind of fluoremetry container
And fluorescence determination device, do not need by centrifuge separation after cellular layer be transferred to other containers can to cellular layer carry out optics
Observation.
The technical solution of the utility model 1 is a kind of fluoremetry container, for adopting to from the position to be detected of organism
The cell of collection carries out fluoremetry, which is characterized in that has: accumulation unit has opening portion, can internally store from the opening portion
Product contains the detection liquid of above-mentioned cell, has bottom in the side opposite with above-mentioned opening portion；Determination part, with above-mentioned accumulation unit
Above-mentioned bottom connection, the thickness of inner space is certain, one on the direction of above-mentioned thickness in two faces opposite each other
Face is aspect of measure, and at least the above aspect of measure can be through the light released from above-mentioned cell.
According to the utility model of technical solution 1, due to having determination part, and the thickness of its inner space is certain, therefore examines
Cell and red blood cell in survey liquid is identical with the thickness of the inner space with determination part respectively by the centrifuge separation for detecting liquid
Thickness stratiform be configured to the determination part, i.e. cellular layer stratiform that suitable optical observation is automatically become by centrifugal force, therefore not
It needs that cellular layer after centrifuge separation is transferred to other containers as previous and can carry out optical observation to cellular layer.
In addition, the intensity of fluorescence is stronger in general, the thickness of fluorescent material (such as cellular layer) is thicker.Therefore, as previous
In the case that the bottom of PCR pipe and centrifuge tube is in coniform or hemispherical, since the thickness of its inner space is (i.e. in Fig. 8 or so
Width on direction) it is different, therefore even if the concentration of fluorescent material is identical, but the position irradiated according to light, what is issued is glimmering
The intensity of light is also different.In this way, if the distance i.e. optical path length that light is passed through in cellular layer be not it is certain, fluorescence it is strong
Degree is also not certain, and the thickness of the inner space of container becomes variable, it is difficult to realize the quantitative of optical detecting, therefore can not
Accurately observe the optical characteristics of cell.
And according to the utility model, since the thickness of the inner space of determination part is certain, optical path length is in determination part
Any position it is certain, so as to realize the quantitative of optical detecting.
In addition, in technical solution 2, the above-mentioned bottom of above-mentioned accumulation unit with being close to said determination portion from above-mentioned accumulation unit and
It becomes narrow gradually.
Determination part, which is easily accessible, thereby, it is possible to making to detect cell and red blood cell in liquid forms cellular layer and red blood cell
Layer.
In addition, in technical solution 3, the non-aspect of measure other than said determination face in said determination portion also can through from
The fluorescence that above-mentioned cellular layer is released.
In addition, the surface of the non-aspect of measure other than said determination face in said determination portion is coloured in technical solution 4
At black.
Thereby, it is possible to absorb stray light, scattering light etc. to the noisy light of fluoremetry.
In addition, being arranged on the surface of the non-aspect of measure other than said determination face in said determination portion in technical solution 5
There are bumps.
Thereby, it is possible to prevent stray light, diffuse etc. to the noisy light of fluoremetry.
In addition, in technical solution 6, the above-mentioned inner space in said determination portion with a thickness of 0.5mm or more and 3mm or less.
As a result, since the inner space of determination part is with a thickness of 0.5mm or more, large-scale cell block can be made also
Enough enter determination part.Also, due to the inner space of determination part with a thickness of 3mm hereinafter, therefore exciting light can be from cell
The side of layer substantially arrives at the other side, can integrally be measured to cellular layer.
In addition, being also equipped with the above-mentioned opening portion lid of closing in technical solution 7.
Thereby, it is possible to prevent detection liquid from overflowing from opening portion.
In addition, the technical solution of the utility model 8 is a kind of fluorescence determination device, which is characterized in that have: aforementioned techniques
Fluoremetry container described in any one of scheme 1~7；Light source, the said determination portion of Xiang Shangshu fluoremetry container it is above-mentioned
Aspect of measure irradiates exciting light；Fluorescence filter transmits the fluorescence that the cellular layer from said determination portion issues；Imaging len makes
Above-mentioned fluorescence is penetrated and is imaged；And light receiving element, it observes through picture made of above-mentioned imaging len.
According to the utility model of technical solution 8, since fluoremetry container has determination part, and the thickness of its inner space
Centainly, therefore the cell in liquid and red blood cell are detected by detecting the centrifuge separation of liquid respectively with the inner space with determination part
The identical thickness stratiform of thickness be configured to the determination part, i.e. cellular layer layer that suitable optical observation is automatically become by centrifugal force
Shape, therefore do not need cellular layer after centrifuge separation is transferred to other containers as previous and can carry out light to cellular layer
Learn observation.Further, since the thickness of the inner space of determination part is certain, therefore optical path length is uniform in any position of determination part
It is fixed, so as to realize the quantitative of optical detecting.
Detailed description of the invention
Fig. 1 is the perspective view for indicating the fluoremetry container of first embodiment.
Fig. 2 is the main view for indicating the fluoremetry container of first embodiment.
Fig. 3 is the side view for indicating the fluoremetry container of first embodiment.
Fig. 4 is the main view for the state that accumulation has detection liquid in the fluoremetry container for indicate first embodiment.
Fig. 5 is the state after the detection liquid accumulated in the fluoremetry container for indicate first embodiment is centrifuged
Main view.
Fig. 6 is the state after the detection liquid accumulated in the fluoremetry container for indicate first embodiment is centrifuged
Side view.
Fig. 7 is the schematic diagram for indicating the fluorescence determination device of second embodiment.
Fig. 8 is the figure for indicating the state after the detection liquid accumulated in previous PCR pipe or centrifuge tube is centrifuged.
Specific embodiment
In the following, being illustrated in conjunction with fluoremetry container and fluorescence determination device of the attached drawing to the utility model.
[first embodiment]
Fluoremetry container 100 based on Detailed description of the invention first embodiment.Fig. 1 is the fluorescence for indicating first embodiment
Measure the perspective view of container 100.Fig. 2 is the main view for indicating the fluoremetry container 100 of first embodiment.Fig. 3 is to indicate
The side view of the fluoremetry container 100 of first embodiment.
It includes the inspection that the cell of detection position acquisition is waited from cervix or tracheae that fluoremetry container 100, which is for accommodating,
The container for surveying liquid, is the one kind for being centrifugated container (centrifuge tube), carries out fluoremetry to the cell acquired from position to be detected.
As shown in FIG. 1 to 3, the fluoremetry container 100 of present embodiment has cylindric accumulation unit 10 and flat measurement
The shape in portion 20, accumulation unit 10 is not particularly limited, and cylindrical shape is only example, can also be polygon prism shape, elliptic cylindrical shape etc.,
The shape of determination part 20 is also not particularly limited, and flat is only example, can also be the bottom surface of determination part 20 in Fig. 1
Length and shape etc. of same size.
One end of accumulation unit 10 has opening portion 11, and detection liquid containing cell can be internally accumulated from the opening portion 11
(referring to Fig. 4).Accumulation unit 10 has bottom 12 in the side opposite with opening portion 11.Accumulation unit 10 passes through bottom 12 and determination part
20 connections.In order to make by centrifuge separation from the cell separated of detection liquid and red blood cell more easily from accumulation unit 10 into
Enter to determination part 20, bottom 12 is preferably formed into determination part 20 is close to from accumulation unit 10 and becomes narrow gradually.But as long as
Cell and red blood cell can enter determination part 20 from accumulation unit 10, then the shape of bottom 12 is not limited to this.
In addition, there is no particular limitation for the diameter of accumulation unit 10, but being preferably configured to can be for be detected for acquiring
The size that the cell collection brush of the cell at position enters.In general, the width of the brush head of cell collection brush is 20mm or so, because
The diameter of this accumulation unit 10 is preferably 20mm or more.Also, the diameter of accumulation unit 10 is preferably suitable for being put into general centrifugation point
From the size in equipment, such as it can be 30mm ± 5mm.
Width in thickness, that is, Fig. 3 of the inner space of determination part 20 on left and right directions is set as centainly.In the determination part
It is configured respectively with thickness stratiform identical with the thickness of the inner space of determination part 20 by carrying out centrifugation point to detection liquid in 20
Cellular layer and layer of red blood cells from obtained from (refer to Fig. 5, Fig. 6), and layer of red blood cells is configured in the lower part of determination part 20, and cellular layer is matched
It sets in the top of layer of red blood cells.At least aspect of measure of determination part 20 is to be used to observe the plane of incidence of the exciting light of cellular layer by can
It is constituted through the material of the wavelength for the fluorescence released from cellular layer.As long as specifically, can be suitable for carrying out optical detecting
, such as can be transparent glass or transparent resin etc..
In addition, the thickness of the inner space of determination part 20 is not particularly limited, as long as being configured to be suitable for carrying out optics
The size of measurement.From the aspect of the distance to inside bio-tissue is able to enter from light, the inside of determination part 20 is empty
Between thickness be preferably 3mm or less.In addition, being examined in terms of being able to enter large-scale cell block to the size in determination part 20
Consider, the thickness of the inner space of determination part 20 is preferably 0.5mm or more.From the aspect of two above, the inside of determination part 20
The thickness in space is preferably 0.5mm or more and 3mm or less.
In addition, the whole height (i.e. overall length) of fluoremetry container 100 is not particularly limited.However, it is preferred to for that can put
Entering to the size in common centrifugal separation equipment, such as the whole height (i.e. overall length) of fluoremetry container 100 can be set
For 120mm or less.
Illustrate the application method of the fluorescence detection container 100 of present embodiment with reference to the accompanying drawing.
Fig. 4 is the main view for indicating to accumulate the state for having detection liquid in fluoremetry container 100.Fig. 5 is to indicate that fluorescence is surveyed
The detection liquid accumulated in constant volume device 100 be centrifuged after state main view.Fig. 6 is to indicate fluoremetry container 100
The detection liquid of middle accumulation be centrifuged after state side view.
Firstly, as shown in figure 4, being put into from the opening portion of fluoremetry container 100 11 to the inside of fluoremetry container 100
The detection liquid of cell containing position to be detected.Then, with general centrifugal separator to the xylometer to be checked equipped with detection liquid
Processing is centrifuged.After centrifuging treatment, as shown in Figure 5, Figure 6, separated by centrifuge separation from detection liquid
Cell and red blood cell out is configured to fluorescence respectively with thickness stratiform identical with the thickness of the inner space of determination part 20 and surveys
In the determination part 20 of constant volume device 100, layer of red blood cells configuration is configured in the lower part of determination part 20, cellular layer in the upper of layer of red blood cells
Side.Then, exciting light is irradiated from the aspect of measure of determination part 20, and observes the fluorescence from cellular layer.
Illustrate the function and effect of the fluoremetry container 100 of present embodiment below.
The fluoremetry container 100 of present embodiment has determination part 20, and the thickness of its inner space is certain, therefore examines
Cell and red blood cell in survey liquid is by detecting the centrifuge separation of liquid respectively with the thickness phase of the inner space with determination part 20
With thickness stratiform be configured to the determination part 20, i.e. cellular layer stratiform that suitable optical observation is automatically become by centrifugal force, because
This does not need cellular layer after centrifuge separation is transferred to other containers as previous and can carry out optics sight to cellular layer
It surveys.
In addition, the intensity of fluorescence is stronger in general, the thickness of fluorescent material (such as cellular layer) is thicker.Therefore, as previous
In the case that the bottom of PCR pipe and centrifuge tube is in coniform or hemispherical, since the thickness of its inner space is (i.e. in Fig. 3 or so
Width on direction) it is different, therefore even if the concentration of fluorescent material is identical, but the position irradiated according to light, what is issued is glimmering
The intensity of light is also different.In this way, if the distance i.e. optical path length that light is passed through in cellular layer be not it is certain, fluorescence it is strong
Degree is also not certain, and the thickness of the inner space of container becomes variable, it is difficult to realize the quantitative of optical detecting, therefore can not
Accurately observe the optical characteristics of cell.
And according to the utility model, since the thickness of the inner space of determination part 20 is certain, optical path length is being measured
Any position in portion 20 is certain, so as to realize the quantitative of optical detecting.
[experimental example]
The fluoremetry container 100 with a thickness of 1mm of the inner space of determination part 20 is prepared.In fluoremetry container
100 inside is put into the liquid for being mixed with white particle, and carries out centrifuging treatment.As a result, white particle is precipitated with stratiform
Into determination part 20, become the shape for being suitable for being observed.
[comparative example]
A kind of PCR pipe of previous common centrifuge separation container (centrifuge tube) is prepared.In the same manner as experimental example,
It is put into the liquid for being mixed with white particle in the inside of PCR pipe, and carries out centrifuging treatment.As a result, white particle is in PCR pipe
Cone elevated bottom perspective precipitate, from no matter being observed from which direction, be difficult to observe the white of opposite side
Grain.
The fluoremetry container of the first embodiment of the utility model is explained above, but the utility model is not limited to
This.The variation of following description first embodiment.
[variation 1]
In the fluoremetry container 100 of first embodiment, the aspect of measure of determination part 20 is put by that can penetrate from cellular layer
The material of the wavelength of fluorescence out is constituted, and it is also possible to be, the non-aspect of measure other than aspect of measure can also be penetrated from cell
The fluorescence that layer is released.
[variation 2]
In the fluoremetry container 100 of first embodiment, illustrate determination part 20 by transparent glass or transparent resin etc.
The example of composition.But as long as determination part 20 can be through the wavelength components for wanting observation.That is, only handling
In the case where the light of infrared region or ultraviolet region, determination part 20 may not be transparent material.
[variation 3]
The material of determination part 20 can also be the low autofluorescence material that fluorescence will not be generated because of exciting light.
[variation 4]
The surface of the non-aspect of measure other than aspect of measure of determination part 20 can also be painted to the colors such as black.By
This, can absorb stray light, scattering light etc. to the noisy light of fluoremetry.
[variation 5]
Subtle bumps are provided on the surface of the non-aspect of measure other than aspect of measure of determination part 20.Thereby, it is possible to
It prevents stray light, diffuse etc. to the noisy light of fluoremetry.
[variation 6]
Fluoremetry container 100 can also have 11 lid of closed peristome.Thereby, it is possible to prevent detection liquid from opening portion
11 overflow.In addition, the lid can be selected with the determination part 20 in first embodiment and 1~variation of variation 5 similarly
Material, or it is carried out same coloring treatment or surface treatment.
[second embodiment]
Illustrate the fluorescence determination device 200 of second embodiment based on Fig. 7.Fig. 7 is the fluorescence for indicating second embodiment
The schematic diagram of measurement device 200.
As shown in fig. 7, fluorescence determination device 200 has: the fluoremetry container of first embodiment and its variation
100；Light source 210 irradiates exciting light to the aspect of measure of the determination part 20 of fluoremetry container 100, and the light that light source 210 is issued does not have
It is particularly limited to, such as can arbitrarily be become in ultraviolet light to infrared spectral range according to the characteristic of the test object of the desired equation of light
More；Fluorescence filter 220 transmits the fluorescence that the cellular layer from determination part 20 issues；Imaging len 230, make fluorescence penetrate and
Imaging；And light receiving element 240, to through, as observing, light receiving element 240 for example can be made of imaging len 230
Camera, photodiode, photomultiplier tube etc..
Fluorescence determination device 200 according to the present embodiment, since fluoremetry container 100 has determination part 20, and its
The thickness of inner space is certain, thus detect liquid in cell and red blood cell by detection liquid centrifuge separation respectively with survey
The identical thickness stratiform of thickness for determining the inner space in portion 20 is configured to the determination part 20, i.e., cellular layer by centrifugal force automatically at
To be suitble to the stratiform of optical observation, therefore do not need that cellular layer after centrifuge separation is transferred to other containers just as previous
Optical observation can be carried out to cellular layer.Further, since the thickness of the inner space of determination part 20 is certain, therefore optical path length exists
Any position of determination part 200 is certain, so as to realize the quantitative of optical detecting.
Above by reference to Detailed description of the invention the embodiments of the present invention and variation.But described above is only that this is practical new
The specific example of type, for understanding the utility model, rather than restriction the scope of the utility model.Those skilled in the art's energy
Enough technical ideas based on the utility model carry out various modifications to embodiment and combination, thus obtained mode are also included within
In the scope of the utility model.
Claims (8)
1. a kind of fluoremetry container, special for carrying out fluoremetry to the cell acquired from the position to be detected of organism
Sign is have:
Accumulation unit has opening portion, and the detection liquid containing above-mentioned cell can be internally accumulated from the opening portion, is opened with above-mentioned
The opposite side of oral area has bottom；
Determination part is connect with the above-mentioned bottom of above-mentioned accumulation unit, and the thickness of inner space is certain, on the direction of above-mentioned thickness
A face in two faces opposite each other is aspect of measure, and at least the above aspect of measure can be glimmering through releasing from above-mentioned cell
Light.
2. fluoremetry container according to claim 1, which is characterized in that
The above-mentioned bottom of above-mentioned accumulation unit becomes narrow gradually with said determination portion is close to from above-mentioned accumulation unit.
3. fluoremetry container according to claim 1, which is characterized in that
The non-aspect of measure other than said determination face in said determination portion also can be through the fluorescence released from above-mentioned cell.
4. fluoremetry container according to claim 1, which is characterized in that
The surface of the non-aspect of measure other than said determination face in said determination portion is painted to black.
5. fluoremetry container according to claim 1, which is characterized in that
Bumps are provided on the surface of the non-aspect of measure other than said determination face in said determination portion.
6. fluoremetry container according to claim 1, which is characterized in that
The above-mentioned inner space in said determination portion with a thickness of 0.5mm or more and 3mm or less.
7. fluoremetry container described according to claim 1~any one of 6, which is characterized in that
It is also equipped with the above-mentioned opening portion lid of closing.
8. a kind of fluorescence determination device, which is characterized in that have:
Fluoremetry container according to any one of claims 1 to 7；
Exciting light is irradiated in the said determination face of light source, the said determination portion of Xiang Shangshu fluoremetry container；Fluorescence filter, transmission
The fluorescence issued from the cellular layer in said determination portion；
Imaging len makes above-mentioned fluorescence penetrate and be imaged；And
Light receiving element is observed through picture made of above-mentioned imaging len.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821539833.5U CN209215221U (en) | 2018-09-20 | 2018-09-20 | Fluoremetry container and fluorescence determination device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821539833.5U CN209215221U (en) | 2018-09-20 | 2018-09-20 | Fluoremetry container and fluorescence determination device |
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| CN209215221U true CN209215221U (en) | 2019-08-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020057428A1 (en) * | 2018-09-20 | 2020-03-26 | 牛尾电机(苏州)有限公司 | Fluorometric determination container and fluorometric determination device |
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2018
- 2018-09-20 CN CN201821539833.5U patent/CN209215221U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020057428A1 (en) * | 2018-09-20 | 2020-03-26 | 牛尾电机(苏州)有限公司 | Fluorometric determination container and fluorometric determination device |
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