CN209187661U - A kind of snowflake sample bone-grafting material monomer and bone-grafting material - Google Patents
A kind of snowflake sample bone-grafting material monomer and bone-grafting material Download PDFInfo
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- CN209187661U CN209187661U CN201821488097.5U CN201821488097U CN209187661U CN 209187661 U CN209187661 U CN 209187661U CN 201821488097 U CN201821488097 U CN 201821488097U CN 209187661 U CN209187661 U CN 209187661U
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Abstract
The utility model discloses a kind of snowflake sample bone-grafting material monomers, including a center and around six petals of the uniformly distributed congruence in the center, each petal includes a trunk branch, the trunk branch is equipped at least one bifurcation, is respectively connected with a pair of of the branch symmetrical in the two sides of the trunk branch on each bifurcation.Its technical effect is that: bone-grafting material is prepared with the snowflake sample bone-grafting material monomer, the hole filtered for marrow blood is constituted by the way that trunk branch and branch are interlaced with each other, pore size is controllable, and trunk branch provides site with the adherency for branching into stem cell in marrow blood, the drawbacks of can only achieve honeycombed grain material shallow-layer hole so as to avoid marrow blood, the bioaccumulation efficiency of stem cell improves, and adheres to also more uniform.The invention also discloses a kind of bone-grafting materials.
Description
Technical field
The utility model relates to a kind of snowflake sample bone-grafting material monomer of medical instruments field and bone-grafting materials.
Background technique
Beneficiation technologies are quickly screened using stem cell by marrow blood from porous bone-grafting materials such as porous bata-tricalcium phosphate particles
After middle filtration, the mescenchymal stem cell in marrow blood is adhered in bone-grafting material shallow-layer hole, improves its osteogenic ability.By
In defect of the porous bone-grafting material on porous structure, when marrow blood is filtered from porous bone-grafting material, marrow blood is inclined to straight more
It connects and is filtered in intergranular hole, only part marrow blood can penetrate into the hole of particle along particle outer layer, and range has
Limit, particle is bigger, and the hole in deep has been more difficult to blood infiltration, therefore marrow blood is difficult to the hole by bone-grafting material deep, and one
Determine degree and affects the uniformity that the cell of stem cell adhesive efficiency and adherency is distributed in the material.
Utility model content
The purpose of this utility model is to overcome the deficiencies in the prior art, provide a kind of snowflake sample bone-grafting material monomer with
And bone-grafting material, bone-grafting material is prepared with the snowflake sample bone-grafting material monomer, passes through trunk branch and branch composition interlaced with each other
For the hole of marrow blood filtration, pore size is controllable, and trunk branch and the adherency offer for branching into stem cell in marrow blood
The bioaccumulation efficiency in site, the drawbacks of can only achieve honeycombed grain material shallow-layer hole so as to avoid marrow blood, stem cell improves,
It adheres to also more uniform.
Realizing a kind of scheme of above-mentioned purpose is: a kind of snowflake sample bone-grafting material monomer, including a center and surrounds
Six petals of the uniformly distributed congruence in the center, each petal include a trunk branch, and the trunk branch is equipped with extremely
Lack a bifurcation, is respectively connected with a pair of of the branch symmetrical in the two sides of the trunk branch on each bifurcation.
Further, the trunk branch be equipped with successively the first bifurcation far from the center, the second bifurcation and
Third bifurcation；A pair first branch symmetrical in trunk branch two sides, institute are connected on first bifurcation
It states and is connected with a pair second branch symmetrical in trunk branch two sides on the second bifurcation, on the third bifurcation
It is connected with a pair of of the third branch symmetrical in trunk branch two sides.
Further, it is connected in first branch, second branch or the third branch at least a pair of time
Grade branch.
Further, the angle between the trunk branch and first branch, the trunk branch and described the
The angle of the angle between angle and the trunk branch and the third branch between two branches is adjustable.
Further, the end of first branch, second branch, the third branch, with each master
In the regular hexagon that the end of dry branch is made of vertex.
Further, the first branch and/or the second branch successively connect on adjacent petal, connection cyclization.
Further, the snowflake sample bone-grafting material monomer is that 3D printing is molding or sinter molding.
Realizing a kind of technical solution of above-mentioned purpose is: a kind of bone-grafting material, stacked gradually by multilayer bone-grafting material layer and
At every layer of bone-grafting material layer is spliced by snowflake sample bone-grafting material monomer, and the snowflake sample bone-grafting material monomer is in the plant
It is in honeycomb arrangement in the aggregate bed of material；
The snowflake sample bone-grafting material monomer, including a center and around six flowers of the uniformly distributed congruence in the center
Valve, each petal include a trunk branch, and the trunk branch is equipped at least one bifurcation, on each bifurcation
It is connected with a pair of of the branch being axisymmetricly distributed in the two sides of the trunk branch.
Further, the length of the trunk branch of the snowflake sample bone-grafting material monomer in each bone-grafting material layer is adjustable
's.
Further, the deflection angle between two layers of bone-grafting material layer of arbitrary neighborhood is adjustable.
Using a kind of technical solution of snowflake sample bone-grafting material monomer of the utility model, including a center and enclose
Six petals of the congruence uniformly distributed around the center, each petal includes a trunk branch, and the trunk branch is equipped with
At least one bifurcation is respectively connected with a pair of of the branch symmetrical in the two sides of the trunk branch on each bifurcation.Its
It has the technical effect that and prepares bone-grafting material with the snowflake sample bone-grafting material monomer, pass through trunk branch and branch composition interlaced with each other
For the hole of marrow blood filtration, pore size is controllable, and trunk branch and the adherency offer for branching into stem cell in marrow blood
The bioaccumulation efficiency in site, the drawbacks of can only achieve honeycombed grain material shallow-layer hole so as to avoid marrow blood, stem cell improves,
It adheres to also more uniform.
The invention also discloses a kind of technical solution of bone-grafting material, stacked gradually by multilayer bone-grafting material layer and
At every layer of bone-grafting material layer is spliced by snowflake sample bone-grafting material monomer, and the snowflake sample bone-grafting material monomer is in the plant
It is in honeycomb arrangement in the aggregate bed of material；The snowflake sample bone-grafting material monomer, including a center and around the center it is equal
Six petals of the congruence of cloth, each petal include a trunk branch, and the trunk branch is equipped at least one bifurcated
Point is respectively connected with a pair of of the branch being axisymmetricly distributed in the two sides of the trunk branch on each bifurcation.Its technical effect
It is: constitutes the hole filtered for marrow blood, hole by the way that the trunk branch of snowflake sample bone-grafting material monomer and branch are interlaced with each other
Gap size is controllable, and trunk branch and the adherency offer site for branching into stem cell in marrow blood, only so as to avoid marrow blood
The bioaccumulation efficiency of the drawbacks of honeycombed grain material shallow-layer hole can be reached, stem cell improve, and adhere to also more uniform.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of snowflake sample bone-grafting material monomer of the embodiments of the present invention 1.
Fig. 2 is a kind of structural schematic diagram of snowflake sample bone-grafting material monomer of the embodiments of the present invention 2.
Fig. 3 is the first bone-grafting material layer and the second bone-grafting material of a kind of bone-grafting material of the embodiments of the present invention 3
The schematic diagram of relationship between layer.
Fig. 4 is the first bone-grafting material layer and the second bone-grafting material of a kind of bone-grafting material of the embodiments of the present invention 4
The schematic diagram of relationship between layer.
Specific embodiment
Referring to FIG. 1 to FIG. 4, the inventor of the utility model in order to preferably to the technical solution of the utility model into
Row understands, below by specifically embodiment, and will be described in detail with reference to the accompanying drawings:
The snowflake sample bone-grafting material monomer be able to can also both be printed one by one by amorphous packings at bone-grafting material by 3D
Snowflake bone-grafting material monomer is first printed as snowflake bone-grafting material monomer and is in the bone-grafting material layer of honeycomb arrangement, and then is printed as
For bone-grafting material.
The material selection of snowflake sample bone-grafting material monomer can be selected from calcium hydroxy phosphate, bata-tricalcium phosphate, chitosan, phosphorus
Sour calcium/sulfuric acid calcium complexes, the common bone-grafting material such as akermanite are also possible to polylactic acid, the high polymers such as polycaprolactone, or
Other can be used for the material of bone grafting.
Embodiment 1:
In the present embodiment, snowflake sample bone-grafting material monomer, including a center 1 and around the uniformly distributed congruence in center 1
Six petals.
Each petal includes the trunk branch 2 at connection center 1, and trunk branch 2 is equipped with first successively far from center 1
Bifurcation, the second bifurcation and third bifurcation.
The two sides of trunk branch 2 are symmetrically arranged with the first branch 3, the second branch 4 and third branch 5.First branch 3 connection master
First bifurcation of dry branch 2；Second branch 4 connects the second bifurcation of trunk branch 2, and third branch 5 connects trunk branch
Third bifurcation.
The purpose of this design is: after snowflake sample bone-grafting material monomer amorphous packings become bone-grafting material, adjacent snow
For marrow blood filter between the trunk branch 2 and branch of style bone-grafting material monomer composition snowflake sample bone-grafting material monomer interlaced with each other
The hole crossed, pore size is controllable, and trunk branch 2 and the adherency offer site for branching into stem cell in marrow blood, to keep away
The drawbacks of marrow blood can only achieve honeycombed grain material shallow-layer hole is exempted from, the bioaccumulation efficiency of stem cell is improved, adhered to also more
Uniformly.
First bifurcation in the present embodiment, the second bifurcation and third bifurcation are respectively positioned on four etc. of corresponding trunk branch 2
In branch.
It can of course be by adjusting the length d0 and the first bifurcation of trunk branch 2, the second bifurcation and third bifurcated
Position of the point in trunk branch 2, realizes the adjustment between the size and shape of hole snowflake sample bone-grafting material monomer.
In a kind of snowflake sample bone-grafting material monomer of the utility model, the angle between trunk branch 2 and the first branch 3
The angle γ between angle β and trunk branch 2 and third branch 5 between α, trunk branch 2 and the second branch 4 is
60°.Can certainly root by angle α, trunk branch 2 and the second branch 4 between trunk branch 2 and the first branch 3 it
Between angle β and trunk branch 2 and third branch 5 between the angle of angle γ be adjusted, realize to snowflake sample bone grafting
The adjustment of the size and shape of hole between material monomer.
In the present embodiment, what the end of the second branch 4 in two neighboring trunk branch 2 was connected to, two neighboring trunk
The end of the first branch 3 in branch 2 is also possible to connected, two neighboring trunk branch 2 and two neighboring master as a result,
The first branch 3 in dry branch 2 can define monomer inner hole gap structure.By above-mentioned design, can also realize to snowflake sample
The adjustment of the size and shape of hole between bone-grafting material monomer.
Certainly, when carrying out bone-grafting material design, the end of the first branch 3 in two neighboring trunk branch 2 is selected, with
And the end of the second branch 4 in two neighboring trunk branch 2 is all disjunct also possible.
The two sides of trunk branch 2 be symmetrically arranged with the first branch 3, the second branch 4 and third branch 5 length be can
With adjustment, the adjustment between the size and shape of hole snowflake sample bone-grafting material monomer is realized with this.
Simultaneously by trunk branch 2, the first branch 3, the second branch 4 and third branch in snowflake sample bone-grafting material monomer
5 width is also adjustable, and realizes the adjustment between the size and shape of hole snowflake sample bone-grafting material monomer with this.
It must be stated in the present embodiment, the quantity of 2 top set, trunk branch of snowflake sample bone-grafting material monomer is not
It is limited to three pairs.
Snowflake sample bone-grafting material monomer can be by sinter molding, the advantage of sinter molding can be by sintering mold
Sintering chamber surface topography design, the pattern of snowflake sample bone-grafting material monomer surface is designed, snowflake sample bone grafting material is made
Material monomer surface is more in line with the requirement of bone-grafting material.
Snowflake sample bone-grafting material monomer can also be formed by 3D printing, be then printed as by snowflake sample bone grafting material one by one
Material list body is in the bone-grafting material layer that honeycomb is spliced into, then has and be built by bone material layer heap as bone-grafting material.At this point, the first branch
3, regular hexagon that the end of the second branch 4 and third branch 5 should all be constituted using the end of each trunk branch 2 by vertex
In range, in case two snowflake sample bone-grafting material monomers adjacent in bone-grafting material layer interfere.
Therefore the length d0 by adjusting the trunk branch 2 of snowflake sample bone-grafting material monomer and trunk branch 2 and first
Between angle β between angle α, trunk branch 2 and the second branch 4 and trunk branch 2 and third branch 5 between branch 3
Angle γ and the first branch 3, the second branch 4 and third branch 5 length, and be correspondingly connected with the first branch 3, second
The position of first bifurcation of branch 4 and third branch 5, the second bifurcation and third bifurcation is adjusted, and is realized to bone grafting
In material, the shapes and sizes of hole are adjusted between snowflake sample bone-grafting material monomer.
Embodiment 2
As shown in figure 3, embodiment 2 is the further improvement to embodiment 1, improvement is to increase in the second branch 4
A pair of secondary branch 6 symmetrical about the second branch 4, has thus advanced optimized and bone-grafting material moderate snow style has been planted
The means that the shapes and sizes of hole are adjusted between bone material monomer, still further aspect are right in snowflake sample bone-grafting material monomer
More in the site that stem cell is adhered to, bone-grafting material is stronger for the adhesive capacity of stem cell, and adherency is more
Uniformly.
But it should be noted that the position of secondary branch 6 and the tie point of the second branch 4 is adjustable, secondary branch 6
Angle δ between the second branch 4 be it is adjustable, the length of secondary branch 6 be it is adjustable, secondary branch 6 not only can connect
In the second branch 4, also it can connect in third branch 5 or the first branch 3.Above-mentioned parameter adjustment can realize for
The shapes and sizes of hole are adjusted between bone-grafting material moderate snow style bone-grafting material monomer.Bone grafting material is being prepared by 3D printing
When material, the end of secondary branch 6 also must be in the range for the regular hexagon being made of using the end of each trunk branch 2 vertex
It is interior.
Finally it should be noted that, snowflake sample bone-grafting material monomer has laminated structure, than granular bone-grafting material
Monomer is more conducive to carrying out the various physical surface modifications for improving biocompatibility or biochemical modification.
Bone-grafting material in the following example is made of being stacked gradually as several bone-grafting material layers, and every layer of bone grafting
The thickness of material layer be also it is adjustable, the shape for hole between bone-grafting material moderate snow style bone-grafting material monomer can also be realized with this
Shape and size are adjusted.
Embodiment 3
Bone-grafting material in the embodiment be it is molding by 3D printing, by the first bone-grafting material layer 31 and the second bone grafting
Made of material layer 32 stacks gradually.First bone-grafting material layer 31 and the second bone-grafting material layer 32 can be formed by 3D printing.
For the ease of identification, the center 1 of the snowflake sample bone-grafting material monomer in the first bone-grafting material layer 31 be it is circular,
The center 1 of snowflake sample bone-grafting material monomer in second bone-grafting material layer 32 is ring-shaped.
The length d1 of trunk branch 2 in first bone-grafting material layer, 31 moderate snow style bone-grafting material monomer is the second bone grafting
The half of the length d2 of the trunk branch 2 in snowflake sample bone-grafting material monomer in material layer 32.
Simultaneously.The center 1 of snowflake sample bone-grafting material monomer in first bone-grafting material layer 31 and the second bone-grafting material layer 32
Position be also all adjustable.In the present embodiment, the center 1 of 31 moderate snow style bone-grafting material monomer of the first bone-grafting material layer and
Offset distance between the center 1 of two bone-grafting material layers, 32 moderate snow style bone-grafting material monomer is a.
Adjustment by 1 position of center to each bone-grafting material layer moderate snow style bone-grafting material monomer and trunk as a result,
The adjustment of 2 length of branch is realized in bone-grafting material.The tune of the shapes and sizes of hole between snowflake sample bone-grafting material monomer
It is whole.
But the layered relationship between the first bone-grafting material layer 31 and the second bone-grafting material layer 32 is not limited to stack gradually this
A kind of layered relationship.
Embodiment 4
Bone material is molding by 3D printing in the embodiment, by the first bone-grafting material layer 31 and the second bone-grafting material layer
Made of 32 stack gradually.
For the ease of identification, the center 1 of the snowflake sample bone-grafting material monomer in the first bone-grafting material layer 31 be it is circular,
The center 1 of snowflake sample bone-grafting material monomer in second bone-grafting material layer 32 is ring-shaped.
The length d1 and the second bone grafting material of trunk branch in first bone-grafting material layer, 31 moderate snow style bone-grafting material monomer
The length d2 of the trunk branch in snowflake sample bone-grafting material monomer in the bed of material 32 is equal.
Simultaneously.Deflection angle θ between first bone-grafting material layer 31 and the second bone-grafting material layer 32 is also adjustable, this reality
It applies in example, the deflection angle θ between the first bone-grafting material layer 31 and the second bone-grafting material layer 32 is 30 °.
As a result, by the adjustment to deflection angle θ between two layers of bone-grafting material layer of arbitrary neighborhood, realize to bone grafting material
In material.The adjustment of the shapes and sizes of hole between snowflake sample bone-grafting material monomer.
When preparing any one bone-grafting material layer of bone-grafting material using 3D printing molding, snowflake sample bone-grafting material monomer
Shape be not required for unanimously, as long as the length d0 of trunk branch 2 is consistent, to realize snowflake bone-grafting material monomer in bone grafting
Honeycomb close-packed arrays in material layer optimize the pore structure between the snowflake sample bone-grafting material monomer of bone-grafting material more,
Pass through the absorption with stem cell convenient for marrow blood.
The utility model, using a large amount of snowflake sample bone-grafting material monomers as basic unit, or directly amorphous packings are at " snow
The bone-grafting material of bulk ", or bone-grafting material is prepared using 3D printing molding, it can be with stem cell enrichment technology knot by bone-grafting material
It closes, makes marrow blood in bone-grafting material using stem cell enrichment technology, filtered from the hole between snowflake sample bone-grafting material monomer, with
Adhesive efficiency and the stem cell of stem cell are improved by means of the trunk branch 2, branch and secondary branch of snowflake sample bone-grafting material monomer
Distributing homogeneity in bone-grafting material, also more conducively bone graft area autologous bone is grown into, for the bone grafting of bone defect is treated.
In 3D printing molding bone grafting material, by the snowflake sample bone-grafting material monomer with different size and structure in planar honeycomb
Shape arrangement and interlayer combination, prepare the bone-grafting material with the arbitrary shape of different porosities, in conjunction with stem cell enrichment technology
Or it is individually used for the Bone Defect Repari of complex anatomy.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate that this is practical new
Type, and be not used as the restriction to the utility model, as long as in the spirit of the utility model, to the above
Variation, the modification of embodiment will all be fallen in the Claims scope of the utility model.
Claims (10)
1. a kind of snowflake sample bone-grafting material monomer, it is characterised in that: including a center and around uniformly distributed complete in the center
Deng six petals, each petal includes a trunk branch, the trunk branch be equipped at least one bifurcation, each
A pair of of the branch symmetrical in the two sides of the trunk branch is respectively connected on bifurcation.
2. a kind of snowflake sample bone-grafting material monomer according to claim 1, it is characterised in that: the trunk branch is equipped with
Successively the first bifurcation far from the center, the second bifurcation and third bifurcation；It is connected on first bifurcation
Symmetrical the first branch of a pair in trunk branch two sides is connected in the trunk branch two on second bifurcation
Symmetrical the second branch of a pair in side, be connected on the third bifurcation trunk branch two sides it is symmetrical one
To third branch.
3. a kind of snowflake sample bone-grafting material monomer according to claim 2, it is characterised in that: first branch, described
At least a pair of of secondary branch is connected in second branch or the third branch.
4. a kind of snowflake sample bone-grafting material monomer according to claim 2, it is characterised in that: the trunk branch with it is described
Angle, the trunk branch between first branch and the angle between second branch and the trunk branch and institute
The angle for stating the angle between third branch is adjustable.
5. a kind of snowflake sample bone-grafting material monomer according to claim 2, it is characterised in that: first branch, described
The end of second branch, the third branch, in the regular hexagon being made of using the end of each trunk branch vertex.
6. a kind of snowflake sample bone-grafting material monomer according to claim 2, it is characterised in that: the first branch on adjacent petal
And/or second branch successively connect, connection cyclization.
7. a kind of snowflake sample bone-grafting material monomer according to claim 1, it is characterised in that: the snowflake sample bone-grafting material
Monomer is that 3D printing is molding or sinter molding.
8. a kind of bone-grafting material, it is characterised in that: stacked gradually by multilayer bone-grafting material layer, every layer of bone-grafting material layer is by weighing
Benefit require any one of 1~7 described in snowflake sample bone-grafting material monomer be spliced, the snowflake sample bone-grafting material monomer exists
It is in honeycomb arrangement in the bone-grafting material layer.
9. a kind of bone-grafting material according to claim 8, it is characterised in that: the snowflake sample bone grafting material in each bone-grafting material layer
The length of the trunk branch of material list body is adjustable.
10. a kind of bone-grafting material according to claim 8, it is characterised in that: between two layers of bone-grafting material layer of arbitrary neighborhood
Deflection angle be adjustable.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821488097.5U CN209187661U (en) | 2018-09-12 | 2018-09-12 | A kind of snowflake sample bone-grafting material monomer and bone-grafting material |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821488097.5U CN209187661U (en) | 2018-09-12 | 2018-09-12 | A kind of snowflake sample bone-grafting material monomer and bone-grafting material |
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| CN209187661U true CN209187661U (en) | 2019-08-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111904668A (en) * | 2020-09-11 | 2020-11-10 | 王超 | Bone grafting particle |
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2018
- 2018-09-12 CN CN201821488097.5U patent/CN209187661U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111904668A (en) * | 2020-09-11 | 2020-11-10 | 王超 | Bone grafting particle |
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