CN209187603U - A kind of plant hollow capsule - Google Patents

Abstract

The utility model provides a kind of plant hollow capsule, its capsule wall contains outer base layer (1), middle base layer (2) and endobasal-body layer (3), each base layer all contains hypromellose, and the thickness of outer base layer (1) is minimum, endobasal-body layer (3) thickness is maximum.Reflection of the plant hollow capsule of the utility model by the interface of three layers of matrix interlayer to ultraviolet light, improves the ability of capsule UV resistant, slows down discoloration or the fade rates of capsule, extends the holding time.

Description

A kind of plant hollow capsule

Technical field

The utility model relates to a kind of plant hollow capsules.

Background technique

Capsules refer to the bladder made of extraordinary filmogen (such as gelatin, cellulose, polysaccharide etc.) in medicine, Content (such as powdery, liquid various kinds of drug) is packed into wherein, convenient for swallowing.The drug filled with capsule, typically to food Road and gastric mucosa powder excitatory or particle or mouthfeel are bad, are easy to volatilize, easily be decomposed in the oral cavity by saliva, and The easily medicine of sucking tracheae.These medicines are packed into capsule, both medicine property of medicine are protected not to be destroyed, and also protect digestive organs and breathing Road.Remove capsule shells and is likely to result in drug wastage, drug waste, drug effect reduction.

Capsule without containing pigment is that colourless (or yellowish) is transparent.Some drugs are due to its special shape or face Color will affect the mood of patient, therefore patient is not intended to see；Also some drugs are light-exposed can decompose and lose drug effect, need to carry out Shading treatment；In addition, being sometimes also required to increase the identification of capsule.In order to achieve the above object, people would generally be in capsule The middle pigment that various colors is added, makes capsule with color.

But under normal circumstances, the especially organic pigment of pigment used in capsule can decompose under ultraviolet irradiation And occur changing colour or fade, color difference is generated, appearance and the holding time of coloured capsule are influenced.

Summary of the invention

In order to improve the resistance to ultraviolet ability of plant hollow capsule, the holding time of pigment in capsule, the utility model are improved A kind of plant hollow capsule is provided, capsule wall through-thickness contains outer base layer (1), middle base layer (2) from outside to inside With endobasal-body layer (3), each base layer all contains hypromellose, and the thickness of outer base layer (1) is minimum, endobasal-body layer (3) thickness is maximum.

The plant hollow capsule of the utility model is by the interface between 3 layers of base layer to the reflecting effect of ultraviolet light, drop The rate that pigment is decomposed by ultraviolet light irradiation in low capsule, slows down discoloration or the fade rates of capsule, extends the preservation of capsule Time.The number of plies of base layer is very little, and interface is few, bad to the reflecting effect of ultraviolet light, cannot inhibit pigment in capsule well Discoloration or fade rates under ultraviolet light irradiation.Outer base layer (1), middle base layer (2), the thickness of endobasal-body layer (3) are incremental, The interface between each base layer be can increase to the reflecting effect of ultraviolet light, reduce the discoloration of cellulose hollow capsule shells or speed of fading Rate.Wherein, capsule is referred on the inside of the capsule wall after loading content, the side directly contacted with content；Outside Refer to the side being in contact with external environment.

The hypromellose is a kind of non-ionic cellulose mixing ether, is normal in plant fiber cellulose capsule Raw material, relative to other capsule raw materials, comprehensive performance is preferable, and mass production, has price advantage.

Further, the capsule wall of the plant hollow capsule outer base layer (1), middle base layer (2), endobasal-body layer (3) thickness is respectively 5~80 μm.

Further, the outer base layer (1), middle base layer (2), also contain quality hundred in endobasal-body layer (3) respectively Dividing content is 0.05%~2% ultraviolet absorber.

Ultraviolet absorber refers to the substance that can absorb ultraviolet light, is gradually absorbed by the ultraviolet absorber in each base layer Ultraviolet light, the rate for further decreasing capsule discoloration or fading, improves the holding time.When the ultraviolet absorber in each base layer For mass percentage less than 0.05%, the ability of the UV resistant of cellulose hollow capsule shells is lower, cellulose hollow capsule shells Discoloration, fade rates it is very fast, the holding time is shorter；When the mass percentage of the ultraviolet absorber in base layer is greater than 2% When, the ultraviolet-resistant capacity of cellulose hollow capsule shells is not significantly improved, but the other performances such as mechanical performance can reduce, and Increased costs.

Further, the outer base layer (1) of plant hollow capsule, middle base layer (2), the ultraviolet suction in endobasal-body layer (3) Agent mass percentage is received to successively decrease.Because of the reflection of matrix interface layer and the absorption of ultraviolet absorber, in a thickness direction, by The outer and interior ultraviolet light into capsule wall is reduced, and is gradually reduced the content of ultraviolet absorber in base layer, is neither influenced resistance to ultraviolet Line ability, and energy save the cost, improve capsule intensity.

Further, the ultraviolet absorber is salicylic acid esters, Flavonoids, plant polyphenol kind or plant anthraquinone One of or it is a variety of.

Salicylic acid esters refer to the substance containing ester bond that the substance reaction of salicylic acid and hydroxyl obtains, specifically include but It is not limited to gaultherolin, 1-Hexyl salicylate, glycol salicylate, homosalate, 4- octyl benzene One of base salicylate, menthol salicylate or benzyl salicylate etc. are a variety of.

Plant polyphenol kind is specifically including but not limited to tea polyphenols, anthocyanidin, flavanol compound, phenolic acid class, resveratrol or youngster One of theine is a variety of.

Plant anthraquinone is mainly derivative in hydroxy anthraquinones category, is specifically including but not limited to rheum emodin, Rhein, rheum emodin first One of ether, Chrysophanol or aloe-emodin are a variety of.

Further, a layer pigment layer (4) is also contained in the inside of endobasal-body layer (3) in plant hollow capsule wall.It can subtract Slow rate capsule discoloration or faded, extends the holding time.

The coat of colo(u)r includes pigment and hypromellose.The pigment refers to the object that can be painted to capsule Matter can be any pigment known in the art, but preferably natural pigment or inorganic pigment.Specifically including but not limited to ginger Huang, riboflavin, quinoline yellow, chlorophyll, indigo, tomato red, capsanthin, lutein, anthocyanidin, beet red, titanium dioxide, carbonic acid One of calcium or arnotto etc. are a variety of.

Further, the coat of colo(u)r (4) with a thickness of 5~20 μm.

Further, the mass percentage of pigment is 0.05%~10% in the coat of colo(u)r (4).

The utility model provides a kind of plant hollow capsule, and capsule wall contains incremental from outside to inside outer of threeply degree Base layer (1), middle base layer (2) and endobasal-body layer (3), the reflection by the interface of three layers of matrix interlayer to ultraviolet light, slow down The discoloration of capsule or fade rates extend the holding time.Further, also contain ultraviolet absorber in each base layer of capsule wall, It is absorbed into the ultraviolet light of base layer, slows down discoloration or the fade rates of capsule.

It should be appreciated that the terms such as " having " used herein, "comprising" and " comprising " be not precluded one or The presence or addition of a number of other substances, ingredient, performance, state, element or combinations thereof；" being greater than ", " being less than " all do not include number Value itself, " more than ", " following " all comprising numerical value itself.

Detailed description of the invention

Fig. 1 is the diagrammatic cross-section of an embodiment of the utility model, and capsule wall contains outer base layer (1), middle matrix Layer (2) and endobasal-body layer (3) and coat of colo(u)r (4).

Fig. 2 is the diagrammatic cross-section of another embodiment of the utility model, and capsule wall contains outer base layer (1), middle base Body layer (2) and endobasal-body layer (3).

Specific embodiment

The utility model is further illustrated below by the mode of embodiment, the utility model is not therefore limited in institute It states among scope of embodiments.All technologies realized based on the utility model above content belong to the scope of the utility model. For those skilled in the art, other modifications may be easily implemented, therefore without departing substantially from claim and is waiting homotypes Under universal defined by enclosing, the utility model is not limited to specific details.

The utility model relates to test item and its measuring method it is as follows, unless otherwise instructed, each test is all at 25 DEG C Lower progress.

Embodiment 1

As shown in Figure 1, a kind of plant hollow capsule, contains a layer pigment layer (4) in its capsule wall most inner side, 5 μm thick, face The bed of material (4) contains hypromellose and lemon yellow, and wherein the mass percentage of lemon yellow is 10%.In coat of colo(u)r (4) Outside through-thickness contain outer base layer (1), middle base layer (2) and endobasal-body layer (3), each base layer from outside to inside and all contain There is hypromellose, and the thickness of outer base layer (1), middle base layer (2) and endobasal-body layer (3) is respectively 20 μm, 35 μm With 50 μm.

Embodiment 2

As shown in Figure 1, a kind of plant hollow capsule, contains a layer pigment layer (4) in its capsule wall most inner side, it is 20 μm thick, Coat of colo(u)r (4) contains hypromellose and lemon yellow, and wherein the mass percentage of lemon yellow is 0.05%.In coat of colo(u)r (4) outside through-thickness contains outer base layer (1), middle base layer (2) and endobasal-body layer (3), each base layer from outside to inside All contain hypromellose and ultraviolet absorber 1-Hexyl salicylate, and outer base layer (1), middle base layer (2) and endobasal-body The thickness of layer (3) is respectively 25 μm, 30 μm and 35 μm, and wherein the mass percentage of 1-Hexyl salicylate is respectively 2%, 1% and 0.05%.

Embodiment 3

As shown in Fig. 2, a kind of plant hollow capsule, contains outer base layer in its capsule wall through-thickness from outside to inside (1), middle base layer (2) and endobasal-body layer (3), each base layer all contain hypromellose and ultraviolet absorber tea polyphenols, And the thickness of outer base layer (1), middle base layer (2) and endobasal-body layer (3) is respectively 25 μm, 35 μm and 45 μm, wherein tea polyphenols Mass percentage be respectively 1.8%, 1.2% and 0.5%.

Claims (4)

1. a kind of plant hollow capsule, which is characterized in that capsule wall through-thickness contain from outside to inside outer base layer (1), in Base layer (2) and endobasal-body layer (3), and the thickness of outer base layer (1) is minimum, endobasal-body layer (3) thickness is maximum.

2. plant hollow capsule according to claim 1, which is characterized in that the outer base layer (1), middle base layer (2), the thickness of endobasal-body layer (3) is respectively 5~80 μm.

3. plant hollow capsule according to claim 1, which is characterized in that the inside of endobasal-body layer (3) is also in capsule wall Contain a layer pigment layer (4).

4. plant hollow capsule according to claim 3, which is characterized in that the coat of colo(u)r (4) with a thickness of 5~20 μm。