CN209132211U - Sampling device and mass spectrometry system based on induction electron spray - Google Patents
Sampling device and mass spectrometry system based on induction electron spray Download PDFInfo
- Publication number
- CN209132211U CN209132211U CN201821816287.5U CN201821816287U CN209132211U CN 209132211 U CN209132211 U CN 209132211U CN 201821816287 U CN201821816287 U CN 201821816287U CN 209132211 U CN209132211 U CN 209132211U
- Authority
- CN
- China
- Prior art keywords
- spray
- sampling device
- electrode
- driving unit
- current electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The utility model provides a kind of sampling device and mass spectrometry system based on induction electron spray, the sampling device based on induction electron spray includes: at least two spray needles, the spray needle includes capillary, electrode and apart from regulating part, described to adjust the electrode and intercapillary distance apart from regulating part；First driving unit, at least two spray needles translate under first driving unit driving；Current electrode, an only current electrode are adapted to extraneous power supply；Second driving unit, the current electrode translate under second driving unit driving along the direction for the extending direction for being parallel to the spray needle, so that current electrode is contacted and is detached from the electrode in spray needle.The utility model has many advantages, such as that structure is simple, detection efficiency is high.
Description
Technical field
The utility model relates to mass spectral analyses, in particular to sampling device, mass spectrometry system based on induction electron spray.
Background technique
In mass spectral analysis field, Nano-ESI technology is to realize micro volume sample feeding and the most important side of ionization
Method.Due to reducing the bore of spray head, Nano-ESI can be such that the flow velocity of solution substantially reduces, while the jet droplets generated are than one
As electron spray want small, sample ionization is high-efficient.However when carrying out Nano-ESI analysis, electrode and sample solution contact meeting
Cause more serious dead volume problem, to influence the sensitivity of detection.In addition, being used when analyzing pL grades of sample solutions
Nano-ESI can only generate being sprayed for moment, it is difficult to realize that multi-stage ms are analyzed, limit the further genralrlization of the technology.
Dead volume existing for Nano-ESI can be effectively solved using induction electrospray techniques and the electron spray time short etc. asks
Topic, but there is also following deficiencies for the technology at present:
1, it is difficult to realize the adjusting of spray time and intensity for different samples.
2, current this method can only realize the analysis of single sample, be unable to satisfy high throughput automated detection demand.
Utility model content
To solve the deficiency in above-mentioned prior art, the utility model provides a kind of base suitable for mass spectral analysis
In the sampling device of induction electron spray, the automatic sampling of multiple samples is realized, improves detection flux, while realizing EFI
The adjustment of mist time and intensity.
The purpose of this utility model is achieved through the following technical solutions:
A kind of sampling device based on induction electron spray, the sampling device based on induction electron spray include:
At least two spray needles, the spray needle include capillary, electrode and apart from regulating part, described apart from regulating part tune
The whole electrode and intercapillary distance；
First driving unit, at least two spray needles translate under first driving unit driving；
Current electrode, an only current electrode are adapted to extraneous power supply；
Second driving unit, the current electrode is under second driving unit driving along being parallel to the spray needle
Extending direction direction translation so that current electrode contact with the electrode in spray needle and disengaging.
The purpose of this utility model, which also resides in, to be provided using the above-mentioned mass spectral analysis based on induction electron spray sampling device
System, the purpose of utility model have the technical scheme that
Mass spectrometry system, the mass spectrometry system include sampling device, mass spectrum injection port；It is characterized by: described
Sampling device is using the above-mentioned sampling device based on induction electron spray.
Compared with prior art, the utility model has the beneficial effect that
1. spray needle is seriatim moved at mass spectrum injection port by the first driving unit, realize multiple samples automatically into
Sample meets high throughput array analysis and requires；
2. current electrode and intercapillary distance are adjusted by the second driving unit for different solution to be measured, namely
The distance in spray needle between electrode and capillary spout is had adjusted, the control of electron spray intensity and time are realized；
3. device is simple, easy to operate, detection efficiency is improved.
Detailed description of the invention
Referring to attached drawing, the disclosure of the utility model will be easier to understand.Skilled addressee readily understands that
Be: these attached drawings are used only for illustrating the technical solution of the utility model, and are not intended to the protection to the utility model
Range is construed as limiting.In figure:
Fig. 1 is the structure diagram of the mass spectrometry system of the utility model embodiment；
Fig. 2 is the mass spectrogram of honey element in the utility model embodiment 2；
Fig. 3 is the mass spectrogram of sorbic acid in the utility model embodiment 2.
Specific embodiment
Fig. 1-3 and following description describe the optional embodiments of the utility model how to instruct those skilled in the art
Implement and reproduce the utility model.In order to instruct technical solutions of the utility model, it has simplified or omitted some conventional aspects.This
Field technical staff should be understood that the variation or replacement from these embodiments will be in the scope of the utility model.This field
Technical staff should be understood that following characteristics can be combined in various ways to form multiple modifications of the utility model.As a result, originally
Utility model is not limited to following optional embodiments, and is only limited by the claims and their equivalents.
Embodiment 1:
Fig. 1 schematically illustrates the structure diagram of the mass spectrometry system of the utility model embodiment 1, as shown in Figure 1,
The mass spectrometry system includes:
Mass spectrum injection port 61；
Based on the sampling device of induction electron spray, the sampling device includes:
At least two spray needles, the spray needle include capillary 21, electrode 22 and apart from regulating part 23, and the distance is adjusted
It saves part and adjusts the electrode and intercapillary distance；The capillary outer diameter is 1-1.2mm, internal diameter 0.6-0.8mm, front end
1-3 μm of nozzle diameter；It is spring or cam apart from regulating part；
First driving unit 11, at least two spray needles translate under first driving unit driving；
Current electrode 32, an only current electrode are adapted to extraneous power supply；
Second driving unit 31, the current electrode are described spraying along being parallel under second driving unit driving
The direction of the extending direction of needle translates, so that current electrode is contacted and is detached from the electrode in spray needle.
In order to spray needle is fixed on the first driving unit and mobile spray needle, optionally, the spray needle is into one
Step includes:
Fixing piece, the fixing piece connect the capillary, electrode and are arranged in the fixing piece simultaneously apart from regulating part
Suitable for being moved in fixing piece.
In order to improve security performance, it is preferable that the current electrode is arranged in insulation shell.
For the ease of mobile spray needle and current electrode, it is preferable that first driving unit and/or the second driving are single
Member includes:
Motor,
Guide rail, the motor driven guide rail translation.
The working method of the mass spectrometric analysis method of the utility model embodiment namely above-mentioned mass spectrometry system, the matter
Spectral analysis method the following steps are included:
(A1) spray needle is inserted into solution to be measured；
(A2) it takes out spray needle and is placed on the first driving unit；
(A3) mobile spray needle, so that spray needle is corresponding with mass spectrum injection port；
(A4) the second driving unit drives current electrode mobile towards the spray needle, so that in current electrode and spray needle
Electrode contact；
(A5) according to the property of sample to be tested, current electrode is driven using the second driving unit, adjusts current electrode and hair
Distance between tubule；
(A6) current electrode connects extraneous power supply, the solution to be measured formation pulse nebulization technique in capillary, sample ionization, into
Enter the analysis of mass spectrum injection port；
(A7) the second driving unit drives current electrode, so that current electrode and spray needle are detached from；
(A8) step (A3) is returned to, until the solution to be measured in different spray needles is detected one by one.
Embodiment 2:
Sampling device and method according to the utility model embodiment 1 based on induction electron spray is in honey element detection
Application examples.
In the application examples, an only current electrode is coated by insulation shell, current electrode and the mass spectrum injection port
Central axis it is conllinear；First driving unit and the second driving unit are all made of the combination of motor and guide rail；First driving unit
Vertical with the driving direction of the second driving unit: the first driving unit drives spray needle horizontally anterior-posterior translation, and the second driving is single
The horizontally left and right translation of member driving current electrode；Fixing piece is tubular structure, electrode and spring (as apart from regulating part) setting
In fixing piece, when the electrode is powered electrode drive, spring is compressed, so as to adjust electrode and capillary in spray needle
Distance between interior testing liquid (capillary spout), namely have adjusted intensity and the time of electron spray.
Capillary outer diameter is 1mm, and internal diameter 0.6mm, a length of 50mm, nozzle diameter is 2 μm, and spout and mass spectrum injection port hang down
Straight distance is 2cm.Electrode and solution distance to be measured are adjusted to 4mm in spray needle.Mass Spectrometer Method m/z range is set as 100-500, inspection
The honey element (solvent is methanol) that sample is 500ppb, corresponding mass spectrogram is as shown in Fig. 2, therefrom can be observed 177.92
Echo signal peak, intensity 2.62e4, mobile motor four measured value relative standard deviations of gained are 9.72%.
Embodiment 3:
Sampling device and method according to the utility model embodiment 1 based on induction electron spray is in sorbic acid detection
Application examples.
In the application examples, an only current electrode is coated by insulation shell, current electrode and the mass spectrum injection port
Central axis it is conllinear；First driving unit and the second driving unit are all made of the combination of motor and guide rail；First driving unit
Vertical with the driving direction of the second driving unit: the first driving unit drives spray needle horizontally anterior-posterior translation, and the second driving is single
The horizontally left and right translation of member driving current electrode；Fixing piece is tubular structure, electrode and spring (as apart from regulating part) setting
In fixing piece, when the electrode is powered electrode drive, spring is compressed, so as to adjust electrode and capillary in spray needle
Distance between interior testing liquid (capillary spout), namely have adjusted intensity and the time of electron spray.
Capillary outer diameter is 1.2mm, and internal diameter 0.8mm, a length of 50mm, nozzle diameter is 1 μm, spout and mass spectrum injection port
Vertical range is 2cm.Electrode and solution distance to be measured are adjusted to 6mm in spray needle.Mass Spectrometer Method m/z range is set as 50-500,
The sorbic acid (solvent is methanol) that test sample is 500ppb, corresponding mass spectrogram is as shown in figure 3, therefrom can be observed
111.17 echo signal peak, intensity are respectively 6.58e5, four measured value relative standard deviations obtained by mobile motor are
8.23%.
Above-described embodiment is only illustratively to give spray needle to be horizontally oriented anterior-posterior translation, can also be and inclines certainly
Tiltedly upper and lower translation, but an only current electrode is still that up and down direction is fixed, and has translation only in horizontal direction.
Claims (8)
1. a kind of sampling device based on induction electron spray, it is characterised in that: the sampling device packet based on induction electron spray
It includes:
At least two spray needles, the spray needle include capillary, electrode and apart from regulating part, described to adjust institute apart from regulating part
State electrode and intercapillary distance；
First driving unit, at least two spray needles translate under first driving unit driving；
Current electrode, an only current electrode are adapted to extraneous power supply；
Second driving unit, the current electrode is under second driving unit driving along being parallel to prolonging for the spray needle
The direction translation in direction is stretched, so that current electrode is contacted and is detached from the electrode in spray needle.
2. the sampling device according to claim 1 based on induction electron spray, it is characterised in that: the spray needle is further
Include:
Fixing piece, the fixing piece connect the capillary, electrode and are arranged in the fixing piece and are suitable for apart from regulating part
It is moved in fixing piece.
3. the sampling device according to claim 1 based on induction electron spray, it is characterised in that: the current electrode setting
In insulation shell.
4. the sampling device according to claim 1 based on induction electron spray, it is characterised in that: the capillary outer diameter is
1-1.2mm, internal diameter 0.6-0.8mm, 1-3 μm of front end nozzle diameter.
5. the sampling device according to claim 1 based on induction electron spray, it is characterised in that: first driving unit
And/or second driving unit include:
Motor,
Guide rail, the motor driven guide rail translation.
6. the sampling device according to claim 1 based on induction electron spray, it is characterised in that: described to be apart from regulating part
Spring or cam.
7. mass spectrometry system, the mass spectrometry system includes sampling device, mass spectrum injection port；It is characterized by: it is described into
Sampling device is using any sampling device based on induction electron spray of claim 1-6.
8. mass spectrometry system according to claim 7, it is characterised in that: in current electrode and the mass spectrum injection port
Heart axis collinear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821816287.5U CN209132211U (en) | 2018-11-03 | 2018-11-03 | Sampling device and mass spectrometry system based on induction electron spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821816287.5U CN209132211U (en) | 2018-11-03 | 2018-11-03 | Sampling device and mass spectrometry system based on induction electron spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209132211U true CN209132211U (en) | 2019-07-19 |
Family
ID=67243950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821816287.5U Active CN209132211U (en) | 2018-11-03 | 2018-11-03 | Sampling device and mass spectrometry system based on induction electron spray |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209132211U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270157A (en) * | 2018-11-03 | 2019-01-25 | 广州市华粤行仪器有限公司 | Sampling device and mass spectrometric analysis method based on induction electron spray |
-
2018
- 2018-11-03 CN CN201821816287.5U patent/CN209132211U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270157A (en) * | 2018-11-03 | 2019-01-25 | 广州市华粤行仪器有限公司 | Sampling device and mass spectrometric analysis method based on induction electron spray |
| CN109270157B (en) * | 2018-11-03 | 2024-04-09 | 广州市华粤行仪器有限公司 | Sampling device based on induction electric spray and mass spectrometry method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203367223U (en) | Thermal ionization time-of-flight mass spectrometer | |
| Valaskovic et al. | Automated orthogonal control system for electrospray ionization | |
| CN105431921B (en) | Ionization device and mass spectrograph | |
| US8450682B2 (en) | Ionization method and apparatus using a probe, and analytical method and apparatus | |
| CN202120862U (en) | Normal pressure chemical extraction ionization source | |
| CN109270157A (en) | Sampling device and mass spectrometric analysis method based on induction electron spray | |
| US9111739B2 (en) | Ionization method and apparatus using electrospray, and analyzing method and apparatus | |
| CN103972019B (en) | Contactless DC induction electrospray ionization device and ioning method | |
| US8232519B2 (en) | Coupling between axisymmetric differential mobility analyzers and mass spectrometers or other analyzers and detectors | |
| CN209132211U (en) | Sampling device and mass spectrometry system based on induction electron spray | |
| CN106876241A (en) | Ultrasonic atomizatio Atomospheric pressure glow discharge ionization device | |
| CN210897196U (en) | Electrospray ion source and mass spectrum device | |
| CN110021516A (en) | A kind of mass spectrometer for high-throughput online photochemical reaction research | |
| WO2023193481A1 (en) | Micropore oscillation atomization extractive electrospray ionization device for mass spectrum analysis | |
| CN209496810U (en) | A kind of mass spectrograph | |
| CN114975068A (en) | Micropore vibration atomization ionization device | |
| US7067804B2 (en) | Atmospheric pressure ion lens for generating a larger and more stable ion flux | |
| Schneider et al. | An atmospheric pressure ion lens that improves nebulizer assisted electrospray ion sources | |
| CN107946167B (en) | A kind of metal complex mass spectrometer | |
| CN108666201A (en) | Incude Nanoliter electrospray ion source and its working method | |
| CN104008948A (en) | Universal-type ion-source nozzle | |
| CN207068794U (en) | Miniaturized portable mass spectrograph and the ion source device for producing water body cluster ion | |
| CN102243980B (en) | Ion gun used under atmospheric pressure | |
| CN201788939U (en) | Coaxial adjusting mechanism of ESI source mass spectrum sampling cone and electric atomizing needle | |
| CN111157608A (en) | Mass spectrum combination device for directly analyzing aerosol on line |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |