CN209108398U - A kind of microvesicle patch being administered continuously for acupuncture point - Google Patents
A kind of microvesicle patch being administered continuously for acupuncture point Download PDFInfo
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- CN209108398U CN209108398U CN201820288353.XU CN201820288353U CN209108398U CN 209108398 U CN209108398 U CN 209108398U CN 201820288353 U CN201820288353 U CN 201820288353U CN 209108398 U CN209108398 U CN 209108398U
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- microvesicle
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Abstract
The utility model belongs to field of pharmaceutical preparations, be related to it is a kind of suitable for clinic through skin, transmucosal or through channel administration for acupuncture point be administered continuously microvesicle paste, the microvesicle patch include gelatin microvesicle capsule (1), sealed membrane (2), adhesive film (3) and sheath (4);Gelatin microvesicle capsule (1) is in middle empty balloon-shaped;Gelatin microvesicle capsule (1) and sealed membrane (2) heat;Sealed membrane (2) is connected by adhesive film (3) with sheath (4).The utility model provide it is a kind of be directly affixed on affected part or corresponding acupuncture point, by point type administration, be administered continuously, rapid-action, therapeutic effect is good, to skin without allergy and stimulate the reaction, simple production process, environmental protection and the quality controllable microvesicle patch being administered continuously for acupuncture point.
Description
Technical field
The utility model belongs to field of pharmaceutical preparations, is related to a kind of microvesicle patch being administered continuously for acupuncture point.
Background technique
Be divided into skin by percutaneous drug delivery local action (skin surface administration) and the general action that passes through Cutaneous permeation
(Transdermal absorption administration, percutaneous dosing).Percutaneous dosing is a kind of administration for being able to maintain that internal Effective Dose Level, non-damage
The drug controlled release of predictive role time and long term time may be implemented in approach.Diffusion controlled release Transdermal System is design
Therapeutic component is transmitted for controlling drug from drug delivery device to skin or penetrates the device that skin enters body circulation.With it is traditional
Oral administration or drug administration by injection mode are compared, and percutaneous dosing can avoid the first pass effect in gastrointestinal tract and liver metabolism, are subtracted
Few side effect reduces administration frequency and improves blood concentration, thus has wider application prospect.Currently, some be used for whole body
The transdermal for the treatment of has been commercialized.
The drug effect of Chinese medicine moxa-moxibustion is a kind of administration mode through acupuncture point channel.Pass through acupoint injection therapy under this inspiration
Sufficient research has been obtained in the different disease of mode drug treatment, it can make drug concentrate on acupuncture point point pass through channels and collaterals act on
In whole body.But it realizes that point medicine has not been reported with the mode of patch, realizes that dose is adjusted and continued administration using patch
It has not been reported.
Utility model content
In order to solve the above technical problems in background technology, the utility model provides one kind and is directly affixed on affected part
Or corresponding acupuncture point, be administered by acupuncture point channel, be adjustable dose and be administered continuously, be rapid-action, therapeutic effect is good, to skin without mistake
Quick and stimulate the reaction, simple production process, environmental protection and the quality controllable microvesicle patch being administered continuously for acupuncture point.
To achieve the goals above, the utility model adopts the following technical solution:
A kind of microvesicle patch being administered continuously for acupuncture point, it is characterised in that: the microvesicle patch being administered continuously for acupuncture point
Including gelatin microvesicle capsule, sealed membrane, adhesive film and sheath;The gelatin microvesicle capsule is in middle empty balloon-shaped;The gelatin microvesicle capsule
It is equipped with opening, the one side of the sealed membrane is connected with gelatin microvesicle capsule hot melt and by the closure of openings on gelatin microvesicle capsule;Institute
The another side for stating sealed membrane is connected by adhesive film with sheath;
Preferably, window corresponding with the aperture position on gelatin microvesicle capsule is provided on the adhesive film, convenient for giving
Medicine.
Preferably, further including that easily tearing at sheath bottom outer edge is arranged in for the microvesicle patch that acupuncture point is administered continuously
Piece;The easy sheet is triangular in shape;Cohesive force between the easy sheet and sheath is greater than the bonding between sheath and adhesive film
Power.
Preferably, the gelatin microvesicle capsule be it is one or more, projected area of the gelatin microvesicle capsule on sealed membrane it
Be S1;The area of the sealed membrane is S2;S2 >=the S1.
Preferably, multiple gelatin microvesicle capsules are evenly arranged on sealed membrane in matrix form when the gelatin microvesicle capsule is multiple.
Preferably, being provided with easy fracture on the sealed membrane, adhesive film and sheath when gelatin microvesicle capsule is multiple
Line;The position of the easy fracture line on the easy fracture line and sheath on easy fracture line, adhesive film on the sealed membrane coincides.
Preferably, the thickness of shell of gelatin microvesicle capsule is 0.3-0.7mm.
Preferably, the material of gelatin microvesicle capsule is transparent;The thickness of the sealed membrane is 0.3-0.7mm;It is described viscous
Property film is viscous coating;The sheath is silicon oil release paper;The sealed membrane is plastic seal membrana oralis or gelatin sealed membrane.
Compared with prior art, the utility model has the advantages that:
The utility model provides a kind of microvesicle patch being administered continuously for acupuncture point, the microvesicle that should be administered continuously for acupuncture point
Patch includes gelatin microvesicle capsule, sealed membrane, adhesive film and sheath;Gelatin microvesicle capsule is in middle empty balloon-shaped;Infusion of medicine gelatin microvesicle
In capsule, with sealed membrane heat sealing;Sealed membrane is connected by adhesive film with sheath.It is provided by the utility model to be held for acupuncture point
The microvesicle patch of continuous administration is with the direct packaging medicine of gelatin microvesicle capsule, and when treatment directly opens outer packing, is pierced from central empty slot
Broken seal membrana oralis is directly affixed on affected part or corresponding acupuncture point, rapid-action, and it is good to generate therapeutic effect, to skin without allergy and stimulate the reaction,
And simple production process, environmental protection, it is quality controllable.With point type administration, packaging medicine is stable, is applicable in different pharmaceutical ingredient, dose
Controllably, the advantages such as sustainable administration.The mode being administered through skin, mucous membrane, acupuncture point channel has can be used in the utility model, in conjunction with not
It can be pasted by the microvesicle by the transdermal suction of effective ingredient with form drug ingedient such as the dysmenorrhea plaster prescription that Hong Zongguo is taught
Receiving method acts on meridian point by human epidermal, promotes and improves blood circulation and the effect of Lymphatic Circulation, generate town
Bitterly, detumescence and other effects, reaches the curative effect of alleviation and inhibition of pain.Clinical test results show to chronic lumbar strain, knee joint
The diseases such as inflammation, soft tissue injury, dysmenorrhea have preferable therapeutic effect;Other such as oral mucosa, navel, anus mucous membrane and channels
It can also be directly administered using the dosage form.It is inside and outside after the microvesicle patch being administered continuously for acupuncture point of the utility model is made
Packaging is neat, easy to operate, can directly be affixed on skin, and selected raw material is harmless, skin is not generated allergy and
Stimulate the reaction.The aperture that can be utilized and be pierced on sealed membrane corresponding to gelatin microvesicle capsule opening, by contained effective medicine
Object ingredient, especially volatile ingredient are gradually precipitated from gelatin microvesicle capsule, and orientation reaches affected part, directly infiltration lesion deep
Tissue promotes Drug Percutaneous Absorption, enhances therapeutic effect.
Detailed description of the invention
Fig. 1 is the schematic cross-sectional view of the microvesicle patch provided by the utility model being administered continuously for acupuncture point;
Fig. 2 is the present invention looks up structural representation of the microvesicle patch provided by the utility model being administered continuously for acupuncture point;
Fig. 3 is the schematic perspective view of the microvesicle patch provided by the utility model being administered continuously for acupuncture point;
Wherein:
1- gelatin microvesicle capsule;2- sealed membrane;3- adhesive film;4- sheath;The easy sheet of 5-.
Specific embodiment
Referring to Fig. 1, Fig. 2 and Fig. 3, the utility model provides a kind of microvesicle patch being administered continuously for acupuncture point, the needle
The microvesicle patch that acupuncture point is administered continuously is made of gelatin microvesicle capsule 1, sealed membrane 2, adhesive film 3 and sheath 4 from top to bottom, wherein bright
Glue microvesicle capsule 1 and sealed membrane 2 are closely sealed by heating, and then bond again with adhesive film 3 and sheath 4, drug effect ingredient package
In gelatin microvesicle capsule, when use, opens sheath, pokes sealed membrane corresponding to gelatin microvesicle capsule opening, the shape on sealed membrane
At aperture, it will be directly affixed on therapy target containing the microvesicle note that can be administered continuously for acupuncture point, be open using with gelatin microvesicle capsule
The aperture being pierced on the corresponding sealed membrane in place, by contained active drug ingredient, especially volatile ingredient gradually from
It is precipitated in gelatin microvesicle capsule, orientation reaches affected part, directly infiltration lesion deep tissue, promotes Drug Percutaneous Absorption, enhancing treatment
Effect.
The microvesicle patch provided by the utility model being administered continuously for acupuncture point, including it is gelatin microvesicle capsule 1, sealed membrane 2, viscous
Property film 3 and sheath 4;Gelatin microvesicle capsule 1 is in middle empty balloon-shaped;Gelatin microvesicle capsule 1 be equipped with opening, the one side of sealed membrane 2 with it is bright
The hot melt of glue microvesicle capsule 1 is connected and by the closure of openings on gelatin microvesicle capsule 1;The another side of sealed membrane 2 passes through adhesive film 3 and sheath
4 are connected;Preferably, be provided on adhesive film 3 corresponding with the aperture position on gelatin microvesicle capsule 1 window (after opening sheath,
Directly film layer, the setting of the window, it is ensured that the active drug ingredient in gelatin microvesicle capsule 1 is directly through envelope are sealed in exposure at window
The window on aperture and adhesive film 3 on membrana oralis, so that drug effect is faster, more directly, which is similar to adhesive bandage
Structure, centre is exposed containing drug moiety, the outer edge toughness film layer in addition to middle section).
Meanwhile the microvesicle patch being administered continuously for acupuncture point further includes the easy sheet 5 being arranged at 4 bottom outer edge of sheath;
Easy sheet 5 is triangular in shape;Cohesive force between easy sheet 5 and sheath 4 is greater than the cohesive force between sheath 4 and adhesive film 3.
Gelatin microvesicle capsule 1 is one or more, and projected area the sum of of the gelatin microvesicle capsule 1 on sealed membrane 2 is S1, sealing
The area of film 2 is S2, S2 >=S1;When gelatin microvesicle capsule 1 is multiple, multiple gelatin microvesicle capsules 1 are evenly arranged on sealed membrane 2 in matrix form
On.When gelatin microvesicle capsule 1 is multiple, easy fracture line is provided on sealed membrane 2, adhesive film 3 and sheath 4;On sealed membrane 2
The position of the easy fracture line on easy fracture line and sheath 4 on easy fracture line, adhesive film 3 coincides.
The thickness of shell of gelatin microvesicle capsule 1 is 0.3-0.7mm.The diameter of gelatin microvesicle capsule 1 is according to the big of drugloading rate
It is small and change.
The material of gelatin microvesicle capsule 1 is transparent;The thickness of sealed membrane 2 is 0.3-0.7mm;Adhesive film 3 is viscous coating;
Sheath 4 is silicon oil release paper;Sealed membrane 2 is plastic seal membrana oralis or gelatin sealed membrane.
It is provided by the utility model for acupuncture point be administered continuously microvesicle patch forming method include:
1) sealed membrane 2 and gelatin microvesicle capsule 1 are prepared, opening is arranged at 1 bottom of gelatin microvesicle capsule;
2) in gelatin microvesicle capsule 1 after injection of medicine, by sealed membrane 2 and the hot melt fitting of gelatin microvesicle capsule 1, seal sealed membrane
Close the opening on gelatin microvesicle capsule;
3) adhesive film 3 and sheath 4 are set gradually in the bottom of sealed membrane 2, has window on adhesive film 3, which sets
It is placed in the aperture position of gelatin microvesicle capsule 1;
4) easy sheet 5 is set in the outer edge of sheath 4;Easy sheet 5 is triangular in shape;It is viscous between easy sheet 5 and sheath 4
Tie the cohesive force that power is greater than between sheath 4 and adhesive film 3;
The preparation method of gelatin microvesicle capsule 1 is:
A) it is configured to the gelatin solution that mass fraction is 12%;
B) gelatin solution that the mass fraction that step a) is prepared is 12% is mixed with glycerol, obtains mixed solution
One;The mass ratio of glycerol and gelatin is that (1:1.5 refers to the mass ratio of glycerol and gelatin to 1:1.5 here, for example 100g gelatin is molten
Liquid, mass fraction 12%, then gelatin quality is 12g, and the additional amount of glycerol is 8g);
C) preservative is added in the mixed solution one that step b) is prepared;Preservative be methyl p-hydroxybenzoate and
Propylparaben;The dosage of methyl p-hydroxybenzoate is the 0.16% of gelatin quality, propylparaben
Dosage is the 0.04% of gelatin quality;
D) pH=5.0 is adjusted, film liquid is made into, is defoamed at film liquid, by being laid in centre at film liquid and have circle after defoaming
On the plate of shape empty slot, the rubber of gelatin microvesicle capsule is made, the rubber thickness of gelatin microvesicle capsule is 0.3mm-0.7mm, uses mold
Empty slot part is suppressed, rubber is made to convex to form vesica at round empty slot, molding is placed in drying box, dry at 50 DEG C
6h is removed, and cooling film forming, it is spare to take off film at room temperature;
Sealed membrane 2 is plastic seal membrana oralis or gelatin sealed membrane;When sealed membrane 2 is gelatin sealed membrane, gelatin sealed membrane
Preparation method is:
A) it is configured to the gelatin solution that mass fraction is 12%;
B) gelatin solution that the mass fraction that step a) is prepared is 12% is mixed with glycerol, obtains mixed solution
One;The mass ratio of glycerol and gelatin is 1:1.5;
C) preservative is added in the mixed solution one that step b) is prepared;Preservative be methyl p-hydroxybenzoate and
Propylparaben;The dosage of methyl p-hydroxybenzoate is the 0.16% of gelatin quality, propylparaben
Dosage is the 0.04% of gelatin quality.
D) pH=5.0 is adjusted, film liquid is made into, is defoamed at film liquid, plate will be laid at film liquid after defoaming
On, the rubber of sealed membrane is made, the rubber thickness of sealed membrane is 0.3mm-0.7mm, the rubber of sealed membrane put in a drying box,
Dry 6h, removes at 50 DEG C, and cooling film forming, it is spare to take off film at room temperature;
More specifically, the preparation method of gelatin microvesicle capsule 1 is model pressing, and the sphere diameter size of gelatin microvesicle capsule 1 can be with
It is adjusted according to dosage, for the vesicle internal diameter of biggish microvesicle patch up to 1-2cm, the vesicle internal diameter of lesser microvesicle patch is about 1-
2mm;The material of gelatin microvesicle capsule 1 is transparent, feel is soft and compact, and thickness of shell is between 0.3-0.7mm.Sealed membrane with a thickness of
0.3-0.7mm, size and utricule model agree with, and are the spherical empty slot of 0.1mm in the corresponding compacting radius of a ball in utricule center,
Easy fracture line is suppressed at utricule model interval location axis, is convenient for single medical separation;Gelatin microvesicle utricule and sealed membrane
Heat it is closely sealed, heat it is closely sealed refers to gelatin microvesicle utricule and sealed membrane it is whole under the conditions of certain temperature at utricule modal position
Partial melting is closely sealed.Adhesive film refers to viscous coating, for sheath to be sticked to sealed membrane, then at each easy fracture line edge
The isosceles right triangle for pasting a 0.2mm × 0.2mm in advance, forms easy sheet 5, sheath is opened when easy to use.Sheath is
Silicon oil release paper, and processing is split to sheath according to sealed membrane easy fracture line position.
The preparation method of gelatin microvesicle capsule 1 is:
The gelatin for taking certain mass adds water to be at least swollen 30min at room temperature, then at 50 DEG C of water-bath heating 1h stir to
It is completely dissolved, is configured to the gelatin solution that mass fraction is 12%;The mass ratio of addition glycerol, glycerol and gelatin is 1:1.5, is added
Enter preservative;Preservative is methyl p-hydroxybenzoate and propylparaben (methyl p-hydroxybenzoate and to hydroxyl
Propyl benzoate plays antisepsis simultaneously);The dosage of methyl p-hydroxybenzoate is the 0.16% of gelatin quality, para hydroxybenzene
The dosage of propyl formate is the 0.04% of gelatin quality, adjusts solution ph 5.0, film liquid is made into, at film liquid ultrasound defoaming
After 1-2min, is defoamed and (directly sprayed with alcohol watering can, according to foam volume by spraying with a small amount of dehydrated alcohol again after standing 10min
Deal on the merits of each case), being laid in centre has on the plate of round empty slot, the rubber of gelatin microvesicle capsule is made, rubber thickness is 0.3mm-
0.7mm suppresses intermediate empty slot part with round or ellipse mold, makes its concave shape at vesica, places it in after its molding
In drying box, dry 6h, is removed at 50 DEG C, and cooling film forming, it is spare to take off film at room temperature;
When sealed membrane 2 is gelatin sealed membrane, the preparation method of gelatin sealed membrane is:
The gelatin for taking certain mass adds water to be at least swollen 30min at room temperature, then heats 1-2h at 40-80 DEG C of water-bath
Stir to be completely dissolved be configured to mass fraction be 12% gelatin solution;The mass ratio of addition glycerol, glycerol and gelatin is 1:
1.5, preservative methyl p-hydroxybenzoate and propylparaben is added.Methyl p-hydroxybenzoate dosage is gelatin matter
The 0.16% of amount, propylparaben dosage are the 0.04% of gelatin quality, adjust solution ph 5.0, film liquid is made into,
At film liquid with after ultrasound defoaming 1-2min, is defoamed, is laid on plate by spraying with a small amount of dehydrated alcohol again after standing 10min,
The rubber of sealed membrane is made, rubber thickness is 0.3mm-0.7mm, and rubber is put in a drying box, and dry 6h, is moved at 50 DEG C
Out, cooling at room temperature to form a film, it is spare to take off film;
Adhesive film refers to viscous coating, for sheath to be sticked to sealed membrane, then pastes one at each easy fracture line edge
The isosceles right triangle edge strip of a 0.2mm × 0.2mm, edge strip are coated with adhesive on one side, are fixed on the side table of sealed membrane
Face is used to when use record date of manufacture or trade mark logo, and is pasted onto sheath edge, and sheath is opened when in order to use as original
Then.
Sheath can be square, rectangle, diamond shape or circle, sheath are silicon oil release paper.The utility model is provided
The microvesicle being administered continuously for acupuncture point be attached to safe satellite with patient, microvesicle patch transfers fast almost without absorbent properties
Degree depends on drug molecular structure and absorption rate.
The microvesicle provided by the utility model being administered continuously for acupuncture point pastes application method: removing sheath first, exposes
Adhesive film 3 is careful not to stretch gelatin microvesicle utricule and sealed membrane, pokes sealed membrane corresponding to gelatin microvesicle capsule opening,
Aperture is formed on sealed membrane, needs for microvesicle patch to be pasted onto suitable position (therapy target) according to patient, opening alignment sufferer
At position or acupuncture point;Preliminary fixed microvesicle patch, the viscose glue part for smoothing microvesicle patch periphery, which is fixed, completes.Microvesicle patch removes after
When, operator holds the edge of microvesicle patch, pastes microvesicle remove along the direction of fine hair at leisure.It is opened using with gelatin microvesicle capsule
The aperture being pierced on the corresponding sealed membrane in mouth place, by contained active drug ingredient, especially volatile ingredient is gradually
It is precipitated from gelatin microvesicle capsule, orientation reaches affected part, directly infiltration lesion deep tissue, promotes Drug Percutaneous Absorption, enhancing is controlled
Therapeutic effect.
The microvesicle patch provided by the utility model being administered continuously for acupuncture point may be implemented microvesicle by adhesive film and be attached to
Positioning function on skin is designed by the opening and sealed membrane of microvesicle capsule, drug storage function may be implemented, sealed when opening
Point type administration can be realized after film for acupuncture point, continued administration function is also able to achieve by the storage function of microvesicle capsule.
It is provided by the utility model for acupuncture point be administered continuously microvesicle patch be with the direct packaging medicine of gelatin microvesicle capsule,
Outer packing is directly opened when treatment, sealed membrane is punctured from central empty slot, is directly affixed on affected part or corresponding acupuncture point, it is rapid-action, it produces
Raw therapeutic effect is good, to skin without allergy and stimulate the reaction, and simple production process, environmental protection, it is quality controllable.It is given with point type
Medicine, packaging medicine are stable, are applicable in the controllable advantage of different pharmaceutical ingredient, dose.The utility model use through skin, mucous membrane,
The mode of acupuncture point channel administration can pass through the microvesicle such as the dysmenorrhea plaster prescription that Hong Zongguo is taught in conjunction with different shape drug ingedient
Patch acts on meridian point by effective ingredient Transdermal absorption method, by human epidermal, promotes and improve blood circulation
And the effect of Lymphatic Circulation, analgesia, detumescence and other effects are generated, reaches alleviation and inhibits the curative effect of illness institute pain.Clinical test
The result shows that having preferable therapeutic effect to diseases such as chronic lumbar strain, gonitis, soft tissue injury, dysmenorrheas;Other are such as
The mucous membranes such as oral mucosa, navel, anus and channel can also be directly administered using the dosage form.
After the microvesicle patch being administered continuously for acupuncture point of the utility model is made, exterior and interior packing is neat, easy to operate, can be straight
It connects and is affixed on skin, selected raw material is harmless, does not generate allergy and stimulate the reaction to skin.Using with gelatin microvesicle
The aperture being pierced on sealed membrane corresponding to capsule opening, by contained active drug ingredient, especially volatile ingredient
It is gradually precipitated from gelatin microvesicle capsule, orientation reaches affected part, directly infiltration lesion deep tissue, promotes Drug Percutaneous Absorption, increases
Strong therapeutic effect.
Claims (7)
1. a kind of microvesicle being administered continuously for acupuncture point pastes, it is characterised in that: the microvesicle being administered continuously for acupuncture point pastes packet
Include gelatin microvesicle capsule (1), sealed membrane (2), adhesive film (3) and sheath (4);The gelatin microvesicle capsule (1) is in middle empty balloon-shaped;Institute
It states glue microvesicle capsule (1) clearly and is equipped with opening, the one side of the sealed membrane (2) is connected with gelatin microvesicle capsule (1) hot melt and by gelatin
Closure of openings on microvesicle capsule (1);The another side of the sealed membrane (2) is connected by adhesive film (3) with sheath (4).
2. the microvesicle patch according to claim 1 being administered continuously for acupuncture point, it is characterised in that: described to continue for acupuncture point
The microvesicle patch of administration further includes the easy sheet (5) being arranged at sheath (4) bottom outer edge;The easy sheet (5) is triangular in shape;
Cohesive force between the easy sheet (5) and sheath (4) is greater than the cohesive force between sheath (4) and adhesive film (3).
3. the microvesicle patch according to claim 2 being administered continuously for acupuncture point, it is characterised in that: the gelatin microvesicle capsule
It (1) is one or more, projected area the sum of of the gelatin microvesicle capsule (1) on sealed membrane (2) is S1;The sealed membrane
(2) area is S2;S2 >=the S1.
4. the microvesicle patch according to claim 3 being administered continuously for acupuncture point, it is characterised in that: the gelatin microvesicle capsule
(1) when being multiple, multiple gelatin microvesicle capsules (1) are evenly arranged on sealed membrane (2) in matrix form.
5. the microvesicle patch according to claim 4 being administered continuously for acupuncture point, it is characterised in that: the gelatin microvesicle capsule
(1) when being multiple, easy fracture line is provided on the sealed membrane (2), adhesive film (3) and sheath (4);The sealed membrane
(2) position of the easy fracture line on, the easy fracture line on adhesive film (3) and the easy fracture line on sheath (4) coincides.
6. the microvesicle patch being administered continuously described according to claim 1 or 2 or 3 or 4 or 5 for acupuncture point, it is characterised in that: described
The thickness of shell of gelatin microvesicle capsule (1) is 0.3-0.7mm.
7. the microvesicle patch according to claim 6 being administered continuously for acupuncture point, it is characterised in that: the gelatin microvesicle capsule
(1) material is transparent;The thickness of the sealed membrane (2) is 0.3-0.7mm;The adhesive film (3) is viscous coating;It is described
Sheath (4) is silicon oil release paper;The sealed membrane (2) is plastic seal membrana oralis or gelatin sealed membrane.
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CN201820288353.XU CN209108398U (en) | 2018-03-01 | 2018-03-01 | A kind of microvesicle patch being administered continuously for acupuncture point |
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CN201820288353.XU CN209108398U (en) | 2018-03-01 | 2018-03-01 | A kind of microvesicle patch being administered continuously for acupuncture point |
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