CN209091721U - A kind of laboratory mice irrigation stomach device - Google Patents

Abstract

The utility model provides a kind of laboratory mice irrigation stomach device, needle holder side wall is equipped with groove, syringe head is equipped with clamping ring, clamping ring is embedded in groove, needle holder can be made around clamping ring rotation, so that gastric perfusion needle be made to rotate, gastric perfusion needle can be rotated while pushing away medicine in stomach-filling, make the medical fluid released can be with each position in homogeneous immersion stomach, to avoid the illness rate and the death rate that single position liquor strength is excessively high or pressure is excessive leads to the damage of mouse stomach, reduces mouse；For the vacuum environment for avoiding poor sealing between needle holder and syringe, destroying syringe, lead to not draw medical fluid, soft sealing ring is set between needle holder bottom and syringe inner wall, good sealing effect can be reached, again because its good elasticity rotates needle holder smoothly, to ensure that the success rate of stomach-filling.

Description

A kind of laboratory mice irrigation stomach device

Technical field

The utility model belongs to pharmaceutical test apparatus field, in particular to a kind of laboratory mice irrigation stomach device.

Background technique

Most of drug is used by way of oral in daily life, and drug passes through mesenterium/intestinal wall/abdominal cavity After capillary or lymphatic vessel pipe on wall absorb, it being back to portal vein -- liver enters lymphatic system reflux, intestines system through cisterna chyli Film upper section venous backflow has first pass effect to portal vein；Lower section has blood per rectum lower section vein to be directly entered body circulation, Flow back portal vein -- and some drugs will be eliminated by first close after liver.These processes can all lead to the loss of drug, it is considered that 80% or so of intravenous injection.Therefore, in the upstream development phase of medicament, by the administration mode of abdominal cavity stomach-filling to mouse Equal animals carry out pharmacological evaluation, have important role for the research of first pass effect.Traditional irrigation stomach device is equipped with syringe End syringe needle spherical in shape, it is possible thereby to which syringe needle is avoided to cause to damage to the gastrointestinal tract of mouse；But it often needs to keep single when stomach-filling One posture and single angle, therefore still mouse may be damaged due to topical agent excessive concentration.

Utility model content

In order to solve the above-mentioned technical problem, the utility model provides a kind of laboratory mice irrigation stomach device.

The utility model specific technical solution is as follows:

The utility model provides a kind of laboratory mice irrigation stomach device, including syringe, is inserted with core bar in the syringe, institute It states core bar tail portion and stretches out the syringe；The syringe head is equipped with needle holder, and the needle holder connects gastric perfusion needle, the gastric perfusion needle End is equipped with syringe needle spherical in shape；The outlet tube being connected to the syringe, the outlet tube and institute are equipped at the top of the needle holder Gastric perfusion needle connection is stated, the needle holder outer wall is equipped with the groove of annular, and the syringe head is equipped with compatible with the groove Be clamped ring, the clamping ring is embedded in the groove, the needle holder bottom equipped with soft sealing ring, the needle holder with it is described It is closely connected between syringe inner wall by the soft sealing ring.

Further, the syringe needle side wall is equipped with multiple through-holes.

Further, the gastric perfusion needle includes hour hand and minute hand, and the minute hand is plugged in the needle holder, the hour hand The syringe needle is connected, the minute hand is connected with the hour hand by hose.

Further, the irrigation stomach device further includes telescopic connecting rod, and the connecting rod both ends are separately connected the needle Headstock and the core bar tail portion, the syringe inner wall are equipped with internal screw thread, and the core bar head is equipped with block, and the block outer wall is set There is external screw thread compatible with the internal screw thread.

Further, the connecting rod includes the vertical pole of two cross bars of two cross bars and connection, two cross bars It is separately connected the needle holder and the core bar tail portion, the vertical pole includes the first vertical pole and the second hollow vertical pole, and described The outer diameter of one vertical pole is no more than the internal diameter of second vertical pole, and first vertical pole be plugged on far from described cross bar one end it is described In the one end of second vertical pole far from the cross bar and can in second vertical pole pull.

Further, the core bar tail portion is equipped with handle.

The beneficial effects of the utility model are as follows: the utility model provides a kind of laboratory mice irrigation stomach device, needle holder Side wall is equipped with groove, and clamping ring is embedded in groove equipped with clamping ring, needle holder can be made to rotate around clamping ring by syringe head, To make gastric perfusion needle rotate, gastric perfusion needle can be rotated while pushing away medicine in stomach-filling, make the medical fluid released can be with homogeneous immersion Each position in stomach, thus avoid that single position liquor strength is excessively high or pressure is excessive and cause the damage of mouse stomach, reduce it is small The illness rate and the death rate of mouse；For the vacuum environment for avoiding poor sealing between needle holder and syringe, destroying syringe, lead to not Draw medical fluid, soft sealing ring is set between needle holder bottom and syringe inner wall, can reach good sealing effect and Its good elasticity rotates needle holder smoothly, to ensure that the success rate of stomach-filling.

Detailed description of the invention

Fig. 1 is a kind of structural schematic diagram of laboratory mice irrigation stomach device described in embodiment 1；

Fig. 2 is the structural schematic diagram of needle holder in a kind of laboratory mice irrigation stomach device described in embodiment 1；

Fig. 3 is the structural schematic diagram of syringe needle in a kind of laboratory mice irrigation stomach device as described in example 2；

Fig. 4 is the structural schematic diagram of gastric perfusion needle in a kind of laboratory mice irrigation stomach device as described in example 2；

Fig. 5 is a kind of structural schematic diagram of laboratory mice irrigation stomach device described in embodiment 3.

Wherein: 1, syringe；11, it is clamped ring；2, core bar, 21, block；22, handle；3, needle holder；31, outlet tube；32, recessed Slot；33, soft sealing ring；4, gastric perfusion needle；41, syringe needle；42, through-hole；43, hour hand；44, minute hand；45, hose；5, connecting rod； 51, cross bar；52, the first vertical pole；53, the second vertical pole.

Specific embodiment

The utility model is described in further detail with following embodiment with reference to the accompanying drawing.

Embodiment 1

As shown in Fig. 1~2, the utility model embodiment 1 provides a kind of laboratory mice irrigation stomach device, including syringe 1, institute It states and is inserted with core bar 2 in syringe 1, the syringe 1 is stretched out in 2 tail portion of core bar；1 head of syringe is equipped with needle holder 3, described Needle holder 3 connects gastric perfusion needle 4, and 4 end of gastric perfusion needle is equipped with syringe needle 41 spherical in shape；It is equipped with and institute at the top of the needle holder 3 The outlet tube 31 of the connection of syringe 1 is stated, the outlet tube 31 is connect with the gastric perfusion needle 4, and 3 outer wall of needle holder is equipped with annular Groove 32,1 head of syringe are equipped with clamping ring 11 compatible with the groove 32, and the clamping ring 11 is embedded in the groove In 32,3 bottom of needle holder is equipped with soft sealing ring 33, passes through between 1 inner wall of the needle holder 3 and the syringe described soft Property sealing ring 33 closely connect.

Laboratory mice irrigation stomach device provided by the utility model, 3 side wall of needle holder are equipped with groove 32, and 1 head of syringe is equipped with It is clamped ring 11, clamping ring 11 is embedded in groove 32, needle holder 3 can be made to rotate around clamping ring 11, so that gastric perfusion needle 4 be made to revolve Turn, gastric perfusion needle 4 can be rotated while pushing away medicine in stomach-filling, makes the medical fluid released can be with each portion in homogeneous immersion stomach Position, so that avoiding that single position liquor strength is excessively high or pressure is excessive causes mouse stomach to damage, reduce mouse illness rate and The death rate.For the vacuum environment for avoiding poor sealing between needle holder 3 and syringe 1, destroying syringe 1, lead to not draw medical fluid, Soft sealing ring 33 (being made of rubber elastomeric material) is set between 1 inner wall of 3 bottom of needle holder and syringe, can be reached good Good sealing effect, and because its good elasticity rotates needle holder 3 smoothly, to ensure that the success rate of stomach-filling.

Embodiment 2

As shown in figs. 34, the present embodiment 2 provides a kind of laboratory mice irrigation stomach device on the basis of embodiment 1, It is characterized in that, 41 side wall of syringe needle is equipped with multiple through-holes 42.

When injection liquid, medical fluid can be flowed out from multiple through-holes 42 along different directions, can be into one under rotation status Step expands the area of medical fluid infiltration stomach, the injury for further increasing the uniformity coefficient of medical fluid, reducing it to mouse.

The gastric perfusion needle 4 includes hour hand 43 and minute hand 44, and the minute hand 44 is plugged in the needle holder 3, the hour hand The 43 connection syringe needles 41, the minute hand 44 and the hour hand 43 are connected by hose 45.

Minute hand 44 and hour hand 43 are connected by hose 45, since hose 45 can be bent, gastric perfusion needle 4 can be soft Bending is in various angles at pipe 45, and hose 45 can change angle with the character of enteron aisle during stomach-filling, to make stomach-filling Needle 4 can be protruded into smoothly in Mouse Stomach, thus reduce gastric perfusion needle to the injury of mouse, the success rate of raising stomach-filling.

Embodiment 3

As shown in figure 5, the present embodiment 3 provides a kind of laboratory mice irrigation stomach device on the basis of embodiment 1, further include Telescopic connecting rod 5,5 both ends of connecting rod are separately connected the needle holder 3 and 2 tail portion of core bar, in the syringe 1 Wall is equipped with internal screw thread, and 2 head of core bar is equipped with block 21, and 21 outer wall of block is equipped with compatible with the internal screw thread outer Screw thread.The connecting rod 5 includes the vertical pole of two cross bars 51 of two cross bars 51 and connection, and two cross bars 51 connect respectively Connecing the needle holder 3 and 2 tail portion of core bar, the vertical pole includes the first vertical pole 52 and the second hollow vertical pole 53, and described the The outer diameter of one vertical pole 52 is no more than the internal diameter of second vertical pole 53, and first vertical pole 52 is inserted far from described 51 one end of cross bar Connect in the one end of second vertical pole 53 far from the cross bar 51 and can in second vertical pole 53 pull.

By the above structure of connecting rod 5, core bar 2 and needle holder 3 are connected, rotate synchronously the two can；It will Vertical pole is divided into the first vertical pole 52 and the second hollow vertical pole 53, and the first vertical pole 52 can be inserted in the second vertical pole 53 and along Two vertical poles, about 53 pull, so that vertical pole be allow flexibly to change length with the movement of core bar 2 in suction or injection liquid. In use, rotation core bar 2 can drive needle holder 3 to rotate by connecting rod 5, while the rotation of block 21 is also rotated with core bar 2, due to Block 21 is matched with 1 inner wall of syringe by internal and external threads, therefore block 21 can be pushed away gradually into syringe 1 in rotary course Into so that medical fluid is released outlet tube 31 and is sent into Mouse Stomach from gastric perfusion needle 4.By above structure, rotary core can be passed through Bar 2 is synchronous to realize 3 two functions of injection liquid and rotary needle headstock.

The rotation of core bar 2 is controlled by handle 22 in the also settable handle 22 in 2 tail portion of core bar for convenience of use.

The utility model is not limited to above-mentioned preferred forms, anyone can obtain under the enlightenment of the utility model Other various forms of products, however, make any variation in its shape or structure, it is all that there is same as the present application or phase Approximate technical solution, all falls within the protection scope of the utility model.

Claims (6)

1. a kind of laboratory mice irrigation stomach device, which is characterized in that including syringe (1), core bar (2) are inserted in the syringe (1), The syringe (1) is stretched out in core bar (2) tail portion；Syringe (1) head is equipped with needle holder (3), needle holder (3) connection Gastric perfusion needle (4), gastric perfusion needle (4) end are equipped with syringe needle (41) spherical in shape；It is equipped with and the needle at the top of the needle holder (3) The outlet tube (31) of cylinder (1) connection, the outlet tube (31) connect with the gastric perfusion needle (4), and needle holder (3) outer wall is equipped with The groove (32) of annular, syringe (1) head are equipped with the groove (32) compatible clamping ring (11), the clamping ring (11) it is embedded in the groove (32), needle holder (3) bottom is equipped with soft sealing ring (33), the needle holder (3) and institute It states and is closely connected between syringe (1) inner wall by the soft sealing ring (33).

2. laboratory mice irrigation stomach device as described in claim 1, which is characterized in that syringe needle (41) side wall is equipped with multiple logical Hole (42).

3. laboratory mice irrigation stomach device as described in claim 1, which is characterized in that the gastric perfusion needle (4) includes hour hand (43) With minute hand (44), the minute hand (44) is plugged on the needle holder (3), and the hour hand (43) connects the syringe needle (41), institute Minute hand (44) and the hour hand (43) is stated to connect by hose (45).

4. laboratory mice irrigation stomach device as described in claim 1, which is characterized in that further include telescopic connecting rod (5), institute It states connecting rod (5) both ends and is separately connected the needle holder (3) and the core bar (2) tail portion, syringe (1) inner wall is equipped with interior spiral shell Line, core bar (2) head are equipped with block (21), and block (21) outer wall is equipped with outer spiral shell compatible with the internal screw thread Line.

5. laboratory mice irrigation stomach device as claimed in claim 4, which is characterized in that the connecting rod (5) includes two cross bars (51) and connection two cross bars (51) vertical pole, two cross bars (51) be separately connected the needle holder (3) with it is described Core bar (2) tail portion, the vertical pole include the first vertical pole (52) and hollow the second vertical pole (53), first vertical pole (52) outside Diameter is no more than the internal diameter of second vertical pole (53), and first vertical pole (52) is plugged on institute far from the cross bar (51) one end State the second vertical pole (53) far from the cross bar (51) one end in and can be in the interior pull of second vertical pole (53).

6. laboratory mice irrigation stomach device as claimed in claim 5, which is characterized in that core bar (2) tail portion is equipped with handle (22)。