CN209075800U - A kind of head end sets the releasable microtubular of double coatings - Google Patents
A kind of head end sets the releasable microtubular of double coatings Download PDFInfo
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- CN209075800U CN209075800U CN201820506992.9U CN201820506992U CN209075800U CN 209075800 U CN209075800 U CN 209075800U CN 201820506992 U CN201820506992 U CN 201820506992U CN 209075800 U CN209075800 U CN 209075800U
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Abstract
The utility model relates to the releasable microtubulars that a kind of head end sets double coatings, including microtubular main body, the catheter block of one end connection of the microtubular main body, the other end of the microtubular main body is also connected with disengageable microtubular head end, microtubular head end outer surface is coated with expandable internal layer coating, and also sealing compresses to be coated with and can be changed loose outer coating on the internal layer coating.The utility model has the beneficial effects that the curative thrombosis rate of Minimally Interventional Therapy cerebrovascular malformation can be improved, the bleeding of complication caused by backflowing because of liquid embolizing agent and embolism not total correlation is reduced, simplifies therapeutic process, reduces financial burden.
Description
Technical field
The utility model relates to the design of medical microtubular, specifically a kind of head end sets the releasable microtubular of double coatings.
Background technique
Cerebral arteriovenous malformation (arterioovenous malformation, AVM) is the common congenital vascular disease of encephalic
Disease, treatment method mainly include operation excision, Endovascular Embolization and stereotactic radiotherapy.In recent years, with embolism material
The progress of material and technology, has become using new liquid suppository (Onyx, Phil etc. call " glue " in the following text) Endovascular Treatment of External
A kind of important method for treating brain AVM.Backflowing for a small amount of suppository is usually required in embolic processes, to block proximal end blood supply dynamic
Arteries and veins, to guarantee subsequent injecting glue preferably to target position disperse.But the glue to backflow may cause kinds of risks, first is that backflowing
Feeding artery into normal cerebral tissue leads to cerebral infarction, and on the other hand the viscous conduit of meeting, pull out it can not, or lead in tube drawing
Cause angiorrhoxis bleeding risk.And due to worrying that both risks will lead to deficiency of backflowing, can not make glue sufficiently to
Intralesional disperse, to be unable to reach the set goal.Microtubular (the detachable tip of head end releasable design
Microcatheter, DTM) it has been applied to clinic in recent years, and significantly reduce difficulty in decannulation and relevant complication.But
Backflowing causes natural arterial occlusion to be still important potential risk.It can be led at present by another microtubular of cooperation to embolism is micro-
Pipe proximal end filling spring ring or the help of injecting medicinal glue block proximal end blood flow, and this technology is referred to as " pressure cooker technology ".Facing
The validity of this technology is had confirmed in bed practice, but operationally since the operation of double duct increases the complexity of operation
Degree, postoperative complication rate and surgery cost.And the diameter of feeding artery also will limit the application of this technology, when blood supply is dynamic
When arteries and veins diameter is meticulous, two conduits can not be made while carrying out aforesaid operations in place.
Utility model content
The purpose of the utility model is to overcome the deficiencies in the prior art, solve single microtubular and realize " pressure cooker technology " behaviour
Make complicated problem.
To reach above-mentioned purpose of utility model, the releasable microtubular that a kind of head end sets double coatings, including microtubular are provided
Main body, the catheter block of one end connection of the microtubular main body, the other end of the microtubular main body is also connected with disengageable
Microtubular head end, microtubular head end outer surface are coated with expandable internal layer coating, and also sealing is pressed on the internal layer coating
Hard-pressed bale, which is covered with, can be changed loose outer coating.
Catheter block is for transferring；Microtubular main body is one section for entering the big blood vessel of patient, is traditionally arranged to be tubulose；It is micro-
Conduit head end selects distal vessels part for super, is traditionally arranged to be tubulose or rod-shaped.In use, seal wire or injecting fluid are by leading
Tube socket enters microtubular.
The connecting portion of microtubular head end sets expansion tube, and the distal end caliber for comparing microtubular head end increases, microtubular master
Body is inserted into the distal end of expansion tube, microtubular main body can be made to disconnect from expansion tube by pulling microtubular in vitro.
Sealing compress refer to the internal layer coating it is fully wrapped around live, be allowed to not contact with external environment, at the same maintenance in
Layer coating is in compressive state before being delivered to target blood.
Variable loosely to refer to outer coating after specifically physically or chemically reacting, the form that this sealing compresses becomes
Situations such as loose/thawing/dissolution/degradation, the internal layer coating material for allowing originally be closed in it internal touch the external world.
Preferably, the internal layer coating is the ring structure for being placed on microtubular head end outer peripheral surface, the ring structure setting
In the position on microtubular head end close to microtubular main body one end.
The ring structure for being placed on microtubular head end outer peripheral surface refers to continuously to be coated in the circumferential direction of microtubular head end.
Preferably, the internal layer coating is the ring structure for being placed on microtubular head end outer peripheral surface, and multiple ring structures it
Between spaced apart.
Spaced apart can also be described as, and be fixed on outside microtubular head end pipe in segmental annular in the longitudinal direction.Ring
Gap between shape structure can direct exposed microtubular head end pipe, can also be filled with outer coating.
Preferably, the internal layer coating is hydrogel foam material.
The characteristic of hydrogel foam material is hydrophilic, macropore, polymerization, generally can be used and contains foam stabiliser and can be free
The polymer or copolymer of the cross-linking agents of the hydrophilic olefinic monomer and polyenoid functional group of base polymerization.
Preferably, developer is added in the hydrogel foam material.
Tantalum powder generally can be used in developer.
Preferably, the internal layer coating composition is mainly that homogeneous is laid with the particle being fixed on microtubular head end outer peripheral surface,
The outer coating is wrapped in particle exterior surface.
The particle modes such as inlays by binder or physics, is connected to outside microtubular head end in the form of non-releasable
Surface.
Preferably, the outer coating ingredient is a kind of material for contacting with dimethyl sulfoxide and degradation occurring and is insoluble in water
Material.
The material generally optional 3,3 ', 4,4 '-two that degradation occurs and is insoluble in water is contacted with dimethyl sulfoxide (DMSO)
Main component of the benzene sulfone tetracarboxylic dianhydride (DSDA) as outer coating.
Preferably, the outer coating is the temperature sensitive coating of a little higher than human body of critical point.
The temperature sensitive coating that this place refers to is disintegrated under a little higher than human body temperature.In application, using the micro-wire of heating
Or the injection of short duration entrance of hot-salt solution, outer coating can melt degradation.
Preferably, the outer coating is water-soluble degradation material.
Starch, chitosan etc. can be selected in water-soluble degradation material.
Preferably, the close terminal position of the microtubular head end and close another end position of microtubular main body respectively have one
A developing mark.
The end of microtubular head end refers to the end on microtubular head end far from microtubular main body, i.e. its free end.It is micro- to lead
The other end of pipe main body is the end for referring to microtubular main body connection microtubular head end side.Developing mark is all disposed in proximity to end
End position.
Developing mark may be configured as the ring-type for being placed on microtubular head end, microtubular body outer surface, to promote it in blood
Recognizable angle in pipe.
There is outer coating protection outside internal layer coating, on the one hand improves the passability of conduit, on the other hand avoid internal layer coating
Premature inflation；Microtubular in place after, internal layer coating slowly expands after meeting blood, can block the vascular flow completely, effectively anti-
Suppository only occurs during injected plug to backflow；Due to microtubular head end sufficiently fixed after internal layer coating expansion, note is completed
After glue, in disengaged position, detachment microtubular ontology will be more easier, and reduce tube drawing related complication.
The ring structure of internal layer coating constructs, and the outer peripheral surface of microtubular head end is seamlessly wrapped up, to avoid expanding
Microtubular head end itself is contacted with vascular wall afterwards, reduces the generation of related complication；And ring structure is set to microtubular head end
The upper position close to microtubular main body one end, reduces the invalid usage amount of glue.
Spaced apart between multiple ring structures can avoid that microtubular head end compliance is made to be deteriorated, increase it in tortuous blood
Handling capacity in pipe, while increasing the whole frictional force with blood vessel of internal layer coating.
Internal layer coating uses hydrogel foam material, has self-aggrandizement ability after meeting blood, using containing foam stabiliser
After the polymer or copolymer of the cross-linking agents of the hydrophilic olefinic monomer and polyenoid functional group of free redical polymerization, diameter
25 times or more can be increased, hydrogel is not easy to produce stimulation to vascular wall；On the other hand, if you need to accelerated expansion, can also pass through through
By microtubular ontology injection salting liquid enhancing and promote expansion, microtubular ontology outlet with coating close in the case where, can in fact
The quick response now expanded.
Developer, such as tantalum powder are added in hydrogel foam material, keep implantation material visible by conventional image technology.
Homogeneous is laid with fixed particle, avoids the surface layer rupture that hydrogel may occur during expansion, reduces and therefore produce
Raw a possibility that predicting outer gap, so that the controllability for blocking efficiency is promoted.
When outer coating is using contacting generation degradation with dimethyl sulfoxide and being insoluble in material (such as DSD A) of water, leading
Pipe can promote coating degradation after in place to intravascular injection dimethyl sulfoxide (DMSO), and it is swollen that internal layer hydrogel is exposed to blood generation
It is swollen.
When outer coating uses the temperature sensitive coating of a little higher than human body of critical point, it can allow it under a little higher than human body temperature
Realize disintegration；When necessary, it is possible to use the of short duration entrance of micro-wire or injection hot-salt solution of heating is so that outer melting layer, leads micro-
Tube body outlet in the case where, is able to achieve the quick response of expansion with coating.
Outer coating using water-soluble degradation material, such as starch, chitosan so that internal layer coating be able to postpone it is swollen
It is swollen.
The setting of two developing marks, so that the positioning in the blood vessels of the distal end of clear microtubular and embolism under fluoroscopy
The relative position of agent and with whether finally successfully free.
In use, outer coating maintains internal layer coating to be in compressive state before being delivered to target blood, microtubular is arrived
Outer coating slowly becomes loosely to expose internal layer coating water swelling, occluded blood vessel blocking blood flow after up to target position.
The utility model has the beneficial effects that the curative thrombosis rate of Minimally Interventional Therapy cerebrovascular malformation can be improved, reduce
The bleeding of complication caused by backflowing because of liquid embolizing agent and embolism not total correlation, simplifies therapeutic process, reduces financial burden.
Detailed description of the invention
Fig. 1 is the overall schematic of the utility model.
Wherein:
1- microtubular main body 2- catheter block 3- microtubular head end
4- internal layer coating 5- outer coating 6- developing mark
Specific embodiment
Below in conjunction with the drawings and specific embodiments, the utility model is described further.
A kind of head end according to figure 1 sets the releasable microtubular of double coatings, including microtubular main body 1, described micro- to lead
The catheter block 2 of one end connection of pipe main body 1, catheter block 2 use female Luer, and the female Luer is for connecting other Medical Devices
Conduit or injecting fluid such as syringe, or for being inserted into seal wire enter microtubular main body 1；The connecting portion of microtubular head end 3
If expansion tube, the distal end caliber for comparing microtubular head end 3 increases, and microtubular main body 1 is inserted into the distal end of expansion tube, allows to
Microtubular main body 1 is disconnected from expansion tube by pulling microtubular in vitro；The other end of the microtubular main body 1 is also connected with
Disengageable microtubular head end 3,3 outer surface of microtubular head end are coated with expandable internal layer coating 4, the internal layer coating
Also sealing compression is coated with and can be changed loose outer coating 5 on 4.
The internal layer coating 4 is the ring structure for being placed on 3 outer peripheral surface of microtubular head end, and the ring structure is set to micro- lead
The position of close described 1 one end of microtubular main body on tube head end 3, and spaced apart between multiple ring structures.The internal layer applies
Layer 4 is hydrogel foam material, specifically a kind of hydrophilic olefinic monomer containing foam stabiliser and free redical polymerization and more
The polymer or copolymer of the cross-linking agents of alkene functional group.Developer, developer tool are added in the hydrogel foam material
Body is tantalum powder.4 ingredient of internal layer coating is mainly that homogeneous is laid with the particle being fixed on 3 outer peripheral surface of microtubular head end, described
Outer coating 5 is wrapped in particle exterior surface.The close terminal position of the microtubular head end 3 and microtubular main body 1 close to another
One end position respectively has a developing mark 6.
5 ingredient of outer coating can be there are three types of specific embodiment, the first is dropped to contact with dimethyl sulfoxide
The material for solving and being insoluble in water specifically can be 3,3 ', 4,4 '-diphenylsulfone acid's dianhydrides (DSDA)；Second is critical point
The temperature sensitive coating of a little higher than human body；The third is water-soluble degradation material, specifically can be starch, chitosan etc..
Biodegradable polycaprolactone and starch acetate ester blend can be used in the specific material of temperature sensitive coating, then
It is that initiator is crosslinked by benzoyl peroxide, ultimately forms coating of the fusing point at 50 DEG C or so.
Foam stabiliser and polymerizable hydrophilic of free radical can be used in the specific material of hydrogel foam material and its proportion
The condensate or copolymer (such as acrylamide and polyacrylate sodium be cross-linked to form copolymer) of olefinic monomer, wherein the monomer with
The polyene functional cross-link agent of about 0.1%-10% weight is crosslinked；This foam matrix is characterized in that quickly swelling and high water swelling
Rate.It can also be the materials such as porous hydration polyvinyl alcohol foam (PAF) gel, polymethylacrylic acid -2- hydroxyl ethyl ester (PHEMA)
Matter.
The preferred embodiment of the present invention has been described in detail above, but the invention be not limited to it is described
Embodiment, those skilled in the art can also make various etc. on the premise of not violating the inventive spirit of the present invention
Same variation or replacement, these equivalent modifications or replacement are all included in the scope defined by the claims of the present application.
Claims (10)
1. a kind of head end sets the releasable microtubular of double coatings, including microtubular main body, one end connection of the microtubular main body
Catheter block, which is characterized in that the other end of the microtubular main body is also connected with disengageable microtubular head end, described micro- to lead
Tube head end outer surface is coated with expandable internal layer coating, on the internal layer coating also sealing compress be coated with it is variable loose outer
Layer coating.
2. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the internal layer coating is
It is placed on the ring structure of microtubular head end outer peripheral surface, the ring structure is set on microtubular head end close to the microtubular master
The position of body one end.
3. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the internal layer coating is
It is placed on the ring structure of microtubular head end outer peripheral surface, and spaced apart between multiple ring structures.
4. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the internal layer coating is
Hydrogel foam material.
5. the releasable microtubular that head end according to claim 4 sets double coatings, which is characterized in that the hydrogel foam
Developer is added in material.
6. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the internal layer coating at
Predominantly homogeneous is divided to be laid with the particle being fixed on microtubular head end outer peripheral surface, the outer coating is wrapped in particle exterior surface.
7. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the outer coating at
It is divided into a kind of material for contacting with dimethyl sulfoxide and degradation occurring and is insoluble in water.
8. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the outer coating is
The temperature sensitive coating of a little higher than human body of critical point.
9. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the outer coating is
Water-soluble degradation material.
10. the releasable microtubular that head end according to claim 1 sets double coatings, which is characterized in that the microtubular head
The close terminal position at end and close another end position of microtubular main body respectively have a developing mark.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201820506992.9U CN209075800U (en) | 2018-04-11 | 2018-04-11 | A kind of head end sets the releasable microtubular of double coatings |
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| CN201820506992.9U CN209075800U (en) | 2018-04-11 | 2018-04-11 | A kind of head end sets the releasable microtubular of double coatings |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434580A (en) * | 2018-04-11 | 2018-08-24 | 上海长海医院 | A kind of head end sets the releasable microtubular of double coatings |
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2018
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434580A (en) * | 2018-04-11 | 2018-08-24 | 上海长海医院 | A kind of head end sets the releasable microtubular of double coatings |
| CN108434580B (en) * | 2018-04-11 | 2024-04-30 | 上海长海医院 | Releasable microcatheter with double-coating at head end |
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